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The map label for this gene is lytC [H]

Identifier: 220932387

GI number: 220932387

Start: 1659936

End: 1662176

Strand: Reverse

Name: lytC [H]

Synonym: Hore_15510

Alternate gene names: 220932387

Gene position: 1662176-1659936 (Counterclockwise)

Preceding gene: 220932389

Following gene: 220932386

Centisome position: 64.47

GC content: 39.67

Gene sequence:

>2241_bases
GTGTTAAGGCACACTTTTTATATATTTATAATTACAATACTCTTACTTATATGGCTGATCCCGGCCCAGGCTGGAGCCCG
GGAGGTAAACATAGTCTTTAATGGTAAAGATGTAACTCAGGACTTTAATCCCATAATCTACGGGGGTCAGCTCCTTATAA
AATCCCGTTCCCTGGCCGAATACACAGGGTCTACCGTTAAATGGTATAAGCCCATTAAGACCCTGACCATGTCCCTCAAT
GGGGTGACTGTCAAGTTAATGGTCAATAACCCCTATATTCAGGTTAATAACAGAACTATAAAAGTTGATAATGGTATGCT
CTTGAGAGAGGGACAGACCTATGTTCCTGTTCAGGTGGTAAGTGGTTTTGGATATTTGATTAATCAGGAAGGTGATACCT
GGTATATCTATAAACCCGAGTCCTATATTAAAGGAATTACCTGGCTAAAAGAGGGTCAGCAGCTCCTGATTGATATGGAT
AAGATAACTCCTTACCGGGTTATCAAGTCTGATGACCCCCGTCAGTTAATAATTGAAATCGATAAGGCAATGCTTTCGAA
AAACTTTAAGGATAGCCTTTCTAATGAAAACTTTTATTTGAAAATAAATAAGGCCGTCAACAGGGCCAGGTTGCAGCTGG
TGGTCAGTTCAAAATACCCCATCCCCTTTAAACTGGATGGAGGGGTGGAAGAGACGGATTCAGGTATTTTAATTAAATTT
TTACCCCACATTAAAAGTGTTAAATGGGAGAAAGAACGGCTGGTAATAAAATCAACCGGTAGTATTAAAAAACCTGAGAT
ATCCTTGCTTTCCAACCCCAGGAGGCTTGTTCTTGATATCCCCGATATGATGCAGAGTGATTTTGATATCGATCTCCCTA
TAAATAAATGGGTCAGTGATATTGAAGTCAGTCAGTATAGTTATGATCCCATTATTCTCAGGGTAGTTGTTGTATTGAAA
AAAGGTAGTTATTTAAATTTAAAGACAGATTCTCAGGGGAATCAACTGGTGCTTGTTCCCGGCCAGATTACAAAAGTTGC
CGACCTGAAGTGTGTTGATAACAGGATTGAATTTACAACAAACCGGAAGATTAAGCCCGATATTTTTATTCTTCAGAACC
CAGATCGCCTGGTGGTGGATTTAATAAATTCAGTCAGGGATAAGGATTTTCCTGAAAAAATAAATGTGCAAAATGGGTTG
ATTAAAAGAATTCGTTCAGCCCGGTTCAATGAAGAAACAGTCAGGATAGTAGCTGATTTATTGGAATATACAGGTTATAC
CTGGAATCAGGTAAAGGAAACAAATAACCGGTATCAACATATGATAATATTAAATAACAAAATAGAGAAGATAAAATTAG
ATAATACCAAAAAATTTACAGATATAAGTATATTTTTAAGTGGAAAGGTCAATTATGAAATTAAGGAGTTTTTCTATCCC
AACAGGCTGGTCGTTGATGCCAGGGGTATTGTCAACAACCTGGATGAAGAGGACTTACCTACTTCTTCTCCGTTGATTAA
GGATATTAGATTGAGTCAGTTTAGTAAAGAACCCCGGATTGCCAGATTTGTTTTTGAGCTGGGTAAGAGGTATGAATATG
AAGTATTGTCACCGACTCCGTCCCATGTTATAAAGGTCAGGTTAAAGAAAGAAGAGAAAAAGGAGCTAACCAATATAATA
GCTATTGATGCCGGACACGGTGGTTTTGATCCCGGGGCGCTGGGGGTAACGGGTCTCAAGGAAAAGATTGTGACCCTTGA
TATTGCCCGGAAGGTAAAAACCCTTCTGGAAGATGAAGGATACCGGGTCTTAATGACCAGAACTGATGACACCTTTATCT
CTCTAAAAGACCGGGTCAAAAAGGCAAATGATGCCCGGGCGAGAATATTTGTAAGTATTCATGCCAATGCCTTCAATGAA
TCCTATTCAGAAGGGATAGAGACCTATATTTCCCCTGATAAAACAGGGAATAGTCTTCTTCTGGCCCAGAATTTACAGGA
ACAACTGGTTAGGGAATTGAAGCTTGAAAATCGGGGTGTGAAACAGGAGGAACTCTATGTCCTGAATCACTCCTCTATGC
CAGCAGCTCTGGTAGAAGTCGGCTTTTTATCCAATCCCCATGAAGAAACTCTGCTGAGGAGTGAGTTGTTCCGGAAGAGA
GTGGCCAGGGCCCTCTATCGGGGTATATTAAATTATATTAAAAAAATTGAACAGGGAGATGGAAACACCCATGATAAATA
A

Upstream 100 bases:

>100_bases
GAAAAGGGTGCCCGGGGCAAGAAATATATATAATAATGTAGAATACTTGGGAATATTATTGGAATTATGAGGAAATAAAT
TATAAAGGGGCGGGGTAAAA

Downstream 100 bases:

>100_bases
AGATAAACTTCTTTTGATAATCATTACACTTGTAGTGATTGGTTTTTTTGCCTTTTATCAATATAATAACCAGGAAACTG
AACCGACCAATAACGAACTT

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MLRHTFYIFIITILLLIWLIPAQAGAREVNIVFNGKDVTQDFNPIIYGGQLLIKSRSLAEYTGSTVKWYKPIKTLTMSLN
GVTVKLMVNNPYIQVNNRTIKVDNGMLLREGQTYVPVQVVSGFGYLINQEGDTWYIYKPESYIKGITWLKEGQQLLIDMD
KITPYRVIKSDDPRQLIIEIDKAMLSKNFKDSLSNENFYLKINKAVNRARLQLVVSSKYPIPFKLDGGVEETDSGILIKF
LPHIKSVKWEKERLVIKSTGSIKKPEISLLSNPRRLVLDIPDMMQSDFDIDLPINKWVSDIEVSQYSYDPIILRVVVVLK
KGSYLNLKTDSQGNQLVLVPGQITKVADLKCVDNRIEFTTNRKIKPDIFILQNPDRLVVDLINSVRDKDFPEKINVQNGL
IKRIRSARFNEETVRIVADLLEYTGYTWNQVKETNNRYQHMIILNNKIEKIKLDNTKKFTDISIFLSGKVNYEIKEFFYP
NRLVVDARGIVNNLDEEDLPTSSPLIKDIRLSQFSKEPRIARFVFELGKRYEYEVLSPTPSHVIKVRLKKEEKKELTNII
AIDAGHGGFDPGALGVTGLKEKIVTLDIARKVKTLLEDEGYRVLMTRTDDTFISLKDRVKKANDARARIFVSIHANAFNE
SYSEGIETYISPDKTGNSLLLAQNLQEQLVRELKLENRGVKQEELYVLNHSSMPAALVEVGFLSNPHEETLLRSELFRKR
VARALYRGILNYIKKIEQGDGNTHDK

Sequences:

>Translated_746_residues
MLRHTFYIFIITILLLIWLIPAQAGAREVNIVFNGKDVTQDFNPIIYGGQLLIKSRSLAEYTGSTVKWYKPIKTLTMSLN
GVTVKLMVNNPYIQVNNRTIKVDNGMLLREGQTYVPVQVVSGFGYLINQEGDTWYIYKPESYIKGITWLKEGQQLLIDMD
KITPYRVIKSDDPRQLIIEIDKAMLSKNFKDSLSNENFYLKINKAVNRARLQLVVSSKYPIPFKLDGGVEETDSGILIKF
LPHIKSVKWEKERLVIKSTGSIKKPEISLLSNPRRLVLDIPDMMQSDFDIDLPINKWVSDIEVSQYSYDPIILRVVVVLK
KGSYLNLKTDSQGNQLVLVPGQITKVADLKCVDNRIEFTTNRKIKPDIFILQNPDRLVVDLINSVRDKDFPEKINVQNGL
IKRIRSARFNEETVRIVADLLEYTGYTWNQVKETNNRYQHMIILNNKIEKIKLDNTKKFTDISIFLSGKVNYEIKEFFYP
NRLVVDARGIVNNLDEEDLPTSSPLIKDIRLSQFSKEPRIARFVFELGKRYEYEVLSPTPSHVIKVRLKKEEKKELTNII
AIDAGHGGFDPGALGVTGLKEKIVTLDIARKVKTLLEDEGYRVLMTRTDDTFISLKDRVKKANDARARIFVSIHANAFNE
SYSEGIETYISPDKTGNSLLLAQNLQEQLVRELKLENRGVKQEELYVLNHSSMPAALVEVGFLSNPHEETLLRSELFRKR
VARALYRGILNYIKKIEQGDGNTHDK
>Mature_746_residues
MLRHTFYIFIITILLLIWLIPAQAGAREVNIVFNGKDVTQDFNPIIYGGQLLIKSRSLAEYTGSTVKWYKPIKTLTMSLN
GVTVKLMVNNPYIQVNNRTIKVDNGMLLREGQTYVPVQVVSGFGYLINQEGDTWYIYKPESYIKGITWLKEGQQLLIDMD
KITPYRVIKSDDPRQLIIEIDKAMLSKNFKDSLSNENFYLKINKAVNRARLQLVVSSKYPIPFKLDGGVEETDSGILIKF
LPHIKSVKWEKERLVIKSTGSIKKPEISLLSNPRRLVLDIPDMMQSDFDIDLPINKWVSDIEVSQYSYDPIILRVVVVLK
KGSYLNLKTDSQGNQLVLVPGQITKVADLKCVDNRIEFTTNRKIKPDIFILQNPDRLVVDLINSVRDKDFPEKINVQNGL
IKRIRSARFNEETVRIVADLLEYTGYTWNQVKETNNRYQHMIILNNKIEKIKLDNTKKFTDISIFLSGKVNYEIKEFFYP
NRLVVDARGIVNNLDEEDLPTSSPLIKDIRLSQFSKEPRIARFVFELGKRYEYEVLSPTPSHVIKVRLKKEEKKELTNII
AIDAGHGGFDPGALGVTGLKEKIVTLDIARKVKTLLEDEGYRVLMTRTDDTFISLKDRVKKANDARARIFVSIHANAFNE
SYSEGIETYISPDKTGNSLLLAQNLQEQLVRELKLENRGVKQEELYVLNHSSMPAALVEVGFLSNPHEETLLRSELFRKR
VARALYRGILNYIKKIEQGDGNTHDK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=228, Percent_Identity=32.0175438596491, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790611, Length=223, Percent_Identity=32.7354260089686, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI87082163, Length=378, Percent_Identity=27.2486772486773, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 85637; Mature: 85637

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRHTFYIFIITILLLIWLIPAQAGAREVNIVFNGKDVTQDFNPIIYGGQLLIKSRSLAE
CCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEECCEEEEECCCHHH
YTGSTVKWYKPIKTLTMSLNGVTVKLMVNNPYIQVNNRTIKVDNGMLLREGQTYVPVQVV
HCCCCEEEECCCEEEEEEECCEEEEEEECCCEEEECCEEEEECCCEEEECCCEEEEEEEE
SGFGYLINQEGDTWYIYKPESYIKGITWLKEGQQLLIDMDKITPYRVIKSDDPRQLIIEI
CCCCEEEECCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCHHHHHHH
DKAMLSKNFKDSLSNENFYLKINKAVNRARLQLVVSSKYPIPFKLDGGVEETDSGILIKF
HHHHHCCCHHHHCCCCEEEEEEHHHCCCEEEEEEEECCCCCCEEECCCCCCCCCCEEEEE
LPHIKSVKWEKERLVIKSTGSIKKPEISLLSNPRRLVLDIPDMMQSDFDIDLPINKWVSD
HHHHHCCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEECHHHHHCCCCEECCHHHHHHH
IEVSQYSYDPIILRVVVVLKKGSYLNLKTDSQGNQLVLVPGQITKVADLKCVDNRIEFTT
HECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCEEECEEEECCCEEEEE
NRKIKPDIFILQNPDRLVVDLINSVRDKDFPEKINVQNGLIKRIRSARFNEETVRIVADL
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LEYTGYTWNQVKETNNRYQHMIILNNKIEKIKLDNTKKFTDISIFLSGKVNYEIKEFFYP
HHHCCCCHHHHHHCCCCEEEEEEEECCEEEEEECCCCCEEEEEEEEECCCCEEEHHEECC
NRLVVDARGIVNNLDEEDLPTSSPLIKDIRLSQFSKEPRIARFVFELGKRYEYEVLSPTP
CEEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCC
SHVIKVRLKKEEKKELTNIIAIDAGHGGFDPGALGVTGLKEKIVTLDIARKVKTLLEDEG
CCEEEEEECCHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
YRVLMTRTDDTFISLKDRVKKANDARARIFVSIHANAFNESYSEGIETYISPDKTGNSLL
CEEEEEECCCCEEEHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEE
LAQNLQEQLVRELKLENRGVKQEELYVLNHSSMPAALVEVGFLSNPHEETLLRSELFRKR
EHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
VARALYRGILNYIKKIEQGDGNTHDK
HHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLRHTFYIFIITILLLIWLIPAQAGAREVNIVFNGKDVTQDFNPIIYGGQLLIKSRSLAE
CCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEECCEEEEECCCHHH
YTGSTVKWYKPIKTLTMSLNGVTVKLMVNNPYIQVNNRTIKVDNGMLLREGQTYVPVQVV
HCCCCEEEECCCEEEEEEECCEEEEEEECCCEEEECCEEEEECCCEEEECCCEEEEEEEE
SGFGYLINQEGDTWYIYKPESYIKGITWLKEGQQLLIDMDKITPYRVIKSDDPRQLIIEI
CCCCEEEECCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCHHHHHHH
DKAMLSKNFKDSLSNENFYLKINKAVNRARLQLVVSSKYPIPFKLDGGVEETDSGILIKF
HHHHHCCCHHHHCCCCEEEEEEHHHCCCEEEEEEEECCCCCCEEECCCCCCCCCCEEEEE
LPHIKSVKWEKERLVIKSTGSIKKPEISLLSNPRRLVLDIPDMMQSDFDIDLPINKWVSD
HHHHHCCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEECHHHHHCCCCEECCHHHHHHH
IEVSQYSYDPIILRVVVVLKKGSYLNLKTDSQGNQLVLVPGQITKVADLKCVDNRIEFTT
HECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCEEECEEEECCCEEEEE
NRKIKPDIFILQNPDRLVVDLINSVRDKDFPEKINVQNGLIKRIRSARFNEETVRIVADL
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LEYTGYTWNQVKETNNRYQHMIILNNKIEKIKLDNTKKFTDISIFLSGKVNYEIKEFFYP
HHHCCCCHHHHHHCCCCEEEEEEEECCEEEEEECCCCCEEEEEEEEECCCCEEEHHEECC
NRLVVDARGIVNNLDEEDLPTSSPLIKDIRLSQFSKEPRIARFVFELGKRYEYEVLSPTP
CEEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCC
SHVIKVRLKKEEKKELTNIIAIDAGHGGFDPGALGVTGLKEKIVTLDIARKVKTLLEDEG
CCEEEEEECCHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
YRVLMTRTDDTFISLKDRVKKANDARARIFVSIHANAFNESYSEGIETYISPDKTGNSLL
CEEEEEECCCCEEEHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEE
LAQNLQEQLVRELKLENRGVKQEELYVLNHSSMPAALVEVGFLSNPHEETLLRSELFRKR
EHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
VARALYRGILNYIKKIEQGDGNTHDK
HHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]