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The map label for this gene is rmlC [H]

Identifier: 221230543

GI number: 221230543

Start: 2349261

End: 2349869

Strand: Direct

Name: rmlC [H]

Synonym: MLBr_01965

Alternate gene names: 221230543

Gene position: 2349261-2349869 (Clockwise)

Preceding gene: 221230542

Following gene: 221230544

Centisome position: 71.89

GC content: 54.52

Gene sequence:

>609_bases
ATGAACGTCAAAGAACTGGATATCTCGGGCGCCTGGGAGATCACCCCTACTATTCATAGCGATTCCCGCGGAATGTTTTT
CGAATGGCTCACAGCCAGTAGGTTCAGCGCATTCACCGGTCACCGCTTAGACGTCCGGCAAGCCAACTGCTCGGTGTCCT
CGGCCGGTGTGTTGCGGGGCCTGCATTTCGCTCAAGTGCCACCGAGCCAGGCCAAATATGTTACCTGCGTGACCGGTTCG
GTGTTCGATGTCGTAGTCGATATCCGTTTAGGATCACCAACATTCGGCTGTTGGACCTCAATTACGCTCAACGACTCCAA
CCGGAAGACCATTTATATCTCCGAGAGTCTCGCACACGGATTCCTTGCACTGCAAGATAATTCTACAGTTATGTACCTAT
GCTCTGCTGAATACAACCCTGCGCGCGAACACGCCATCTGCGCCACGGATCCGGACCTGGCAATCGACTGGCCGGTGGTC
GACGGTGTTGACACGCACTTGTCCAAGCGTGATGCCACAGCCCCCAATCTTGATGACATACGCGCGTCTGGACTACTGCC
GACCTGGGATGAAACGCAGAATTTTATCGCCAACCTCGGCAGCAAATAG

Upstream 100 bases:

>100_bases
GGATTGCGCGCCACCATTGACTGGTATCGGAACAACGAATCGTGGTGGAGACCGTTGAAGGACGCCGTGGAAGCGCGCTA
CGAAGAACGAGGTCGGTGAA

Downstream 100 bases:

>100_bases
CAACGCGGCCATCACAAGTTACTACCGACATAAGGAGAATTTTGGTGAGGCATAAGTTATTGGCCGCCATCTACGCCGTC
ACGATCATGGCCGGCGCGGC

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAFTGHRLDVRQANCSVSSAGVLRGLHFAQVPPSQAKYVTCVTGS
VFDVVVDIRLGSPTFGCWTSITLNDSNRKTIYISESLAHGFLALQDNSTVMYLCSAEYNPAREHAICATDPDLAIDWPVV
DGVDTHLSKRDATAPNLDDIRASGLLPTWDETQNFIANLGSK

Sequences:

>Translated_202_residues
MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAFTGHRLDVRQANCSVSSAGVLRGLHFAQVPPSQAKYVTCVTGS
VFDVVVDIRLGSPTFGCWTSITLNDSNRKTIYISESLAHGFLALQDNSTVMYLCSAEYNPAREHAICATDPDLAIDWPVV
DGVDTHLSKRDATAPNLDDIRASGLLPTWDETQNFIANLGSK
>Mature_202_residues
MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAFTGHRLDVRQANCSVSSAGVLRGLHFAQVPPSQAKYVTCVTGS
VFDVVVDIRLGSPTFGCWTSITLNDSNRKTIYISESLAHGFLALQDNSTVMYLCSAEYNPAREHAICATDPDLAIDWPVV
DGVDTHLSKRDATAPNLDDIRASGLLPTWDETQNFIANLGSK

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N- acetylglucosamine-L-r

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=180, Percent_Identity=38.3333333333333, Blast_Score=128, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17550412, Length=159, Percent_Identity=40.251572327044, Blast_Score=123, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 22127; Mature: 22127

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAFTGHRLDVRQANCSVSSAGVLRG
CCCEEEECCCCEEEEEEEECCCCCEEEEEEHHHHHHHCCCCEEEEEECCCCCCCCHHHHC
LHFAQVPPSQAKYVTCVTGSVFDVVVDIRLGSPTFGCWTSITLNDSNRKTIYISESLAHG
CEECCCCCCCCCEEEEECCCEEEEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCC
FLALQDNSTVMYLCSAEYNPAREHAICATDPDLAIDWPVVDGVDTHLSKRDATAPNLDDI
EEEEECCCEEEEEEECCCCCCCCCEEEECCCCCEEECCCCCCCHHHCCCCCCCCCCHHHH
RASGLLPTWDETQNFIANLGSK
HHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MNVKELDISGAWEITPTIHSDSRGMFFEWLTASRFSAFTGHRLDVRQANCSVSSAGVLRG
CCCEEEECCCCEEEEEEEECCCCCEEEEEEHHHHHHHCCCCEEEEEECCCCCCCCHHHHC
LHFAQVPPSQAKYVTCVTGSVFDVVVDIRLGSPTFGCWTSITLNDSNRKTIYISESLAHG
CEECCCCCCCCCEEEEECCCEEEEEEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCC
FLALQDNSTVMYLCSAEYNPAREHAICATDPDLAIDWPVVDGVDTHLSKRDATAPNLDDI
EEEEECCCEEEEEEECCCCCCCCCEEEECCCCCEEECCCCCCCHHHCCCCCCCCCCHHHH
RASGLLPTWDETQNFIANLGSK
HHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]