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The map label for this gene is thrB

Identifier: 220931645

GI number: 220931645

Start: 860545

End: 861480

Strand: Direct

Name: thrB

Synonym: Hore_08010

Alternate gene names: 220931645

Gene position: 860545-861480 (Clockwise)

Preceding gene: 220931644

Following gene: 220931646

Centisome position: 33.38

GC content: 37.93

Gene sequence:

>936_bases
ATGTTTACAATAAAAATACCGGCAACATCTGCAAACCTGGGGCCTGGCTTTGATAGCCTCGGTCTTTCTTTACAATTATA
TAATAAATTTACTTTTAAAAGACTTAAAAGTTCTGATATCAGAATTAAAATTAAGGAAGTAGACACAGGTAATATTATTG
AATTACCGATTAAAGATAATTTAATTTACCGGGCCATGATGTATCTTTTTGAGCGTTATGATGTTAGACCTGAGGGCATA
GAACTTATGGAAGAAGTTGCTATTCCCTTTGCCCGGGGACTTGGTAGTAGTGCCACCGCTATACTCGGTGGCTTATTTGG
GGCTAACATCATGTTAGGGGAACCCCTAGAAGACGAAGAACTATTAAAGATTGCTGTTAAATTGGAAAAACACCCTGATA
ATGTAGTTCCTGCCCTGAAAGGTGGTTTTGTTATAAATGTTTTAAAGGGTAGTGACCTTTATTATAAAAAGATTAACCCC
GGTGAGCAATTAAGGGTAATTCTGTGTATCCCTGAATTTCAATTAAAAACAGAAGATTTAAGGCAGGTTTTACCCCGCCA
AATAGAATTTAAAGATGCTGTTTTTAACCACAGTAGAACCGCTTTTTTAACTTCCTGTTTTTATGAAAGAGACTGGGAAA
GTCTAAGGGTTGCCATGCAGGATAGATTACATCAGGATTACCGTTCCTCGCTAATTCCCGGGTTTGATGAAGTTGTTAAG
AGTGCCTATGACAATGGGGCGGTAGGTGTAGCTTTAAGTGGGGCCGGCCCAACTGTTATCAGTTTTGCAAAAGATAAAGG
AGATAAAATTGGTGAAGCTATGGTTAAGGCCTTTGGTCATTATAACATAAACAGTAAATATATCGAAACAGGACTGGATA
ATAAGGGATTAATTTTAAAAGGACACAAGTTCAGTCTGTCAGGAGGGAGCAGGTAG

Upstream 100 bases:

>100_bases
CTAAATAAATATCCATCAGGAACAAAATACTCTTGTTTTTTATGCAAAATAGTGATAGAATATACGATAAGAATTTTTTT
ACAGGATAAGGTGGATAGCA

Downstream 100 bases:

>100_bases
ATGATTAAAATAGGTTTACTGGGTCTGGGTACTGTCGGTAGTGGAGTTGTTACAATTATGGAGAACAATAAGGAGAGTAT
AAGGAGAAAAGTGGGGACCT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MFTIKIPATSANLGPGFDSLGLSLQLYNKFTFKRLKSSDIRIKIKEVDTGNIIELPIKDNLIYRAMMYLFERYDVRPEGI
ELMEEVAIPFARGLGSSATAILGGLFGANIMLGEPLEDEELLKIAVKLEKHPDNVVPALKGGFVINVLKGSDLYYKKINP
GEQLRVILCIPEFQLKTEDLRQVLPRQIEFKDAVFNHSRTAFLTSCFYERDWESLRVAMQDRLHQDYRSSLIPGFDEVVK
SAYDNGAVGVALSGAGPTVISFAKDKGDKIGEAMVKAFGHYNINSKYIETGLDNKGLILKGHKFSLSGGSR

Sequences:

>Translated_311_residues
MFTIKIPATSANLGPGFDSLGLSLQLYNKFTFKRLKSSDIRIKIKEVDTGNIIELPIKDNLIYRAMMYLFERYDVRPEGI
ELMEEVAIPFARGLGSSATAILGGLFGANIMLGEPLEDEELLKIAVKLEKHPDNVVPALKGGFVINVLKGSDLYYKKINP
GEQLRVILCIPEFQLKTEDLRQVLPRQIEFKDAVFNHSRTAFLTSCFYERDWESLRVAMQDRLHQDYRSSLIPGFDEVVK
SAYDNGAVGVALSGAGPTVISFAKDKGDKIGEAMVKAFGHYNINSKYIETGLDNKGLILKGHKFSLSGGSR
>Mature_311_residues
MFTIKIPATSANLGPGFDSLGLSLQLYNKFTFKRLKSSDIRIKIKEVDTGNIIELPIKDNLIYRAMMYLFERYDVRPEGI
ELMEEVAIPFARGLGSSATAILGGLFGANIMLGEPLEDEELLKIAVKLEKHPDNVVPALKGGFVINVLKGSDLYYKKINP
GEQLRVILCIPEFQLKTEDLRQVLPRQIEFKDAVFNHSRTAFLTSCFYERDWESLRVAMQDRLHQDYRSSLIPGFDEVVK
SAYDNGAVGVALSGAGPTVISFAKDKGDKIGEAMVKAFGHYNINSKYIETGLDNKGLILKGHKFSLSGGSR

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=277, Percent_Identity=27.0758122743682, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321814, Length=343, Percent_Identity=29.4460641399417, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_HALOH (B8CW89)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508553.1
- ProteinModelPortal:   B8CW89
- SMR:   B8CW89
- GeneID:   7314788
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_08010
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 34631; Mature: 34631

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTIKIPATSANLGPGFDSLGLSLQLYNKFTFKRLKSSDIRIKIKEVDTGNIIELPIKDN
CEEEEECCCCCCCCCCCHHHCCEEEEHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCC
LIYRAMMYLFERYDVRPEGIELMEEVAIPFARGLGSSATAILGGLFGANIMLGEPLEDEE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCHHH
LLKIAVKLEKHPDNVVPALKGGFVINVLKGSDLYYKKINPGEQLRVILCIPEFQLKTEDL
HHHHHHHHHCCCCCCCHHCCCCEEEEEEECCCEEEEECCCCCEEEEEEEECCCCCCHHHH
RQVLPRQIEFKDAVFNHSRTAFLTSCFYERDWESLRVAMQDRLHQDYRSSLIPGFDEVVK
HHHCCHHCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SAYDNGAVGVALSGAGPTVISFAKDKGDKIGEAMVKAFGHYNINSKYIETGLDNKGLILK
HHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHEECCCCCCCEEEE
GHKFSLSGGSR
CCEEECCCCCC
>Mature Secondary Structure
MFTIKIPATSANLGPGFDSLGLSLQLYNKFTFKRLKSSDIRIKIKEVDTGNIIELPIKDN
CEEEEECCCCCCCCCCCHHHCCEEEEHHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCC
LIYRAMMYLFERYDVRPEGIELMEEVAIPFARGLGSSATAILGGLFGANIMLGEPLEDEE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCHHH
LLKIAVKLEKHPDNVVPALKGGFVINVLKGSDLYYKKINPGEQLRVILCIPEFQLKTEDL
HHHHHHHHHCCCCCCCHHCCCCEEEEEEECCCEEEEECCCCCEEEEEEEECCCCCCHHHH
RQVLPRQIEFKDAVFNHSRTAFLTSCFYERDWESLRVAMQDRLHQDYRSSLIPGFDEVVK
HHHCCHHCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SAYDNGAVGVALSGAGPTVISFAKDKGDKIGEAMVKAFGHYNINSKYIETGLDNKGLILK
HHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHEECCCCCCCEEEE
GHKFSLSGGSR
CCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA