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The map label for this gene is htpX

Identifier: 221230698

GI number: 221230698

Start: 2701192

End: 2702055

Strand: Direct

Name: htpX

Synonym: MLBr_02278

Alternate gene names: 221230698

Gene position: 2701192-2702055 (Clockwise)

Preceding gene: 221230697

Following gene: 221230700

Centisome position: 82.65

GC content: 60.42

Gene sequence:

>864_bases
ATGACCTGGCATCCCCAAGCAAACAGGTTGAAGACCTTCGTCCTGTTGGTCGGTATGTCCACATTGATCGTGGTTGTCGG
CGCGATATTTGGCAGGACGGCGCTTTTCTTTGCGACCCTGGTTGCTGTAGGAATCAACGTCTACACGTACTACAACAGTG
ACAAGCTCGCGTTACGGGCGATGCATGCGCAACCGGTTTCGGAGGTGCAAGCACCGGTGATGTACCGGATCGTGCGCGAG
CTGGCTACCGGAGCGCACCAGCCGATGCCGCGGCTCTATATAAGTGATACAAACGCGCCCAACGCTTTCGCCACTGGCCG
TAATCCACGCAATGCCGCGGTGTGTTGCACTACCGGCATATTGGAGATCCTCAACGAGCGCGAGCTGCGTGCCGTGCTGG
GGCACGAACTCTCTCACGTGTACAACCGTGACATTCTGATCTCCTGTGTGGCCGGTGCGCTGGCAGGCGTGATTACCGCG
CTGGCCAACATGGCCATGTGGGCTGGCACGTTTGGCACCACTCGGGACGAAGAGAATCCTTTTGCACTGCTGCTGGTTTC
GTTACTGGGCCCGATCGCCGCGACGGTGGTGCGACTAGCGGTATCGCGATCGCGGGAGTATCAGGCCGACGAATCGGGCG
CTATGCTCACCGGCGACCCTCTGGCCCTGGCGTCGGCGTTACGCAAGATTTCCAGCGGCGTACAGGCAGCGCCGTTGCCC
CCGGAACCGCAGCTGGCCAGCCAGGCGCACTTGATGATCGCCAACCCGTTCCGTGTTGGCGATCGGATCGGGTCACTGTT
CTCGACACACCCGCCGATCGAAGACCGCATTCGCCGGCTAGAAACGATGGTGGCTGGTCGATAA

Upstream 100 bases:

>100_bases
ACTCCTGGGTCGCGGAACCCGCAGGGTTGTCCTGGGCGTTAAATTGTCAGTAGTCCGCAAGAACCGTTGTGTGTCGAAAC
CTTTGCAAGGAGGACACTGA

Downstream 100 bases:

>100_bases
GAACTAACCTGCACCCCTCCTGGTCTAAACGTCGAGCTGACCTTCGGGTCAGAACATGCGTGGTTTCGCTGAGTTGATAT
CGCATGTTCCTGCTGTCTGT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTWHPQANRLKTFVLLVGMSTLIVVVGAIFGRTALFFATLVAVGINVYTYYNSDKLALRAMHAQPVSEVQAPVMYRIVRE
LATGAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGILEILNERELRAVLGHELSHVYNRDILISCVAGALAGVITA
LANMAMWAGTFGTTRDEENPFALLLVSLLGPIAATVVRLAVSRSREYQADESGAMLTGDPLALASALRKISSGVQAAPLP
PEPQLASQAHLMIANPFRVGDRIGSLFSTHPPIEDRIRRLETMVAGR

Sequences:

>Translated_287_residues
MTWHPQANRLKTFVLLVGMSTLIVVVGAIFGRTALFFATLVAVGINVYTYYNSDKLALRAMHAQPVSEVQAPVMYRIVRE
LATGAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGILEILNERELRAVLGHELSHVYNRDILISCVAGALAGVITA
LANMAMWAGTFGTTRDEENPFALLLVSLLGPIAATVVRLAVSRSREYQADESGAMLTGDPLALASALRKISSGVQAAPLP
PEPQLASQAHLMIANPFRVGDRIGSLFSTHPPIEDRIRRLETMVAGR
>Mature_286_residues
TWHPQANRLKTFVLLVGMSTLIVVVGAIFGRTALFFATLVAVGINVYTYYNSDKLALRAMHAQPVSEVQAPVMYRIVREL
ATGAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGILEILNERELRAVLGHELSHVYNRDILISCVAGALAGVITAL
ANMAMWAGTFGTTRDEENPFALLLVSLLGPIAATVVRLAVSRSREYQADESGAMLTGDPLALASALRKISSGVQAAPLPP
EPQLASQAHLMIANPFRVGDRIGSLFSTHPPIEDRIRRLETMVAGR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=265, Percent_Identity=29.811320754717, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_MYCLB (B8ZSY8)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002504114.1
- ProteinModelPortal:   B8ZSY8
- EnsemblBacteria:   EBMYCT00000086947
- GeneID:   7324880
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016372
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK03072
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 30998; Mature: 30867

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 136-136

Signals:

None

Transmembrane regions:

HASH(0x218bed80)-; HASH(0x4524bad8)-; HASH(0x4524c570)-; HASH(0x21c01b5c)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWHPQANRLKTFVLLVGMSTLIVVVGAIFGRTALFFATLVAVGINVYTYYNSDKLALRA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHH
MHAQPVSEVQAPVMYRIVRELATGAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
LEILNERELRAVLGHELSHVYNRDILISCVAGALAGVITALANMAMWAGTFGTTRDEENP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
FALLLVSLLGPIAATVVRLAVSRSREYQADESGAMLTGDPLALASALRKISSGVQAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCCCC
PEPQLASQAHLMIANPFRVGDRIGSLFSTHPPIEDRIRRLETMVAGR
CCCCHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH
>Mature Secondary Structure 
TWHPQANRLKTFVLLVGMSTLIVVVGAIFGRTALFFATLVAVGINVYTYYNSDKLALRA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHH
MHAQPVSEVQAPVMYRIVRELATGAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGI
HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
LEILNERELRAVLGHELSHVYNRDILISCVAGALAGVITALANMAMWAGTFGTTRDEENP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
FALLLVSLLGPIAATVVRLAVSRSREYQADESGAMLTGDPLALASALRKISSGVQAAPLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCCCC
PEPQLASQAHLMIANPFRVGDRIGSLFSTHPPIEDRIRRLETMVAGR
CCCCHHCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA