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The map label for this gene is hisB [H]

Identifier: 220931069

GI number: 220931069

Start: 229060

End: 229653

Strand: Direct

Name: hisB [H]

Synonym: Hore_02210

Alternate gene names: 220931069

Gene position: 229060-229653 (Clockwise)

Preceding gene: 220931068

Following gene: 220931070

Centisome position: 8.88

GC content: 43.27

Gene sequence:

>594_bases
GTGGTTGAAATAACGAGAAAAACAAAGGAGACAAAAATAAAACTAAATCTTGACCTGGATGGACAGGGAAGGGCAAAGAT
TAATACAGGTATAGGTTTTTTTGATCATATGCTGGAATTGTGGGCAGTTCATGGTTTTTTTGACCTGGTGTTGTCTGTTG
AGGGGGATCTGGAAGTTGATGGGCATCACACTGTGGAAGATACTGGGATTGTCCTTGGGGAAGGACTTAAAAAAGCCCTT
GGTAATAAAGCTGGCCTTAAGAGGTATGGGAATGTTATTATCCCAATGGATGAGAGCCTGGTCCTGGTTTCCCTTGACTT
AAGCGGTCGTCCCTATTATGAAGATGATCTTGTTTTTAACAGGACTCAGGTCGGGGGGTTTCCAGTTGAACTCCTGGAAG
AATTTTTCCGGGCTCTGACCAATAATGCTGGAATTACTCTTCATATAAAAATGTTAAGGGGAAAGAATACTCACCACCTG
ATTGAAGCCTGCTTTAAAGGTTTTGGTCGAGCCCTGGATGTAGCATTGACCGGAGAAGAAAGGTTAAATAATACTCCCCT
GTCCTCCAAAGGTTCTCTGGGGGAGGGTGGTTAA

Upstream 100 bases:

>100_bases
TTTCAGGGTTCTAATAATTTATGTTTCTGGTCGCAAAAATAGGTGACTTATCTAGGAAAATTATTTTAATGAAAACTTAA
AGAAAGGCAGCTGGTTTACC

Downstream 100 bases:

>100_bases
AAGTGATTGTTGTTATTGATTATGGTATTGGAAATCTGGGGAGTGTTGTTAAAGCCTTTAAATATTTAGGTGTTCCTGTG
AAATTAACAGCCAGCCCTGA

Product: Imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MVEITRKTKETKIKLNLDLDGQGRAKINTGIGFFDHMLELWAVHGFFDLVLSVEGDLEVDGHHTVEDTGIVLGEGLKKAL
GNKAGLKRYGNVIIPMDESLVLVSLDLSGRPYYEDDLVFNRTQVGGFPVELLEEFFRALTNNAGITLHIKMLRGKNTHHL
IEACFKGFGRALDVALTGEERLNNTPLSSKGSLGEGG

Sequences:

>Translated_197_residues
MVEITRKTKETKIKLNLDLDGQGRAKINTGIGFFDHMLELWAVHGFFDLVLSVEGDLEVDGHHTVEDTGIVLGEGLKKAL
GNKAGLKRYGNVIIPMDESLVLVSLDLSGRPYYEDDLVFNRTQVGGFPVELLEEFFRALTNNAGITLHIKMLRGKNTHHL
IEACFKGFGRALDVALTGEERLNNTPLSSKGSLGEGG
>Mature_197_residues
MVEITRKTKETKIKLNLDLDGQGRAKINTGIGFFDHMLELWAVHGFFDLVLSVEGDLEVDGHHTVEDTGIVLGEGLKKAL
GNKAGLKRYGNVIIPMDESLVLVSLDLSGRPYYEDDLVFNRTQVGGFPVELLEEFFRALTNNAGITLHIKMLRGKNTHHL
IEACFKGFGRALDVALTGEERLNNTPLSSKGSLGEGG

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=190, Percent_Identity=50.5263157894737, Blast_Score=183, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=214, Percent_Identity=37.3831775700935, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21635; Mature: 21635

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEITRKTKETKIKLNLDLDGQGRAKINTGIGFFDHMLELWAVHGFFDLVLSVEGDLEVD
CCEECCCCCCEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCEEEC
GHHTVEDTGIVLGEGLKKALGNKAGLKRYGNVIIPMDESLVLVSLDLSGRPYYEDDLVFN
CCCEECCCCEEEHHHHHHHHCCHHHHHHHCCEEEECCCCEEEEEEECCCCCCCCCCEEEE
RTQVGGFPVELLEEFFRALTNNAGITLHIKMLRGKNTHHLIEACFKGFGRALDVALTGEE
ECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHH
RLNNTPLSSKGSLGEGG
HCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVEITRKTKETKIKLNLDLDGQGRAKINTGIGFFDHMLELWAVHGFFDLVLSVEGDLEVD
CCEECCCCCCEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCEEEC
GHHTVEDTGIVLGEGLKKALGNKAGLKRYGNVIIPMDESLVLVSLDLSGRPYYEDDLVFN
CCCEECCCCEEEHHHHHHHHCCHHHHHHHCCEEEECCCCEEEEEEECCCCCCCCCCEEEE
RTQVGGFPVELLEEFFRALTNNAGITLHIKMLRGKNTHHLIEACFKGFGRALDVALTGEE
ECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHH
RLNNTPLSSKGSLGEGG
HCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA