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The map label for this gene is yqeC [H]

Identifier: 220932464

GI number: 220932464

Start: 1749836

End: 1750735

Strand: Reverse

Name: yqeC [H]

Synonym: Hore_16280

Alternate gene names: 220932464

Gene position: 1750735-1749836 (Counterclockwise)

Preceding gene: 220932465

Following gene: 220932463

Centisome position: 67.91

GC content: 44.56

Gene sequence:

>900_bases
ATGAGAATTGGTCTGGTAGGTTTAGGAAGGATGGGGTATAATCTGGCCCTTAATTTAAAGGAACATGGTCATGAGGTGGT
AGCTTACAATAGAAGTAAGGAAAAAGTAAAAAAGGCAGAAAAAGAGGGAATAGAAGGGGCCTATAGTTTAGAAGAGCTTG
TCGATAAGCTCAGGACACGGCGAGTTATCTGGGTTATGGTTCCGGCCGGGGCTCCTGTAGAACAGGTCATAGATGATTTA
ACACCCCTGCTCGACCGGGGTGATATTATAATAGACGGTGGTAATTCCCATTACCGGGATACCCTGAGACGTTACAAGGA
GTTAAAAGAACGGGGAATTCATCTGGTTGACGCCGGTACCAGTGGGGGAGTAGAAGGAGCCCGTCATGGGGCCTGTATGA
TGATTGGGGCTGAAGATGAGGTATTTAGTTATCTTGAGCCTGTATTTAAGGATATTAATGTTGATAAGGGTTATCTCCAT
ACCGGCCGGGTTGGGTCTGGCCATTTTGTAAAAATGGTTCATAATGGAATAGAATATGGAATGCTTCAGGCTATCGGGGA
AGGATTTGAAGTCCTCAAAGAGAGTGATTTTGACATTAACTATCAGGAAGTAGCCCGGGTCTGGTCCCATGGTTCGGTAA
TAAGGGGCTGGTTAATGGAACTGACAGAGGAGGCCTTTAAGAAGGATCCGGAACTGGATGAAATCAGGGGTATAGTTCAT
TCATCAGGAGAAGGTCTATGGACTGTAGAAGAGGCTCTAAAACTTAAAGTCCCGGTGCCCATTATTGCCGGTTCCCTGTT
TATGAGGTATCGTTCTCAGCAGGAAGATAGTTTTGCCGGTAAAGTTATTGCCGCGTTAAGGAATGAATTTGGAGGTCATA
AAGTTGAAAAGAAAGAATAA

Upstream 100 bases:

>100_bases
TTATAGTTATTTTTTTTATGTTATATTTACCTTACATATTATAAAAAACAAAATAAAGTTCTACGATTTTACTAATAATA
TTAAGAAGAGGTGATAGAAA

Downstream 100 bases:

>100_bases
CGAACTGGAACCCTGCCAGATTATTATATTCGGGGGAACCGGTGATTTAACCCATCGCAAATTAATGCCAGCCCTTTATA
ATCTCCAGGCCCAGGGTCTG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MRIGLVGLGRMGYNLALNLKEHGHEVVAYNRSKEKVKKAEKEGIEGAYSLEELVDKLRTRRVIWVMVPAGAPVEQVIDDL
TPLLDRGDIIIDGGNSHYRDTLRRYKELKERGIHLVDAGTSGGVEGARHGACMMIGAEDEVFSYLEPVFKDINVDKGYLH
TGRVGSGHFVKMVHNGIEYGMLQAIGEGFEVLKESDFDINYQEVARVWSHGSVIRGWLMELTEEAFKKDPELDEIRGIVH
SSGEGLWTVEEALKLKVPVPIIAGSLFMRYRSQQEDSFAGKVIAALRNEFGGHKVEKKE

Sequences:

>Translated_299_residues
MRIGLVGLGRMGYNLALNLKEHGHEVVAYNRSKEKVKKAEKEGIEGAYSLEELVDKLRTRRVIWVMVPAGAPVEQVIDDL
TPLLDRGDIIIDGGNSHYRDTLRRYKELKERGIHLVDAGTSGGVEGARHGACMMIGAEDEVFSYLEPVFKDINVDKGYLH
TGRVGSGHFVKMVHNGIEYGMLQAIGEGFEVLKESDFDINYQEVARVWSHGSVIRGWLMELTEEAFKKDPELDEIRGIVH
SSGEGLWTVEEALKLKVPVPIIAGSLFMRYRSQQEDSFAGKVIAALRNEFGGHKVEKKE
>Mature_299_residues
MRIGLVGLGRMGYNLALNLKEHGHEVVAYNRSKEKVKKAEKEGIEGAYSLEELVDKLRTRRVIWVMVPAGAPVEQVIDDL
TPLLDRGDIIIDGGNSHYRDTLRRYKELKERGIHLVDAGTSGGVEGARHGACMMIGAEDEVFSYLEPVFKDINVDKGYLH
TGRVGSGHFVKMVHNGIEYGMLQAIGEGFEVLKESDFDINYQEVARVWSHGSVIRGWLMELTEEAFKKDPELDEIRGIVH
SSGEGLWTVEEALKLKVPVPIIAGSLFMRYRSQQEDSFAGKVIAALRNEFGGHKVEKKE

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=291, Percent_Identity=40.893470790378, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1788341, Length=314, Percent_Identity=38.2165605095541, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1786719, Length=195, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693186, Length=214, Percent_Identity=25.2336448598131, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17542558, Length=291, Percent_Identity=38.8316151202749, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321695, Length=292, Percent_Identity=43.1506849315069, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321977, Length=305, Percent_Identity=39.672131147541, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24639279, Length=287, Percent_Identity=39.7212543554007, Blast_Score=174, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 33449; Mature: 33449

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGLVGLGRMGYNLALNLKEHGHEVVAYNRSKEKVKKAEKEGIEGAYSLEELVDKLRTR
CEEEEEEECCCCCEEEEEEHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
RVIWVMVPAGAPVEQVIDDLTPLLDRGDIIIDGGNSHYRDTLRRYKELKERGIHLVDAGT
EEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEECCC
SGGVEGARHGACMMIGAEDEVFSYLEPVFKDINVDKGYLHTGRVGSGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHCCHHHH
MLQAIGEGFEVLKESDFDINYQEVARVWSHGSVIRGWLMELTEEAFKKDPELDEIRGIVH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SSGEGLWTVEEALKLKVPVPIIAGSLFMRYRSQQEDSFAGKVIAALRNEFGGHKVEKKE
CCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRIGLVGLGRMGYNLALNLKEHGHEVVAYNRSKEKVKKAEKEGIEGAYSLEELVDKLRTR
CEEEEEEECCCCCEEEEEEHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCC
RVIWVMVPAGAPVEQVIDDLTPLLDRGDIIIDGGNSHYRDTLRRYKELKERGIHLVDAGT
EEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEECCC
SGGVEGARHGACMMIGAEDEVFSYLEPVFKDINVDKGYLHTGRVGSGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHCCHHHH
MLQAIGEGFEVLKESDFDINYQEVARVWSHGSVIRGWLMELTEEAFKKDPELDEIRGIVH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SSGEGLWTVEEALKLKVPVPIIAGSLFMRYRSQQEDSFAGKVIAALRNEFGGHKVEKKE
CCCCCEEEHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]