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The map label for this gene is relA [H]

Identifier: 220932056

GI number: 220932056

Start: 1311784

End: 1313934

Strand: Reverse

Name: relA [H]

Synonym: Hore_12190

Alternate gene names: 220932056

Gene position: 1313934-1311784 (Counterclockwise)

Preceding gene: 220932057

Following gene: 220932055

Centisome position: 50.96

GC content: 37.89

Gene sequence:

>2151_bases
ATGCAGCTTAAGAATTTATTATTGAAAATAAAAGAATATACTACAAATCCTGATCTGGAACTGGTAAAAAGGGCTTACAA
TTTTGCTAAAGATGCTCATGAGGGACAGTTCCGGGTTTCAGGAGAACCCTTTATAGAGCATCCCCTCGGGGTTGCCTGTA
TTCTGGCCGAGTTAGAACTTGATATTATTTCTATCTCGGCTGCTTTATTACACGATGTTGTTGAGGATACTTCAGTTACC
AGTAAAAATATAGAAGAAGAGTTTGGAGATGAAATAGCCCTGTTAGTGGATGGTGTGACCAAACTGACCAGGCTTGAGTT
TAAATCAAAAGAAGAACATCAGGCCGAAAATTTACGGAAAATGTTTCTGGCCATGTCTGAGGATATAAGGGTGGTTTTAA
TAAAACTGGCTGACAGGCTTCATAATATGAGGACCTTACGCTTTCTTGCGAAGGAAAAACAGGTAGAGAAGGCTAAAGAA
ACCCTGGAAATATATGCTCCTCTGGCTCACCGCCTTGGAATGTCCAGATTAAAATGGGAGCTTGAAGATTTGAGTTTTAG
ATTTATTGATTCCAAAATGTATTATGAAATTGCAGAAAAAGTTGCTGCCAACCGTAAACAGAGAATTAGAGATATAAAGG
AAGCTATAAAAATTCTTAATGATAAACTGGGTAACCAGGGAATACTGGCAGAGATATATGGTCGGCCTAAACATCTTTAT
AGTATATATCAAAAAATGAAAAGAAAAGAAGTTGATTTTAATGAGATATACGACCTGACAGCAATTAGAATTATTGTAAA
TTCTGTTAAAGAATGTTATGAAGTCCTGGGAATAGTTCATGAAATCTGGAAACCTATTCCCGGTCGCTTTAAAGATTATA
TTGCCATGCCTAAATCAAATATGTATCAATCCCTTCATACAACAGTAATCGGTCCCAAAGGGGATCCCCTGGAGGTTCAG
ATCAGGACACCGGAAATGCACAGGACGGCTGAATATGGTATTGCTGCCCACTGGAAATATAAAGAGGGGAAAACCGGTAA
AGATGATTTTGAAGAAAAACTCTCCTGGTTGAGGCAGATACTGGAGTGGCAGAAAGACCTCAAAGAACCCCAGGAATTTA
TTGAAAACTTAAAGATTGACCTCTTTGAAGATGAAGTTTTTGTTTTTACACCAAAGGGTGATGTCATTTCTCTTCCTACA
GGGAGTACCCCCGTTGATTTTGCCTACAATATTCATACAGAAGTGGGTCATAGCTGTGTTGGAGCCAAAGTTAACGGGAA
AATTGTCCCCCTTGAATACCGTATGAGCAATGGTGATATTGTAGAAATATTGACTTCGAAAAATAGTACAGGTCCCAGTC
GTGACTGGTTAAAGTTTGTAAAAACATCAAGGGCAAGAAGTAAGATAAAAAGGTGGTTTAAACAGCAGGAAAGGGACCAG
ATAATACAGAGAGGTAAGGAATTATTTGATCGGGAGTTAAAAAGACTTAATGTGGAACTTAAAGAGGATGCAAAAGAAAA
AGAACTGGTTGAAATAGCCCGAAAAATGGGGAAAAATAATGCCGATGAGCTTTTTGAGGTCATTGGTTATAATCAGGTTA
GCCCCAAAACTATTATAAATAAACTGCCTTCAGTCCAGATTAAAGAAGAGAGCCAGCTTGAGAAACTGAAGAAAACTCCC
AGGAGGAGAAAGTCTACCAGTAAAGGTGTAAAGGTTGAAGGAATGGATGATCTACTTGTTAGAATTGCTAAATGCTGTAA
TCCCGTTCCTGGTGATAAAATAATCGGGTATATTACCAGGGGAAGGGGGGTTTCCGTTCATCGTACTGATTGTCCCAATC
TTCTACAATTATCAAAACGGGATAAAAACAGGTTAATAAATGTTTACTGGAATAACTACAGGACTGATTCTTATGAAGTT
AACCTGGTTATAGATGCATTTAACAAAAAGGCTCTGTTAAATGATATTACTTCTCTTATTAAAGAAGAGGATGTTAATCT
GTTATCGGTCATGGCCAGGACTGACCGTTATAACCGGGCCAAAATTGAATTATCACTGGAGTTAAGCAGTCTGGAGCATA
TGAGGGATATTATAAATAAACTTGAAAAAATAACTGGTGTTCTTTCTGTTAAACGGGCAAAACCAACCTAA

Upstream 100 bases:

>100_bases
TAAGTTTAGGGTTTTTAATTGAACTAGTTGATCTGAAAGGGAGAGAGAAACTGGAAGGTTATGATGTTTTTACATTACTC
CAGGAATGAAGGGATAAAAT

Downstream 100 bases:

>100_bases
GGAGTGATGTTATGAGGGCTGTTGTTCAACGGGTAAAAGAAGCCAGTGTTACTGTTGCAGGTGATATAAAAGGAAAAATA
GATAAGGGTTTACTTGTCTT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 716; Mature: 716

Protein sequence:

>716_residues
MQLKNLLLKIKEYTTNPDLELVKRAYNFAKDAHEGQFRVSGEPFIEHPLGVACILAELELDIISISAALLHDVVEDTSVT
SKNIEEEFGDEIALLVDGVTKLTRLEFKSKEEHQAENLRKMFLAMSEDIRVVLIKLADRLHNMRTLRFLAKEKQVEKAKE
TLEIYAPLAHRLGMSRLKWELEDLSFRFIDSKMYYEIAEKVAANRKQRIRDIKEAIKILNDKLGNQGILAEIYGRPKHLY
SIYQKMKRKEVDFNEIYDLTAIRIIVNSVKECYEVLGIVHEIWKPIPGRFKDYIAMPKSNMYQSLHTTVIGPKGDPLEVQ
IRTPEMHRTAEYGIAAHWKYKEGKTGKDDFEEKLSWLRQILEWQKDLKEPQEFIENLKIDLFEDEVFVFTPKGDVISLPT
GSTPVDFAYNIHTEVGHSCVGAKVNGKIVPLEYRMSNGDIVEILTSKNSTGPSRDWLKFVKTSRARSKIKRWFKQQERDQ
IIQRGKELFDRELKRLNVELKEDAKEKELVEIARKMGKNNADELFEVIGYNQVSPKTIINKLPSVQIKEESQLEKLKKTP
RRRKSTSKGVKVEGMDDLLVRIAKCCNPVPGDKIIGYITRGRGVSVHRTDCPNLLQLSKRDKNRLINVYWNNYRTDSYEV
NLVIDAFNKKALLNDITSLIKEEDVNLLSVMARTDRYNRAKIELSLELSSLEHMRDIINKLEKITGVLSVKRAKPT

Sequences:

>Translated_716_residues
MQLKNLLLKIKEYTTNPDLELVKRAYNFAKDAHEGQFRVSGEPFIEHPLGVACILAELELDIISISAALLHDVVEDTSVT
SKNIEEEFGDEIALLVDGVTKLTRLEFKSKEEHQAENLRKMFLAMSEDIRVVLIKLADRLHNMRTLRFLAKEKQVEKAKE
TLEIYAPLAHRLGMSRLKWELEDLSFRFIDSKMYYEIAEKVAANRKQRIRDIKEAIKILNDKLGNQGILAEIYGRPKHLY
SIYQKMKRKEVDFNEIYDLTAIRIIVNSVKECYEVLGIVHEIWKPIPGRFKDYIAMPKSNMYQSLHTTVIGPKGDPLEVQ
IRTPEMHRTAEYGIAAHWKYKEGKTGKDDFEEKLSWLRQILEWQKDLKEPQEFIENLKIDLFEDEVFVFTPKGDVISLPT
GSTPVDFAYNIHTEVGHSCVGAKVNGKIVPLEYRMSNGDIVEILTSKNSTGPSRDWLKFVKTSRARSKIKRWFKQQERDQ
IIQRGKELFDRELKRLNVELKEDAKEKELVEIARKMGKNNADELFEVIGYNQVSPKTIINKLPSVQIKEESQLEKLKKTP
RRRKSTSKGVKVEGMDDLLVRIAKCCNPVPGDKIIGYITRGRGVSVHRTDCPNLLQLSKRDKNRLINVYWNNYRTDSYEV
NLVIDAFNKKALLNDITSLIKEEDVNLLSVMARTDRYNRAKIELSLELSSLEHMRDIINKLEKITGVLSVKRAKPT
>Mature_716_residues
MQLKNLLLKIKEYTTNPDLELVKRAYNFAKDAHEGQFRVSGEPFIEHPLGVACILAELELDIISISAALLHDVVEDTSVT
SKNIEEEFGDEIALLVDGVTKLTRLEFKSKEEHQAENLRKMFLAMSEDIRVVLIKLADRLHNMRTLRFLAKEKQVEKAKE
TLEIYAPLAHRLGMSRLKWELEDLSFRFIDSKMYYEIAEKVAANRKQRIRDIKEAIKILNDKLGNQGILAEIYGRPKHLY
SIYQKMKRKEVDFNEIYDLTAIRIIVNSVKECYEVLGIVHEIWKPIPGRFKDYIAMPKSNMYQSLHTTVIGPKGDPLEVQ
IRTPEMHRTAEYGIAAHWKYKEGKTGKDDFEEKLSWLRQILEWQKDLKEPQEFIENLKIDLFEDEVFVFTPKGDVISLPT
GSTPVDFAYNIHTEVGHSCVGAKVNGKIVPLEYRMSNGDIVEILTSKNSTGPSRDWLKFVKTSRARSKIKRWFKQQERDQ
IIQRGKELFDRELKRLNVELKEDAKEKELVEIARKMGKNNADELFEVIGYNQVSPKTIINKLPSVQIKEESQLEKLKKTP
RRRKSTSKGVKVEGMDDLLVRIAKCCNPVPGDKIIGYITRGRGVSVHRTDCPNLLQLSKRDKNRLINVYWNNYRTDSYEV
NLVIDAFNKKALLNDITSLIKEEDVNLLSVMARTDRYNRAKIELSLELSSLEHMRDIINKLEKITGVLSVKRAKPT

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=139, Percent_Identity=37.410071942446, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790082, Length=710, Percent_Identity=41.830985915493, Blast_Score=553, Evalue=1e-158,
Organism=Escherichia coli, GI1789147, Length=682, Percent_Identity=39.7360703812317, Blast_Score=552, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25143118, Length=138, Percent_Identity=36.9565217391304, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82843; Mature: 82843

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKNLLLKIKEYTTNPDLELVKRAYNFAKDAHEGQFRVSGEPFIEHPLGVACILAELEL
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCHHCCCCHHHHHHHHHHH
DIISISAALLHDVVEDTSVTSKNIEEEFGDEIALLVDGVTKLTRLEFKSKEEHQAENLRK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MFLAMSEDIRVVLIKLADRLHNMRTLRFLAKEKQVEKAKETLEIYAPLAHRLGMSRLKWE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LEDLSFRFIDSKMYYEIAEKVAANRKQRIRDIKEAIKILNDKLGNQGILAEIYGRPKHLY
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHH
SIYQKMKRKEVDFNEIYDLTAIRIIVNSVKECYEVLGIVHEIWKPIPGRFKDYIAMPKSN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHH
MYQSLHTTVIGPKGDPLEVQIRTPEMHRTAEYGIAAHWKYKEGKTGKDDFEEKLSWLRQI
HHHHHHHEEECCCCCCEEEEEECCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHH
LEWQKDLKEPQEFIENLKIDLFEDEVFVFTPKGDVISLPTGSTPVDFAYNIHTEVGHSCV
HHHHHHHHHHHHHHHHCCCEEEECCEEEECCCCCEEECCCCCCCCCEEEEECHHHCCCCC
GAKVNGKIVPLEYRMSNGDIVEILTSKNSTGPSRDWLKFVKTSRARSKIKRWFKQQERDQ
CCEECCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIQRGKELFDRELKRLNVELKEDAKEKELVEIARKMGKNNADELFEVIGYNQVSPKTIIN
HHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHH
KLPSVQIKEESQLEKLKKTPRRRKSTSKGVKVEGMDDLLVRIAKCCNPVPGDKIIGYITR
HCCCCEECCHHHHHHHHHCHHHHCCCCCCCEECCHHHHHHHHHHHCCCCCCCCEEEEEEC
GRGVSVHRTDCPNLLQLSKRDKNRLINVYWNNYRTDSYEVNLVIDAFNKKALLNDITSLI
CCCCEEECCCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHH
KEEDVNLLSVMARTDRYNRAKIELSLELSSLEHMRDIINKLEKITGVLSVKRAKPT
HHCCCHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQLKNLLLKIKEYTTNPDLELVKRAYNFAKDAHEGQFRVSGEPFIEHPLGVACILAELEL
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCHHCCCCHHHHHHHHHHH
DIISISAALLHDVVEDTSVTSKNIEEEFGDEIALLVDGVTKLTRLEFKSKEEHQAENLRK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MFLAMSEDIRVVLIKLADRLHNMRTLRFLAKEKQVEKAKETLEIYAPLAHRLGMSRLKWE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LEDLSFRFIDSKMYYEIAEKVAANRKQRIRDIKEAIKILNDKLGNQGILAEIYGRPKHLY
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHH
SIYQKMKRKEVDFNEIYDLTAIRIIVNSVKECYEVLGIVHEIWKPIPGRFKDYIAMPKSN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHH
MYQSLHTTVIGPKGDPLEVQIRTPEMHRTAEYGIAAHWKYKEGKTGKDDFEEKLSWLRQI
HHHHHHHEEECCCCCCEEEEEECCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHH
LEWQKDLKEPQEFIENLKIDLFEDEVFVFTPKGDVISLPTGSTPVDFAYNIHTEVGHSCV
HHHHHHHHHHHHHHHHCCCEEEECCEEEECCCCCEEECCCCCCCCCEEEEECHHHCCCCC
GAKVNGKIVPLEYRMSNGDIVEILTSKNSTGPSRDWLKFVKTSRARSKIKRWFKQQERDQ
CCEECCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIQRGKELFDRELKRLNVELKEDAKEKELVEIARKMGKNNADELFEVIGYNQVSPKTIIN
HHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHH
KLPSVQIKEESQLEKLKKTPRRRKSTSKGVKVEGMDDLLVRIAKCCNPVPGDKIIGYITR
HCCCCEECCHHHHHHHHHCHHHHCCCCCCCEECCHHHHHHHHHHHCCCCCCCCEEEEEEC
GRGVSVHRTDCPNLLQLSKRDKNRLINVYWNNYRTDSYEVNLVIDAFNKKALLNDITSLI
CCCCEEECCCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHH
KEEDVNLLSVMARTDRYNRAKIELSLELSSLEHMRDIINKLEKITGVLSVKRAKPT
HHCCCHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]