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The map label for this gene is arcB [H]

Identifier: 220931510

GI number: 220931510

Start: 722040

End: 723035

Strand: Direct

Name: arcB [H]

Synonym: Hore_06660

Alternate gene names: 220931510

Gene position: 722040-723035 (Clockwise)

Preceding gene: 220931509

Following gene: 220931511

Centisome position: 28.01

GC content: 37.95

Gene sequence:

>996_bases
ATGCCTTTAAACTTAAGAGGAAGAAACTTTTTAACTTTACTTGATTTTACTAAAGATGAAATTCAGTATTTACTTGACCT
ATCCGAGAAATTAAAAGCAAAAAAAATGATGGGAATCAGGGGTAATTCTCTGGAAGGGAAGAATATCGCCCTTATTTTTG
AAAAACCATCAACCCGTACCCGGTGTGCTTTTGTTGTTGCTGCCCGGGATGAAGGTGGTATGCCCGAATACCTGGGGAAA
AATGATATTCAGCTGGGTAAAAAAGAATCTGTAGCTGATACCGCCCGCGTCCTTGGAAGGATGTTTGACGGTATTCAGTT
CAGGGGGTTTAAACATGAAACAGTAGAAATTCTGGGTGAATATGCAGGTGTACCGGTCTGGAATGGTTTAACTGATAAAT
ACCACCCAACTCAGGTTCTGGCAGATTTAATGACTATCCAGGAGAATTTTGGTTACCTCGAAGGAATTAATCTAGTTTAT
GTCGGGGATGGAAGAAATAATATGGCCAATTCCCTGATGATTGGTAGTGCTAAAATGGGATTAAATTATAAAATTGTTTC
CCCCAAAGAACTGTGGCCTGAAAAAGAACTGGTTGAAGAGTGTAAAAAGGTAGCTAAAGAAACTGGAAGTAAAATAGAAA
TTACCGATGACCCCGTTGAAGGAGTAAAAGATGCTGATGTTCTATATACCGACGTCTGGTTCTCAATGGGTGAAGAAGAT
AAATTTGTAGAAAGGGTAGAATTATTAAAACCATTCCAGGTAAACATGGATATGATTAAAAATACCGGAAATGACAATGT
CATCTTCCTGCACTGTCTACCCTCCTATCATAATACAGAAACTGAAAACGGCAAGATGATTTATGAAAAATATGGTATTG
CTGAAATGGAAGTTACAGATGAAGTATTTGAAAGTTCCTATTCCAAGGTGTTTGATGAAGCAGAAAATAGAATGCACACC
ATTAAAGCTGTAATGGTGTCAACCCTGGGTGAATAA

Upstream 100 bases:

>100_bases
GATGAAAGACTAAAAAAATATTTAAAACAAACTCAAAGGAATAAATTTAGAAATTAAAGAAATAAAAATACAATAATTTC
AAGAAAGGGGAGTTTAAAAA

Downstream 100 bases:

>100_bases
TTAAAAAATGGGTTCGCCCCGGCCCCGGGGCGGCCCCACCCTTAAATTAACCCCATTATGTTATTCAGATTTAATTAAAA
ATCTTCCATGTCATGATTTA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MPLNLRGRNFLTLLDFTKDEIQYLLDLSEKLKAKKMMGIRGNSLEGKNIALIFEKPSTRTRCAFVVAARDEGGMPEYLGK
NDIQLGKKESVADTARVLGRMFDGIQFRGFKHETVEILGEYAGVPVWNGLTDKYHPTQVLADLMTIQENFGYLEGINLVY
VGDGRNNMANSLMIGSAKMGLNYKIVSPKELWPEKELVEECKKVAKETGSKIEITDDPVEGVKDADVLYTDVWFSMGEED
KFVERVELLKPFQVNMDMIKNTGNDNVIFLHCLPSYHNTETENGKMIYEKYGIAEMEVTDEVFESSYSKVFDEAENRMHT
IKAVMVSTLGE

Sequences:

>Translated_331_residues
MPLNLRGRNFLTLLDFTKDEIQYLLDLSEKLKAKKMMGIRGNSLEGKNIALIFEKPSTRTRCAFVVAARDEGGMPEYLGK
NDIQLGKKESVADTARVLGRMFDGIQFRGFKHETVEILGEYAGVPVWNGLTDKYHPTQVLADLMTIQENFGYLEGINLVY
VGDGRNNMANSLMIGSAKMGLNYKIVSPKELWPEKELVEECKKVAKETGSKIEITDDPVEGVKDADVLYTDVWFSMGEED
KFVERVELLKPFQVNMDMIKNTGNDNVIFLHCLPSYHNTETENGKMIYEKYGIAEMEVTDEVFESSYSKVFDEAENRMHT
IKAVMVSTLGE
>Mature_330_residues
PLNLRGRNFLTLLDFTKDEIQYLLDLSEKLKAKKMMGIRGNSLEGKNIALIFEKPSTRTRCAFVVAARDEGGMPEYLGKN
DIQLGKKESVADTARVLGRMFDGIQFRGFKHETVEILGEYAGVPVWNGLTDKYHPTQVLADLMTIQENFGYLEGINLVYV
GDGRNNMANSLMIGSAKMGLNYKIVSPKELWPEKELVEECKKVAKETGSKIEITDDPVEGVKDADVLYTDVWFSMGEEDK
FVERVELLKPFQVNMDMIKNTGNDNVIFLHCLPSYHNTETENGKMIYEKYGIAEMEVTDEVFESSYSKVFDEAENRMHTI
KAVMVSTLGE

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=328, Percent_Identity=41.4634146341463, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI18105007, Length=336, Percent_Identity=25.297619047619, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1790703, Length=328, Percent_Identity=56.0975609756098, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1786469, Length=332, Percent_Identity=55.7228915662651, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI2367364, Length=237, Percent_Identity=31.6455696202532, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI48994908, Length=375, Percent_Identity=25.0666666666667, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=236, Percent_Identity=27.9661016949153, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322373, Length=327, Percent_Identity=35.1681957186544, Blast_Score=192, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6322331, Length=284, Percent_Identity=28.5211267605634, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24642586, Length=235, Percent_Identity=28.5106382978723, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37478; Mature: 37347

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNLRGRNFLTLLDFTKDEIQYLLDLSEKLKAKKMMGIRGNSLEGKNIALIFEKPSTRT
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCC
RCAFVVAARDEGGMPEYLGKNDIQLGKKESVADTARVLGRMFDGIQFRGFKHETVEILGE
EEEEEEEECCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
YAGVPVWNGLTDKYHPTQVLADLMTIQENFGYLEGINLVYVGDGRNNMANSLMIGSAKMG
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCEEEEECCCCC
LNYKIVSPKELWPEKELVEECKKVAKETGSKIEITDDPVEGVKDADVLYTDVWFSMGEED
CEEEEECHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEHHHHHCCCCH
KFVERVELLKPFQVNMDMIKNTGNDNVIFLHCLPSYHNTETENGKMIYEKYGIAEMEVTD
HHHHHHHHHCCHHCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCEEEHHHH
EVFESSYSKVFDEAENRMHTIKAVMVSTLGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLNLRGRNFLTLLDFTKDEIQYLLDLSEKLKAKKMMGIRGNSLEGKNIALIFEKPSTRT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCC
RCAFVVAARDEGGMPEYLGKNDIQLGKKESVADTARVLGRMFDGIQFRGFKHETVEILGE
EEEEEEEECCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
YAGVPVWNGLTDKYHPTQVLADLMTIQENFGYLEGINLVYVGDGRNNMANSLMIGSAKMG
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCEEEEECCCCC
LNYKIVSPKELWPEKELVEECKKVAKETGSKIEITDDPVEGVKDADVLYTDVWFSMGEED
CEEEEECHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEHHHHHCCCCH
KFVERVELLKPFQVNMDMIKNTGNDNVIFLHCLPSYHNTETENGKMIYEKYGIAEMEVTD
HHHHHHHHHCCHHCCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCEEEHHHH
EVFESSYSKVFDEAENRMHTIKAVMVSTLGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9851988 [H]