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The map label for this gene is ubiE [H]

Identifier: 221230694

GI number: 221230694

Start: 2697208

End: 2697924

Strand: Direct

Name: ubiE [H]

Synonym: MLBr_02273

Alternate gene names: 221230694

Gene position: 2697208-2697924 (Clockwise)

Preceding gene: 221230693

Following gene: 221230697

Centisome position: 82.53

GC content: 62.2

Gene sequence:

>717_bases
TTGCCTCCCGGTAGCGTCGACGTCGTGAGTCGCGCTGCCCTGGACAAGGACCCCCGGGATGTCGTAGCGATGTTCGACGA
CGTCGCCCACCGATACGATCTGACCAACACTGTGCTGTCGCTGGGTCAAGATCGGTACTGGCGACGAGCCACGCGGTCGG
CGCTGCGGATTGGGCCCGGGCAGAAAGTGCTGGACCTGGCCGCAGGCACGGCGGTGTCCACAGCGGAACTGAGTAAATCC
GGCGCCTGGTGTGTGGCTGCGGATTTTTCGGTCAGGATGCTAGCAACCGGCGGTGCGCGAAAGGTACCTAAGGTGGCCGC
AGATGCCACCCAACTTCCCTTTAGCGATGGTGTATTCGATGCAGTCACTATCAGTTTCGGGTTGCGCAATATCGCCGACT
ATCAGGCGGCGCTGCGCGAGATGGCCCGCGTCACCCGGCCCGGCGGTCAATTAGTAGTGTGCGAGTTCTCCACACCCACC
AATGCGCTGGTCGCCAATGTCTACACGGAATACCTGATGCGGGCACTGCCGCAAGTGGCGCGACTGGTGTCTAGTAATCC
CGATGCCTACATCTACTTGGCGGAGTCCATCAGAGCCTGGCCCGATCAGGTTACGCTGGCCTGCCAGCTGTCGCGGACCG
GTTGGGCGTCGCCGCGCTGGCGTAACCTCACCGGCGGAATTGTGGCTTTGCATGCAGCAGATAAGCCGGTGCGGTAA

Upstream 100 bases:

>100_bases
TGGCCATTACCAGGAAGTACGAGGCAGACTCGGGGCTCGGGCCTCCTAGTTAGAATCGCAAGCGCGGCGACATCGGGCAC
AGCGAGTCATCACAATCGAT

Downstream 100 bases:

>100_bases
GCCGACCTGAAGAAAACCTAGCGAGCGCCGGCACGTTGCAGGATGCCTATTTGGTTAGGGCAATAGTGATTGATCGCGGC
GCCCAGGAACTGCAATGATT

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTAELSKS
GAWCVAADFSVRMLATGGARKVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTPT
NALVANVYTEYLMRALPQVARLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR

Sequences:

>Translated_238_residues
MPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTAELSKS
GAWCVAADFSVRMLATGGARKVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTPT
NALVANVYTEYLMRALPQVARLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR
>Mature_237_residues
PPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTAELSKSG
AWCVAADFSVRMLATGGARKVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTPTN
ALVANVYTEYLMRALPQVARLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=259, Percent_Identity=29.7297297297297, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI48994983, Length=228, Percent_Identity=42.9824561403509, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17557039, Length=230, Percent_Identity=32.6086956521739, Blast_Score=133, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6323526, Length=249, Percent_Identity=30.1204819277108, Blast_Score=105, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24641702, Length=246, Percent_Identity=31.3008130081301, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 25738; Mature: 25606

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGPG
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
QKVLDLAAGTAVSTAELSKSGAWCVAADFSVRMLATGGARKVPKVAADATQLPFSDGVFD
CHHHHHHCCCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCCCHHHCCCCCCCCCCCCHH
AVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTPTNALVANVYTEYLMRALPQVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR
HHHHCCCCEEEEEHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
PPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRATRSALRIGPG
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
QKVLDLAAGTAVSTAELSKSGAWCVAADFSVRMLATGGARKVPKVAADATQLPFSDGVFD
CHHHHHHCCCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCCCHHHCCCCCCCCCCCCHH
AVTISFGLRNIADYQAALREMARVTRPGGQLVVCEFSTPTNALVANVYTEYLMRALPQVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RLVSSNPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTGGIVALHAADKPVR
HHHHCCCCEEEEEHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]