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The map label for this gene is lpxC [H]

Identifier: 220932593

GI number: 220932593

Start: 1877783

End: 1878649

Strand: Reverse

Name: lpxC [H]

Synonym: Hore_17570

Alternate gene names: 220932593

Gene position: 1878649-1877783 (Counterclockwise)

Preceding gene: 220932594

Following gene: 220932592

Centisome position: 72.87

GC content: 41.06

Gene sequence:

>867_bases
ATGTTTATTGATGGTAATTTACAGCAAACTATAGAAAAACCTGTTAAGGCTTCAGGAACGGCACTCCACACCGGTAAAGA
AGTTAATGTCAGGTTTCTTCCGGCCGGTGAAGATACGGGAGTAGTCTTCAAAAGAGTTGATTTGCCAGATAACCCGGAGA
TCAAGGCTGAGCCATGGCAGGTTGTATCAACCAGGAGATGTACCAGTATTGGCCTTTCTAAAGATAGTGATTCTCCTAAG
GTTCATACAATTGAGCATTTAATGGCCGCCCTGTGGGCCCTGGAAATAGATAATGTTATTGTTGAAATTGATGCGCCAGA
AACACCTGTTATGGATGGGAGTGCCCTTCCCTATCTGAAATTGCTTAAAAAAGCAGGTATCAGAGAATTGAGTTCACCCA
GAAAAATATGGGTGATTGATGAGCCTGTCTGGGTAAAAAGGGGTCATATGTATATGGTCATTTTACCCTATGATGGGTTT
AAAATAAGTTATACCCTTGATTATGACCACAAGGTTATTGGGACCCAGTTTTTTGAGTTTGATAAAGGTGAAAATTCCTT
TGAAGAGGAGATTGCTCCGGCCAGGACATTTGGTTTTGAAAGGGAAGTAGAGGCTCTACATAGAAGGGGCCTGGCTTTAG
GTGGCAGTCTTGAGAATGCTGTCCTCATCGGAGATGAGGATACTGTAAATCCTTTAAGGTTTTCTAATGAATTTGTCAGG
CATAAGATTCTGGATGTAATAGGTGATATGGCTTTAAATGGATTTGTTTCGGGACATATAATAACCGTCAGGTCAGGCCA
TTCCTTACACGTTGAATTAGCTCAGGAGATTAATAAAAAACTTATACAGGAGAGTGAACGAGTATGA

Upstream 100 bases:

>100_bases
GTATAAAAGCATCATAAATTACTATTAATTAATATATTTTTGCAGGATTTTTGTCATAATCTCTTGAATAAATATATATT
CAGAAGGGAGGGAGGGAACT

Downstream 100 bases:

>100_bases
TGTATATCCAGGATATTAAAAATATACTACCACACCGGTTCCCTTTCTTGCTGGTTGATAGAATTACAGAGTTAGAGCCT
GGTAAAAAAGTAGTTGGTTT

Product: UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MFIDGNLQQTIEKPVKASGTALHTGKEVNVRFLPAGEDTGVVFKRVDLPDNPEIKAEPWQVVSTRRCTSIGLSKDSDSPK
VHTIEHLMAALWALEIDNVIVEIDAPETPVMDGSALPYLKLLKKAGIRELSSPRKIWVIDEPVWVKRGHMYMVILPYDGF
KISYTLDYDHKVIGTQFFEFDKGENSFEEEIAPARTFGFEREVEALHRRGLALGGSLENAVLIGDEDTVNPLRFSNEFVR
HKILDVIGDMALNGFVSGHIITVRSGHSLHVELAQEINKKLIQESERV

Sequences:

>Translated_288_residues
MFIDGNLQQTIEKPVKASGTALHTGKEVNVRFLPAGEDTGVVFKRVDLPDNPEIKAEPWQVVSTRRCTSIGLSKDSDSPK
VHTIEHLMAALWALEIDNVIVEIDAPETPVMDGSALPYLKLLKKAGIRELSSPRKIWVIDEPVWVKRGHMYMVILPYDGF
KISYTLDYDHKVIGTQFFEFDKGENSFEEEIAPARTFGFEREVEALHRRGLALGGSLENAVLIGDEDTVNPLRFSNEFVR
HKILDVIGDMALNGFVSGHIITVRSGHSLHVELAQEINKKLIQESERV
>Mature_288_residues
MFIDGNLQQTIEKPVKASGTALHTGKEVNVRFLPAGEDTGVVFKRVDLPDNPEIKAEPWQVVSTRRCTSIGLSKDSDSPK
VHTIEHLMAALWALEIDNVIVEIDAPETPVMDGSALPYLKLLKKAGIRELSSPRKIWVIDEPVWVKRGHMYMVILPYDGF
KISYTLDYDHKVIGTQFFEFDKGENSFEEEIAPARTFGFEREVEALHRRGLALGGSLENAVLIGDEDTVNPLRFSNEFVR
HKILDVIGDMALNGFVSGHIITVRSGHSLHVELAQEINKKLIQESERV

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=278, Percent_Identity=40.6474820143885, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32312; Mature: 32312

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIDGNLQQTIEKPVKASGTALHTGKEVNVRFLPAGEDTGVVFKRVDLPDNPEIKAEPWQ
CEECCCHHHHHHHHHHCCCCEEECCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCHH
VVSTRRCTSIGLSKDSDSPKVHTIEHLMAALWALEIDNVIVEIDAPETPVMDGSALPYLK
HHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCEEEEECCCCCCCCCCCCCHHHH
LLKKAGIRELSSPRKIWVIDEPVWVKRGHMYMVILPYDGFKISYTLDYDHKVIGTQFFEF
HHHHCCHHHCCCCCEEEEECCCCEEECCCEEEEEEECCCEEEEEEECCCCEEECCEEEEC
DKGENSFEEEIAPARTFGFEREVEALHRRGLALGGSLENAVLIGDEDTVNPLRFSNEFVR
CCCCCHHHHHHCHHHHCCCHHHHHHHHHCCCEECCCCCCEEEECCCCCCCHHHHHHHHHH
HKILDVIGDMALNGFVSGHIITVRSGHSLHVELAQEINKKLIQESERV
HHHHHHHHHHHHHCEECCEEEEEECCCEEEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFIDGNLQQTIEKPVKASGTALHTGKEVNVRFLPAGEDTGVVFKRVDLPDNPEIKAEPWQ
CEECCCHHHHHHHHHHCCCCEEECCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCHH
VVSTRRCTSIGLSKDSDSPKVHTIEHLMAALWALEIDNVIVEIDAPETPVMDGSALPYLK
HHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHEECCEEEEECCCCCCCCCCCCCHHHH
LLKKAGIRELSSPRKIWVIDEPVWVKRGHMYMVILPYDGFKISYTLDYDHKVIGTQFFEF
HHHHCCHHHCCCCCEEEEECCCCEEECCCEEEEEEECCCEEEEEEECCCCEEECCEEEEC
DKGENSFEEEIAPARTFGFEREVEALHRRGLALGGSLENAVLIGDEDTVNPLRFSNEFVR
CCCCCHHHHHHCHHHHCCCHHHHHHHHHCCCEECCCCCCEEEECCCCCCCHHHHHHHHHH
HKILDVIGDMALNGFVSGHIITVRSGHSLHVELAQEINKKLIQESERV
HHHHHHHHHHHHHCEECCEEEEEECCCEEEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA