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The map label for this gene is guaB [C]

Identifier: 220930942

GI number: 220930942

Start: 112220

End: 113008

Strand: Direct

Name: guaB [C]

Synonym: Hore_00940

Alternate gene names: 220930942

Gene position: 112220-113008 (Clockwise)

Preceding gene: 220930941

Following gene: 220930943

Centisome position: 4.35

GC content: 41.19

Gene sequence:

>789_bases
ATGCTGGTTAAAAATATAATGTCAAAAGACCCGATAACTATTTCTCCTGAAACTACAGTTGTAGAAGCAGAAAAATTAAT
GTCTATCAATAACATCGGGCGGTTAATAGTTGTTGAGGATGAAGGACTTGTTGGAATCCTAACAGATGGGGATCTGGTTA
TTCAGCATGACCTTAATGCGCCCATTGATAAGTTTATGTCCAGAGAAGTTATCACCATCAGTCAAAATGCCACTGTTCAG
GAAGCTGCTAAAGTATTATCAGATCATGGGATTGGTGGTCTACCAGTTCTCGATGAAGATGGAAAACTGGTAGGAATTGT
GACTGCTGATGATATAGTTTATGGGTACTTAAAGGACGAGGAAGAAGAACGCAAGATGGAGAAAAAAACAATTACCCCGG
AAAGTTCTGCTATCTATCTGGCAATGACCAGGAGCCGGGAGTATGAAGAATACTGGCTTGACAAGATAAAAGGCTATGGT
TATAAAGGGGCAATAACCCAGACTGGGGCCAGTGCTGAAAAACTCCCCATTAAGTTGAGGGAAAGTACAACTGTAGCTGC
CATTGCCCGTGGAGTTATTTCCGAAAATGCCAGAGAAAAAATTGCAGTTTCCAATGCAGTTAAGGATGCATATAGCCAGC
TGGCTCTTATAAACCCTGGACTTGGTGGTGGTTTCAAGATAGCTGTTGTTAAAGGTGATGGTTATGTTTCTGTAGCTATA
TTTGGTAAATTTGGTCATGCCCTGGTAGATGGCCCTGAACAACTGGCTATAGGAACCAGTGTTATTTAA

Upstream 100 bases:

>100_bases
AAAGCGACTACCACTGAAAATTTAGGTTTTGTAGGCAGGGAAGAAGGGATTGCTGCTCAGGCTGCTGTGTTATTAATTGA
TACCAAGGAAGGTGATATTA

Downstream 100 bases:

>100_bases
CGGGTATCATTTAAAGTTTAATAAATTAGTCCTTCCTTTTTATGCTTAATATTGCTGGGGTTTTATTTACTTTTATTAAA
AATTTACGCAAGAAGTTTGC

Product: CBS domain containing protein

Products: H+; Nicotinamide adenine dinucleotide - reduced; Xanthosine 5'-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MLVKNIMSKDPITISPETTVVEAEKLMSINNIGRLIVVEDEGLVGILTDGDLVIQHDLNAPIDKFMSREVITISQNATVQ
EAAKVLSDHGIGGLPVLDEDGKLVGIVTADDIVYGYLKDEEEERKMEKKTITPESSAIYLAMTRSREYEEYWLDKIKGYG
YKGAITQTGASAEKLPIKLRESTTVAAIARGVISENAREKIAVSNAVKDAYSQLALINPGLGGGFKIAVVKGDGYVSVAI
FGKFGHALVDGPEQLAIGTSVI

Sequences:

>Translated_262_residues
MLVKNIMSKDPITISPETTVVEAEKLMSINNIGRLIVVEDEGLVGILTDGDLVIQHDLNAPIDKFMSREVITISQNATVQ
EAAKVLSDHGIGGLPVLDEDGKLVGIVTADDIVYGYLKDEEEERKMEKKTITPESSAIYLAMTRSREYEEYWLDKIKGYG
YKGAITQTGASAEKLPIKLRESTTVAAIARGVISENAREKIAVSNAVKDAYSQLALINPGLGGGFKIAVVKGDGYVSVAI
FGKFGHALVDGPEQLAIGTSVI
>Mature_262_residues
MLVKNIMSKDPITISPETTVVEAEKLMSINNIGRLIVVEDEGLVGILTDGDLVIQHDLNAPIDKFMSREVITISQNATVQ
EAAKVLSDHGIGGLPVLDEDGKLVGIVTADDIVYGYLKDEEEERKMEKKTITPESSAIYLAMTRSREYEEYWLDKIKGYG
YKGAITQTGASAEKLPIKLRESTTVAAIARGVISENAREKIAVSNAVKDAYSQLALINPGLGGGFKIAVVKGDGYVSVAI
FGKFGHALVDGPEQLAIGTSVI

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644 [H]

Pfam domain/function: PF00571 CBS [H]

EC number: 1.1.1.205 [C]

Molecular weight: Translated: 28196; Mature: 28196

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKNIMSKDPITISPETTVVEAEKLMSINNIGRLIVVEDEGLVGILTDGDLVIQHDLNA
CCCHHHCCCCCEEECCCCEEEEHHHHHHHCCCCEEEEEECCCEEEEEECCCEEEEECCCC
PIDKFMSREVITISQNATVQEAAKVLSDHGIGGLPVLDEDGKLVGIVTADDIVYGYLKDE
CHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCEEEEEECCC
EEERKMEKKTITPESSAIYLAMTRSREYEEYWLDKIKGYGYKGAITQTGASAEKLPIKLR
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEE
ESTTVAAIARGVISENAREKIAVSNAVKDAYSQLALINPGLGGGFKIAVVKGDGYVSVAI
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCEEEEEE
FGKFGHALVDGPEQLAIGTSVI
EECCCHHHHCCCHHEEECCCCC
>Mature Secondary Structure
MLVKNIMSKDPITISPETTVVEAEKLMSINNIGRLIVVEDEGLVGILTDGDLVIQHDLNA
CCCHHHCCCCCEEECCCCEEEEHHHHHHHCCCCEEEEEECCCEEEEEECCCEEEEECCCC
PIDKFMSREVITISQNATVQEAAKVLSDHGIGGLPVLDEDGKLVGIVTADDIVYGYLKDE
CHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCEEEEEECCC
EEERKMEKKTITPESSAIYLAMTRSREYEEYWLDKIKGYGYKGAITQTGASAEKLPIKLR
HHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEE
ESTTVAAIARGVISENAREKIAVSNAVKDAYSQLALINPGLGGGFKIAVVKGDGYVSVAI
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCEEEEEE
FGKFGHALVDGPEQLAIGTSVI
EECCCHHHHCCCHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; IMP; Nicotinamide adenine dinucleotide [C]

Specific reaction: H2O + IMP + Nicotinamide adenine dinucleotide --> H+ + Nicotinamide adenine dinucleotide - reduced + Xanthosine 5'-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]