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The map label for this gene is lpxD [H]

Identifier: 220932600

GI number: 220932600

Start: 1888884

End: 1889930

Strand: Reverse

Name: lpxD [H]

Synonym: Hore_17640

Alternate gene names: 220932600

Gene position: 1889930-1888884 (Counterclockwise)

Preceding gene: 220932601

Following gene: 220932599

Centisome position: 73.31

GC content: 47.09

Gene sequence:

>1047_bases
ATGGTGGTAATGGACAGGGAGAAAAATAGTTATACGGCCCGGGAACTGGCCCACCTGGTGGGTGGAGAACTGGTTGGAGA
CCCCGACCTGGTTATCAAGGGGGTCAGCGGTGTTGGAGAAAGCAGGCCAGACACTGTTACCTTTGCTGAAAATTCCACTT
ATTTAGACAAGGCTGAACAGTCCAGAGCAGGGTTAGTTATTGTTCCCGAGGAGATAGAGGAGAGTAGCAAAAATATAATC
AGGGTTAAAAATCCCCGTCTGGCCTTTGCCAGAATTGCTTCCCATTTTGCCCCTGATATGCTGTATCGCCCCGGGATAGA
TGAGACTGCTGTTATTTCCAGTACTGCCTGTATTGGGGAGGATGTATCCATTCATCCCCATGTAGTTATTGATAAAGAGG
CAGTAATTGGTGACAGGGTTATACTTGCTCCCGGGGTCTATGTAGGTCCCGGGGTGGAAATTGGGGATGATACAGTCATC
CATGCCAATGTTGTTATTGAGTATGATACTGTTATTGGTAGTAATGTTATTATCCACGGGGGAACTGTTATCGGATCTGA
TGGTTATGGTTTTGTGACTGATGAAAAAGGCCATCATAAAATTCCCCAGTTGGGGAATGTTATTATTGAAGATAATGTAG
AAATCGGGGCCAATGTTACTGTAGACCGCGGTACCAGTGGGCCGACTGTAATAAAACAGGGGACCAAGATCGATAACCTG
GTTCAGGTTGCCCATAATGTTCAGGTTGGAGAGGAAAACTTAATTGTGGCCCAGGTCGGGGTTGCCGGTAGTACCAGGCT
CGGCCGGCGTGTTACCCTGGCAGGAAAAGTCGGGGTGGCCGGTCATATTGAGCTCGGTGATAATAGTACTATTGCTGCTG
GAAGCATAGTTACCAAGAATACCCCCTCAGGGGTTTTTTATTCTGGCAACCCGGCTCATGACCATCGGGAGGAATTGAAG
GAACAGGCTGCAAAAAGAAGACTACCGGAATTGCTTAAAAAAGTTAAGGAGCTGGAAAAAAGAATACAGGAACTTGAAAG
GAGCTAG

Upstream 100 bases:

>100_bases
AACCTGGATGTAGTTGTAGATAAAAATAGTACCTATTATGGTGGAATTGACATTACAGGAGAAGTTATAGAACGTCTAGA
TGAAATAGCTGGAGAGGATG

Downstream 100 bases:

>100_bases
CTGAAATGAAGAAGATTACCCTGTTTATGTTTCTGTTTCTATTCCTTGTGGCTGTAAATGGTGTATCAGAGGCAGTAGTT
AAGGGAGAGCTGGTTAATAT

Product: UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVVMDREKNSYTARELAHLVGGELVGDPDLVIKGVSGVGESRPDTVTFAENSTYLDKAEQSRAGLVIVPEEIEESSKNII
RVKNPRLAFARIASHFAPDMLYRPGIDETAVISSTACIGEDVSIHPHVVIDKEAVIGDRVILAPGVYVGPGVEIGDDTVI
HANVVIEYDTVIGSNVIIHGGTVIGSDGYGFVTDEKGHHKIPQLGNVIIEDNVEIGANVTVDRGTSGPTVIKQGTKIDNL
VQVAHNVQVGEENLIVAQVGVAGSTRLGRRVTLAGKVGVAGHIELGDNSTIAAGSIVTKNTPSGVFYSGNPAHDHREELK
EQAAKRRLPELLKKVKELEKRIQELERS

Sequences:

>Translated_348_residues
MVVMDREKNSYTARELAHLVGGELVGDPDLVIKGVSGVGESRPDTVTFAENSTYLDKAEQSRAGLVIVPEEIEESSKNII
RVKNPRLAFARIASHFAPDMLYRPGIDETAVISSTACIGEDVSIHPHVVIDKEAVIGDRVILAPGVYVGPGVEIGDDTVI
HANVVIEYDTVIGSNVIIHGGTVIGSDGYGFVTDEKGHHKIPQLGNVIIEDNVEIGANVTVDRGTSGPTVIKQGTKIDNL
VQVAHNVQVGEENLIVAQVGVAGSTRLGRRVTLAGKVGVAGHIELGDNSTIAAGSIVTKNTPSGVFYSGNPAHDHREELK
EQAAKRRLPELLKKVKELEKRIQELERS
>Mature_348_residues
MVVMDREKNSYTARELAHLVGGELVGDPDLVIKGVSGVGESRPDTVTFAENSTYLDKAEQSRAGLVIVPEEIEESSKNII
RVKNPRLAFARIASHFAPDMLYRPGIDETAVISSTACIGEDVSIHPHVVIDKEAVIGDRVILAPGVYVGPGVEIGDDTVI
HANVVIEYDTVIGSNVIIHGGTVIGSDGYGFVTDEKGHHKIPQLGNVIIEDNVEIGANVTVDRGTSGPTVIKQGTKIDNL
VQVAHNVQVGEENLIVAQVGVAGSTRLGRRVTLAGKVGVAGHIELGDNSTIAAGSIVTKNTPSGVFYSGNPAHDHREELK
EQAAKRRLPELLKKVKELEKRIQELERS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=334, Percent_Identity=35.9281437125749, Blast_Score=198, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37196; Mature: 37196

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVMDREKNSYTARELAHLVGGELVGDPDLVIKGVSGVGESRPDTVTFAENSTYLDKAEQ
CEEEECCCCCHHHHHHHHHHCCCCCCCCHHEEEECCCCCCCCCCEEEEECCCCHHHHHHH
SRAGLVIVPEEIEESSKNIIRVKNPRLAFARIASHFAPDMLYRPGIDETAVISSTACIGE
CCCCEEEECHHHHCCCCCEEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHEEECHHHCCC
DVSIHPHVVIDKEAVIGDRVILAPGVYVGPGVEIGDDTVIHANVVIEYDTVIGSNVIIHG
CCCCCCEEEEECCHHCCCEEEEECCEEECCCCCCCCCEEEEEEEEEEEECCCCCCEEEEC
GTVIGSDGYGFVTDEKGHHKIPQLGNVIIEDNVEIGANVTVDRGTSGPTVIKQGTKIDNL
CEEECCCCCEEEECCCCCCCCCCCCCEEEECCCEECCEEEEECCCCCCCEEECCCCHHHH
VQVAHNVQVGEENLIVAQVGVAGSTRLGRRVTLAGKVGVAGHIELGDNSTIAAGSIVTKN
HHHHHHCEECCCCEEEEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCEEEECEEEECC
TPSGVFYSGNPAHDHREELKEQAAKRRLPELLKKVKELEKRIQELERS
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVMDREKNSYTARELAHLVGGELVGDPDLVIKGVSGVGESRPDTVTFAENSTYLDKAEQ
CEEEECCCCCHHHHHHHHHHCCCCCCCCHHEEEECCCCCCCCCCEEEEECCCCHHHHHHH
SRAGLVIVPEEIEESSKNIIRVKNPRLAFARIASHFAPDMLYRPGIDETAVISSTACIGE
CCCCEEEECHHHHCCCCCEEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHEEECHHHCCC
DVSIHPHVVIDKEAVIGDRVILAPGVYVGPGVEIGDDTVIHANVVIEYDTVIGSNVIIHG
CCCCCCEEEEECCHHCCCEEEEECCEEECCCCCCCCCEEEEEEEEEEEECCCCCCEEEEC
GTVIGSDGYGFVTDEKGHHKIPQLGNVIIEDNVEIGANVTVDRGTSGPTVIKQGTKIDNL
CEEECCCCCEEEECCCCCCCCCCCCCEEEECCCEECCEEEEECCCCCCCEEECCCCHHHH
VQVAHNVQVGEENLIVAQVGVAGSTRLGRRVTLAGKVGVAGHIELGDNSTIAAGSIVTKN
HHHHHHCEECCCCEEEEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCEEEECEEEECC
TPSGVFYSGNPAHDHREELKEQAAKRRLPELLKKVKELEKRIQELERS
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA