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The map label for this gene is hisD [H]

Identifier: 220931068

GI number: 220931068

Start: 227639

End: 228922

Strand: Direct

Name: hisD [H]

Synonym: Hore_02200

Alternate gene names: 220931068

Gene position: 227639-228922 (Clockwise)

Preceding gene: 220931067

Following gene: 220931069

Centisome position: 8.83

GC content: 44.78

Gene sequence:

>1284_bases
GTGGAAATACTGAGATATCCAGAAAATAAGGACAGGATTAAAGAGATAGCAAAAAAGAGGGCTGATTTTATTGATGAAGA
TAAATTAAAATCAGTCCAGGAGATTGTTAACAGGGTTAAGGTAAGAGGGGATGAAGCCCTGTTTGAATATACCCGCAAAT
TTGACCGGGTTAACCTTAAAAAACTTAGGGTGAGTGAGAAAGAGATTGAAGAAGCCTATCAGAGTGTTGACAAGGGTTTT
CTCCAAGATTTAAAACAGGCAATAAATAATATTGGTGATTATCACCGGAAACAGTTAAAGGAAAGCTGGTTCAGCCATGA
TCGGAAGGGGAATATCATGGGTCAGTTAATAAATCCTGTACAGCGGGTTGGAGCCTATGTCCCCGGAGGGCGGGCCCCTT
ATCCTTCTTCAGTAATAATGACCGTTATTCCGGCCAGGGTGGCCGGGGTAGATGAAGTGGTAGTGGTAACTCCACCTGAT
AAAGAGGGTAAGGTCAACAGTTATACCCTTGTAGCTACAAGAGAGGCAGGGGCTGATGAAATATACAGGGTCGGGGGAGC
CCAGGCGGTAGCTGCCCTGACCTATGGTACTGAATCTATTAAACCTGTAGAGAAAATTGTGGGACCGGGTAATATTTATG
TGACTCTGGCTAAAAAGATGGTATCAGGTATTGTTGGTATCGATATGCTGGCTGGTCCCAGCGAAATTATGATTCTGGCT
GACGAAACAGCTGAGCCGGAGTATATAGCCGCTGATCTCCTGTCACAGGCAGAACATGATCCTCTGGCAGCCCCGGTGTT
TGTTACCCCGGACTGGAAATTGGTTGAAGAGGTTATTTCTCACCTGGAAAACCAGATGAAAGATCAGCCCCGCCGGGAGA
CTATGGCAAAATCCTGGGAAAATCAGGGATTAATAATAATTGTTGAAGATATTAAAACTGGACTGGAAATGGTAAACCTG
TTTGGCCCGGAACACTTTGAGCTGATGGTTGAAGACCCTTTTAAGTACTTACCGGATATTAAAAACGCCGGTGCCATATT
CCTGGGGAAATATTCACCCGAACCCCTGGGGGACTATGTAGCCGGTCCGAATCATGTTTTGCCGACCGGAGGTACTGCCC
GTTTTTCTTCACCATTAAGTGTTGATGATTTTATAAAAAAATCTAGCCTTATCTTTTATTCCAGAGAAGGTTTTAATGAA
GTAGCAGGGGGGGCTATTTCCCTGGCCCAGAAAGAGGGATTTAACGGTCATGCCAGTTCGGTTTCCATCAGATTAGGACG
GTGA

Upstream 100 bases:

>100_bases
GTAACCTCATCAGCCCGTTTAGTAGTTAATAATGTGAGTTATAAAATTAAACATAAGCAAATAAGTGAGTTAATCAATAA
AATCAATGAGGTGGTCAAGA

Downstream 100 bases:

>100_bases
TTATCCTGATTTAACCTGAGTAAATTTTAGAACTATATTTCAGGGTTCTAATAATTTATGTTTCTGGTCGCAAAAATAGG
TGACTTATCTAGGAAAATTA

Product: Histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MEILRYPENKDRIKEIAKKRADFIDEDKLKSVQEIVNRVKVRGDEALFEYTRKFDRVNLKKLRVSEKEIEEAYQSVDKGF
LQDLKQAINNIGDYHRKQLKESWFSHDRKGNIMGQLINPVQRVGAYVPGGRAPYPSSVIMTVIPARVAGVDEVVVVTPPD
KEGKVNSYTLVATREAGADEIYRVGGAQAVAALTYGTESIKPVEKIVGPGNIYVTLAKKMVSGIVGIDMLAGPSEIMILA
DETAEPEYIAADLLSQAEHDPLAAPVFVTPDWKLVEEVISHLENQMKDQPRRETMAKSWENQGLIIIVEDIKTGLEMVNL
FGPEHFELMVEDPFKYLPDIKNAGAIFLGKYSPEPLGDYVAGPNHVLPTGGTARFSSPLSVDDFIKKSSLIFYSREGFNE
VAGGAISLAQKEGFNGHASSVSIRLGR

