| Definition | Halothermothrix orenii H 168 chromosome, complete genome. |
|---|---|
| Accession | NC_011899 |
| Length | 2,578,146 |
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The map label for this gene is polA [H]
Identifier: 220931331
GI number: 220931331
Start: 525669
End: 528281
Strand: Direct
Name: polA [H]
Synonym: Hore_04860
Alternate gene names: 220931331
Gene position: 525669-528281 (Clockwise)
Preceding gene: 220931330
Following gene: 220931332
Centisome position: 20.39
GC content: 40.87
Gene sequence:
>2613_bases GTGAAGAAAAAGCTTTATTTGCTGGATGGACAAAGCCTGGCCCACAGGGCTTTTTATGCATTGCCCCTGCTTTCAACTTC CCGGGGGGAGTATACTAATGCTGTGTTTGGATTTACCAGGATGTTATTAAAACTACTTGACGAGGAAAAACCTGATTTAA TTGCGGTTGCCTTTGATAAAAAGGCCCCTACCTTCCGACATAAGGAATATAAAGAATACAAGGCTCATCGCAAAAAGATG CCGGAAGAATTAAAACCACAGCTGTCTTTAATTAAAGAAGTACTTAAATCTTTTAGTATTCCCATTATTGAAATTGAGGG TTTTGAGGCCGATGATATTATAGGGACAATGGCACGAAAGGGGGAAGAGGAGGGATTTGAGGTCGTTATTGTAACCGGTG ACCGGGATGCCCTCCAGCTGGTTACAGAAGATGTTTCTGTAATGTATACCAAAAGAGGCATATCAGATATTGTAAGGTAT GATTTAAATAAGGTAAGGGAAAGGTACGAACTGGAACCTCAACAGCTTATCGATATGAAGGGTTTGATGGGAGATAGTTC TGACAATATTCCCGGTGTTCCTGGTATCGGTGAAAAGACGGCCATAAAGTTATTAAAGGAGTTTTCTTCACTGGAAGAGA TCCTTGACAATATTGATAAGGTCTCCGGTAAAAAGCGGAAGGAAAACCTCCAAAAATATGCTGATCAGGCCCGGCTTAGT AAGAGACTGGGTGAAATAAAGGTTGATGTTCCCCTGGATGTAGAACTTGACGAGTGCCACCTTGGTAAGTTCCATAAAAA GAACATCAGGGAGTTATTTGAAAGACTTGAGTTTGCCAGTCTATTGAACAGGTTTAAAGAGAAAACGAGTATTAGTATTG ATGATATCTCTGTAAAAGAACTGGACAGGAAGGGGCTTGAAAATATCTGTGATAAAGCCCGGAATTTGGGAAAATTGGGG TTAACCTTAAGGCTTAATAATTATACTACCCCTGTCCGGGCTCATGCCAGCCAGGGAATAATTTCCCTGGGGGAAGGAAA CCTTTACATCTTTACTGATATAAATGAGGCCATAAGTATTTTAAAACCTATTTTGACAGATATTAGTGTTAAGAAATATA TTTTAAATTCCAAGGAATGTACTGTATTTTTAAAAAAACACGATATCGAGTTAGAAGGGCTTGTTTTTGATCCTTTACTG GCATATTACCTCCTCAAACCATCGGGTAAACTACCCGGCCTCAGGGACTTACTGGATCAGGAGTTAAGCCTGTCTCTACC TGAGGACATAAAAGAAGATAATCTGTATCTTGTTTTCATGGATAATATCTTCAAACTGGCTGAGGGTATGGTTCCTAAAC TTGAGGATATGGAGCTTATAGAATTATTTAATGATATTGAAATACCTTTAATTACAGTTTTAGCAGAACTGGAGTATAAT GGTATCAAAGTTGATGCTGAATACCTTGAAAGCCTTTCCCGAAAATGGGAAGAAGAACTAAATGGACTGGAGAGTAAAAT CCATGAGCTTGCCGGTGAAAAGTTCAATATTAATTCACCCAAACAGCTCGGGGGAATTCTCTTTGAAAAACTGGGGCTCC CGGTGATAAAGAAAACAAAGACTGGTTATTCTACAGGGGCTAAGGTCCTGGAAAAGCTGGAAGATAAACATCCGATAATA CCCTTGATTTCTGAATACAGGCAGCTTATGAAGTTGAAGTCAACCTATGTTGATGCCCTGCCTCCGATGATTAACCCCGA TACCGGGCGGCTCCACACCAGTTTTAATCAGATGGTTACTGCAACCGGGAGGTTAAGCAGTACTGAACCCAACCTTCAGA ATATTCCTGTAAGGACTGATGAGGGTCGAGAAATTAGACGGGCCTTTATTACAGAAAATGAAGACTGGGTCCTTCTGGCA GCAGATTATTCCCAGATAGAATTGAGGGTACTGGCCCATATCAGTGATGATGAAGGTTTAAAGGCAGCCTTTAACACCGG TCAGGATATTCATACCCAGACCGCCAGTGAGGTTTTTGAAGTTGAACCTGATGAAGTAACTCCAAATATGAGGCGGCATG CCAAGGTTATTAACTTCGGTATTGCTTATGGAATGAGCCCGTATGGACTGGCCCGGGACCTGGGTATTTCTAGACAGGAG GCCAGTGATTATATAAATAAATATTTTGAGAGGTTTACCGGGGTAAAAGATTATATGGAAAGGGTTGTAACTGAGGCCAA AACTAAAGGTTATGTAACCACTATTTTTAACCGGAGACGGTATATTCCCGAAATTAATAGTCGTAATTACCACCGGCGTT CATTTGCTGAAAGAACAGCAATAAATACTCCCATTCAGGGTACTGCTGCTGATATTATGAAACTGGCCATGATAAAAGTT TATAATCGTCTTAAAGAAAATGGCTCCCCGGCCCGGATTTTACTCCAGGTTCATGATGAGCTAATTCTTGAGGTGCCCCG GGAGGACCTTACTGAAATGGCCCGGATTGTTAAATCAGAGATGGAAAAAGCAGTTGATATGAAAGTCCCACTTGTGGTTA ACTTGGAGAGTGGTCCCAACTGGCTTAATAAAGAGGAATTAGATATAGAGTAA
Upstream 100 bases:
>100_bases TATAATAAAATTTAATGATAAAAGGTGAAAGATATTAATAAGCAGGGGAGGTTTTTTTGATTTTATAGTGAATAATTATA GTTGAAGGAGTTGGTTTTTA
Downstream 100 bases:
>100_bases AAAGAGGTGGTATTTTGCCTGAATTACCGGAAGTGGAAACGGTAGTTAGAGGTTTAAAGGAATTAATAAAAGGGGTTAAA ATAAATAAAGTTATCATTAG
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 870; Mature: 870
Protein sequence:
>870_residues MKKKLYLLDGQSLAHRAFYALPLLSTSRGEYTNAVFGFTRMLLKLLDEEKPDLIAVAFDKKAPTFRHKEYKEYKAHRKKM PEELKPQLSLIKEVLKSFSIPIIEIEGFEADDIIGTMARKGEEEGFEVVIVTGDRDALQLVTEDVSVMYTKRGISDIVRY DLNKVRERYELEPQQLIDMKGLMGDSSDNIPGVPGIGEKTAIKLLKEFSSLEEILDNIDKVSGKKRKENLQKYADQARLS KRLGEIKVDVPLDVELDECHLGKFHKKNIRELFERLEFASLLNRFKEKTSISIDDISVKELDRKGLENICDKARNLGKLG LTLRLNNYTTPVRAHASQGIISLGEGNLYIFTDINEAISILKPILTDISVKKYILNSKECTVFLKKHDIELEGLVFDPLL AYYLLKPSGKLPGLRDLLDQELSLSLPEDIKEDNLYLVFMDNIFKLAEGMVPKLEDMELIELFNDIEIPLITVLAELEYN GIKVDAEYLESLSRKWEEELNGLESKIHELAGEKFNINSPKQLGGILFEKLGLPVIKKTKTGYSTGAKVLEKLEDKHPII PLISEYRQLMKLKSTYVDALPPMINPDTGRLHTSFNQMVTATGRLSSTEPNLQNIPVRTDEGREIRRAFITENEDWVLLA ADYSQIELRVLAHISDDEGLKAAFNTGQDIHTQTASEVFEVEPDEVTPNMRRHAKVINFGIAYGMSPYGLARDLGISRQE ASDYINKYFERFTGVKDYMERVVTEAKTKGYVTTIFNRRRYIPEINSRNYHRRSFAERTAINTPIQGTAADIMKLAMIKV YNRLKENGSPARILLQVHDELILEVPREDLTEMARIVKSEMEKAVDMKVPLVVNLESGPNWLNKEELDIE
Sequences:
>Translated_870_residues MKKKLYLLDGQSLAHRAFYALPLLSTSRGEYTNAVFGFTRMLLKLLDEEKPDLIAVAFDKKAPTFRHKEYKEYKAHRKKM PEELKPQLSLIKEVLKSFSIPIIEIEGFEADDIIGTMARKGEEEGFEVVIVTGDRDALQLVTEDVSVMYTKRGISDIVRY DLNKVRERYELEPQQLIDMKGLMGDSSDNIPGVPGIGEKTAIKLLKEFSSLEEILDNIDKVSGKKRKENLQKYADQARLS KRLGEIKVDVPLDVELDECHLGKFHKKNIRELFERLEFASLLNRFKEKTSISIDDISVKELDRKGLENICDKARNLGKLG LTLRLNNYTTPVRAHASQGIISLGEGNLYIFTDINEAISILKPILTDISVKKYILNSKECTVFLKKHDIELEGLVFDPLL AYYLLKPSGKLPGLRDLLDQELSLSLPEDIKEDNLYLVFMDNIFKLAEGMVPKLEDMELIELFNDIEIPLITVLAELEYN GIKVDAEYLESLSRKWEEELNGLESKIHELAGEKFNINSPKQLGGILFEKLGLPVIKKTKTGYSTGAKVLEKLEDKHPII PLISEYRQLMKLKSTYVDALPPMINPDTGRLHTSFNQMVTATGRLSSTEPNLQNIPVRTDEGREIRRAFITENEDWVLLA ADYSQIELRVLAHISDDEGLKAAFNTGQDIHTQTASEVFEVEPDEVTPNMRRHAKVINFGIAYGMSPYGLARDLGISRQE ASDYINKYFERFTGVKDYMERVVTEAKTKGYVTTIFNRRRYIPEINSRNYHRRSFAERTAINTPIQGTAADIMKLAMIKV YNRLKENGSPARILLQVHDELILEVPREDLTEMARIVKSEMEKAVDMKVPLVVNLESGPNWLNKEELDIE >Mature_870_residues MKKKLYLLDGQSLAHRAFYALPLLSTSRGEYTNAVFGFTRMLLKLLDEEKPDLIAVAFDKKAPTFRHKEYKEYKAHRKKM PEELKPQLSLIKEVLKSFSIPIIEIEGFEADDIIGTMARKGEEEGFEVVIVTGDRDALQLVTEDVSVMYTKRGISDIVRY DLNKVRERYELEPQQLIDMKGLMGDSSDNIPGVPGIGEKTAIKLLKEFSSLEEILDNIDKVSGKKRKENLQKYADQARLS KRLGEIKVDVPLDVELDECHLGKFHKKNIRELFERLEFASLLNRFKEKTSISIDDISVKELDRKGLENICDKARNLGKLG LTLRLNNYTTPVRAHASQGIISLGEGNLYIFTDINEAISILKPILTDISVKKYILNSKECTVFLKKHDIELEGLVFDPLL AYYLLKPSGKLPGLRDLLDQELSLSLPEDIKEDNLYLVFMDNIFKLAEGMVPKLEDMELIELFNDIEIPLITVLAELEYN GIKVDAEYLESLSRKWEEELNGLESKIHELAGEKFNINSPKQLGGILFEKLGLPVIKKTKTGYSTGAKVLEKLEDKHPII PLISEYRQLMKLKSTYVDALPPMINPDTGRLHTSFNQMVTATGRLSSTEPNLQNIPVRTDEGREIRRAFITENEDWVLLA ADYSQIELRVLAHISDDEGLKAAFNTGQDIHTQTASEVFEVEPDEVTPNMRRHAKVINFGIAYGMSPYGLARDLGISRQE ASDYINKYFERFTGVKDYMERVVTEAKTKGYVTTIFNRRRYIPEINSRNYHRRSFAERTAINTPIQGTAADIMKLAMIKV YNRLKENGSPARILLQVHDELILEVPREDLTEMARIVKSEMEKAVDMKVPLVVNLESGPNWLNKEELDIE
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=520, Percent_Identity=33.6538461538462, Blast_Score=268, Evalue=1e-71, Organism=Homo sapiens, GI139394648, Length=635, Percent_Identity=30.3937007874016, Blast_Score=246, Evalue=9e-65, Organism=Escherichia coli, GI1790294, Length=936, Percent_Identity=39.5299145299145, Blast_Score=588, Evalue=1e-169, Organism=Escherichia coli, GI226510970, Length=224, Percent_Identity=32.5892857142857, Blast_Score=120, Evalue=3e-28, Organism=Caenorhabditis elegans, GI86563272, Length=392, Percent_Identity=32.1428571428571, Blast_Score=192, Evalue=7e-49, Organism=Drosophila melanogaster, GI17933644, Length=483, Percent_Identity=33.3333333333333, Blast_Score=244, Evalue=2e-64,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR003583 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 99255; Mature: 99255
Theoretical pI: Translated: 5.53; Mature: 5.53
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKKLYLLDGQSLAHRAFYALPLLSTSRGEYTNAVFGFTRMLLKLLDEEKPDLIAVAFDK CCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC KAPTFRHKEYKEYKAHRKKMPEELKPQLSLIKEVLKSFSIPIIEIEGFEADDIIGTMARK CCCCCHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHC GEEEGFEVVIVTGDRDALQLVTEDVSVMYTKRGISDIVRYDLNKVRERYELEPQQLIDMK CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH GLMGDSSDNIPGVPGIGEKTAIKLLKEFSSLEEILDNIDKVSGKKRKENLQKYADQARLS HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH KRLGEIKVDVPLDVELDECHLGKFHKKNIRELFERLEFASLLNRFKEKTSISIDDISVKE HHHCCEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH LDRKGLENICDKARNLGKLGLTLRLNNYTTPVRAHASQGIISLGEGNLYIFTDINEAISI HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCCEEECCCCEEEEECHHHHHHH LKPILTDISVKKYILNSKECTVFLKKHDIELEGLVFDPLLAYYLLKPSGKLPGLRDLLDQ HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHH ELSLSLPEDIKEDNLYLVFMDNIFKLAEGMVPKLEDMELIELFNDIEIPLITVLAELEYN HHCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCC GIKVDAEYLESLSRKWEEELNGLESKIHELAGEKFNINSPKQLGGILFEKLGLPVIKKTK CEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECC TGYSTGAKVLEKLEDKHPIIPLISEYRQLMKLKSTYVDALPPMINPDTGRLHTSFNQMVT CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH ATGRLSSTEPNLQNIPVRTDEGREIRRAFITENEDWVLLAADYSQIELRVLAHISDDEGL HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCC KAAFNTGQDIHTQTASEVFEVEPDEVTPNMRRHAKVINFGIAYGMSPYGLARDLGISRQE HHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHH ASDYINKYFERFTGVKDYMERVVTEAKTKGYVTTIFNRRRYIPEINSRNYHRRSFAERTA HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEHHHHCHHCCCCCCCCCCHHHHHHHHHH INTPIQGTAADIMKLAMIKVYNRLKENGSPARILLQVHDELILEVPREDLTEMARIVKSE CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHH MEKAVDMKVPLVVNLESGPNWLNKEELDIE HHHHHCCCCCEEEEECCCCCCCCCCCCCCC >Mature Secondary Structure MKKKLYLLDGQSLAHRAFYALPLLSTSRGEYTNAVFGFTRMLLKLLDEEKPDLIAVAFDK CCCEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC KAPTFRHKEYKEYKAHRKKMPEELKPQLSLIKEVLKSFSIPIIEIEGFEADDIIGTMARK CCCCCHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHC GEEEGFEVVIVTGDRDALQLVTEDVSVMYTKRGISDIVRYDLNKVRERYELEPQQLIDMK CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH GLMGDSSDNIPGVPGIGEKTAIKLLKEFSSLEEILDNIDKVSGKKRKENLQKYADQARLS HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH KRLGEIKVDVPLDVELDECHLGKFHKKNIRELFERLEFASLLNRFKEKTSISIDDISVKE HHHCCEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH LDRKGLENICDKARNLGKLGLTLRLNNYTTPVRAHASQGIISLGEGNLYIFTDINEAISI HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCCEEECCCCEEEEECHHHHHHH LKPILTDISVKKYILNSKECTVFLKKHDIELEGLVFDPLLAYYLLKPSGKLPGLRDLLDQ HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHH ELSLSLPEDIKEDNLYLVFMDNIFKLAEGMVPKLEDMELIELFNDIEIPLITVLAELEYN HHCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCC GIKVDAEYLESLSRKWEEELNGLESKIHELAGEKFNINSPKQLGGILFEKLGLPVIKKTK CEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECC TGYSTGAKVLEKLEDKHPIIPLISEYRQLMKLKSTYVDALPPMINPDTGRLHTSFNQMVT CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH ATGRLSSTEPNLQNIPVRTDEGREIRRAFITENEDWVLLAADYSQIELRVLAHISDDEGL HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCC KAAFNTGQDIHTQTASEVFEVEPDEVTPNMRRHAKVINFGIAYGMSPYGLARDLGISRQE HHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHH ASDYINKYFERFTGVKDYMERVVTEAKTKGYVTTIFNRRRYIPEINSRNYHRRSFAERTA HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEHHHHCHHCCCCCCCCCCHHHHHHHHHH INTPIQGTAADIMKLAMIKVYNRLKENGSPARILLQVHDELILEVPREDLTEMARIVKSE CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHH MEKAVDMKVPLVVNLESGPNWLNKEELDIE HHHHHCCCCCEEEEECCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]