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The map label for this gene is dxr

Identifier: 220931617

GI number: 220931617

Start: 828711

End: 829865

Strand: Direct

Name: dxr

Synonym: Hore_07730

Alternate gene names: 220931617

Gene position: 828711-829865 (Clockwise)

Preceding gene: 220931616

Following gene: 220931618

Centisome position: 32.14

GC content: 41.39

Gene sequence:

>1155_bases
ATGAAAAAGAAATTAGTTGTCCTGGGTTCAACTGGCTCAATCGGAACCCAGACCCTTGAAGTTCTCTCCCATCTTGAAGA
CCAGTGGGAGATTCTGGCTTTAAGTGCCAATAAAAGTACTGGTTTAATTGAAAAACAGGCTAGAAAGTTTAAACCCCGTT
ATCTTGTTATGATGAATGAAAGGGCAGCCCTGGAGCTTAAACATAGATTGAGTGATATGTCTTCTGAGGTTTTAAGTGGT
ATGGAAGGGTTAATAACCATTTCTTCTCTTGAAGAGGCTGACCTGGTTATAAATGCCCTGGTCGGTGCGGTTGGTTTAAA
ACCGACTGTTGCTGCTCTGCAGTCAGGGAATACCCTTGGTCTTGCCAACAAGGAGAGTCTGGTTATCGGAGGCGAGATTA
TAAAGAGTTATTTAAACGAAGAGGGGCGGGTTTTACCAGTTGATAGTGAACATAATGCAATATTTCAGTTGCTAAACGGA
CATAATGATAAAGAGGTTGAAAGATTAATCCTGACAGCCTCGGGGGGACCATTTTTAGAATTGCCCCGGGAGAGGTTTAA
AGATGTATCCGTAAAAGATGCCCTTAAACACCCTAACTGGGATATGGGTGGCAAGATAACCATAGATTCAGCTACCCTGA
TGAATAAGGGGTTAGAAGTTATAGAAGCCCATTATCTTTTTCGACAACCATATCATAACATAAATGTAGTTGTTCATCCT
GAAAGTATTATTCACTCTATGGTAGAGTTTGTAGATAAATCAGTTATAGCTGAAATGGGGTCGGCTGATATGAGGATGCC
GATCCAGTATGTATTGACCTATCCCCGGAAGGTAAAAAGTTTAGCTAAAAGACTAGATTTAACCGAACTTGGTTATCTTA
CTTTTAAAAAACCGGATACCGTAAAGTTTCCGGCTCTAAAACTTGCCTATGAAGCCGGGCAACAGGGAGGGACTATGCCT
GTTGTCTTAAATGCCGCTAATGAAATAGCGGTTTCTGCCTTTATGAATGAAAAGATTACATTTGATAAAATACCGGTGGT
AATAGAGCGGGTTATGGAAAACCATCAGATAATTTCTTCTCCGGACCTGGAAGATGTAATAGAGGTTGATAACTGGGCCC
GGGCCAGGGCTAAGGAGGTAACTGGACAATGTTAA

Upstream 100 bases:

>100_bases
ATGATTGGTTTTATTATGGGTCCTGCTATTTTAGTAATTATTAAGGCTTTGATTAATGCAGAAATTATACCACCTGATAA
AAAAATAAAGGGGTGAAATA

Downstream 100 bases:

>100_bases
CAACTATTATAAGCTTTATAATTGTTTTAGGAATATTAATCTTTATTCATGAGTTTGGTCATTATATTACTGCCAAAAAA
GCGGGTATCAGGGTTGAAGA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKKKLVVLGSTGSIGTQTLEVLSHLEDQWEILALSANKSTGLIEKQARKFKPRYLVMMNERAALELKHRLSDMSSEVLSG
MEGLITISSLEEADLVINALVGAVGLKPTVAALQSGNTLGLANKESLVIGGEIIKSYLNEEGRVLPVDSEHNAIFQLLNG
HNDKEVERLILTASGGPFLELPRERFKDVSVKDALKHPNWDMGGKITIDSATLMNKGLEVIEAHYLFRQPYHNINVVVHP
ESIIHSMVEFVDKSVIAEMGSADMRMPIQYVLTYPRKVKSLAKRLDLTELGYLTFKKPDTVKFPALKLAYEAGQQGGTMP
VVLNAANEIAVSAFMNEKITFDKIPVVIERVMENHQIISSPDLEDVIEVDNWARARAKEVTGQC

Sequences:

>Translated_384_residues
MKKKLVVLGSTGSIGTQTLEVLSHLEDQWEILALSANKSTGLIEKQARKFKPRYLVMMNERAALELKHRLSDMSSEVLSG
MEGLITISSLEEADLVINALVGAVGLKPTVAALQSGNTLGLANKESLVIGGEIIKSYLNEEGRVLPVDSEHNAIFQLLNG
HNDKEVERLILTASGGPFLELPRERFKDVSVKDALKHPNWDMGGKITIDSATLMNKGLEVIEAHYLFRQPYHNINVVVHP
ESIIHSMVEFVDKSVIAEMGSADMRMPIQYVLTYPRKVKSLAKRLDLTELGYLTFKKPDTVKFPALKLAYEAGQQGGTMP
VVLNAANEIAVSAFMNEKITFDKIPVVIERVMENHQIISSPDLEDVIEVDNWARARAKEVTGQC
>Mature_384_residues
MKKKLVVLGSTGSIGTQTLEVLSHLEDQWEILALSANKSTGLIEKQARKFKPRYLVMMNERAALELKHRLSDMSSEVLSG
MEGLITISSLEEADLVINALVGAVGLKPTVAALQSGNTLGLANKESLVIGGEIIKSYLNEEGRVLPVDSEHNAIFQLLNG
HNDKEVERLILTASGGPFLELPRERFKDVSVKDALKHPNWDMGGKITIDSATLMNKGLEVIEAHYLFRQPYHNINVVVHP
ESIIHSMVEFVDKSVIAEMGSADMRMPIQYVLTYPRKVKSLAKRLDLTELGYLTFKKPDTVKFPALKLAYEAGQQGGTMP
VVLNAANEIAVSAFMNEKITFDKIPVVIERVMENHQIISSPDLEDVIEVDNWARARAKEVTGQC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=390, Percent_Identity=44.3589743589744, Blast_Score=310, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_HALOH (B8CW61)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508525.1
- ProteinModelPortal:   B8CW61
- SMR:   B8CW61
- GeneID:   7314760
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_07730
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42497; Mature: 42497

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: BINDING 124-124 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKLVVLGSTGSIGTQTLEVLSHLEDQWEILALSANKSTGLIEKQARKFKPRYLVMMNE
CCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECC
RAALELKHRLSDMSSEVLSGMEGLITISSLEEADLVINALVGAVGLKPTVAALQSGNTLG
CHHHHHHHHHHHHHHHHHCCHHHEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEE
LANKESLVIGGEIIKSYLNEEGRVLPVDSEHNAIFQLLNGHNDKEVERLILTASGGPFLE
CCCCCCEEECHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCHHHEEEEEEEECCCCCCC
LPRERFKDVSVKDALKHPNWDMGGKITIDSATLMNKGLEVIEAHYLFRQPYHNINVVVHP
CCHHHHCCCCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
ESIIHSMVEFVDKSVIAEMGSADMRMPIQYVLTYPRKVKSLAKRLDLTELGYLTFKKPDT
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHCCHHHCCEEEECCCCC
VKFPALKLAYEAGQQGGTMPVVLNAANEIAVSAFMNEKITFDKIPVVIERVMENHQIISS
CCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
PDLEDVIEVDNWARARAKEVTGQC
CCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKKLVVLGSTGSIGTQTLEVLSHLEDQWEILALSANKSTGLIEKQARKFKPRYLVMMNE
CCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECC
RAALELKHRLSDMSSEVLSGMEGLITISSLEEADLVINALVGAVGLKPTVAALQSGNTLG
CHHHHHHHHHHHHHHHHHCCHHHEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHCCCEEE
LANKESLVIGGEIIKSYLNEEGRVLPVDSEHNAIFQLLNGHNDKEVERLILTASGGPFLE
CCCCCCEEECHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCHHHEEEEEEEECCCCCCC
LPRERFKDVSVKDALKHPNWDMGGKITIDSATLMNKGLEVIEAHYLFRQPYHNINVVVHP
CCHHHHCCCCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
ESIIHSMVEFVDKSVIAEMGSADMRMPIQYVLTYPRKVKSLAKRLDLTELGYLTFKKPDT
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHCCHHHCCEEEECCCCC
VKFPALKLAYEAGQQGGTMPVVLNAANEIAVSAFMNEKITFDKIPVVIERVMENHQIISS
CCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
PDLEDVIEVDNWARARAKEVTGQC
CCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA