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The map label for this gene is apt

Identifier: 220932057

GI number: 220932057

Start: 1313946

End: 1314458

Strand: Reverse

Name: apt

Synonym: Hore_12200

Alternate gene names: 220932057

Gene position: 1314458-1313946 (Counterclockwise)

Preceding gene: 220932058

Following gene: 220932056

Centisome position: 50.98

GC content: 35.28

Gene sequence:

>513_bases
ATGGAATTAAAAAAGTTTATCAGAGATATCCCGGACTTCCCTAAAAAAGGAATCATTTTTAAGGATATAACCCCACTTTT
AAAAGATAAAGAGGCTTTTAACCTGGCTATTGAAAAGATGAAGGACTATTATAAGGATTTTGATATTGATTATATTGTGG
GAATTGAAGCCAGGGGATTTATAATAGGGACTCCCCTCGCTTTAGCATTAAATAAAGGGTTTATCCCCATTAGAAAACCC
GGTAAATTACCTGCTGAAAGGATTTCAACCAGTTATGAACTGGAGTATGGTACCAATGAAATAGAAATTCATCGTGATGC
TATTCAGCCTGGTGATAAAATATTACTGGTAGATGATCTCCTGGCTACCGGAGGAACAGTAAAGGCTGCTATAGAATTAA
TCAATAAATTACAGGGAGAGATTGTAAGTTTAGGGTTTTTAATTGAACTAGTTGATCTGAAAGGGAGAGAGAAACTGGAA
GGTTATGATGTTTTTACATTACTCCAGGAATGA

Upstream 100 bases:

>100_bases
CAACAAGGGAATTTGGTAGTTTTTCCACACTTGCTTTTGAGGATAATTTATTTAAATTAATTAATAAATTGAATGAAGAT
TAACAGGAGGAGGAAGAGCA

Downstream 100 bases:

>100_bases
AGGGATAAAATATGCAGCTTAAGAATTTATTATTGAAAATAAAAGAATATACTACAAATCCTGATCTGGAACTGGTAAAA
AGGGCTTACAATTTTGCTAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MELKKFIRDIPDFPKKGIIFKDITPLLKDKEAFNLAIEKMKDYYKDFDIDYIVGIEARGFIIGTPLALALNKGFIPIRKP
GKLPAERISTSYELEYGTNEIEIHRDAIQPGDKILLVDDLLATGGTVKAAIELINKLQGEIVSLGFLIELVDLKGREKLE
GYDVFTLLQE

Sequences:

>Translated_170_residues
MELKKFIRDIPDFPKKGIIFKDITPLLKDKEAFNLAIEKMKDYYKDFDIDYIVGIEARGFIIGTPLALALNKGFIPIRKP
GKLPAERISTSYELEYGTNEIEIHRDAIQPGDKILLVDDLLATGGTVKAAIELINKLQGEIVSLGFLIELVDLKGREKLE
GYDVFTLLQE
>Mature_170_residues
MELKKFIRDIPDFPKKGIIFKDITPLLKDKEAFNLAIEKMKDYYKDFDIDYIVGIEARGFIIGTPLALALNKGFIPIRKP
GKLPAERISTSYELEYGTNEIEIHRDAIQPGDKILLVDDLLATGGTVKAAIELINKLQGEIVSLGFLIELVDLKGREKLE
GYDVFTLLQE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=48.2352941176471, Blast_Score=165, Evalue=1e-41,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=47.2, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=55.0632911392405, Blast_Score=186, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=42.9411764705882, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=44.1860465116279, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320649, Length=172, Percent_Identity=37.2093023255814, Blast_Score=94, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=42.8571428571429, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_HALOH (B8CXF1)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508965.1
- ProteinModelPortal:   B8CXF1
- SMR:   B8CXF1
- GeneID:   7313921
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_12200
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19184; Mature: 19184

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKKFIRDIPDFPKKGIIFKDITPLLKDKEAFNLAIEKMKDYYKDFDIDYIVGIEARGF
CCHHHHHHCCCCCCCCCEEHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCE
IIGTPLALALNKGFIPIRKPGKLPAERISTSYELEYGTNEIEIHRDAIQPGDKILLVDDL
EEECHHHHHHCCCCCCCCCCCCCCHHHCCCEEEEEECCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKAAIELINKLQGEIVSLGFLIELVDLKGREKLEGYDVFTLLQE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MELKKFIRDIPDFPKKGIIFKDITPLLKDKEAFNLAIEKMKDYYKDFDIDYIVGIEARGF
CCHHHHHHCCCCCCCCCEEHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCE
IIGTPLALALNKGFIPIRKPGKLPAERISTSYELEYGTNEIEIHRDAIQPGDKILLVDDL
EEECHHHHHHCCCCCCCCCCCCCCHHHCCCEEEEEECCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKAAIELINKLQGEIVSLGFLIELVDLKGREKLEGYDVFTLLQE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA