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The map label for this gene is hisG

Identifier: 220931067

GI number: 220931067

Start: 226996

End: 227667

Strand: Direct

Name: hisG

Synonym: Hore_02190

Alternate gene names: 220931067

Gene position: 226996-227667 (Clockwise)

Preceding gene: 220931066

Following gene: 220931068

Centisome position: 8.8

GC content: 37.8

Gene sequence:

>672_bases
ATGAAATCAGTTATTACAGCCCTTCCCAAGGGAAGATTGATGGGAGAGGTTATAGATATCCTTAAACAAAGTGGGTTTAT
ATCCAATAATATTGATATTAATACTTTATCCAGGCAGCTGGTTTTTCATGATAAAAAAACCCGTAATTCTTTTTTGCTGG
CCAAACCTAAAGATGTCCCTGTATATGTGGAACACGGGGCGGCAGACCTGGGGATCACCGGTAAGGATGTCCTGTTAGAA
CATGGTCGTAATTTATATGAAATGGTTGATCTTGGGGTCGGTAAATGCAAACTGGTAGTAGCTGTTCCCGAGAGTAAAGG
TTATAAAAGCCTGGCCGATATACCAGAATATAGCCGGGTTGCTACATCCTATCCTGAAATTGTTAAGAAGTTTTTTCAGG
GAAAGGGTATTCAGGTAGAGGTTATAAAACTCAATGGTTCTGTAGAACTGGCTCCCCTGGTAGATCTGGCTGATGTTATT
GTAGATATATCTTCTACAGGAACCACTCTGAAAAAAAATAACCTTATACCTATGGAGACAATTGTAACCTCATCAGCCCG
TTTAGTAGTTAATAATGTGAGTTATAAAATTAAACATAAGCAAATAAGTGAGTTAATCAATAAAATCAATGAGGTGGTCA
AGAGTGGAAATACTGAGATATCCAGAAAATAA

Upstream 100 bases:

>100_bases
AAAAAATTATTTCATTCTGTGAATACTCCAGTAACCAGAAAATTAAAGTTATTGATGACAGGGGAAACATCGAGCTATTG
ACACCCGGGGGTGATTTGCC

Downstream 100 bases:

>100_bases
GGACAGGATTAAAGAGATAGCAAAAAAGAGGGCTGATTTTATTGATGAAGATAAATTAAAATCAGTCCAGGAGATTGTTA
ACAGGGTTAAGGTAAGAGGG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKSVITALPKGRLMGEVIDILKQSGFISNNIDINTLSRQLVFHDKKTRNSFLLAKPKDVPVYVEHGAADLGITGKDVLLE
HGRNLYEMVDLGVGKCKLVVAVPESKGYKSLADIPEYSRVATSYPEIVKKFFQGKGIQVEVIKLNGSVELAPLVDLADVI
VDISSTGTTLKKNNLIPMETIVTSSARLVVNNVSYKIKHKQISELINKINEVVKSGNTEISRK

Sequences:

>Translated_223_residues
MKSVITALPKGRLMGEVIDILKQSGFISNNIDINTLSRQLVFHDKKTRNSFLLAKPKDVPVYVEHGAADLGITGKDVLLE
HGRNLYEMVDLGVGKCKLVVAVPESKGYKSLADIPEYSRVATSYPEIVKKFFQGKGIQVEVIKLNGSVELAPLVDLADVI
VDISSTGTTLKKNNLIPMETIVTSSARLVVNNVSYKIKHKQISELINKINEVVKSGNTEISRK
>Mature_223_residues
MKSVITALPKGRLMGEVIDILKQSGFISNNIDINTLSRQLVFHDKKTRNSFLLAKPKDVPVYVEHGAADLGITGKDVLLE
HGRNLYEMVDLGVGKCKLVVAVPESKGYKSLADIPEYSRVATSYPEIVKKFFQGKGIQVEVIKLNGSVELAPLVDLADVI
VDISSTGTTLKKNNLIPMETIVTSSARLVVNNVSYKIKHKQISELINKINEVVKSGNTEISRK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=215, Percent_Identity=32.093023255814, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320896, Length=199, Percent_Identity=30.6532663316583, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_HALOH (B8D111)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002507975.1
- ProteinModelPortal:   B8D111
- SMR:   B8D111
- GeneID:   7312539
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_02190
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   CLSK2806185
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24501; Mature: 24501

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVITALPKGRLMGEVIDILKQSGFISNNIDINTLSRQLVFHDKKTRNSFLLAKPKDVP
CCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCCCCEEEECCCCCE
VYVEHGAADLGITGKDVLLEHGRNLYEMVDLGVGKCKLVVAVPESKGYKSLADIPEYSRV
EEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCHHHHH
ATSYPEIVKKFFQGKGIQVEVIKLNGSVELAPLVDLADVIVDISSTGTTLKKNNLIPMET
HHHHHHHHHHHHCCCCCEEEEEEECCCEEEHHHHHHHHHHEECCCCCCEEECCCCCCHHH
IVTSSARLVVNNVSYKIKHKQISELINKINEVVKSGNTEISRK
HHCCCCEEEEECCEEEECHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKSVITALPKGRLMGEVIDILKQSGFISNNIDINTLSRQLVFHDKKTRNSFLLAKPKDVP
CCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCCCCEEEECCCCCE
VYVEHGAADLGITGKDVLLEHGRNLYEMVDLGVGKCKLVVAVPESKGYKSLADIPEYSRV
EEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCHHHHH
ATSYPEIVKKFFQGKGIQVEVIKLNGSVELAPLVDLADVIVDISSTGTTLKKNNLIPMET
HHHHHHHHHHHHCCCCCEEEEEEECCCEEEHHHHHHHHHHEECCCCCCEEECCCCCCHHH
IVTSSARLVVNNVSYKIKHKQISELINKINEVVKSGNTEISRK
HHCCCCEEEEECCEEEECHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA