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The map label for this gene is pyrC [H]

Identifier: 220931781

GI number: 220931781

Start: 1011323

End: 1012627

Strand: Direct

Name: pyrC [H]

Synonym: Hore_09380

Alternate gene names: 220931781

Gene position: 1011323-1012627 (Clockwise)

Preceding gene: 220931780

Following gene: 220931782

Centisome position: 39.23

GC content: 42.15

Gene sequence:

>1305_bases
ATGATGAGGACCTTGCTTAAAAACGGTACAGTAATTGATCCGGTTAATAATATCAGGGGCCAATATGATATTTTGATAGA
AGGAAAACACATCATTAATATAAAAAAAGAAATTAAACCAGAAAATTGTCAGGTTATAAAGCTTGAAGGTAAGGTTGTTA
TTCCCGGGTTGATTGATATGCATACTCATCTGAGGGAACCAGGTTATGAAGAAAAAGAAACAATTATAACTGGATGTGAG
GCTGCAGCAGCAGGTGGTTTTACGACAATAGCCTGTATGCCCAATACCAGACCGGTAGCTGATAACCCGGCAACAGTTGA
ATATATTAAATCAAAAGCCAGGGAGGCTGTAGTAAAAGTACTGCCCGTCGGGAGTATTACTAAAAATCTTGAAGGGAAAG
AACTGGCCGAAATTGGTTTTCTGGCCAGGGCCGGGGTTTGTGGACTTTCTGATGACGGCAATCCGGTCATGAATTCTGAG
ATAATGAGACGGGCCATGGAATATGCCCGGGCTTTCGACCTTCCTATTATTAGCCACTGTGAAGACCTGGACCTGGTAGG
TGATGGGGTCATGAATGAAGGTTACTATTCAACTATACTCGGGTTAAAACCAATTCCGGCTGCAGCTGAAGAGGTAATGA
TTTCCAGAGATATTATTCTTGCTGATTTTACCGGTGCCCGTCTCCATATTGACCATCTCAGTACCAGAAAAGGGGTTGAA
ATGGTTGCCCGGGCCAAGGAAAAAGGGTTACGGGTAACAGCAGAGGTTACCCCTCATCATCTAATATTGACTGATAAAGC
AGTTAAGGGCTATAATCCAAATACCCGTGTGAATCCTCCCCTCAGGTCTTCAGAAGATAGAGCAGCCTTAAGACAGGGGA
TTAAAGAAGGGATAATAGATGTAATAGCTACTGACCATGCTCCCCATACCTTTGAAGATAAACTCGGTGAATATGATTAT
GCAGAAAACGGAATATCGGGACTGGAGACAGCACTATCCCTTATTTATGATAGATTGATTAAAACAGGCGAAATCAGCTG
GGAGGACCTGGTCAGGTTAATGGTTATTAATCCGTCAGAAATAGTCGGGGTCAAAGCTGAAGGTATTAAACGATACGCCA
GGGCAGATATTACTATATTTGATCCGGATCGCACCTGGCAGGTTAACCCGGAAAACTTTAAATCAAAAGGGAAAAATACT
CCTTTCGCCGACTGGGAACTTACCGGTAAAGTTGTTATGACTATAGTGGATGGTAAAATAGTTTATGATGACCGGAGTGG
TAATAATGAAGTCCTTTATAGATAG

Upstream 100 bases:

>100_bases
ATTGTTGCCGATGGGGAACAATCTGTCATCACTGAACAGGTTACTAACGGGGTTGCTATAAGAATGGCTTTATTATACTT
ACTGGCCGGGAGGGAGATAA

Downstream 100 bases:

>100_bases
GTTAATAGAAAAGGTGAAAAAAAAGCGGAGTCATGTCTGTGTTGGACTGGATCCCCACCTTGAGCAGTTGCCCAAGCACC
TGATGAATAAAGCCCGGGAA

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MMRTLLKNGTVIDPVNNIRGQYDILIEGKHIINIKKEIKPENCQVIKLEGKVVIPGLIDMHTHLREPGYEEKETIITGCE
AAAAGGFTTIACMPNTRPVADNPATVEYIKSKAREAVVKVLPVGSITKNLEGKELAEIGFLARAGVCGLSDDGNPVMNSE
IMRRAMEYARAFDLPIISHCEDLDLVGDGVMNEGYYSTILGLKPIPAAAEEVMISRDIILADFTGARLHIDHLSTRKGVE
MVARAKEKGLRVTAEVTPHHLILTDKAVKGYNPNTRVNPPLRSSEDRAALRQGIKEGIIDVIATDHAPHTFEDKLGEYDY
AENGISGLETALSLIYDRLIKTGEISWEDLVRLMVINPSEIVGVKAEGIKRYARADITIFDPDRTWQVNPENFKSKGKNT
PFADWELTGKVVMTIVDGKIVYDDRSGNNEVLYR

Sequences:

>Translated_434_residues
MMRTLLKNGTVIDPVNNIRGQYDILIEGKHIINIKKEIKPENCQVIKLEGKVVIPGLIDMHTHLREPGYEEKETIITGCE
AAAAGGFTTIACMPNTRPVADNPATVEYIKSKAREAVVKVLPVGSITKNLEGKELAEIGFLARAGVCGLSDDGNPVMNSE
IMRRAMEYARAFDLPIISHCEDLDLVGDGVMNEGYYSTILGLKPIPAAAEEVMISRDIILADFTGARLHIDHLSTRKGVE
MVARAKEKGLRVTAEVTPHHLILTDKAVKGYNPNTRVNPPLRSSEDRAALRQGIKEGIIDVIATDHAPHTFEDKLGEYDY
AENGISGLETALSLIYDRLIKTGEISWEDLVRLMVINPSEIVGVKAEGIKRYARADITIFDPDRTWQVNPENFKSKGKNT
PFADWELTGKVVMTIVDGKIVYDDRSGNNEVLYR
>Mature_434_residues
MMRTLLKNGTVIDPVNNIRGQYDILIEGKHIINIKKEIKPENCQVIKLEGKVVIPGLIDMHTHLREPGYEEKETIITGCE
AAAAGGFTTIACMPNTRPVADNPATVEYIKSKAREAVVKVLPVGSITKNLEGKELAEIGFLARAGVCGLSDDGNPVMNSE
IMRRAMEYARAFDLPIISHCEDLDLVGDGVMNEGYYSTILGLKPIPAAAEEVMISRDIILADFTGARLHIDHLSTRKGVE
MVARAKEKGLRVTAEVTPHHLILTDKAVKGYNPNTRVNPPLRSSEDRAALRQGIKEGIIDVIATDHAPHTFEDKLGEYDY
AENGISGLETALSLIYDRLIKTGEISWEDLVRLMVINPSEIVGVKAEGIKRYARADITIFDPDRTWQVNPENFKSKGKNT
PFADWELTGKVVMTIVDGKIVYDDRSGNNEVLYR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=383, Percent_Identity=29.7650130548303, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI19923821, Length=466, Percent_Identity=23.8197424892704, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=28.8329519450801, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87082175, Length=469, Percent_Identity=25.7995735607676, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=390, Percent_Identity=30.5128205128205, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17539558, Length=458, Percent_Identity=25.5458515283843, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=392, Percent_Identity=27.5510204081633, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642586, Length=376, Percent_Identity=31.3829787234043, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18859883, Length=416, Percent_Identity=27.1634615384615, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47972; Mature: 47972

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRTLLKNGTVIDPVNNIRGQYDILIEGKHIINIKKEIKPENCQVIKLEGKVVIPGLIDM
CCCHHHCCCCEECCHHHCCCCEEEEEECCEEEEEHHHCCCCCCEEEEECCCEEECCHHHH
HTHLREPGYEEKETIITGCEAAAAGGFTTIACMPNTRPVADNPATVEYIKSKAREAVVKV
HHHHCCCCCCCCHHEEECCCHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
LPVGSITKNLEGKELAEIGFLARAGVCGLSDDGNPVMNSEIMRRAMEYARAFDLPIISHC
CCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCC
EDLDLVGDGVMNEGYYSTILGLKPIPAAAEEVMISRDIILADFTGARLHIDHLSTRKGVE
CCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCEEEEECCCCEEEEECCCCHHHHH
MVARAKEKGLRVTAEVTPHHLILTDKAVKGYNPNTRVNPPLRSSEDRAALRQGIKEGIID
HHHHHHHCCCEEEEECCCCEEEEECCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHE
VIATDHAPHTFEDKLGEYDYAENGISGLETALSLIYDRLIKTGEISWEDLVRLMVINPSE
EEECCCCCCCHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCHH
IVGVKAEGIKRYARADITIFDPDRTWQVNPENFKSKGKNTPFADWELTGKVVMTIVDGKI
EEEECHHHHHHHHHCCEEEECCCCCEEECCHHHHHCCCCCCCCCEEECCEEEEEEECCEE
VYDDRSGNNEVLYR
EEECCCCCCCCCCC
>Mature Secondary Structure
MMRTLLKNGTVIDPVNNIRGQYDILIEGKHIINIKKEIKPENCQVIKLEGKVVIPGLIDM
CCCHHHCCCCEECCHHHCCCCEEEEEECCEEEEEHHHCCCCCCEEEEECCCEEECCHHHH
HTHLREPGYEEKETIITGCEAAAAGGFTTIACMPNTRPVADNPATVEYIKSKAREAVVKV
HHHHCCCCCCCCHHEEECCCHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
LPVGSITKNLEGKELAEIGFLARAGVCGLSDDGNPVMNSEIMRRAMEYARAFDLPIISHC
CCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCC
EDLDLVGDGVMNEGYYSTILGLKPIPAAAEEVMISRDIILADFTGARLHIDHLSTRKGVE
CCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCEEEEECCCCEEEEECCCCHHHHH
MVARAKEKGLRVTAEVTPHHLILTDKAVKGYNPNTRVNPPLRSSEDRAALRQGIKEGIID
HHHHHHHCCCEEEEECCCCEEEEECCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHE
VIATDHAPHTFEDKLGEYDYAENGISGLETALSLIYDRLIKTGEISWEDLVRLMVINPSE
EEECCCCCCCHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCHH
IVGVKAEGIKRYARADITIFDPDRTWQVNPENFKSKGKNTPFADWELTGKVVMTIVDGKI
EEEECHHHHHHHHHCCEEEECCCCCEEECCHHHHHCCCCCCCCCEEECCEEEEEEECCEE
VYDDRSGNNEVLYR
EEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA