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The map label for this gene is dapA [H]

Identifier: 220931712

GI number: 220931712

Start: 936091

End: 936975

Strand: Direct

Name: dapA [H]

Synonym: Hore_08690

Alternate gene names: 220931712

Gene position: 936091-936975 (Clockwise)

Preceding gene: 220931711

Following gene: 220931713

Centisome position: 36.31

GC content: 40.79

Gene sequence:

>885_bases
ATGGCTAAAGATTTTGGGGAAGTTTTAACTGCCATGGTTACACCCCTTGATGCCGGGAATGCTGTAGATTATAGCCAGGC
CCGCAGGTTAGCTTCATATTTAATTGAAAACGGTTCTGATGGGTTGGTGGTACTGGGTACTACTGGAGAGACTCCAACCC
TTACCAAAACAGAAAAAATAAGGCTTCTTGAGGAAATCGTTGATGAAGTTGGGGGTAGGGCCTCTATTGTTGCTGGAACT
GGTTCTTATTCAACAGAAGAAAGTATTGAACTGACTGTTAAGGCAGAAGATATCGGGGTAGATGGTGTTATGCTGGTTGT
ACCTTATTATAATAAGCCACCACAGGATGGTCTTTATAATCATTTTAAGTTAATAGCTGAAAAAACTTCCCTACCGGTCA
TGCTTTATAATGTTCCAGGAAGGACGTCCAGAAATATAGAACCCGGGACTGTTAAAAAACTCGCTCAGGTTGATAATATT
GTGGCTATAAAGGAAGCCAGTGGTAACTTAGAACAGGTTTCTACCCTGGCCCGGATACTGCCCGATGATTTTTATATATA
CAGTGGAGATGATACTTTAACTTTACCGGTCCTTTCAGTAGGGGGCCATGGTGTTGTGAGTGTAGCTTCTCATCTGGTAG
GTAATAAGATTAAGGAAATGATAAGAGACTTTAAAGATGGAAGAATTAATAAAGCTATACAATTAAACAAAGAGCTGGGT
CCCATATTCTCTGCCATGTTTTTAACCACTAATCCTATTCCGGTTAAAGCTGCTCTGAATATGGCCGGACACAGGGTTGG
CAGTTTAAGACCACCACTTATGGAGTTGAGCCATTCCCAACAGGAACAGTTACGTCAAATACTTGAAGAGTATAAATTAA
TATAG

Upstream 100 bases:

>100_bases
ACTATTTCATGTCTGGTTAAAAAACAGGAAGAAAAAAAGGCTTTGAATGCATTGCATTCTGCCTTTAAACTGGAAGAATA
ATATAGTCTGGAGGGATAAA

Downstream 100 bases:

>100_bases
AATTAATTAAGATTATTAAATATGGGTTTTTCTTCAATTTAATTAAAATAATATGGCTTTTTAAACAAGCACCATATTGG
TGCTTGTTTTTTTTACCAGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MAKDFGEVLTAMVTPLDAGNAVDYSQARRLASYLIENGSDGLVVLGTTGETPTLTKTEKIRLLEEIVDEVGGRASIVAGT
GSYSTEESIELTVKAEDIGVDGVMLVVPYYNKPPQDGLYNHFKLIAEKTSLPVMLYNVPGRTSRNIEPGTVKKLAQVDNI
VAIKEASGNLEQVSTLARILPDDFYIYSGDDTLTLPVLSVGGHGVVSVASHLVGNKIKEMIRDFKDGRINKAIQLNKELG
PIFSAMFLTTNPIPVKAALNMAGHRVGSLRPPLMELSHSQQEQLRQILEEYKLI

Sequences:

>Translated_294_residues
MAKDFGEVLTAMVTPLDAGNAVDYSQARRLASYLIENGSDGLVVLGTTGETPTLTKTEKIRLLEEIVDEVGGRASIVAGT
GSYSTEESIELTVKAEDIGVDGVMLVVPYYNKPPQDGLYNHFKLIAEKTSLPVMLYNVPGRTSRNIEPGTVKKLAQVDNI
VAIKEASGNLEQVSTLARILPDDFYIYSGDDTLTLPVLSVGGHGVVSVASHLVGNKIKEMIRDFKDGRINKAIQLNKELG
PIFSAMFLTTNPIPVKAALNMAGHRVGSLRPPLMELSHSQQEQLRQILEEYKLI
>Mature_293_residues
AKDFGEVLTAMVTPLDAGNAVDYSQARRLASYLIENGSDGLVVLGTTGETPTLTKTEKIRLLEEIVDEVGGRASIVAGTG
SYSTEESIELTVKAEDIGVDGVMLVVPYYNKPPQDGLYNHFKLIAEKTSLPVMLYNVPGRTSRNIEPGTVKKLAQVDNIV
AIKEASGNLEQVSTLARILPDDFYIYSGDDTLTLPVLSVGGHGVVSVASHLVGNKIKEMIRDFKDGRINKAIQLNKELGP
IFSAMFLTTNPIPVKAALNMAGHRVGSLRPPLMELSHSQQEQLRQILEEYKLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=285, Percent_Identity=26.3157894736842, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI13540533, Length=233, Percent_Identity=25.7510729613734, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=39.1752577319588, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87082415, Length=292, Percent_Identity=29.4520547945205, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789620, Length=250, Percent_Identity=28.8, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786463, Length=284, Percent_Identity=27.8169014084507, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31950; Mature: 31819

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDFGEVLTAMVTPLDAGNAVDYSQARRLASYLIENGSDGLVVLGTTGETPTLTKTEKI
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
RLLEEIVDEVGGRASIVAGTGSYSTEESIELTVKAEDIGVDGVMLVVPYYNKPPQDGLYN
HHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCHHHH
HFKLIAEKTSLPVMLYNVPGRTSRNIEPGTVKKLAQVDNIVAIKEASGNLEQVSTLARIL
HHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHC
PDDFYIYSGDDTLTLPVLSVGGHGVVSVASHLVGNKIKEMIRDFKDGRINKAIQLNKELG
CCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCHHH
PIFSAMFLTTNPIPVKAALNMAGHRVGSLRPPLMELSHSQQEQLRQILEEYKLI
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKDFGEVLTAMVTPLDAGNAVDYSQARRLASYLIENGSDGLVVLGTTGETPTLTKTEKI
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHH
RLLEEIVDEVGGRASIVAGTGSYSTEESIELTVKAEDIGVDGVMLVVPYYNKPPQDGLYN
HHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCHHHH
HFKLIAEKTSLPVMLYNVPGRTSRNIEPGTVKKLAQVDNIVAIKEASGNLEQVSTLARIL
HHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHC
PDDFYIYSGDDTLTLPVLSVGGHGVVSVASHLVGNKIKEMIRDFKDGRINKAIQLNKELG
CCCEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCHHH
PIFSAMFLTTNPIPVKAALNMAGHRVGSLRPPLMELSHSQQEQLRQILEEYKLI
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA