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The map label for this gene is purM [H]

Identifier: 221230660

GI number: 221230660

Start: 2619346

End: 2620440

Strand: Reverse

Name: purM [H]

Synonym: MLBr_02205

Alternate gene names: 221230660

Gene position: 2620440-2619346 (Counterclockwise)

Preceding gene: 221230661

Following gene: 221230657

Centisome position: 80.18

GC content: 60.37

Gene sequence:

>1095_bases
ATGATGGATCCCGGAAAAAGCCCCGGAGGCCAGCTGGGCAATCATGGCATCACCTATGCGTCGACAGGGGTGGACATTGA
AGCCGGTGACCGCTCGGTCGAGTTGTTCAAGCCGATGGCAGTTAAGGCCATCAGAACCGAGGTGCTTGGAGGTCTAGGAG
GATTCGCTGGGTTGTTCGCTCTACGCAGCGGCTACCGCGAACCGGTGTTAGCGGCTTCCACCGACGGTGTTGGTACCAAG
CTGGCAGTCGCTCAGGCGATGGATAAGCACGACACCGTTGGCTTGGACCTGGTGGCGATGGTGGTCGACGACCTGGTGGT
CTGTGGCGCTGAGCCACTGTTTTTGCAGGACTACATTGCTGTCGGCCGAACGGTGCCGGAACGACTGAGCGCGATCGTCG
ACGGTATTGCCGAGGGGTGCATGCTCGCGGGCTGTGCGTTACTGGGTGGTGAGACCGCAGAACACCCTGGTCTGATGGAA
GTCGACCACTACGACATCGCGGCGACCGGCGTCGGTGTTGTGGAAGCCGACGATACCCTGGGGCCAGATCGTGTCAAACC
CGGTGACGTAATCATCGCGCTGAGGTCTTCGGGTCTCCATTCCAACGGATACTCGCTGGCTCGCTCGGTCCTACTCGAGA
TCGATCGGATGAACCTGGCCGGTTATGTGGAGGAGTTCGGTCGCACCCTGGGCGAAGAGCTATTGGAGCCCACCCGCATC
TACGCCAAGGACTGTCTGGCATTGGCGGCCGAAACTCACGTCCGTACCTTCTGTCACGTTACCGGCGGCGGGCTGGCCGG
CAATCTTCAACGCGTTATCCCACACGGATTGGTCGCCGAAGTTGACCGCGGCACGTGGACACCTGCACCGGTGTTCGCCA
TGATAGCCCAGCGTGGCAGGGTCGCGCGTGAAGAGATGGAAAAGACGTTCAACATGGGCGTCGGCATGATCGCCGTGGTC
GCGCCTGAAGATACTGACCGTGCTTTGGCGATATTGACCGCACGTCACTTGGACTGCTGGGTGCTGGGCACTGTCTGCAA
AGGCAGCAAAGTAGGCCCACGGGCAAAACTGGTCGGACAACACCCGAGATTCTAA

Upstream 100 bases:

>100_bases
ACACGATGTGAGTCCCGGCAGCACGGGGTGCTTGGTGGGCAACCGTTCAAATGTAGTACCTGATTCCGACTGTGAGTGAC
GACCGGTAGCCTTTATCGCG

Downstream 100 bases:

>100_bases
TGAACTGCGCTTAACTGAAACGAACAGTAACACTAAAACTAACACTAACACCGTGCCGATGCGGAATACATCGGCACGAC
AGAGTTGGGAGTGCTAGCGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MMDPGKSPGGQLGNHGITYASTGVDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREPVLAASTDGVGTK
LAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLME
VDHYDIAATGVGVVEADDTLGPDRVKPGDVIIALRSSGLHSNGYSLARSVLLEIDRMNLAGYVEEFGRTLGEELLEPTRI
YAKDCLALAAETHVRTFCHVTGGGLAGNLQRVIPHGLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVV
APEDTDRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQHPRF

Sequences:

>Translated_364_residues
MMDPGKSPGGQLGNHGITYASTGVDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREPVLAASTDGVGTK
LAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLME
VDHYDIAATGVGVVEADDTLGPDRVKPGDVIIALRSSGLHSNGYSLARSVLLEIDRMNLAGYVEEFGRTLGEELLEPTRI
YAKDCLALAAETHVRTFCHVTGGGLAGNLQRVIPHGLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVV
APEDTDRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQHPRF
>Mature_364_residues
MMDPGKSPGGQLGNHGITYASTGVDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREPVLAASTDGVGTK
LAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLME
VDHYDIAATGVGVVEADDTLGPDRVKPGDVIIALRSSGLHSNGYSLARSVLLEIDRMNLAGYVEEFGRTLGEELLEPTRI
YAKDCLALAAETHVRTFCHVTGGGLAGNLQRVIPHGLVAEVDRGTWTPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVV
APEDTDRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQHPRF

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=344, Percent_Identity=44.1860465116279, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI209869995, Length=344, Percent_Identity=44.1860465116279, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI209869993, Length=344, Percent_Identity=44.1860465116279, Blast_Score=283, Evalue=2e-76,
Organism=Escherichia coli, GI1788845, Length=329, Percent_Identity=47.4164133738602, Blast_Score=289, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17567511, Length=363, Percent_Identity=33.6088154269972, Blast_Score=190, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=42.6900584795322, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24582400, Length=272, Percent_Identity=38.6029411764706, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38353; Mature: 38353

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDPGKSPGGQLGNHGITYASTGVDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFA
CCCCCCCCCCCCCCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSGYREPVLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIA
HHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGRTVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLMEVDHYDIAATGVGVVEADDTL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCEEEECCCCC
GPDRVKPGDVIIALRSSGLHSNGYSLARSVLLEIDRMNLAGYVEEFGRTLGEELLEPTRI
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAKDCLALAAETHVRTFCHVTGGGLAGNLQRVIPHGLVAEVDRGTWTPAPVFAMIAQRGR
HHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHCCCCHHEECCCCCCCCHHHHHHHHHHCH
VAREEMEKTFNMGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQ
HHHHHHHHHHCCCCCEEEEECCCCCCCEEEEHHHHCCCEEEEEECCCCCCCCCCHHHCCC
HPRF
CCCC
>Mature Secondary Structure
MMDPGKSPGGQLGNHGITYASTGVDIEAGDRSVELFKPMAVKAIRTEVLGGLGGFAGLFA
CCCCCCCCCCCCCCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSGYREPVLAASTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIA
HHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
VGRTVPERLSAIVDGIAEGCMLAGCALLGGETAEHPGLMEVDHYDIAATGVGVVEADDTL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCEEEECCCCC
GPDRVKPGDVIIALRSSGLHSNGYSLARSVLLEIDRMNLAGYVEEFGRTLGEELLEPTRI
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAKDCLALAAETHVRTFCHVTGGGLAGNLQRVIPHGLVAEVDRGTWTPAPVFAMIAQRGR
HHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHCCCCHHEECCCCCCCCHHHHHHHHHHCH
VAREEMEKTFNMGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVCKGSKVGPRAKLVGQ
HHHHHHHHHHCCCCCEEEEECCCCCCCEEEEHHHHCCCEEEEEECCCCCCCCCCHHHCCC
HPRF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA