Click here to switch to the map view.

The map label for this gene is hepT [H]

Identifier: 221230697

GI number: 221230697

Start: 2700089

End: 2701081

Strand: Direct

Name: hepT [H]

Synonym: MLBr_02277

Alternate gene names: 221230697

Gene position: 2700089-2701081 (Clockwise)

Preceding gene: 221230694

Following gene: 221230698

Centisome position: 82.62

GC content: 60.73

Gene sequence:

>993_bases
ATGGTGGTAGCGGGCATTAATTTCGGAGACGCTGCGTTTGCGGCGACTGTACAAGACAGGGTAGTGAGGATCGAGCAACT
CATGGATGCCGAGTTGCGAGACACGGACGAGGTGATGACCGAGTCAGTACTACACTTGTTCGCAGCCGGTGGTAAGCGGT
TCCGACCGCTGTTTACAGTGCTATCCGCCCAGATCGGACCCCGGCCCGACGCTCCAGAAGTTATAATAGCCGGTGCGGTC
ATTGAACTGGTCCACCTAGCGTCGCTTTACCACGACGACGTGATGGACGAGGCCGAGGTCCGGCGCGGGGCGCCCAGTGC
CAACCTGCGATGGAGTAACAGCGTTGCCATTCTTGCCGGCGATTATCTATTTGCTACGGCGTCGCGGTTGGTATCACAGC
TTGGACTGGATGCTGTGCGGATTATCGCTGACACGTTTGCCCAGCTGGTGACCGGGCAGATGCGCGAAACCCGCGGTGTG
CCGGAAGGTGCAGATTCGATCGAGCAGTACCTGAAGGTGGTGTATGAAAAAACGGGTTGTCTGATCGGCTCGGCTGGTCG
GCTTGGTGGTTTGTTTGCTGGCGCACACGCCGAGCAGGTCGAGCGGCTGAGCCGACTCGGGAGCATCGTGGGCACCGCGT
TTCAGATTTCCGACGACATCATCGATATCGACAGCGACTACACCAAGTCCGGCAAGCTTCCCGGCACAGATGTGCGTGAA
GGCGTGCGCACTTTACCGATACTCTATGCGCTGCGTGAGACCGGGCCCGATAGCGAGCGGCTACGAGCACTGTTGGCCGG
ACCCGTCGACAACGACGCAGAGGTAGTCGAAGCACTAGCGCTGTTGCGGGCGTCGCCCGGGATGGCGAGGGCCAGGCAAG
TGTTGGCGCATTACGCGGACCAGGCCAGTGGCGAGCTGGCTCAGTTGCCCGACGGCCCCAGTCGGGATGCGCTGGCGACT
CTGGTCGACTACACAACCAACCGGCACGGTTAG

Upstream 100 bases:

>100_bases
AGGTGGCTGCAGCTGACCCCGCTGGTCCGGCGCCCACCACTACCACGTCTGCGCTAGTCTCCACCCTCACTAGTATGTTG
GTTGGATGACGACTACGCCG

Downstream 100 bases:

>100_bases
AGCGCAGGCAACTCCTGGGTCGCGGAACCCGCAGGGTTGTCCTGGGCGTTAAATTGTCAGTAGTCCGCAAGAACCGTTGT
GTGTCGAAACCTTTGCAAGG

Product: polyprenyl diphosphate synthase component

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAAGGKRFRPLFTVLSAQIGPRPDAPEVIIAGAV
IELVHLASLYHDDVMDEAEVRRGAPSANLRWSNSVAILAGDYLFATASRLVSQLGLDAVRIIADTFAQLVTGQMRETRGV
PEGADSIEQYLKVVYEKTGCLIGSAGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVRE
GVRTLPILYALRETGPDSERLRALLAGPVDNDAEVVEALALLRASPGMARARQVLAHYADQASGELAQLPDGPSRDALAT
LVDYTTNRHG

Sequences:

>Translated_330_residues
MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAAGGKRFRPLFTVLSAQIGPRPDAPEVIIAGAV
IELVHLASLYHDDVMDEAEVRRGAPSANLRWSNSVAILAGDYLFATASRLVSQLGLDAVRIIADTFAQLVTGQMRETRGV
PEGADSIEQYLKVVYEKTGCLIGSAGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVRE
GVRTLPILYALRETGPDSERLRALLAGPVDNDAEVVEALALLRASPGMARARQVLAHYADQASGELAQLPDGPSRDALAT
LVDYTTNRHG
>Mature_330_residues
MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAAGGKRFRPLFTVLSAQIGPRPDAPEVIIAGAV
IELVHLASLYHDDVMDEAEVRRGAPSANLRWSNSVAILAGDYLFATASRLVSQLGLDAVRIIADTFAQLVTGQMRETRGV
PEGADSIEQYLKVVYEKTGCLIGSAGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVRE
GVRTLPILYALRETGPDSERLRALLAGPVDNDAEVVEALALLRASPGMARARQVLAHYADQASGELAQLPDGPSRDALAT
LVDYTTNRHG

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=319, Percent_Identity=28.2131661442006, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4758430, Length=252, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI83700220, Length=252, Percent_Identity=27.7777777777778, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1789578, Length=288, Percent_Identity=32.9861111111111, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786623, Length=226, Percent_Identity=31.858407079646, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17505681, Length=239, Percent_Identity=30.5439330543933, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319475, Length=295, Percent_Identity=26.1016949152542, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6325188, Length=304, Percent_Identity=26.9736842105263, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24651612, Length=292, Percent_Identity=28.7671232876712, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281365769, Length=294, Percent_Identity=26.8707482993197, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24660002, Length=294, Percent_Identity=26.8707482993197, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 35335; Mature: 35335

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAAGGKRFRPLFTV
CEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
LSAQIGPRPDAPEVIIAGAVIELVHLASLYHDDVMDEAEVRRGAPSANLRWSNSVAILAG
HHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCEECCCEEEEEC
DYLFATASRLVSQLGLDAVRIIADTFAQLVTGQMRETRGVPEGADSIEQYLKVVYEKTGC
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
LIGSAGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVRE
EEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCCCCHHHH
GVRTLPILYALRETGPDSERLRALLAGPVDNDAEVVEALALLRASPGMARARQVLAHYAD
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QASGELAQLPDGPSRDALATLVDYTTNRHG
HCCCCHHCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLHLFAAGGKRFRPLFTV
CEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
LSAQIGPRPDAPEVIIAGAVIELVHLASLYHDDVMDEAEVRRGAPSANLRWSNSVAILAG
HHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCEECCCEEEEEC
DYLFATASRLVSQLGLDAVRIIADTFAQLVTGQMRETRGVPEGADSIEQYLKVVYEKTGC
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
LIGSAGRLGGLFAGAHAEQVERLSRLGSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVRE
EEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCCCCCCCCCHHHH
GVRTLPILYALRETGPDSERLRALLAGPVDNDAEVVEALALLRASPGMARARQVLAHYAD
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QASGELAQLPDGPSRDALATLVDYTTNRHG
HCCCCHHCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]