| Definition | Halothermothrix orenii H 168 chromosome, complete genome. |
|---|---|
| Accession | NC_011899 |
| Length | 2,578,146 |
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The map label for this gene is comEC [H]
Identifier: 220932129
GI number: 220932129
Start: 1384976
End: 1387303
Strand: Reverse
Name: comEC [H]
Synonym: Hore_12920
Alternate gene names: 220932129
Gene position: 1387303-1384976 (Counterclockwise)
Preceding gene: 220932130
Following gene: 220932126
Centisome position: 53.81
GC content: 34.62
Gene sequence:
>2328_bases ATGAAATCAAGACCCCTTTTCTGGACGGCTTTATTTTTAATAATGGGAATCACCCTGGGTTATTTTATTAATATTAATAT ATATATTTTAATTGTTTTATTAGTATTTTTTATAACATGTGGAACTTTCTGCTGGCTTAAAAATTATGAAAAATATAGTC GAGTGGTTATAGTAATAACTGTTATATTAACAGGTTTATTTTTAGTTGAATTTGAAGAAGCTAAATATAACAGTAAATGG TCGATAGCTGACTGGAATGGAAATGGTGAAAAAGTGGTACTCGGTGAAGTAGTATTAGATTTAGCTGCTCTGGAGGGCAA TAAAATATATTTGAAACCTCTTTATGTTAATGGCCACCGGGTTAAATATGGATTGATTCAGCTGGACCAGCGGTATATAA AAGAAGATTTGGTAAATGGAGATATAGTAAGAGTATACCTGGTATTACAGACCCCCTACAGGCAAACTAACCCGGGATCC TTTTCCCAGTATAAATACTTATTTAAAAAAGGCGTCTTCAGCAAAGGTTATGTTACTGGTCCTGTAAGTAAAACCTATTT TAAAAAACACCCTGTTAAAAAAATAATTATATCCCTTAAACGACAGTTAATTAAAAATATAGATTCTAATCTGATTTCCC CGTATAATGAGGTTATTAAGGCTTTGACTCTGGGGGAGAAAAGCAATTTGCCCCGGGAGTGGGACCGCTGGTTTAGCCAG GCCGGTGCCAATCACCTTCTGGCTATCTCGGGTTTACATGTTGGATTTATTGTAATTATGCTTTTAACGATTGTAAAGAT TTTTAAATTACCGACAGGATGGCAAAATTTTTTTATCACGCTTTTTTTAGTTATATATATAATCATGACCGGTTTCAGGA GTTCTGTATTCAGGGCCGGGATACTATCGTTGGTGTTTTTGTGGGCACCATATTTCAATAGGGAAGCTGATTTTTTCAAT ACCCTGGGACTGGCAGCTATACTTAATCTGGTTATAAATCCCCTGTCATTATTTATGGTTGGTTTTCAGTTAACTTACCT TGTTTTAATATTTATTATATTATGGAGTGGAATTTTAAAAAAATATTTAGGCAATATTGTTGCAGTTTCCGGGGCTGCTT TACTGGGTTCATCACCCATTATAAGTTATTATTTTAATATTATTACCCCGATAGGTATTTTAACAAATATATGGGCTATT CCGCTGGCCGGCCTTGTTGTCAGTATGAGCATGATAGGCTTAATCCTGGGCCTGGTTCATCCGGTCTTTAGCTTGGTAAT TTTTCGTTTGTTTGTATACTATCTCTTAAGGTTACTGGGGACCGGTATGAAATTTATGGCCCTGTTACCTTTTGATATTG AAGTACCTCAACCACCATTGTTTATTTTACTGGCTATATATTCAGTACTGATTTACTTACCATTTTTGTTAAAAACCAGG TATATTCCATATAATATTAAAAGGCAAAAAATGAAGTTGAAATGGGCAGGTGTCCTGGTTACCTGTTTAATAGTTATGAT GGTATTAATGGGTATTTTTCCGTCACAGCTTGAAATAATATTTTTTGATGTAGGTCAGGGGGATGCAATAATAATTAACC TGCCAGATGGGCACCACATTATGGTGGATGGAGGAGGGTGGTTAACAAAATCTTCAACCCGGGCAGATAAGGTTTTATTA CCTTACTTAAGGGACAGGGGAATAAAAAAGATAGATATAGTATTCATAACCCATTTTGATGCTGACCACGCCCTGGGGGT ATTAACCATTCTCAAAAACCGTGAGGTTGGTTTGTTGTGTATTCCTGAGGTAGATAAAAACTCTACCCTTTGTCAAAAGA TATTAGCGGTGGCATTTAAAAAAGATATTCCGGTTCATATAGTTAAAAAAGGTGATTATTTTAAATCCGGTTCAGTTTTT TTAAAAATATTTAATTCAGGAACAAAAGGTAGTTTATATAGTAGAAATGATAATTCTATAGTACTTAAATTAAGTTACGG AAAATTTGACCTCCTTTTAACTGGAGATGCCGGGAAAAAGGTTGAATATAATCTTATGAGGTCAGGTCAATTATTAAAAA GTGAAGTATTGAAACTTGCCCATCATGGGAGTGAAGATTCTTCAAGTTCCCTTTTTCTTAAAAAAGTTTTGCCTGAAGAT GTTATTATATCAGTAGGTCCAAATAAATATGGTCACCCTTCACCATCTGTATTAAATCGTGTTCAAAATATCAGGGCCAG GGTGTGGAGGACGGACAAGCAGGGAGCAATAGTTATTAATACAAATGGCAGGGAATATGAAATAAAAAGTTTTTTACAGC AAAATTAA
Upstream 100 bases:
>100_bases GAAAACGGCTTTTTTACAGATAAGGCACAACTACTTAATGTTTCCGGGATTGGGGAGAAGACTTATGAAAAATTAAAAGA TAAAGTGAGTTTAAGATGAG
Downstream 100 bases:
>100_bases AATGAGCGGGATTCAATCCCGCTCATTTTAGGGTCGACTTACTTTACAGTATTAAAAGGAGATGATTTTTATAATTCCAG GATAATTAAACCAGAAACGT
Product: DNA internalization-related competence protein ComEC/Rec2
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 775; Mature: 775
Protein sequence:
>775_residues MKSRPLFWTALFLIMGITLGYFININIYILIVLLVFFITCGTFCWLKNYEKYSRVVIVITVILTGLFLVEFEEAKYNSKW SIADWNGNGEKVVLGEVVLDLAALEGNKIYLKPLYVNGHRVKYGLIQLDQRYIKEDLVNGDIVRVYLVLQTPYRQTNPGS FSQYKYLFKKGVFSKGYVTGPVSKTYFKKHPVKKIIISLKRQLIKNIDSNLISPYNEVIKALTLGEKSNLPREWDRWFSQ AGANHLLAISGLHVGFIVIMLLTIVKIFKLPTGWQNFFITLFLVIYIIMTGFRSSVFRAGILSLVFLWAPYFNREADFFN TLGLAAILNLVINPLSLFMVGFQLTYLVLIFIILWSGILKKYLGNIVAVSGAALLGSSPIISYYFNIITPIGILTNIWAI PLAGLVVSMSMIGLILGLVHPVFSLVIFRLFVYYLLRLLGTGMKFMALLPFDIEVPQPPLFILLAIYSVLIYLPFLLKTR YIPYNIKRQKMKLKWAGVLVTCLIVMMVLMGIFPSQLEIIFFDVGQGDAIIINLPDGHHIMVDGGGWLTKSSTRADKVLL PYLRDRGIKKIDIVFITHFDADHALGVLTILKNREVGLLCIPEVDKNSTLCQKILAVAFKKDIPVHIVKKGDYFKSGSVF LKIFNSGTKGSLYSRNDNSIVLKLSYGKFDLLLTGDAGKKVEYNLMRSGQLLKSEVLKLAHHGSEDSSSSLFLKKVLPED VIISVGPNKYGHPSPSVLNRVQNIRARVWRTDKQGAIVINTNGREYEIKSFLQQN
Sequences:
>Translated_775_residues MKSRPLFWTALFLIMGITLGYFININIYILIVLLVFFITCGTFCWLKNYEKYSRVVIVITVILTGLFLVEFEEAKYNSKW SIADWNGNGEKVVLGEVVLDLAALEGNKIYLKPLYVNGHRVKYGLIQLDQRYIKEDLVNGDIVRVYLVLQTPYRQTNPGS FSQYKYLFKKGVFSKGYVTGPVSKTYFKKHPVKKIIISLKRQLIKNIDSNLISPYNEVIKALTLGEKSNLPREWDRWFSQ AGANHLLAISGLHVGFIVIMLLTIVKIFKLPTGWQNFFITLFLVIYIIMTGFRSSVFRAGILSLVFLWAPYFNREADFFN TLGLAAILNLVINPLSLFMVGFQLTYLVLIFIILWSGILKKYLGNIVAVSGAALLGSSPIISYYFNIITPIGILTNIWAI PLAGLVVSMSMIGLILGLVHPVFSLVIFRLFVYYLLRLLGTGMKFMALLPFDIEVPQPPLFILLAIYSVLIYLPFLLKTR YIPYNIKRQKMKLKWAGVLVTCLIVMMVLMGIFPSQLEIIFFDVGQGDAIIINLPDGHHIMVDGGGWLTKSSTRADKVLL PYLRDRGIKKIDIVFITHFDADHALGVLTILKNREVGLLCIPEVDKNSTLCQKILAVAFKKDIPVHIVKKGDYFKSGSVF LKIFNSGTKGSLYSRNDNSIVLKLSYGKFDLLLTGDAGKKVEYNLMRSGQLLKSEVLKLAHHGSEDSSSSLFLKKVLPED VIISVGPNKYGHPSPSVLNRVQNIRARVWRTDKQGAIVINTNGREYEIKSFLQQN >Mature_775_residues MKSRPLFWTALFLIMGITLGYFININIYILIVLLVFFITCGTFCWLKNYEKYSRVVIVITVILTGLFLVEFEEAKYNSKW SIADWNGNGEKVVLGEVVLDLAALEGNKIYLKPLYVNGHRVKYGLIQLDQRYIKEDLVNGDIVRVYLVLQTPYRQTNPGS FSQYKYLFKKGVFSKGYVTGPVSKTYFKKHPVKKIIISLKRQLIKNIDSNLISPYNEVIKALTLGEKSNLPREWDRWFSQ AGANHLLAISGLHVGFIVIMLLTIVKIFKLPTGWQNFFITLFLVIYIIMTGFRSSVFRAGILSLVFLWAPYFNREADFFN TLGLAAILNLVINPLSLFMVGFQLTYLVLIFIILWSGILKKYLGNIVAVSGAALLGSSPIISYYFNIITPIGILTNIWAI PLAGLVVSMSMIGLILGLVHPVFSLVIFRLFVYYLLRLLGTGMKFMALLPFDIEVPQPPLFILLAIYSVLIYLPFLLKTR YIPYNIKRQKMKLKWAGVLVTCLIVMMVLMGIFPSQLEIIFFDVGQGDAIIINLPDGHHIMVDGGGWLTKSSTRADKVLL PYLRDRGIKKIDIVFITHFDADHALGVLTILKNREVGLLCIPEVDKNSTLCQKILAVAFKKDIPVHIVKKGDYFKSGSVF LKIFNSGTKGSLYSRNDNSIVLKLSYGKFDLLLTGDAGKKVEYNLMRSGQLLKSEVLKLAHHGSEDSSSSLFLKKVLPED VIISVGPNKYGHPSPSVLNRVQNIRARVWRTDKQGAIVINTNGREYEIKSFLQQN
Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]
COG id: COG2333
COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]
Homologues:
Organism=Escherichia coli, GI87081801, Length=720, Percent_Identity=22.9166666666667, Blast_Score=104, Evalue=2e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001279 - InterPro: IPR004477 - InterPro: IPR004797 [H]
Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]
EC number: NA
Molecular weight: Translated: 87645; Mature: 87645
Theoretical pI: Translated: 10.17; Mature: 10.17
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKSRPLFWTALFLIMGITLGYFININIYILIVLLVFFITCGTFCWLKNYEKYSRVVIVIT CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH VILTGLFLVEFEEAKYNSKWSIADWNGNGEKVVLGEVVLDLAALEGNKIYLKPLYVNGHR HHHHHHHHEEECCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHCCCCEEEEEEEEECCCE VKYGLIQLDQRYIKEDLVNGDIVRVYLVLQTPYRQTNPGSFSQYKYLFKKGVFSKGYVTG EEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEC PVSKTYFKKHPVKKIIISLKRQLIKNIDSNLISPYNEVIKALTLGEKSNLPREWDRWFSQ CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHH AGANHLLAISGLHVGFIVIMLLTIVKIFKLPTGWQNFFITLFLVIYIIMTGFRSSVFRAG CCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH ILSLVFLWAPYFNREADFFNTLGLAAILNLVINPLSLFMVGFQLTYLVLIFIILWSGILK HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KYLGNIVAVSGAALLGSSPIISYYFNIITPIGILTNIWAIPLAGLVVSMSMIGLILGLVH HHHCCEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH PVFSLVIFRLFVYYLLRLLGTGMKFMALLPFDIEVPQPPLFILLAIYSVLIYLPFLLKTR HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC YIPYNIKRQKMKLKWAGVLVTCLIVMMVLMGIFPSQLEIIFFDVGQGDAIIINLPDGHHI CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCCCEE MVDGGGWLTKSSTRADKVLLPYLRDRGIKKIDIVFITHFDADHALGVLTILKNREVGLLC EEECCCEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCEEE IPEVDKNSTLCQKILAVAFKKDIPVHIVKKGDYFKSGSVFLKIFNSGTKGSLYSRNDNSI CCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCEE VLKLSYGKFDLLLTGDAGKKVEYNLMRSGQLLKSEVLKLAHHGSEDSSSSLFLKKVLPED EEEEECCCEEEEEECCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC VIISVGPNKYGHPSPSVLNRVQNIRARVWRTDKQGAIVINTNGREYEIKSFLQQN EEEEECCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEEECCCCCHHHHHHHHCC >Mature Secondary Structure MKSRPLFWTALFLIMGITLGYFININIYILIVLLVFFITCGTFCWLKNYEKYSRVVIVIT CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH VILTGLFLVEFEEAKYNSKWSIADWNGNGEKVVLGEVVLDLAALEGNKIYLKPLYVNGHR HHHHHHHHEEECCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHCCCCEEEEEEEEECCCE VKYGLIQLDQRYIKEDLVNGDIVRVYLVLQTPYRQTNPGSFSQYKYLFKKGVFSKGYVTG EEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEC PVSKTYFKKHPVKKIIISLKRQLIKNIDSNLISPYNEVIKALTLGEKSNLPREWDRWFSQ CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHH AGANHLLAISGLHVGFIVIMLLTIVKIFKLPTGWQNFFITLFLVIYIIMTGFRSSVFRAG CCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH ILSLVFLWAPYFNREADFFNTLGLAAILNLVINPLSLFMVGFQLTYLVLIFIILWSGILK HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KYLGNIVAVSGAALLGSSPIISYYFNIITPIGILTNIWAIPLAGLVVSMSMIGLILGLVH HHHCCEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH PVFSLVIFRLFVYYLLRLLGTGMKFMALLPFDIEVPQPPLFILLAIYSVLIYLPFLLKTR HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC YIPYNIKRQKMKLKWAGVLVTCLIVMMVLMGIFPSQLEIIFFDVGQGDAIIINLPDGHHI CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCCCEE MVDGGGWLTKSSTRADKVLLPYLRDRGIKKIDIVFITHFDADHALGVLTILKNREVGLLC EEECCCEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCEEE IPEVDKNSTLCQKILAVAFKKDIPVHIVKKGDYFKSGSVFLKIFNSGTKGSLYSRNDNSI CCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCCEE VLKLSYGKFDLLLTGDAGKKVEYNLMRSGQLLKSEVLKLAHHGSEDSSSSLFLKKVLPED EEEEECCCEEEEEECCCCCCEEEHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC VIISVGPNKYGHPSPSVLNRVQNIRARVWRTDKQGAIVINTNGREYEIKSFLQQN EEEEECCCCCCCCCHHHHHHHHHHHHHHEECCCCCEEEEECCCCCHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 7968523; 8969508; 9384377 [H]