Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 220931332

GI number: 220931332

Start: 528296

End: 529120

Strand: Direct

Name: mutM [H]

Synonym: Hore_04870

Alternate gene names: 220931332

Gene position: 528296-529120 (Clockwise)

Preceding gene: 220931331

Following gene: 220931333

Centisome position: 20.49

GC content: 39.64

Gene sequence:

>825_bases
TTGCCTGAATTACCGGAAGTGGAAACGGTAGTTAGAGGTTTAAAGGAATTAATAAAAGGGGTTAAAATAAATAAAGTTAT
CATTAGAGAGACGAAGTTGCTTGTGTATCCTGACCCCGATACTTTTATCGACCTTGTAGAGGGGAGCCGGGTAATTGATG
TTTTAAGAAGGGGTAAATATATATTAATAAAACTTGATAATAACAGGTTCCTGGTTTTCCATCTCAAGATGACCGGCCAG
CTGGTAGTGTATGAAAGAAATAATAAATATGATAAACATACCCATTTTGTTTTTGAACTTGAGGATGGTCGGGACCTGAG
ATTTAATAATATGAGAAAGTTCGGGCGGGTTTATCTGGTAACAAAAGGGGAATTTGATAAAGCCGGATCCCTGGCCGATC
TTGGTCCAGAACCCCTGTCAGATGAGTTTACTGTAGATGAATTTGCCGATATAATAAAAAGGAGAAAGGGCAATATAAAG
GGCCTCCTGCTCAATCAAAAATTTATCGCTGGTCTGGGTAATATTTATGCAGATGAAGCCCTCTTTGAGGCCGGTATATC
ACCTGAAAGGAAGGCTGACTCCCTTGATGATAGTGAAATAGAGAGACTGTACCATGCCATCCGCAAAGTCCTGAAGATGG
GAATTAAGTATGGTGGCACATCAATGAAGGATTATGTAAATGCCCGGGGTCGAATAGGTGAATTTCAGAATAAATTAAAA
GTTTACCGTAAAACCGGAGAAGAATGTGTAAACTGTGGCCATGAAATTCAAAAAAAAGTCATCAGGGGAAGAAGTAGCCA
CTACTGTCCTGGATGTCAGAAGTAA

Upstream 100 bases:

>100_bases
AAGCAGTTGATATGAAAGTCCCACTTGTGGTTAACTTGGAGAGTGGTCCCAACTGGCTTAATAAAGAGGAATTAGATATA
GAGTAAAAAGAGGTGGTATT

Downstream 100 bases:

>100_bases
TCACATTTATTCTGCCTCCTTCATATAAATGTAGGGTAATGATACAAAATTGGGGGGGCAGCTATGGAATTCTGGACAGT
TTGTATCCTGGCTATTGCTA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPELPEVETVVRGLKELIKGVKINKVIIRETKLLVYPDPDTFIDLVEGSRVIDVLRRGKYILIKLDNNRFLVFHLKMTGQ
LVVYERNNKYDKHTHFVFELEDGRDLRFNNMRKFGRVYLVTKGEFDKAGSLADLGPEPLSDEFTVDEFADIIKRRKGNIK
GLLLNQKFIAGLGNIYADEALFEAGISPERKADSLDDSEIERLYHAIRKVLKMGIKYGGTSMKDYVNARGRIGEFQNKLK
VYRKTGEECVNCGHEIQKKVIRGRSSHYCPGCQK

Sequences:

>Translated_274_residues
MPELPEVETVVRGLKELIKGVKINKVIIRETKLLVYPDPDTFIDLVEGSRVIDVLRRGKYILIKLDNNRFLVFHLKMTGQ
LVVYERNNKYDKHTHFVFELEDGRDLRFNNMRKFGRVYLVTKGEFDKAGSLADLGPEPLSDEFTVDEFADIIKRRKGNIK
GLLLNQKFIAGLGNIYADEALFEAGISPERKADSLDDSEIERLYHAIRKVLKMGIKYGGTSMKDYVNARGRIGEFQNKLK
VYRKTGEECVNCGHEIQKKVIRGRSSHYCPGCQK
>Mature_273_residues
PELPEVETVVRGLKELIKGVKINKVIIRETKLLVYPDPDTFIDLVEGSRVIDVLRRGKYILIKLDNNRFLVFHLKMTGQL
VVYERNNKYDKHTHFVFELEDGRDLRFNNMRKFGRVYLVTKGEFDKAGSLADLGPEPLSDEFTVDEFADIIKRRKGNIKG
LLLNQKFIAGLGNIYADEALFEAGISPERKADSLDDSEIERLYHAIRKVLKMGIKYGGTSMKDYVNARGRIGEFQNKLKV
YRKTGEECVNCGHEIQKKVIRGRSSHYCPGCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=274, Percent_Identity=38.3211678832117, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786932, Length=276, Percent_Identity=26.4492753623188, Blast_Score=95, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31474; Mature: 31343

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00070 ALDEHYDE_DEHYDR_CYS ; PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVVRGLKELIKGVKINKVIIRETKLLVYPDPDTFIDLVEGSRVIDVLRRGKY
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHCCHHHHHHHHCCCE
ILIKLDNNRFLVFHLKMTGQLVVYERNNKYDKHTHFVFELEDGRDLRFNNMRKFGRVYLV
EEEEECCCEEEEEEEEECCEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHCCCEEEEE
TKGEFDKAGSLADLGPEPLSDEFTVDEFADIIKRRKGNIKGLLLNQKFIAGLGNIYADEA
ECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHH
LFEAGISPERKADSLDDSEIERLYHAIRKVLKMGIKYGGTSMKDYVNARGRIGEFQNKLK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHH
VYRKTGEECVNCGHEIQKKVIRGRSSHYCPGCQK
HHHHCCHHHHHCHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVVRGLKELIKGVKINKVIIRETKLLVYPDPDTFIDLVEGSRVIDVLRRGKY
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCHHHHHHCCHHHHHHHHCCCE
ILIKLDNNRFLVFHLKMTGQLVVYERNNKYDKHTHFVFELEDGRDLRFNNMRKFGRVYLV
EEEEECCCEEEEEEEEECCEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHCCCEEEEE
TKGEFDKAGSLADLGPEPLSDEFTVDEFADIIKRRKGNIKGLLLNQKFIAGLGNIYADEA
ECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHH
LFEAGISPERKADSLDDSEIERLYHAIRKVLKMGIKYGGTSMKDYVNARGRIGEFQNKLK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHH
VYRKTGEECVNCGHEIQKKVIRGRSSHYCPGCQK
HHHHCCHHHHHCHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]