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The map label for this gene is tkt [H]

Identifier: 220931177

GI number: 220931177

Start: 338023

End: 340008

Strand: Direct

Name: tkt [H]

Synonym: Hore_03290

Alternate gene names: 220931177

Gene position: 338023-340008 (Clockwise)

Preceding gene: 220931176

Following gene: 220931178

Centisome position: 13.11

GC content: 46.68

Gene sequence:

>1986_bases
TTGTTAACACAGATTGCCGATACTGTCAGAGGATTATCAGCAGATGCAGTAGAAAAAGCAAACTCTGGTCATCCGGGTCT
TCCCATCGGATGTGCTGATATAGGGGCTTTGCTCTATGGGAAGGTTATGAAATATGACCCGACTCAGCCGGAGTGGCCTG
ACCGGGATCGGTTTATCCTTTCAGCAGGCCATGGCTCCATGCTTGTATATTCATTACTCCATTTAGCCGGTTTTGAAGTT
AGTCTCGATGACCTTAAATCATTCCGTCAGTTAGGTTCCAAAACCCCGGGACATCCCGAATACGGAGAAACCCCCGGTGT
TGAAACCACAACCGGCCCTCTGGGTCAGGGCTTTGCCAATGCTGTAGGAATGGCTATTGCCGAAAGAATGCTGGCCCAGC
GCTTTAACACCGAAGGACATACCATAGTTGATCACTATACATATACCCTCCTCGGAGATGGCTGTATGATGGAAGGAATT
TCATCTGAAGCTGCTTCCCTGGCCGGTCACCTTGGCCTGGGAAAACTGATTGCCATCTATGATGACAATGAAATCTCCAT
CGGGGGTAGTACCGATATAACCTTTACCGAATCAGTAGCTGATAGATTTAAGGCCTATAACTGGCATGTCATTGAAGGGG
TAGACGGCCATGACCTTAAGGCTCTGGAAGAGGCCGTTAAAGAAGCTAAGGAGGCAAATGATAAACCCAGTTTAATAATT
GCTAAAACTAAAATTGCTTTCGGGGCTCCCACCAAAGAAGGGAGCAGTTCGGCCCACGGGGCTCCACTGGGTGAAGAAGA
GATAAGGGGATTAAAGAAAAATATCGGTTTCCCTGAAGATAAGGAATTCTATATCCCGGATGAGGTAAAAGAATTCTTTA
AGGACCATACCGAAAAGCTCAAAAAAGAACGTGAAGAATGGGAAAAAGCCTTTACTGAATGGGCTGAAGAAAACCCTGAC
CTGAAAGAAGAATGGGATAAGGCCCATAATCTCGAGCTTCCCGGAGACTTAGAAGAAACAATCAATAATCTTGAGATAAA
AACCCCCGTGGCTACCAGGAAGGCTTCAGGGGAGACTTTAAGAAAAATTGCCGATGAAATACCATACCTGGTCGGCGGTT
CAGCAGACCTGGCCCCATCCAATAAGACCTATTTAGATAAATATGGAGAGATACAGAAAGACAGCTTTGATGGGCGTAAC
TTCCGCTTCGGTGTCAGGGAGCATGCTATGGGAGCCATAGTAAACGGGTTATCCCTCCACAAAGGGGTAAGGCCCTTCTG
TGCTACCTTTTTAGTCTTCTCAGATTACATGAGGCCTGCTATCAGAATGGCTGCCTTAATGAAACAGCCTGTAATCTATG
TCTTTACCCATGACTCTGTATATGTAGGAGAAGATGGTCCTACCCACCAGCCTATCGAACATGTTGAAGCCCTGAGAGTG
ATACCTAATCTCAAAGTTTTAAGACCGGCTGATGCCGAAGAGACCAAAGCAGCCTGGCTTGAGGCTGTAAAGAGGACCGA
TGGACCTACAGCCCTGGTACTGACAAGACAGGGATTGCCCCATATTGAAAAAGAAGAGGGGATCGTAGGATTCAAACGTG
GTGGTTATATTGTCCACAAGGAAAAAGGAGATAGAACCGATGCTGTCCTTATGGCCAGTGGTAGTGAGGTTTCCCTGGCT
GTAGAGGTAGCTAAACTGCTTGAGGAAAAAGGTAAAGAGGTCAGGGTAGTATCTGTACCTGAGCGGCGGGAATTTGTAAA
CCAGGGTACAGAATATATAGAAGAAGTCCTCGGTAAGGATACTTTCAGGGTAGTCCTGGAGGCTGGAGTCGGAAATGGCT
GGTACCGTCTATTAGGTCATAAATGCCATGTGGTAAGCCTTGAGGATTTCGGTATGAGTGGTCCCGGGGAGGAAGTGGCC
CGTGAGCTTGGATTTGATGCTGAAAAGATTGCTTCTGATATCCTGGGAAATTATGAAAGACTGTAA

Upstream 100 bases:

>100_bases
TGTTATCGAAAAAATGTCCAAACATCCATTAACAAATATTGGTATTGAGCGCTTTCTTAATGACTGGAAGAAAGTACAGC
AAGGATAGGAGGGTATTATC

Downstream 100 bases:

>100_bases
TAGTGTTTAAATTATATTATTTGTGATTTAAGGGAGGTGGTAAATTACTTATATGGAGTTTTAGCAGGTTATATACTAAA
ACTTCCGTAATATTTGACTA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MLTQIADTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFILSAGHGSMLVYSLLHLAGFEV
SLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMMEGI
SSEAASLAGHLGLGKLIAIYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEANDKPSLII
AKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKLKKEREEWEKAFTEWAEENPD
LKEEWDKAHNLELPGDLEETINNLEIKTPVATRKASGETLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDGRN
FRFGVREHAMGAIVNGLSLHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEALRV
IPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHKEKGDRTDAVLMASGSEVSLA
VEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEEVA
RELGFDAEKIASDILGNYERL

Sequences:

>Translated_661_residues
MLTQIADTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFILSAGHGSMLVYSLLHLAGFEV
SLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMMEGI
SSEAASLAGHLGLGKLIAIYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEANDKPSLII
AKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKLKKEREEWEKAFTEWAEENPD
LKEEWDKAHNLELPGDLEETINNLEIKTPVATRKASGETLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDGRN
FRFGVREHAMGAIVNGLSLHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEALRV
IPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHKEKGDRTDAVLMASGSEVSLA
VEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEEVA
RELGFDAEKIASDILGNYERL
>Mature_661_residues
MLTQIADTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFILSAGHGSMLVYSLLHLAGFEV
SLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFANAVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMMEGI
SSEAASLAGHLGLGKLIAIYDDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEANDKPSLII
AKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKLKKEREEWEKAFTEWAEENPD
LKEEWDKAHNLELPGDLEETINNLEIKTPVATRKASGETLRKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDGRN
FRFGVREHAMGAIVNGLSLHKGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEALRV
IPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHKEKGDRTDAVLMASGSEVSLA
VEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKDTFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEEVA
RELGFDAEKIASDILGNYERL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=582, Percent_Identity=28.1786941580756, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4507521, Length=582, Percent_Identity=28.1786941580756, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI133778974, Length=590, Percent_Identity=27.1186440677966, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI225637459, Length=522, Percent_Identity=22.9885057471264, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI225637461, Length=490, Percent_Identity=22.8571428571429, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=487, Percent_Identity=22.5872689938398, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=49.6978851963746, Blast_Score=626, Evalue=1e-180,
Organism=Escherichia coli, GI48994911, Length=656, Percent_Identity=48.6280487804878, Blast_Score=620, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17539652, Length=582, Percent_Identity=27.6632302405498, Blast_Score=166, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=667, Percent_Identity=44.9775112443778, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6319593, Length=659, Percent_Identity=42.6403641881639, Blast_Score=509, Evalue=1e-145,
Organism=Drosophila melanogaster, GI45551847, Length=589, Percent_Identity=27.1646859083192, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45550715, Length=589, Percent_Identity=27.1646859083192, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24666278, Length=592, Percent_Identity=26.5202702702703, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24645119, Length=555, Percent_Identity=26.8468468468468, Blast_Score=156, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72695; Mature: 72695

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQIADTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFIL
CCCHHHHHHHCCCHHHHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
SAGHGSMLVYSLLHLAGFEVSLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFAN
ECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMMEGISSEAASLAGHLGLGKLIAIY
HHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCEEEEE
DDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEANDKPSLII
ECCEEEECCCCCCEEHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEE
AKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKL
EEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHH
KKEREEWEKAFTEWAEENPDLKEEWDKAHNLELPGDLEETINNLEIKTPVATRKASGETL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHCCCEEECCCHHCCCCHHHH
RKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDGRNFRFGVREHAMGAIVNGLSLH
HHHHHHCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHH
KGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEALRV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCCCCHHHHHHHHHH
IPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHK
CCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEEEC
EKGDRTDAVLMASGSEVSLAVEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKD
CCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
TFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEEVARELGFDAEKIASDILGNYER
CEEHHEECCCCCHHHHHHCCEEEEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
L
C
>Mature Secondary Structure
MLTQIADTVRGLSADAVEKANSGHPGLPIGCADIGALLYGKVMKYDPTQPEWPDRDRFIL
CCCHHHHHHHCCCHHHHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
SAGHGSMLVYSLLHLAGFEVSLDDLKSFRQLGSKTPGHPEYGETPGVETTTGPLGQGFAN
ECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AVGMAIAERMLAQRFNTEGHTIVDHYTYTLLGDGCMMEGISSEAASLAGHLGLGKLIAIY
HHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCEEEEE
DDNEISIGGSTDITFTESVADRFKAYNWHVIEGVDGHDLKALEEAVKEAKEANDKPSLII
ECCEEEECCCCCCEEHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEE
AKTKIAFGAPTKEGSSSAHGAPLGEEEIRGLKKNIGFPEDKEFYIPDEVKEFFKDHTEKL
EEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHH
KKEREEWEKAFTEWAEENPDLKEEWDKAHNLELPGDLEETINNLEIKTPVATRKASGETL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHCCCEEECCCHHCCCCHHHH
RKIADEIPYLVGGSADLAPSNKTYLDKYGEIQKDSFDGRNFRFGVREHAMGAIVNGLSLH
HHHHHHCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHH
KGVRPFCATFLVFSDYMRPAIRMAALMKQPVIYVFTHDSVYVGEDGPTHQPIEHVEALRV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEECCCCCCCCHHHHHHHHHH
IPNLKVLRPADAEETKAAWLEAVKRTDGPTALVLTRQGLPHIEKEEGIVGFKRGGYIVHK
CCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEEEC
EKGDRTDAVLMASGSEVSLAVEVAKLLEEKGKEVRVVSVPERREFVNQGTEYIEEVLGKD
CCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
TFRVVLEAGVGNGWYRLLGHKCHVVSLEDFGMSGPGEEVARELGFDAEKIASDILGNYER
CEEHHEECCCCCHHHHHHCCEEEEEEHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]