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The map label for this gene is proC [H]

Identifier: 220931043

GI number: 220931043

Start: 200658

End: 201458

Strand: Direct

Name: proC [H]

Synonym: Hore_01940

Alternate gene names: 220931043

Gene position: 200658-201458 (Clockwise)

Preceding gene: 220931042

Following gene: 220931044

Centisome position: 7.78

GC content: 43.7

Gene sequence:

>801_bases
ATGAAACTCTGCATCATAGGTCTGGGAAAAATGGGGACCACTTTACTTTATGGTATTCTGGATAATAATATCCTGGAAGC
CAAAGATATTATAGGATGTGACCCGGTCGTAGATGAAAGGGAACATAACAAGGATTATAGAGGAATCAGGACTACTGGCA
GTAACTATAGAGGGGTTGAGCAGGCAGATAATATTTTACTGGCAGTAAAGCCTCAGGTACTTAAAAATGTCCTTCAGGGT
ATTAAACCGGCCTCAGAAAATAAATTATTTATATCTATTGCAGCCGGGGTCAGTACTGATAGGATAAAAGAAAATCTGCC
TGAAAGCTGCCGGGTTATCAGGGTAATGCCCAACACCCCGGCTCTGGTTAACCAGGGGGTTTCAGCTATTTCACCGGGAG
AAAAGGCAACTGATGATGATATAGAGTTTGTTAAAAAGATTTGTAACGGGGTTGGTAAAGGTGTGGTCATTGAAGAACAT
TTAATAGATGCAGTAACCGGTTTAAGTGGTAGTGGTCCGGCATATATATATGTGATTATAGAAGCTCTGGCCGATGCCGG
GGTTTTAAATGGTCTATCCCGGGATCTGGCCCTGGAGTTGGCTGTAAGGACAGTAGCCGGTTCGGCTGAAATGGTTTTAA
AAACCGGACAACATCCAGGGCAATTAAAAGATATGGTAACCTCACCTGGAGGAACGACAATAAATGGACTACAGGTTATT
GAAAAAAGGGGGTTGAGGGGCATCTTAATGGAGGCCGTTTCCCGGGCTGTAGAGAGGTCGAGGGAACTGGGAGAAGAATA
A

Upstream 100 bases:

>100_bases
CCAGAAGTTACATGCCAGGGGTCCAATGGGATTAGAAGAGCTGACAACAACCAAATATATTATTTTTGGTCAGGGTCAGA
TCAGGGAGTAGGTGATATTT

Downstream 100 bases:

>100_bases
TTACAGTAAGGGATGTAACCGGGCTCTTTAGATGAAGCCCGGTTATTTTTATTTTACTTTTTAATACTTTGTGTTATAAT
GGTAATGCTAAAGACAGGGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKLCIIGLGKMGTTLLYGILDNNILEAKDIIGCDPVVDEREHNKDYRGIRTTGSNYRGVEQADNILLAVKPQVLKNVLQG
IKPASENKLFISIAAGVSTDRIKENLPESCRVIRVMPNTPALVNQGVSAISPGEKATDDDIEFVKKICNGVGKGVVIEEH
LIDAVTGLSGSGPAYIYVIIEALADAGVLNGLSRDLALELAVRTVAGSAEMVLKTGQHPGQLKDMVTSPGGTTINGLQVI
EKRGLRGILMEAVSRAVERSRELGEE

Sequences:

>Translated_266_residues
MKLCIIGLGKMGTTLLYGILDNNILEAKDIIGCDPVVDEREHNKDYRGIRTTGSNYRGVEQADNILLAVKPQVLKNVLQG
IKPASENKLFISIAAGVSTDRIKENLPESCRVIRVMPNTPALVNQGVSAISPGEKATDDDIEFVKKICNGVGKGVVIEEH
LIDAVTGLSGSGPAYIYVIIEALADAGVLNGLSRDLALELAVRTVAGSAEMVLKTGQHPGQLKDMVTSPGGTTINGLQVI
EKRGLRGILMEAVSRAVERSRELGEE
>Mature_266_residues
MKLCIIGLGKMGTTLLYGILDNNILEAKDIIGCDPVVDEREHNKDYRGIRTTGSNYRGVEQADNILLAVKPQVLKNVLQG
IKPASENKLFISIAAGVSTDRIKENLPESCRVIRVMPNTPALVNQGVSAISPGEKATDDDIEFVKKICNGVGKGVVIEEH
LIDAVTGLSGSGPAYIYVIIEALADAGVLNGLSRDLALELAVRTVAGSAEMVLKTGQHPGQLKDMVTSPGGTTINGLQVI
EKRGLRGILMEAVSRAVERSRELGEE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=39.5522388059701, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=39.5522388059701, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=38.4328358208955, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI198041662, Length=260, Percent_Identity=35.7692307692308, Blast_Score=168, Evalue=5e-42,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=41.1320754716981, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=45.5223880597015, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17540664, Length=214, Percent_Identity=35.981308411215, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=34.3859649122807, Blast_Score=142, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21358587, Length=263, Percent_Identity=41.8250950570342, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=35.6363636363636, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=47.6190476190476, Blast_Score=153, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28381; Mature: 28381

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLCIIGLGKMGTTLLYGILDNNILEAKDIIGCDPVVDEREHNKDYRGIRTTGSNYRGVE
CEEEEEECCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHCCCCCCCEECCCCCCCCHH
QADNILLAVKPQVLKNVLQGIKPASENKLFISIAAGVSTDRIKENLPESCRVIRVMPNTP
HHCCEEEEECHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEECCCCC
ALVNQGVSAISPGEKATDDDIEFVKKICNGVGKGVVIEEHLIDAVTGLSGSGPAYIYVII
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCEEHHHHH
EALADAGVLNGLSRDLALELAVRTVAGSAEMVLKTGQHPGQLKDMVTSPGGTTINGLQVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHH
EKRGLRGILMEAVSRAVERSRELGEE
HHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLCIIGLGKMGTTLLYGILDNNILEAKDIIGCDPVVDEREHNKDYRGIRTTGSNYRGVE
CEEEEEECCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHCCCCCCCEECCCCCCCCHH
QADNILLAVKPQVLKNVLQGIKPASENKLFISIAAGVSTDRIKENLPESCRVIRVMPNTP
HHCCEEEEECHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEECCCCC
ALVNQGVSAISPGEKATDDDIEFVKKICNGVGKGVVIEEHLIDAVTGLSGSGPAYIYVII
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCEEHHHHH
EALADAGVLNGLSRDLALELAVRTVAGSAEMVLKTGQHPGQLKDMVTSPGGTTINGLQVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHH
EKRGLRGILMEAVSRAVERSRELGEE
HHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]