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The map label for this gene is ispD [H]

Identifier: 220930940

GI number: 220930940

Start: 111039

End: 111728

Strand: Direct

Name: ispD [H]

Synonym: Hore_00920

Alternate gene names: 220930940

Gene position: 111039-111728 (Clockwise)

Preceding gene: 220930939

Following gene: 220930941

Centisome position: 4.31

GC content: 39.57

Gene sequence:

>690_bases
ATGAAGGTTGGAGTAATTATACCTGCAGCCGGGCAGGGGCGGCGAATGGGTAGGGATATGAACAAACAATATTTATTACT
TAATGGCCGCCCTATTCTTGCCCATACCCTCTCTCTTTTTTTTTCTTCTGGTAAGAAGTTTGACCAGATTACAGTAGTTG
TCAGGCCACAGGAAAAAGAATACTGTTATCAGAATGTTATCCAGAAATATTTTCCCGGTAAGCCAATTAAACTGGTATCG
GGTGGAGAGACTCGAAGGGAATCTGTTTATGCTGGATTAAAATCCTTTTCACCAGAAATTGATTATGTTATAATACATGA
TGGTGCTCGTCCCCTGATGCCTTACCCTGTTCTTGAGAGGGTATTAAAAGGGATTGTAGAATATGATGCAGTTACAACCG
GTGTCAGGGTTAAGGATACCATAAAATTTATTAATGGGGGAGGGTTTGTCAGCAATACCCCTGACCGGGGTAAATTAATA
GCTGTCCAAACACCCCAGGCCTTCCGTTATGATATAATTAAAAAGGCCCATGAGGAAATATCTTCTGATATTCAGGTAAC
TGATGATGCTTTCCTGGTAGAAAAACTCGGTTATCCAGTTAAGGTTATCAAAGGTTCTTATGATAATATTAAAGTAACAA
CACCGGTTGATTTAATTATTGCTGAAGCAATACTAAAAACAGGAGACTAG

Upstream 100 bases:

>100_bases
AAGGTTTCTGTTCTGGTAACCAGTATTTTACAGACAGCTGCCGGGAGAATGATATTTGCTAAACCCAAAGCTCAGGAACA
GGTAATGTAGAGGGGTAATT

Downstream 100 bases:

>100_bases
AACTATGAGGATTGGGATTGGATTTGATGTTCATCCCCTGAAAAAAGGGGAAACCTTGATTCTAGGTGGTGTACATATAC
AGGGTGAATATGGTCTTGCC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKVGVIIPAAGQGRRMGRDMNKQYLLLNGRPILAHTLSLFFSSGKKFDQITVVVRPQEKEYCYQNVIQKYFPGKPIKLVS
GGETRRESVYAGLKSFSPEIDYVIIHDGARPLMPYPVLERVLKGIVEYDAVTTGVRVKDTIKFINGGGFVSNTPDRGKLI
AVQTPQAFRYDIIKKAHEEISSDIQVTDDAFLVEKLGYPVKVIKGSYDNIKVTTPVDLIIAEAILKTGD

Sequences:

>Translated_229_residues
MKVGVIIPAAGQGRRMGRDMNKQYLLLNGRPILAHTLSLFFSSGKKFDQITVVVRPQEKEYCYQNVIQKYFPGKPIKLVS
GGETRRESVYAGLKSFSPEIDYVIIHDGARPLMPYPVLERVLKGIVEYDAVTTGVRVKDTIKFINGGGFVSNTPDRGKLI
AVQTPQAFRYDIIKKAHEEISSDIQVTDDAFLVEKLGYPVKVIKGSYDNIKVTTPVDLIIAEAILKTGD
>Mature_229_residues
MKVGVIIPAAGQGRRMGRDMNKQYLLLNGRPILAHTLSLFFSSGKKFDQITVVVRPQEKEYCYQNVIQKYFPGKPIKLVS
GGETRRESVYAGLKSFSPEIDYVIIHDGARPLMPYPVLERVLKGIVEYDAVTTGVRVKDTIKFINGGGFVSNTPDRGKLI
AVQTPQAFRYDIIKKAHEEISSDIQVTDDAFLVEKLGYPVKVIKGSYDNIKVTTPVDLIIAEAILKTGD

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=238, Percent_Identity=31.9327731092437, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1789104, Length=231, Percent_Identity=32.034632034632, Blast_Score=106, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25492; Mature: 25492

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGVIIPAAGQGRRMGRDMNKQYLLLNGRPILAHTLSLFFSSGKKFDQITVVVRPQEKE
CCEEEEEECCCCCCHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCHHH
YCYQNVIQKYFPGKPIKLVSGGETRRESVYAGLKSFSPEIDYVIIHDGARPLMPYPVLER
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
VLKGIVEYDAVTTGVRVKDTIKFINGGGFVSNTPDRGKLIAVQTPQAFRYDIIKKAHEEI
HHHHHHHHHHHHCCCEEEHEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
SSDIQVTDDAFLVEKLGYPVKVIKGSYDNIKVTTPVDLIIAEAILKTGD
CCCEEECCHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVGVIIPAAGQGRRMGRDMNKQYLLLNGRPILAHTLSLFFSSGKKFDQITVVVRPQEKE
CCEEEEEECCCCCCHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCHHH
YCYQNVIQKYFPGKPIKLVSGGETRRESVYAGLKSFSPEIDYVIIHDGARPLMPYPVLER
HHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
VLKGIVEYDAVTTGVRVKDTIKFINGGGFVSNTPDRGKLIAVQTPQAFRYDIIKKAHEEI
HHHHHHHHHHHHCCCEEEHEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
SSDIQVTDDAFLVEKLGYPVKVIKGSYDNIKVTTPVDLIIAEAILKTGD
CCCEEECCHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA