BacMap

Definition	Halothermothrix orenii H 168 chromosome, complete genome.
Accession	NC_011899
Length	2,578,146

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The map label for this gene is gmk [H]

Identifier: 220931824

GI number: 220931824

Start: 1070615

End: 1071199

Strand: Direct

Name: gmk [H]

Synonym: Hore_09810

Alternate gene names: 220931824

Gene position: 1070615-1071199 (Clockwise)

Preceding gene: 220931823

Following gene: 220931825

Centisome position: 41.53

GC content: 35.04

Gene sequence:

>585_bases
ATGGGAAAGGGGAAACTTTTTGTACTGTCAGGTCCTTCTGGTGTAGGTAAAGGGACGGTTTTAGATAAATTATTATCTGA
TTTTAAAGATGTCCAGTACTCTGTTTCTGCCACTACAAGAAAACCCAGACCGGGGGAGAAAGATGGAGTAGATTACTTTT
TTCTCAGCCGTGAGAAGTTTTTTAAAATGGTTGAGAATAATGAATTTATCGAATGGGCCGAAGTCCATAATAATTATTAC
GGAACTCCTAAAATATTTGTAGATAAATGCCTGGCTGAGGGTAAAGATGTTATTCTGGAAATAGATATTCAGGGGGCACG
CCAGGTCAAAAAGCTCTACCCCGATGCCATCTTTATTTTTTTGGTTCCCCCGTCTCTTAATGAATTAAAAAGGCGTTTAA
ATCATCGTGGTTCAGAAGATGAAAAAAATATGAAAATCAGGTTAAATAATGCTGAAGATGAATTAAAAGAGGTTAAAAAT
TATGATTATAAAGTTGTTAATGACCGGCTTGATGATGCTGTTGAAAAATTAAAATCTATAATTATAGCTGAAAAATGTAA
AATAAGGGAGGAGGATTGTCAATGA

Upstream 100 bases:

>100_bases
GTGATCATGTTATTCTATCAGCTATTCAACCAGAAACAGTCTCCCACCGTTTAAGCGGGGAAGATGGGAACAGATAGGGA
GTAGTGAAAGGAGACCTAAA

Downstream 100 bases:

>100_bases
TAACCTATCCTTCAATGGGAAAGCTTTTAAAAAAAGTGGACAGTCCTTATACTTTAGTTATACTGGCTTCAAGGAGGGCC
CGTCAATTAAACGTGGGAGC

Product: Guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MGKGKLFVLSGPSGVGKGTVLDKLLSDFKDVQYSVSATTRKPRPGEKDGVDYFFLSREKFFKMVENNEFIEWAEVHNNYY
GTPKIFVDKCLAEGKDVILEIDIQGARQVKKLYPDAIFIFLVPPSLNELKRRLNHRGSEDEKNMKIRLNNAEDELKEVKN
YDYKVVNDRLDDAVEKLKSIIIAEKCKIREEDCQ

Sequences:

>Translated_194_residues
MGKGKLFVLSGPSGVGKGTVLDKLLSDFKDVQYSVSATTRKPRPGEKDGVDYFFLSREKFFKMVENNEFIEWAEVHNNYY
GTPKIFVDKCLAEGKDVILEIDIQGARQVKKLYPDAIFIFLVPPSLNELKRRLNHRGSEDEKNMKIRLNNAEDELKEVKN
YDYKVVNDRLDDAVEKLKSIIIAEKCKIREEDCQ
>Mature_193_residues
GKGKLFVLSGPSGVGKGTVLDKLLSDFKDVQYSVSATTRKPRPGEKDGVDYFFLSREKFFKMVENNEFIEWAEVHNNYYG
TPKIFVDKCLAEGKDVILEIDIQGARQVKKLYPDAIFIFLVPPSLNELKRRLNHRGSEDEKNMKIRLNNAEDELKEVKNY
DYKVVNDRLDDAVEKLKSIIIAEKCKIREEDCQ

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=39.3617021276596, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=39.3617021276596, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=39.3617021276596, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI111154074, Length=123, Percent_Identity=37.3983739837398, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=28.2485875706215, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=28.2485875706215, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=28.2485875706215, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=28.2485875706215, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI14780902, Length=195, Percent_Identity=29.2307692307692, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI186972120, Length=182, Percent_Identity=23.6263736263736, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI186700629, Length=182, Percent_Identity=23.6263736263736, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI186700627, Length=182, Percent_Identity=23.6263736263736, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI21389483, Length=181, Percent_Identity=27.6243093922652, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=29.7752808988764, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4557529, Length=177, Percent_Identity=31.638418079096, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI21361598, Length=188, Percent_Identity=27.1276595744681, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI148539578, Length=177, Percent_Identity=33.8983050847458, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI148539628, Length=177, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI192447426, Length=181, Percent_Identity=30.3867403314917, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI218156338, Length=175, Percent_Identity=34.2857142857143, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=193, Percent_Identity=43.5233160621762, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=171, Percent_Identity=40.9356725146199, Blast_Score=133, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17508835, Length=171, Percent_Identity=40.9356725146199, Blast_Score=132, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71988048, Length=180, Percent_Identity=25.5555555555556, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=180, Percent_Identity=25.5555555555556, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=180, Percent_Identity=28.8888888888889, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556244, Length=123, Percent_Identity=32.520325203252, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=47.2527472527472, Blast_Score=161, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=41.2087912087912, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45554481, Length=172, Percent_Identity=27.3255813953488, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI85724806, Length=172, Percent_Identity=27.3255813953488, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640542, Length=172, Percent_Identity=27.3255813953488, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45554489, Length=172, Percent_Identity=27.3255813953488, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161077626, Length=172, Percent_Identity=27.3255813953488, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI116007136, Length=172, Percent_Identity=27.3255813953488, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161078487, Length=180, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281362232, Length=180, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078485, Length=180, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648810, Length=180, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281362230, Length=180, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648808, Length=180, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641280, Length=175, Percent_Identity=32, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45554804, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161077752, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281360700, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641282, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45554818, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45554791, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554813, Length=175, Percent_Identity=32, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077754, Length=175, Percent_Identity=32, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85816106, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85816281, Length=132, Percent_Identity=31.8181818181818, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551002, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22356; Mature: 22225

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKGKLFVLSGPSGVGKGTVLDKLLSDFKDVQYSVSATTRKPRPGEKDGVDYFFLSREKF
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEECHHHH
FKMVENNEFIEWAEVHNNYYGTPKIFVDKCLAEGKDVILEIDIQGARQVKKLYPDAIFIF
HHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCEEEEE
LVPPSLNELKRRLNHRGSEDEKNMKIRLNNAEDELKEVKNYDYKVVNDRLDDAVEKLKSI
EECCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
IIAEKCKIREEDCQ
HHHHHHCCCCCCCC
>Mature Secondary Structure 
GKGKLFVLSGPSGVGKGTVLDKLLSDFKDVQYSVSATTRKPRPGEKDGVDYFFLSREKF
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEECHHHH
FKMVENNEFIEWAEVHNNYYGTPKIFVDKCLAEGKDVILEIDIQGARQVKKLYPDAIFIF
HHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCCCEEEEE
LVPPSLNELKRRLNHRGSEDEKNMKIRLNNAEDELKEVKNYDYKVVNDRLDDAVEKLKSI
EECCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
IIAEKCKIREEDCQ
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA