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The map label for this gene is zwf [H]

Identifier: 220932463

GI number: 220932463

Start: 1748356

End: 1749852

Strand: Reverse

Name: zwf [H]

Synonym: Hore_16270

Alternate gene names: 220932463

Gene position: 1749852-1748356 (Counterclockwise)

Preceding gene: 220932464

Following gene: 220932462

Centisome position: 67.87

GC content: 42.69

Gene sequence:

>1497_bases
TTGAAAAGAAAGAATAACGAACTGGAACCCTGCCAGATTATTATATTCGGGGGAACCGGTGATTTAACCCATCGCAAATT
AATGCCAGCCCTTTATAATCTCCAGGCCCAGGGTCTGTTACCAGATAATGCTCCTATTATTTCTATAGGGCGTCGCGATA
AAAATAACGAAATCTACCGGGATGAAATATATCATTCTATTAATAAATATTCAAGGAATGAAGTGGAGGACAGTGTTTGG
TCCTCTCTTTCTTCCAGGATATTTTATCAGAGATTTGACTTCAGGGAAGATGAGGGTTATAGCAGATTTAAGAATTTTTT
ATGCCAGAATCAGAGGGAGTACCAGACCGGAGGAAACAGGATTTTCTATCTGGCAGTAGCCCCTGAATACTTTGGAATCA
TTGTCGATAAACTAAAGGAGTTTAACATAGTAAACCAGGGCGGGAGTGGCTGGAACAGGGTTGTTATTGAAAAGCCATTT
GGACATGACCTGGATTCTGCCAGAAAACTTAATGATAAAATTACAGCAGTCTTTAATGAAGAAAACACCTACCGGATTGA
CCATTATCTGGGAAAAGAGATGCTCCAGAACATAATGACTATTAGATTTGCCAATACCATTTTTGAACCGGTCTGGAATA
ATCGTTATATAGATAATATCCAGATTGTCTCCAGTGAATCGGCCGGGGTGGGGCGTAGAGGCGGCTATTACGAGCAGGCC
GGGGCCTTAAAGGATATGGTCCAGAACCATATGCTTCAATTATTAACCCTGACAGCAATGGAGCCTCCTGCTACTCTGGA
TACTGAGTCAATCCGGGATGAGAAGGTCAAGGTCCTGAAGGCTTTACTGGAGATGGATACCGCTGATATCAGGAAATTCG
CTGTAAGGGGTCAGTATGGTCCCGGGAAAATAAAGGGAAGACGGGTTCCCGGTTATCGTGATGAAGAAAGGACAGATCCG
GATTCAAAGACGGAGACCTTTGTTGCCCTTAAGGTTTATATCAATAACATCAGATGGTCAGGTGTTCCATTTTATATCAA
GACAGGGAAACGTCTTCAGAAAAAATCAACTGAGGTTATTATTGAGTTTAAAGATATGCTTCACCCTATTTATTTGAAAA
ATTTTAATTCCATTAACCCCAATTTGCTGGTTATAAGGATTCAACCCCGGGAAGGGGTATATTTTCGCTTTAATACCAAG
AAACCGGGAACCAGGCAGACTATAATACCGGTTAACATGGACTTCTGCCAGAATTGTCAGATCGGGCAGAATTCCCCTGA
AGCCTATGAACGCCTACTGCAGGATGTAATTCTCGGGGACCAGACCCTTTTTACGAGGTGGGATGAAGTTGAATACTCCT
GGAGCTTTATAGATAAAATTGCAGAGGCCTGGCAGGATAACAACCCCGATTTTCCAAATTATCATGCCGGCTCTCAGGGT
CCGATAGCGGCTGAGAAAATGCTGCAGCAGGAAGGCCATCACTGGTGGAATGTTTAA

Upstream 100 bases:

>100_bases
ATTGCCGGTTCCCTGTTTATGAGGTATCGTTCTCAGCAGGAAGATAGTTTTGCCGGTAAAGTTATTGCCGCGTTAAGGAA
TGAATTTGGAGGTCATAAAG

Downstream 100 bases:

