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The map label for this gene is crt [H]

Identifier: 221230768

GI number: 221230768

Start: 2871664

End: 2872701

Strand: Direct

Name: crt [H]

Synonym: MLBr_02401

Alternate gene names: 221230768

Gene position: 2871664-2872701 (Clockwise)

Preceding gene: 221230763

Following gene: 221230769

Centisome position: 87.87

GC content: 59.54

Gene sequence:

>1038_bases
GTGGCTGGCGAATCAGATGAGGTCTTGGCGCGCGTTGAGGCCGGTATCGGCCTTATCACACTTAACCGCCCTAAGGCGAT
CAACTCGCTGAACCAGCAGATGGTGGACGCGCTGACCGCCATACTCACCAGCTGGGCAGACGACGACGCGGTACGTGCAG
TGGTGCTATCTGGAGCCGGGGAACGCGGACTATGCGCCGGTGGCGATGTGGTGGCGATCTATCACAGTGCTCTCAAGGAT
GGGGTTGAGGCACGGCGGTTTTGGCGCAGCGAATATCTGCTCAACAGCCAAATCGCCCGGTTCCCCAAGCCGTACGTGTC
GTTGATGGACGGCATCGTGATGGGCGGTGGCGTCGGCATCGGTGCACACGCAAACACTCGAGTGGTAACCGATACCTCGC
AAGTGGCAATGCCCGAGGTCGGCATCGGGTTTATCCCAGACGTCGGCGGGACATATCTGTTGTCTCGGGCGCCCGGTGCG
CTGGGTCTGCATGTTGCGCTAACCGGAGCACCGTTTTCCGGTGCCGACGCTATCGAGCTGGGCTTCGCTGACCACTATGT
GCCGCACAGCGACCTTAACGCGTTCACCCGAGCGGTCGTTACCGACGGCGTTAACAGTGCGCTAGCCGGCTACGCTATCG
AACCTCCACCAAGCTACCTTGCCGCACAACGTGATTGGATCGACGAATGCTACGTTGGCGAAACCGTCAAAGACATCATC
ACCGCTTTGCGTGGGCATGATGCGGAACCTGCTGAAGGCGCCTTCAACCTGATCGTTAGCCGCTCCCCCGTCGCATTGTC
AGTCACACTGGAGGCGATGCGTCGAGCAGCCAAACTGGAAACACTGACAGATGTTCTGACTCAAGACTATCGGGTGTCGT
CGGCTTCACTGCACTCACACGACCTGGTGGAAGGCATCCGCGCGCAGCTGGTCCACAAGGATCGCAATCCACAATGGGCG
CCGACGACACTGGCCGAAGTCACTGCAGCCGACATCTGTGGATATTTCGAGCCGGTTGACGATGACTTGAGTTTCTAG

Upstream 100 bases:

>100_bases
CCGCGGACGGCTATCGAGCTAGCCACAGTCTAGAGTGCTGATCAATCCGTTGGGTGGCATTTTTGGGTCGTATTCTCCAA
TTGACGTGGAAGGCTAGGGT

Downstream 100 bases:

>100_bases
AAAGGCAATTTGGTGACGAATAACATGAAGTACGACACAATCCTCGTTGACGGCTACCAGCGAGTTGGCATCATCACACT
GAACCGGCCACAGGCTCTGA

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAGESDEVLARVEAGIGLITLNRPKAINSLNQQMVDALTAILTSWADDDAVRAVVLSGAGERGLCAGGDVVAIYHSALKD
GVEARRFWRSEYLLNSQIARFPKPYVSLMDGIVMGGGVGIGAHANTRVVTDTSQVAMPEVGIGFIPDVGGTYLLSRAPGA
LGLHVALTGAPFSGADAIELGFADHYVPHSDLNAFTRAVVTDGVNSALAGYAIEPPPSYLAAQRDWIDECYVGETVKDII
TALRGHDAEPAEGAFNLIVSRSPVALSVTLEAMRRAAKLETLTDVLTQDYRVSSASLHSHDLVEGIRAQLVHKDRNPQWA
PTTLAEVTAADICGYFEPVDDDLSF

Sequences:

>Translated_345_residues
MAGESDEVLARVEAGIGLITLNRPKAINSLNQQMVDALTAILTSWADDDAVRAVVLSGAGERGLCAGGDVVAIYHSALKD
GVEARRFWRSEYLLNSQIARFPKPYVSLMDGIVMGGGVGIGAHANTRVVTDTSQVAMPEVGIGFIPDVGGTYLLSRAPGA
LGLHVALTGAPFSGADAIELGFADHYVPHSDLNAFTRAVVTDGVNSALAGYAIEPPPSYLAAQRDWIDECYVGETVKDII
TALRGHDAEPAEGAFNLIVSRSPVALSVTLEAMRRAAKLETLTDVLTQDYRVSSASLHSHDLVEGIRAQLVHKDRNPQWA
PTTLAEVTAADICGYFEPVDDDLSF
>Mature_344_residues
AGESDEVLARVEAGIGLITLNRPKAINSLNQQMVDALTAILTSWADDDAVRAVVLSGAGERGLCAGGDVVAIYHSALKDG
VEARRFWRSEYLLNSQIARFPKPYVSLMDGIVMGGGVGIGAHANTRVVTDTSQVAMPEVGIGFIPDVGGTYLLSRAPGAL
GLHVALTGAPFSGADAIELGFADHYVPHSDLNAFTRAVVTDGVNSALAGYAIEPPPSYLAAQRDWIDECYVGETVKDIIT
ALRGHDAEPAEGAFNLIVSRSPVALSVTLEAMRRAAKLETLTDVLTQDYRVSSASLHSHDLVEGIRAQLVHKDRNPQWAP
TTLAEVTAADICGYFEPVDDDLSF

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=353, Percent_Identity=36.5439093484419, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI37594469, Length=304, Percent_Identity=35.5263157894737, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI194097323, Length=179, Percent_Identity=32.9608938547486, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI31542718, Length=187, Percent_Identity=25.668449197861, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787660, Length=180, Percent_Identity=33.8888888888889, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788682, Length=181, Percent_Identity=30.3867403314917, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI221142681, Length=190, Percent_Identity=27.8947368421053, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787659, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=354, Percent_Identity=35.8757062146893, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI25144157, Length=354, Percent_Identity=35.8757062146893, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17554946, Length=306, Percent_Identity=25.4901960784314, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17540714, Length=182, Percent_Identity=28.021978021978, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=179, Percent_Identity=26.2569832402235, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=152, Percent_Identity=30.9210526315789, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=349, Percent_Identity=31.5186246418338, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI28571730, Length=342, Percent_Identity=35.672514619883, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI28571729, Length=342, Percent_Identity=35.672514619883, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI20129971, Length=180, Percent_Identity=30, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653477, Length=180, Percent_Identity=30, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653139, Length=198, Percent_Identity=30.3030303030303, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922422, Length=251, Percent_Identity=27.4900398406374, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 36627; Mature: 36495

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGESDEVLARVEAGIGLITLNRPKAINSLNQQMVDALTAILTSWADDDAVRAVVLSGAG
CCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCC
ERGLCAGGDVVAIYHSALKDGVEARRFWRSEYLLNSQIARFPKPYVSLMDGIVMGGGVGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEE
GAHANTRVVTDTSQVAMPEVGIGFIPDVGGTYLLSRAPGALGLHVALTGAPFSGADAIEL
CCCCCCEEEECCHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCEEEE
GFADHYVPHSDLNAFTRAVVTDGVNSALAGYAIEPPPSYLAAQRDWIDECYVGETVKDII
CCHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
TALRGHDAEPAEGAFNLIVSRSPVALSVTLEAMRRAAKLETLTDVLTQDYRVSSASLHSH
HHHHCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
DLVEGIRAQLVHKDRNPQWAPTTLAEVTAADICGYFEPVDDDLSF
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AGESDEVLARVEAGIGLITLNRPKAINSLNQQMVDALTAILTSWADDDAVRAVVLSGAG
CCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCC
ERGLCAGGDVVAIYHSALKDGVEARRFWRSEYLLNSQIARFPKPYVSLMDGIVMGGGVGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEE
GAHANTRVVTDTSQVAMPEVGIGFIPDVGGTYLLSRAPGALGLHVALTGAPFSGADAIEL
CCCCCCEEEECCHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCEEEE
GFADHYVPHSDLNAFTRAVVTDGVNSALAGYAIEPPPSYLAAQRDWIDECYVGETVKDII
CCHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
TALRGHDAEPAEGAFNLIVSRSPVALSVTLEAMRRAAKLETLTDVLTQDYRVSSASLHSH
HHHHCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
DLVEGIRAQLVHKDRNPQWAPTTLAEVTAADICGYFEPVDDDLSF
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]