Sequences:

>Translated_427_residues
MEILRYPENKDRIKEIAKKRADFIDEDKLKSVQEIVNRVKVRGDEALFEYTRKFDRVNLKKLRVSEKEIEEAYQSVDKGF
LQDLKQAINNIGDYHRKQLKESWFSHDRKGNIMGQLINPVQRVGAYVPGGRAPYPSSVIMTVIPARVAGVDEVVVVTPPD
KEGKVNSYTLVATREAGADEIYRVGGAQAVAALTYGTESIKPVEKIVGPGNIYVTLAKKMVSGIVGIDMLAGPSEIMILA
DETAEPEYIAADLLSQAEHDPLAAPVFVTPDWKLVEEVISHLENQMKDQPRRETMAKSWENQGLIIIVEDIKTGLEMVNL
FGPEHFELMVEDPFKYLPDIKNAGAIFLGKYSPEPLGDYVAGPNHVLPTGGTARFSSPLSVDDFIKKSSLIFYSREGFNE
VAGGAISLAQKEGFNGHASSVSIRLGR
>Mature_427_residues
MEILRYPENKDRIKEIAKKRADFIDEDKLKSVQEIVNRVKVRGDEALFEYTRKFDRVNLKKLRVSEKEIEEAYQSVDKGF
LQDLKQAINNIGDYHRKQLKESWFSHDRKGNIMGQLINPVQRVGAYVPGGRAPYPSSVIMTVIPARVAGVDEVVVVTPPD
KEGKVNSYTLVATREAGADEIYRVGGAQAVAALTYGTESIKPVEKIVGPGNIYVTLAKKMVSGIVGIDMLAGPSEIMILA
DETAEPEYIAADLLSQAEHDPLAAPVFVTPDWKLVEEVISHLENQMKDQPRRETMAKSWENQGLIIIVEDIKTGLEMVNL
FGPEHFELMVEDPFKYLPDIKNAGAIFLGKYSPEPLGDYVAGPNHVLPTGGTARFSSPLSVDDFIKKSSLIFYSREGFNE
VAGGAISLAQKEGFNGHASSVSIRLGR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=38.9578163771712, Blast_Score=297, Evalue=8e-82,
Organism=Saccharomyces cerevisiae, GI6319819, Length=404, Percent_Identity=37.1287128712871, Blast_Score=264, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47307; Mature: 47307

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILRYPENKDRIKEIAKKRADFIDEDKLKSVQEIVNRVKVRGDEALFEYTRKFDRVNLK
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHH
KLRVSEKEIEEAYQSVDKGFLQDLKQAINNIGDYHRKQLKESWFSHDRKGNIMGQLINPV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
QRVGAYVPGGRAPYPSSVIMTVIPARVAGVDEVVVVTPPDKEGKVNSYTLVATREAGADE
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
IYRVGGAQAVAALTYGTESIKPVEKIVGPGNIYVTLAKKMVSGIVGIDMLAGPSEIMILA
HHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEE
DETAEPEYIAADLLSQAEHDPLAAPVFVTPDWKLVEEVISHLENQMKDQPRRETMAKSWE
CCCCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
NQGLIIIVEDIKTGLEMVNLFGPEHFELMVEDPFKYLPDIKNAGAIFLGKYSPEPLGDYV
CCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCCEEEEECCCCCCCHHHC
AGPNHVLPTGGTARFSSPLSVDDFIKKSSLIFYSREGFNEVAGGAISLAQKEGFNGHASS
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCHHHCCCHHHHHHHCCCCCCCCE
VSIRLGR
EEEEECC
>Mature Secondary Structure
MEILRYPENKDRIKEIAKKRADFIDEDKLKSVQEIVNRVKVRGDEALFEYTRKFDRVNLK
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHH
KLRVSEKEIEEAYQSVDKGFLQDLKQAINNIGDYHRKQLKESWFSHDRKGNIMGQLINPV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
QRVGAYVPGGRAPYPSSVIMTVIPARVAGVDEVVVVTPPDKEGKVNSYTLVATREAGADE
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
IYRVGGAQAVAALTYGTESIKPVEKIVGPGNIYVTLAKKMVSGIVGIDMLAGPSEIMILA
HHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEE
DETAEPEYIAADLLSQAEHDPLAAPVFVTPDWKLVEEVISHLENQMKDQPRRETMAKSWE
CCCCCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
NQGLIIIVEDIKTGLEMVNLFGPEHFELMVEDPFKYLPDIKNAGAIFLGKYSPEPLGDYV
CCCEEEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCCEEEEECCCCCCCHHHC
AGPNHVLPTGGTARFSSPLSVDDFIKKSSLIFYSREGFNEVAGGAISLAQKEGFNGHASS
CCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCHHHCCCHHHHHHHCCCCCCCCE
VSIRLGR
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA