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The map label for this gene is menA

Identifier: 221230770

GI number: 221230770

Start: 2877293

End: 2878177

Strand: Direct

Name: menA

Synonym: MLBr_02406

Alternate gene names: 221230770

Gene position: 2877293-2878177 (Clockwise)

Preceding gene: 221230769

Following gene: 221230782

Centisome position: 88.04

GC content: 64.18

Gene sequence:

>885_bases
ATGGCTAGTTTCGCTCAGTGGATCTCGGGTGCTCGGCCACGGACGCTACCGAACGCGGTGGCGCCCGTTGTTGCAGGCAC
CGGCACTGCGGCATGGCTGCACTCGGCCGTGTGGTGGAAAGCGCTGCTAGCGCTGGTCGTCGCTGTCGCGCTTGTCATCG
GGGTCAACTACGCCAATGACTACTCCGACGGCATCCGTGGCACCGACGACCACCGGGCCGGGCCAATGCGCTTGGTGGGC
TCGCGGCTAGCTTTCCCGCGATCGGTGCTGACCGCCGCGGTTGTAGGCTTGACGGTCAGCACGGTGGCCGGGTTGGCACT
CGCGCTACTCAGCGCACCGTGGCTAATCATGGTCGGCGCTACCTGCATCGCCGGAGCCTGGCTGTACACCGGTAGCTCGA
AGCCCTACGGCTATAAAGGTTTTGGCGAAGTCGCGGTGTTCGTGTTCTTCGGCCTGGTCGCTGTGCTCGGCACCGAATAC
ACCCAAGCATTGCGGGTGGACTGGGTGGGATTGGTGCTGGCGGTGTCGACCGGAGCGCTGTCGTCGTCAGTCCTGGTGGC
CAACAACTTGCGGGATATTCACACCGACACACAGTCACACAAATTCACCCTGGCGGTGCGCTTAGGTGATGCTCACACAC
GGCAATTATATCAAGCACTGCTGGTCGCCACCGGCGTGCTTACCGTGGTGCTGATGGTGGCGACATCATGGTGTGCCGTC
GGATTGGTGGCCACGCCGCTGGCTCTGCGCGCCATGCGGCCGGTGCGCTCCGGCCGCATGGGGCCCGACTTGACCCCGGT
GCTGCGGGACACCGGACTTGCGATGGTGGTGTGGGCGATCGCGGTAGCTGGAGCTTTAACACTGGCGGGGTCAGTGACGT
ACTGA

Upstream 100 bases:

>100_bases
AAAAGTGTAGAAGTCGATGCTGATCACTCCAAGCATTCGCCCATTGTTATGCATGCCCCGCGTTTGATCGCATGCGTCCA
ACCACCGGCAGGATACCCTG

Downstream 100 bases:

>100_bases
CGGTGCGCTTACGGCTTCAACTATGTGAATTGTCCTTGTTGGCAAAACTTTCAGCGCCGCAGCGATCTTACTCCTCGTCA
GGCAAAGGCTCACCGCGCAG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MASFAQWISGARPRTLPNAVAPVVAGTGTAAWLHSAVWWKALLALVVAVALVIGVNYANDYSDGIRGTDDHRAGPMRLVG
SRLAFPRSVLTAAVVGLTVSTVAGLALALLSAPWLIMVGATCIAGAWLYTGSSKPYGYKGFGEVAVFVFFGLVAVLGTEY
TQALRVDWVGLVLAVSTGALSSSVLVANNLRDIHTDTQSHKFTLAVRLGDAHTRQLYQALLVATGVLTVVLMVATSWCAV
GLVATPLALRAMRPVRSGRMGPDLTPVLRDTGLAMVVWAIAVAGALTLAGSVTY

Sequences:

>Translated_294_residues
MASFAQWISGARPRTLPNAVAPVVAGTGTAAWLHSAVWWKALLALVVAVALVIGVNYANDYSDGIRGTDDHRAGPMRLVG
SRLAFPRSVLTAAVVGLTVSTVAGLALALLSAPWLIMVGATCIAGAWLYTGSSKPYGYKGFGEVAVFVFFGLVAVLGTEY
TQALRVDWVGLVLAVSTGALSSSVLVANNLRDIHTDTQSHKFTLAVRLGDAHTRQLYQALLVATGVLTVVLMVATSWCAV
GLVATPLALRAMRPVRSGRMGPDLTPVLRDTGLAMVVWAIAVAGALTLAGSVTY
>Mature_293_residues
ASFAQWISGARPRTLPNAVAPVVAGTGTAAWLHSAVWWKALLALVVAVALVIGVNYANDYSDGIRGTDDHRAGPMRLVGS
RLAFPRSVLTAAVVGLTVSTVAGLALALLSAPWLIMVGATCIAGAWLYTGSSKPYGYKGFGEVAVFVFFGLVAVLGTEYT
QALRVDWVGLVLAVSTGALSSSVLVANNLRDIHTDTQSHKFTLAVRLGDAHTRQLYQALLVATGVLTVVLMVATSWCAVG
LVATPLALRAMRPVRSGRMGPDLTPVLRDTGLAMVVWAIAVAGALTLAGSVTY

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family

Homologues:

Organism=Homo sapiens, GI7019551, Length=258, Percent_Identity=27.1317829457364, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790365, Length=276, Percent_Identity=34.4202898550725, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17737429, Length=256, Percent_Identity=25, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENA_MYCLE (O07134)

Other databases:

- EMBL:   Y13803
- EMBL:   AL583925
- PIR:   B87210
- RefSeq:   NP_302556.1
- ProteinModelPortal:   O07134
- EnsemblBacteria:   EBMYCT00000028991
- GeneID:   908601
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2406
- NMPDR:   fig|272631.1.peg.1428
- Leproma:   ML2406
- GeneTree:   EBGT00050000017548
- HOGENOM:   HBG313998
- OMA:   TVGNSAY
- ProtClustDB:   PRK06080
- BioCyc:   MLEP272631:ML2406-MONOMER
- InterPro:   IPR004657
- InterPro:   IPR000537
- TIGRFAMs:   TIGR00751

Pfam domain/function: PF01040 UbiA

EC number: =2.5.1.74

Molecular weight: Translated: 30671; Mature: 30540

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x225b181c)-; HASH(0x21abc488)-; HASH(0x452db4d8)-; HASH(0x452dc444)-; HASH(0x230971f4)-; HASH(0x231e38f0)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFAQWISGARPRTLPNAVAPVVAGTGTAAWLHSAVWWKALLALVVAVALVIGVNYAND
CCCHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDHRAGPMRLVGSRLAFPRSVLTAAVVGLTVSTVAGLALALLSAPWLIMVGA
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
TCIAGAWLYTGSSKPYGYKGFGEVAVFVFFGLVAVLGTEYTQALRVDWVGLVLAVSTGAL
HHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSSVLVANNLRDIHTDTQSHKFTLAVRLGDAHTRQLYQALLVATGVLTVVLMVATSWCAV
CCCCHHHCCCHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVATPLALRAMRPVRSGRMGPDLTPVLRDTGLAMVVWAIAVAGALTLAGSVTY
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
ASFAQWISGARPRTLPNAVAPVVAGTGTAAWLHSAVWWKALLALVVAVALVIGVNYAND
CCHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDHRAGPMRLVGSRLAFPRSVLTAAVVGLTVSTVAGLALALLSAPWLIMVGA
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
TCIAGAWLYTGSSKPYGYKGFGEVAVFVFFGLVAVLGTEYTQALRVDWVGLVLAVSTGAL
HHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSSVLVANNLRDIHTDTQSHKFTLAVRLGDAHTRQLYQALLVATGVLTVVLMVATSWCAV
CCCCHHHCCCHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVATPLALRAMRPVRSGRMGPDLTPVLRDTGLAMVVWAIAVAGALTLAGSVTY
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002