>100_bases
GATTACTGTTCAGTTTTGAAGTTTCCATTAAACGTCAGATATTTTAATGTTTATATCAAATGCTAATATTTAGTATTAAG
TTCATTTATTTAAGCTAACT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKRKNNELEPCQIIIFGGTGDLTHRKLMPALYNLQAQGLLPDNAPIISIGRRDKNNEIYRDEIYHSINKYSRNEVEDSVW
SSLSSRIFYQRFDFREDEGYSRFKNFLCQNQREYQTGGNRIFYLAVAPEYFGIIVDKLKEFNIVNQGGSGWNRVVIEKPF
GHDLDSARKLNDKITAVFNEENTYRIDHYLGKEMLQNIMTIRFANTIFEPVWNNRYIDNIQIVSSESAGVGRRGGYYEQA
GALKDMVQNHMLQLLTLTAMEPPATLDTESIRDEKVKVLKALLEMDTADIRKFAVRGQYGPGKIKGRRVPGYRDEERTDP
DSKTETFVALKVYINNIRWSGVPFYIKTGKRLQKKSTEVIIEFKDMLHPIYLKNFNSINPNLLVIRIQPREGVYFRFNTK
KPGTRQTIIPVNMDFCQNCQIGQNSPEAYERLLQDVILGDQTLFTRWDEVEYSWSFIDKIAEAWQDNNPDFPNYHAGSQG
PIAAEKMLQQEGHHWWNV

Sequences:

>Translated_498_residues
MKRKNNELEPCQIIIFGGTGDLTHRKLMPALYNLQAQGLLPDNAPIISIGRRDKNNEIYRDEIYHSINKYSRNEVEDSVW
SSLSSRIFYQRFDFREDEGYSRFKNFLCQNQREYQTGGNRIFYLAVAPEYFGIIVDKLKEFNIVNQGGSGWNRVVIEKPF
GHDLDSARKLNDKITAVFNEENTYRIDHYLGKEMLQNIMTIRFANTIFEPVWNNRYIDNIQIVSSESAGVGRRGGYYEQA
GALKDMVQNHMLQLLTLTAMEPPATLDTESIRDEKVKVLKALLEMDTADIRKFAVRGQYGPGKIKGRRVPGYRDEERTDP
DSKTETFVALKVYINNIRWSGVPFYIKTGKRLQKKSTEVIIEFKDMLHPIYLKNFNSINPNLLVIRIQPREGVYFRFNTK
KPGTRQTIIPVNMDFCQNCQIGQNSPEAYERLLQDVILGDQTLFTRWDEVEYSWSFIDKIAEAWQDNNPDFPNYHAGSQG
PIAAEKMLQQEGHHWWNV
>Mature_498_residues
MKRKNNELEPCQIIIFGGTGDLTHRKLMPALYNLQAQGLLPDNAPIISIGRRDKNNEIYRDEIYHSINKYSRNEVEDSVW
SSLSSRIFYQRFDFREDEGYSRFKNFLCQNQREYQTGGNRIFYLAVAPEYFGIIVDKLKEFNIVNQGGSGWNRVVIEKPF
GHDLDSARKLNDKITAVFNEENTYRIDHYLGKEMLQNIMTIRFANTIFEPVWNNRYIDNIQIVSSESAGVGRRGGYYEQA
GALKDMVQNHMLQLLTLTAMEPPATLDTESIRDEKVKVLKALLEMDTADIRKFAVRGQYGPGKIKGRRVPGYRDEERTDP
DSKTETFVALKVYINNIRWSGVPFYIKTGKRLQKKSTEVIIEFKDMLHPIYLKNFNSINPNLLVIRIQPREGVYFRFNTK
KPGTRQTIIPVNMDFCQNCQIGQNSPEAYERLLQDVILGDQTLFTRWDEVEYSWSFIDKIAEAWQDNNPDFPNYHAGSQG
PIAAEKMLQQEGHHWWNV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=491, Percent_Identity=35.4378818737271, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI108773793, Length=486, Percent_Identity=35.8024691358025, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI52145310, Length=393, Percent_Identity=29.0076335877863, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1788158, Length=490, Percent_Identity=39.5918367346939, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17538218, Length=488, Percent_Identity=37.9098360655738, Blast_Score=331, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6324088, Length=485, Percent_Identity=35.8762886597938, Blast_Score=296, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24643350, Length=490, Percent_Identity=35.3061224489796, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24643352, Length=490, Percent_Identity=35.3061224489796, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI221513548, Length=508, Percent_Identity=28.5433070866142, Blast_Score=218, Evalue=9e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57935; Mature: 57935

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKNNELEPCQIIIFGGTGDLTHRKLMPALYNLQAQGLLPDNAPIISIGRRDKNNEIYR
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEECCCCCCCCCEEEECCCCCCCCHHH
DEIYHSINKYSRNEVEDSVWSSLSSRIFYQRFDFREDEGYSRFKNFLCQNQREYQTGGNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHCCCCCE
IFYLAVAPEYFGIIVDKLKEFNIVNQGGSGWNRVVIEKPFGHDLDSARKLNDKITAVFNE
EEEEEECCHHHHHHHHHHHHCCEECCCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEECC
ENTYRIDHYLGKEMLQNIMTIRFANTIFEPVWNNRYIDNIQIVSSESAGVGRRGGYYEQA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEECCCCCCCCCCCCHHHH
GALKDMVQNHMLQLLTLTAMEPPATLDTESIRDEKVKVLKALLEMDTADIRKFAVRGQYG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
PGKIKGRRVPGYRDEERTDPDSKTETFVALKVYINNIRWSGVPFYIKTGKRLQKKSTEVI
CCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEECEEECCCCEEEECCCHHHHCCHHEE
IEFKDMLHPIYLKNFNSINPNLLVIRIQPREGVYFRFNTKKPGTRQTIIPVNMDFCQNCQ
EEHHHHHCHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEECHHHHCCCC
IGQNSPEAYERLLQDVILGDQTLFTRWDEVEYSWSFIDKIAEAWQDNNPDFPNYHAGSQG
CCCCCHHHHHHHHHHHHHCCCHHEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PIAAEKMLQQEGHHWWNV
CHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKRKNNELEPCQIIIFGGTGDLTHRKLMPALYNLQAQGLLPDNAPIISIGRRDKNNEIYR
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEECCCCCCCCCEEEECCCCCCCCHHH
DEIYHSINKYSRNEVEDSVWSSLSSRIFYQRFDFREDEGYSRFKNFLCQNQREYQTGGNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHCCCCCE
IFYLAVAPEYFGIIVDKLKEFNIVNQGGSGWNRVVIEKPFGHDLDSARKLNDKITAVFNE
EEEEEECCHHHHHHHHHHHHCCEECCCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEECC
ENTYRIDHYLGKEMLQNIMTIRFANTIFEPVWNNRYIDNIQIVSSESAGVGRRGGYYEQA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEECCCCCCCCCCCCHHHH
GALKDMVQNHMLQLLTLTAMEPPATLDTESIRDEKVKVLKALLEMDTADIRKFAVRGQYG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
PGKIKGRRVPGYRDEERTDPDSKTETFVALKVYINNIRWSGVPFYIKTGKRLQKKSTEVI
CCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEECEEECCCCEEEECCCHHHHCCHHEE
IEFKDMLHPIYLKNFNSINPNLLVIRIQPREGVYFRFNTKKPGTRQTIIPVNMDFCQNCQ
EEHHHHHCHHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEECHHHHCCCC
IGQNSPEAYERLLQDVILGDQTLFTRWDEVEYSWSFIDKIAEAWQDNNPDFPNYHAGSQG
CCCCCHHHHHHHHHHHHHCCCHHEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PIAAEKMLQQEGHHWWNV
CHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]