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The map label for this gene is hslU [H]

Identifier: 220931601

GI number: 220931601

Start: 815129

End: 816517

Strand: Direct

Name: hslU [H]

Synonym: Hore_07570

Alternate gene names: 220931601

Gene position: 815129-816517 (Clockwise)

Preceding gene: 220931600

Following gene: 220931602

Centisome position: 31.62

GC content: 38.66

Gene sequence:

>1389_bases
ATGAAAGAAGAGCTGACACCGAGACAAATTGTAAAAAAATTAGATAAATATATTGTAGGCCAGGAAGAAGCAAAAAAGGC
AGTAGCTATTGCTTTAAGAAACCGTTACCGCAGAAAAAAGATAATATCTGATCTGCAGGAAGAAGTTATTCCTAAAAATA
TACTCATGATTGGCCCTACGGGTGTTGGTAAGACAGAAATAGCCAGACGTCTAGCCAGGATTGCCAGTGCCCCGTTTATA
AAGGTAGAGGTAACTAAATTTACTGAAGTTGGTTATGTTGGCCGTGATGTTGAGTCCATGGTCAGGGACCTGGTCGAAAC
AGCTATAAGAATGGTAAAAAGTGAAAAAATGAAGGATGTTGAACATAAGGCCCGTGACCTGGCTATAGATAGAATAGTAG
ATATTATCTTACCACTTCCGGGCAAGAAGAGAAGAAATCCATTTGAAGTATTGTTTTCCGACCGGGAAGAGAACCTGGAT
GATGTAGATAGTGATAATTACACCAGTTTAAAAGAAAGAAGAAAGCGCTTGCGTAAAAGGATTGTTAATGGTCAACTTGA
TGATCAGGTTATTGAAATAACAGTTGAATCACAGAATCCCCAGATGTTTGAAGTTTTTTCTGGAGCCGGGGTTGAAGAAA
TGGGTATAAATTTTCAGGATATGTTCGGTAATATTTTCCCGGCCCAAAAGAAAAAAAGAAAGGTTTCTGTTAAAGAAGCT
AAGGAAATATTAAAACAGGAAGAAGCCCAGAAACTCATAGACATGGATGAGGTTAGTTTAGAGGCCATAAAGAAGGTTGA
AAATGATGGTATCATTTTTCTGGATGAAATAGATAAGATTGCCGGACGGGAAAGTGGCAAGGGCCCTGAGGTCTCCAGGG
AGGGTGTACAGCGTGATATCTTACCTATTGTTGAAGGTTCTACAGTTATGACCAAATATGGGGCTGTGAAAACAGATCAT
ATCCTTTTTATTGCTGCTGGAGCATTTCATGTTTCCAAACCCTCTGACCTTATTCCTGAACTGCAGGGACGTTTTCCGAT
CCGGGTAGAATTAAAAAGCCTTTCCCGCGAGCATTTTAAACAAATTTTACTCCAGCCTAAAAATGCTTTAACTAAACAGT
ATGAAGCTCTTATAGAAACAGAAGGAATTAAAATTAAATTTACTGATGAGGCCATTGAGGAAATAGCCGATTTTGCTTAC
AGGGTTAATGAGCAGACCGAAAATATAGGGGCCCGGAGGCTCCATACTATTATGGAAAAACTTCTTGAAGATGTTTCCTT
TAATGCTCCTGACATGGATGTTGAAGAGGTTACAATTGATGTTGACTATGTTAGAAATCAACTGGCTGATGTTGTACAGG
ATAAAGACTTAAGCAAGTATATTTTATAG

Upstream 100 bases:

>100_bases
AGGATATAGCCAGAGAGGCCTTGAAAATAGCCTCAGAAATTTGTATTTATACAAATGGTAATATTGTTGTTGAAGAATTG
TGATGGTGAGGGGGTGAAGT

Downstream 100 bases:

>100_bases
CTTCCTGAGACTATTTATTTTTAAAATCCATGTTATGGGGTATCTAATATTAGTCTACCAACAAGAAAAGTTTATAAGGT
AATAGTTGTTGGTTACTAAA

Product: heat shock protein HslVU, ATPase subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKEELTPRQIVKKLDKYIVGQEEAKKAVAIALRNRYRRKKIISDLQEEVIPKNILMIGPTGVGKTEIARRLARIASAPFI
KVEVTKFTEVGYVGRDVESMVRDLVETAIRMVKSEKMKDVEHKARDLAIDRIVDIILPLPGKKRRNPFEVLFSDREENLD
DVDSDNYTSLKERRKRLRKRIVNGQLDDQVIEITVESQNPQMFEVFSGAGVEEMGINFQDMFGNIFPAQKKKRKVSVKEA
KEILKQEEAQKLIDMDEVSLEAIKKVENDGIIFLDEIDKIAGRESGKGPEVSREGVQRDILPIVEGSTVMTKYGAVKTDH
ILFIAAGAFHVSKPSDLIPELQGRFPIRVELKSLSREHFKQILLQPKNALTKQYEALIETEGIKIKFTDEAIEEIADFAY
RVNEQTENIGARRLHTIMEKLLEDVSFNAPDMDVEEVTIDVDYVRNQLADVVQDKDLSKYIL

Sequences:

>Translated_462_residues
MKEELTPRQIVKKLDKYIVGQEEAKKAVAIALRNRYRRKKIISDLQEEVIPKNILMIGPTGVGKTEIARRLARIASAPFI
KVEVTKFTEVGYVGRDVESMVRDLVETAIRMVKSEKMKDVEHKARDLAIDRIVDIILPLPGKKRRNPFEVLFSDREENLD
DVDSDNYTSLKERRKRLRKRIVNGQLDDQVIEITVESQNPQMFEVFSGAGVEEMGINFQDMFGNIFPAQKKKRKVSVKEA
KEILKQEEAQKLIDMDEVSLEAIKKVENDGIIFLDEIDKIAGRESGKGPEVSREGVQRDILPIVEGSTVMTKYGAVKTDH
ILFIAAGAFHVSKPSDLIPELQGRFPIRVELKSLSREHFKQILLQPKNALTKQYEALIETEGIKIKFTDEAIEEIADFAY
RVNEQTENIGARRLHTIMEKLLEDVSFNAPDMDVEEVTIDVDYVRNQLADVVQDKDLSKYIL
>Mature_462_residues
MKEELTPRQIVKKLDKYIVGQEEAKKAVAIALRNRYRRKKIISDLQEEVIPKNILMIGPTGVGKTEIARRLARIASAPFI
KVEVTKFTEVGYVGRDVESMVRDLVETAIRMVKSEKMKDVEHKARDLAIDRIVDIILPLPGKKRRNPFEVLFSDREENLD
DVDSDNYTSLKERRKRLRKRIVNGQLDDQVIEITVESQNPQMFEVFSGAGVEEMGINFQDMFGNIFPAQKKKRKVSVKEA
KEILKQEEAQKLIDMDEVSLEAIKKVENDGIIFLDEIDKIAGRESGKGPEVSREGVQRDILPIVEGSTVMTKYGAVKTDH
ILFIAAGAFHVSKPSDLIPELQGRFPIRVELKSLSREHFKQILLQPKNALTKQYEALIETEGIKIKFTDEAIEEIADFAY
RVNEQTENIGARRLHTIMEKLLEDVSFNAPDMDVEEVTIDVDYVRNQLADVVQDKDLSKYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=125, Percent_Identity=36.8, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790366, Length=459, Percent_Identity=52.2875816993464, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1786642, Length=235, Percent_Identity=34.8936170212766, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982908, Length=261, Percent_Identity=29.1187739463602, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71982905, Length=261, Percent_Identity=27.9693486590038, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71988663, Length=256, Percent_Identity=25.78125, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319704, Length=118, Percent_Identity=38.9830508474576, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648291, Length=249, Percent_Identity=29.718875502008, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648289, Length=249, Percent_Identity=29.718875502008, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52793; Mature: 52793

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEELTPRQIVKKLDKYIVGQEEAKKAVAIALRNRYRRKKIISDLQEEVIPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GVGKTEIARRLARIASAPFIKVEVTKFTEVGYVGRDVESMVRDLVETAIRMVKSEKMKDV
CCCHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EHKARDLAIDRIVDIILPLPGKKRRNPFEVLFSDREENLDDVDSDNYTSLKERRKRLRKR
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
IVNGQLDDQVIEITVESQNPQMFEVFSGAGVEEMGINFQDMFGNIFPAQKKKRKVSVKEA
HHCCCCCCEEEEEEEECCCCCEEEHHCCCCHHHHCCCHHHHHCCCCCCHHHHHCCCHHHH
KEILKQEEAQKLIDMDEVSLEAIKKVENDGIIFLDEIDKIAGRESGKGPEVSREGVQRDI
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCCCCHHHHHHHH
LPIVEGSTVMTKYGAVKTDHILFIAAGAFHVSKPSDLIPELQGRFPIRVELKSLSREHFK
HHHCCCCCHHHHCCCCEECCEEEEEECCEECCCCHHHHHHHCCCCCEEEEHHHHHHHHHH
QILLQPKNALTKQYEALIETEGIKIKFTDEAIEEIADFAYRVNEQTENIGARRLHTIMEK
HHHHCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEDVSFNAPDMDVEEVTIDVDYVRNQLADVVQDKDLSKYIL
HHHHCCCCCCCCCHHHEEEEHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MKEELTPRQIVKKLDKYIVGQEEAKKAVAIALRNRYRRKKIISDLQEEVIPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GVGKTEIARRLARIASAPFIKVEVTKFTEVGYVGRDVESMVRDLVETAIRMVKSEKMKDV
CCCHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EHKARDLAIDRIVDIILPLPGKKRRNPFEVLFSDREENLDDVDSDNYTSLKERRKRLRKR
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
IVNGQLDDQVIEITVESQNPQMFEVFSGAGVEEMGINFQDMFGNIFPAQKKKRKVSVKEA
HHCCCCCCEEEEEEEECCCCCEEEHHCCCCHHHHCCCHHHHHCCCCCCHHHHHCCCHHHH
KEILKQEEAQKLIDMDEVSLEAIKKVENDGIIFLDEIDKIAGRESGKGPEVSREGVQRDI
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCCCCCHHHHHHHH
LPIVEGSTVMTKYGAVKTDHILFIAAGAFHVSKPSDLIPELQGRFPIRVELKSLSREHFK
HHHCCCCCHHHHCCCCEECCEEEEEECCEECCCCHHHHHHHCCCCCEEEEHHHHHHHHHH
QILLQPKNALTKQYEALIETEGIKIKFTDEAIEEIADFAYRVNEQTENIGARRLHTIMEK
HHHHCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEDVSFNAPDMDVEEVTIDVDYVRNQLADVVQDKDLSKYIL
HHHHCCCCCCCCCHHHEEEEHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA