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The map label for this gene is hgdC [H]

Identifier: 220932443

GI number: 220932443

Start: 1722149

End: 1722931

Strand: Reverse

Name: hgdC [H]

Synonym: Hore_16070

Alternate gene names: 220932443

Gene position: 1722931-1722149 (Counterclockwise)

Preceding gene: 220932444

Following gene: 220932442

Centisome position: 66.83

GC content: 47.38

Gene sequence:

>783_bases
ATGCTGATAGCAGGACTTGATATAGGGTCACGGACTACCAAGACTGTAATTTTAGAAGATGGAGACTTGGTGTCCTGGGA
GATCATGAATACCGGGGCCAGGACAGCGGGACGGGCCCGGGAAGTTATTAAAAAAGCCTTAAGGAAGATTGACTATAGCC
TGGAGCAGGTGAAGAGGGTGGTAGCCACTGGTTACGGGAGGCTGAGTATACCTTTTGCTGATAGAGAAATAACTGAAATA
ACGGCCCATGCCCTCGGTGTTCATCATAAGTACCCGAATACCAGAACGGTTATAGATATCGGGGGACAGGATAGTAAGGT
TATTCGCCTTGATGCCAATGGTAGGGTTGATGACTTTGTTATGAATGACAAATGTGCCGCCGGAACGGGTCGTTTTCTGG
AAGTAATGGCAGAAACCCTGGAGGTGCCTCTGGAGGAGATTGGTCCTCTGTCATTAAAGACTGATACTGCTGCCCCTATA
TCCAGTACCTGTACCGTATTTGCTGAATCGGAAGTGATAAGCCTAATTGCCGATGGGGTGGAGCGGGAAGATATTTTAAG
GGGGCTCCATACCGCAATTGTAAAACGGATTACCGGTATGGCCCGTCAGGTAGGAATAAAGGAAGAAGTAACCCTCAGTG
GTGGGGTATCTCTAAATAAAGGAGTTCGTCAATTACTGGAAAAAGAACTCGAGGTGTCCCTTAATATCCCCCATTACCCT
CAACTCATGGGGGCTTATGGAGCAGCCCTGCTCGGTTATCGTGAAATGTGTGAAATAAATTAG

Upstream 100 bases:

>100_bases
GGTGACCTGGTAGATATCCGCAACTACCGGGAAGGTCAGATTATTACCAGACTTCAGGCCTTTATAGAAGTACTGGAAAG
CAGAAATGGAGGGATAAACT

Downstream 100 bases:

>100_bases
TCTGTCTTTACATATTACTTTTGACCATGGTATAATAACTCTGAATATACAGGGGTGCAGTAGAAAACAAGGAGGAAGAA
AATGTTACTTCAGACGTTAA

Product: putative CoA-substrate-specific enzyme activase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLIAGLDIGSRTTKTVILEDGDLVSWEIMNTGARTAGRAREVIKKALRKIDYSLEQVKRVVATGYGRLSIPFADREITEI
TAHALGVHHKYPNTRTVIDIGGQDSKVIRLDANGRVDDFVMNDKCAAGTGRFLEVMAETLEVPLEEIGPLSLKTDTAAPI
SSTCTVFAESEVISLIADGVEREDILRGLHTAIVKRITGMARQVGIKEEVTLSGGVSLNKGVRQLLEKELEVSLNIPHYP
QLMGAYGAALLGYREMCEIN

Sequences:

>Translated_260_residues
MLIAGLDIGSRTTKTVILEDGDLVSWEIMNTGARTAGRAREVIKKALRKIDYSLEQVKRVVATGYGRLSIPFADREITEI
TAHALGVHHKYPNTRTVIDIGGQDSKVIRLDANGRVDDFVMNDKCAAGTGRFLEVMAETLEVPLEEIGPLSLKTDTAAPI
SSTCTVFAESEVISLIADGVEREDILRGLHTAIVKRITGMARQVGIKEEVTLSGGVSLNKGVRQLLEKELEVSLNIPHYP
QLMGAYGAALLGYREMCEIN
>Mature_260_residues
MLIAGLDIGSRTTKTVILEDGDLVSWEIMNTGARTAGRAREVIKKALRKIDYSLEQVKRVVATGYGRLSIPFADREITEI
TAHALGVHHKYPNTRTVIDIGGQDSKVIRLDANGRVDDFVMNDKCAAGTGRFLEVMAETLEVPLEEIGPLSLKTDTAAPI
SSTCTVFAESEVISLIADGVEREDILRGLHTAIVKRITGMARQVGIKEEVTLSGGVSLNKGVRQLLEKELEVSLNIPHYP
QLMGAYGAALLGYREMCEIN

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=250, Percent_Identity=42.4, Blast_Score=185, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 28333; Mature: 28333

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIAGLDIGSRTTKTVILEDGDLVSWEIMNTGARTAGRAREVIKKALRKIDYSLEQVKRV
CEEEECCCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
VATGYGRLSIPFADREITEITAHALGVHHKYPNTRTVIDIGGQDSKVIRLDANGRVDDFV
HHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCEE
MNDKCAAGTGRFLEVMAETLEVPLEEIGPLSLKTDTAAPISSTCTVFAESEVISLIADGV
ECCCCCCCCHHHHHHHHHHHHCCHHHCCCCEEECCCCCCCCCCEEEEEHHHHHHHHHCCC
EREDILRGLHTAIVKRITGMARQVGIKEEVTLSGGVSLNKGVRQLLEKELEVSLNIPHYP
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCEEECCCCCH
QLMGAYGAALLGYREMCEIN
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIAGLDIGSRTTKTVILEDGDLVSWEIMNTGARTAGRAREVIKKALRKIDYSLEQVKRV
CEEEECCCCCCCEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
VATGYGRLSIPFADREITEITAHALGVHHKYPNTRTVIDIGGQDSKVIRLDANGRVDDFV
HHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCEE
MNDKCAAGTGRFLEVMAETLEVPLEEIGPLSLKTDTAAPISSTCTVFAESEVISLIADGV
ECCCCCCCCHHHHHHHHHHHHCCHHHCCCCEEECCCCCCCCCCEEEEEHHHHHHHHHCCC
EREDILRGLHTAIVKRITGMARQVGIKEEVTLSGGVSLNKGVRQLLEKELEVSLNIPHYP
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCEEECCCCCH
QLMGAYGAALLGYREMCEIN
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]