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The map label for this gene is proA

Identifier: 220931042

GI number: 220931042

Start: 199392

End: 200648

Strand: Direct

Name: proA

Synonym: Hore_01930

Alternate gene names: 220931042

Gene position: 199392-200648 (Clockwise)

Preceding gene: 220931041

Following gene: 220931043

Centisome position: 7.73

GC content: 45.43

Gene sequence:

>1257_bases
ATGGAGATTAAAGAACAGGTGGTATTTCAGGCCCGGAAAGCCAGTAAGGCTTCCCGGAAACTTTCCGGTATTGCAACCGA
TGTTAAAAATAAGGCCCTGGCTGCCATTGCAGAAAAGTTAGTCCAGGCAAAAGACGAAATAATAAGAGCCAACAATATAG
ATATGGAAAGAGGGCGGGAGAAAGGTCTTTCAAAAGCCCTCCTGGACAGGCTGGAACTTAATGAAAAGCGGATTGAGGGT
ATGGCTGAAGGGCTTAAGGAACTGGTTAAGCTTGAAGATCCGGTCGGTGAAGTTATCAAGATGTGGAAACGGCCCAATGG
ACTTCAGATCGGTCAGATGCGGGTTCCTCTGGGAGTTATCGGGATGATTTATGAAGCCCGTCCCAATGTTACGGTTGATG
CAGCCGGTTTGTGTTTGAAAACCGGGAATGCTGTTATTTTAAGGGGTGGTTCTGAAGCCATTAACTCAAATAAAATCCTG
GCCCGGATCATTGAAGATACAGCTGTGGCTGCAGGCCTGCCTGAAGGATGTGTCCAGTTGATTCAGACAACTGACCGTAA
GGCGGTTAAAGTTTTATTTAACCTGACTGAATATTTAGATGTTCTTATTCCCAGGGGTGGGGCTGGACTTATTAACCGGG
TTATAGCTGAAGCAAAGGTGCCCGTAATCCAGACCGGGGTCGGTAACTGCCACGTTTATGTTGATTCTGAAGCTGACCTG
GATATGGCCCTGGATATTGTTTTTAATGCCAAAACGAGTCGGCCTGCCGTTTGTAATGCTGCTGAAAGCCTCCTGGTACA
CCGACAGGTTGCTGATGAATTTCTACCGGAGCTATATAAATTATTTAGAGAAAATAATGTTGAATTAAGGGGCTGTGAAA
ACACCCGGGCAATATTACCCGGGATAAAAAAAGCGGTTGATGATGACTGGTCCCGGGAGTATCTGGATTATATCATGGCA
GTAAAGATTGTAGATAGCTTTGATAAGGCGGTAGAACATATTAACACCTATGGTACGAAACATTCTGAAGCTATAATAAC
TGAAAATTACACCAGAGCCCACCGGTTTCTTCAGGAGATCGATGCTGCCGCTGTTTATGTAAATGCGTCAACACGGTTTA
CTGATGGAGGTCAATTTGGCCTGGGGGCCGAGATCGGTATCAGTACCCAGAAGTTACATGCCAGGGGTCCAATGGGATTA
GAAGAGCTGACAACAACCAAATATATTATTTTTGGTCAGGGTCAGATCAGGGAGTAG

Upstream 100 bases:

>100_bases
GGACACCACACCACAGATATTAGTTCTTTACTCGGTTATATGAAACAGGAAGAAGTAATACACCGGGATAACCTGGTAAT
AGAAAGGGGTAAGATTGATA

Downstream 100 bases:

>100_bases
GTGATATTTATGAAACTCTGCATCATAGGTCTGGGAAAAATGGGGACCACTTTACTTTATGGTATTCTGGATAATAATAT
CCTGGAAGCCAAAGATATTA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MEIKEQVVFQARKASKASRKLSGIATDVKNKALAAIAEKLVQAKDEIIRANNIDMERGREKGLSKALLDRLELNEKRIEG
MAEGLKELVKLEDPVGEVIKMWKRPNGLQIGQMRVPLGVIGMIYEARPNVTVDAAGLCLKTGNAVILRGGSEAINSNKIL
ARIIEDTAVAAGLPEGCVQLIQTTDRKAVKVLFNLTEYLDVLIPRGGAGLINRVIAEAKVPVIQTGVGNCHVYVDSEADL
DMALDIVFNAKTSRPAVCNAAESLLVHRQVADEFLPELYKLFRENNVELRGCENTRAILPGIKKAVDDDWSREYLDYIMA
VKIVDSFDKAVEHINTYGTKHSEAIITENYTRAHRFLQEIDAAAVYVNASTRFTDGGQFGLGAEIGISTQKLHARGPMGL
EELTTTKYIIFGQGQIRE

Sequences:

>Translated_418_residues
MEIKEQVVFQARKASKASRKLSGIATDVKNKALAAIAEKLVQAKDEIIRANNIDMERGREKGLSKALLDRLELNEKRIEG
MAEGLKELVKLEDPVGEVIKMWKRPNGLQIGQMRVPLGVIGMIYEARPNVTVDAAGLCLKTGNAVILRGGSEAINSNKIL
ARIIEDTAVAAGLPEGCVQLIQTTDRKAVKVLFNLTEYLDVLIPRGGAGLINRVIAEAKVPVIQTGVGNCHVYVDSEADL
DMALDIVFNAKTSRPAVCNAAESLLVHRQVADEFLPELYKLFRENNVELRGCENTRAILPGIKKAVDDDWSREYLDYIMA
VKIVDSFDKAVEHINTYGTKHSEAIITENYTRAHRFLQEIDAAAVYVNASTRFTDGGQFGLGAEIGISTQKLHARGPMGL
EELTTTKYIIFGQGQIRE
>Mature_418_residues
MEIKEQVVFQARKASKASRKLSGIATDVKNKALAAIAEKLVQAKDEIIRANNIDMERGREKGLSKALLDRLELNEKRIEG
MAEGLKELVKLEDPVGEVIKMWKRPNGLQIGQMRVPLGVIGMIYEARPNVTVDAAGLCLKTGNAVILRGGSEAINSNKIL
ARIIEDTAVAAGLPEGCVQLIQTTDRKAVKVLFNLTEYLDVLIPRGGAGLINRVIAEAKVPVIQTGVGNCHVYVDSEADL
DMALDIVFNAKTSRPAVCNAAESLLVHRQVADEFLPELYKLFRENNVELRGCENTRAILPGIKKAVDDDWSREYLDYIMA
VKIVDSFDKAVEHINTYGTKHSEAIITENYTRAHRFLQEIDAAAVYVNASTRFTDGGQFGLGAEIGISTQKLHARGPMGL
EELTTTKYIIFGQGQIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=36.0975609756098, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=36.0975609756098, Blast_Score=265, Evalue=6e-71,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=49.0196078431373, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17569967, Length=412, Percent_Identity=36.1650485436893, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17569969, Length=412, Percent_Identity=36.1650485436893, Blast_Score=262, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=37.7049180327869, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=35.5231143552311, Blast_Score=262, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_HALOH (B8D0Y6)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002507950.1
- ProteinModelPortal:   B8D0Y6
- SMR:   B8D0Y6
- GeneID:   7312512
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_01930
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45983; Mature: 45983

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKEQVVFQARKASKASRKLSGIATDVKNKALAAIAEKLVQAKDEIIRANNIDMERGRE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KGLSKALLDRLELNEKRIEGMAEGLKELVKLEDPVGEVIKMWKRPNGLQIGQMRVPLGVI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECEEECCHHHH
GMIYEARPNVTVDAAGLCLKTGNAVILRGGSEAINSNKILARIIEDTAVAAGLPEGCVQL
HHHHCCCCCCEEECCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
IQTTDRKAVKVLFNLTEYLDVLIPRGGAGLINRVIAEAKVPVIQTGVGNCHVYVDSEADL
HHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCC
DMALDIVFNAKTSRPAVCNAAESLLVHRQVADEFLPELYKLFRENNVELRGCENTRAILP
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHH
GIKKAVDDDWSREYLDYIMAVKIVDSFDKAVEHINTYGTKHSEAIITENYTRAHRFLQEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
DAAAVYVNASTRFTDGGQFGLGAEIGISTQKLHARGPMGLEELTTTKYIIFGQGQIRE
CCEEEEEECCCEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC
>Mature Secondary Structure
MEIKEQVVFQARKASKASRKLSGIATDVKNKALAAIAEKLVQAKDEIIRANNIDMERGRE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KGLSKALLDRLELNEKRIEGMAEGLKELVKLEDPVGEVIKMWKRPNGLQIGQMRVPLGVI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECEEECCHHHH
GMIYEARPNVTVDAAGLCLKTGNAVILRGGSEAINSNKILARIIEDTAVAAGLPEGCVQL
HHHHCCCCCCEEECCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
IQTTDRKAVKVLFNLTEYLDVLIPRGGAGLINRVIAEAKVPVIQTGVGNCHVYVDSEADL
HHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCC
DMALDIVFNAKTSRPAVCNAAESLLVHRQVADEFLPELYKLFRENNVELRGCENTRAILP
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHH
GIKKAVDDDWSREYLDYIMAVKIVDSFDKAVEHINTYGTKHSEAIITENYTRAHRFLQEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
DAAAVYVNASTRFTDGGQFGLGAEIGISTQKLHARGPMGLEELTTTKYIIFGQGQIRE
CCEEEEEECCCEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA