BacMap

Definition	Mycobacterium leprae Br4923 chromosome, complete genome.
Accession	NC_011896
Length	3,268,071

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The map label for this gene is fabG1 [H]

Identifier: 221230442

GI number: 221230442

Start: 2187561

End: 2188322

Strand: Reverse

Name: fabG1 [H]

Synonym: MLBr_01807

Alternate gene names: 221230442

Gene position: 2188322-2187561 (Counterclockwise)

Preceding gene: 221230443

Following gene: 221230441

Centisome position: 66.96

GC content: 62.6

Gene sequence:

>762_bases
GTGACTGACGCCGCTGCCAAGGTCTCAGCAGCCCCTGGGAGGGGTAAACCCGCATTCGTGTCTCGTTCAATACTGGTCAC
TGGCGGAAACCGGGGGATCGGGTTGGCGGTGGCGCGCCGCCTGGTCGCTGATGGGCATCGGGTGGCGGTGACCCACCGGG
CGTCCGTCGTCCCTGACTGGTTTTTCGGCGTCGAGTGCGACGTCACCGACAACGATGCCATCGGTGCTGCCTTCAAAGCA
GTCGAAGAGCACCAGGGGCCGGTGGAGGTGTTGGTGGCCAACGCTGGTATCACGTCCGACATGCTGATCATGCGGATGAG
TGAGGAGCAATTCCAGAAAGTCATCGACGTCAACCTGACCGGTGTTTTTCGGGTCGCCAAGCTGGCTTCACGCAACATGA
TCAAGCAGCGGTTCGGTCGCTACATTTTTATGGGATCGGTCGTCGGGCTCAGCGGTGTACCCGGACAAGCGAATTACGCC
GCATCCAAGTCGGGCCTCATCGGAATGGCCCGGTCGTTGGCCCGCGAACTGGGGTCGCGGTCGATCACCGCCAACGTAGT
GGCGCCCGGCTTCATCGACACCGAGATGACCCGTGCCATGGACTCGAAATACCAGGAAGCCGCGCTGCAAGCAATTCCGT
TGGGCCGCATCGGCGCGGTCGAGGAGATCGCCGGTGCTGTCAGTTTCCTGGCATCCGAGGATGCCGGATACATCTCGGGC
GCGGTGATCCCGGTCGATGGCGGCCTGGGTATGGGCCACTGA

Upstream 100 bases:

>100_bases
GCTGATCAACCGCCGGCTGCCGACCTAGTTTTGTTACAGTTGCGTCAGAGTCAGACCGGCCGGTGTTGGGTCGGCCGCGG
TGAGGCGATAGGTTGGCGGG

Downstream 100 bases:

>100_bases
GAAAGTATCGAACACATACAAGGACGAACATGGCAGGACTGCTCGAAGGCAAAAGGATTCTGGTCAGCGGGATCATCACC
GATTCGTCGATCGCGTTTCA

Product: 3-oxoacyl-[ACP] reductase (aka MabA)

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKA
VEEHQGPVEVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYA
ASKSGLIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISG
AVIPVDGGLGMGH

Sequences:

>Translated_253_residues
MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKA
VEEHQGPVEVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYA
ASKSGLIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISG
AVIPVDGGLGMGH
>Mature_252_residues
TDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAVTHRASVVPDWFFGVECDVTDNDAIGAAFKAV
EEHQGPVEVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYAA
SKSGLIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISGA
VIPVDGGLGMGH

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=234, Percent_Identity=40.1709401709402, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=38.8663967611336, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI32483357, Length=241, Percent_Identity=35.2697095435685, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI7705925, Length=238, Percent_Identity=31.5126050420168, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI126723750, Length=249, Percent_Identity=29.718875502008, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=31.8548387096774, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI19923817, Length=249, Percent_Identity=27.710843373494, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI31542939, Length=197, Percent_Identity=31.4720812182741, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4504505, Length=190, Percent_Identity=34.7368421052632, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4758504, Length=249, Percent_Identity=30.1204819277108, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503301, Length=189, Percent_Identity=29.1005291005291, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI10190704, Length=241, Percent_Identity=27.8008298755187, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=30.4568527918782, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI20149619, Length=201, Percent_Identity=27.363184079602, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI66933014, Length=192, Percent_Identity=26.5625, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=32.183908045977, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI83715985, Length=250, Percent_Identity=30, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=26.9565217391304, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI223718074, Length=188, Percent_Identity=31.3829787234043, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7657478, Length=190, Percent_Identity=30.5263157894737, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7706318, Length=131, Percent_Identity=30.5343511450382, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI210032110, Length=159, Percent_Identity=27.0440251572327, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI25282469, Length=140, Percent_Identity=30, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=29.8913043478261, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI109715829, Length=245, Percent_Identity=24.4897959183673, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=47.3029045643153, Blast_Score=210, Evalue=6e-56,
Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=35.6846473029046, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=31.5352697095436, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=30.1204819277108, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367175, Length=242, Percent_Identity=33.0578512396694, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=32.6446280991736, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788459, Length=174, Percent_Identity=36.7816091954023, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789208, Length=191, Percent_Identity=31.9371727748691, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786812, Length=245, Percent_Identity=31.0204081632653, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1789057, Length=250, Percent_Identity=28.4, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789378, Length=271, Percent_Identity=26.5682656826568, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=27.1966527196653, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=38.3064516129032, Blast_Score=154, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=37.9591836734694, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=30.1204819277108, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=29.8804780876494, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=29.3877551020408, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17538182, Length=247, Percent_Identity=29.9595141700405, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=232, Percent_Identity=30.6034482758621, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=28.8, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=111, Percent_Identity=36.9369369369369, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=24.4, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=27.6515151515151, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=257, Percent_Identity=28.4046692607004, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=243, Percent_Identity=27.9835390946502, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=25, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=272, Percent_Identity=26.8382352941176, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=196, Percent_Identity=27.0408163265306, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=28.1954887218045, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=196, Percent_Identity=27.0408163265306, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=26.5384615384615, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=259, Percent_Identity=27.4131274131274, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=251, Percent_Identity=30.2788844621514, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=25.3846153846154, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=25.3846153846154, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=28.1368821292776, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=259, Percent_Identity=27.7992277992278, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=193, Percent_Identity=25.9067357512953, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=27.2030651340996, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=151, Percent_Identity=29.1390728476821, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=151, Percent_Identity=29.1390728476821, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=185, Percent_Identity=34.5945945945946, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=33.160621761658, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320089, Length=225, Percent_Identity=28.8888888888889, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322227, Length=194, Percent_Identity=24.7422680412371, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639444, Length=237, Percent_Identity=34.5991561181435, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI21355319, Length=239, Percent_Identity=33.0543933054393, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=31.3492063492063, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI23397609, Length=241, Percent_Identity=30.2904564315353, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=30.5220883534137, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=29.7619047619048, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=30.9236947791165, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644337, Length=208, Percent_Identity=31.7307692307692, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859837, Length=193, Percent_Identity=34.1968911917098, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24643142, Length=241, Percent_Identity=29.8755186721992, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641232, Length=201, Percent_Identity=28.8557213930348, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007234, Length=198, Percent_Identity=32.3232323232323, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI116007236, Length=230, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581726, Length=133, Percent_Identity=29.3233082706767, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571387, Length=216, Percent_Identity=28.7037037037037, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356301, Length=265, Percent_Identity=25.6603773584906, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26408; Mature: 26276

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAVTHRASVVPDW
CCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCH
FFGVECDVTDNDAIGAAFKAVEEHQGPVEVLVANAGITSDMLIMRMSEEQFQKVIDVNLT
HCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHEEECCHHHHHHHHHCCCH
GVFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSR
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SITANVVAPGFIDTEMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISG
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECC
AVIPVDGGLGMGH
EEEEECCCCCCCC
>Mature Secondary Structure 
TDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAVTHRASVVPDW
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCH
FFGVECDVTDNDAIGAAFKAVEEHQGPVEVLVANAGITSDMLIMRMSEEQFQKVIDVNLT
HCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHEEECCHHHHHHHHHCCCH
GVFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSR
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SITANVVAPGFIDTEMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISG
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEECC
AVIPVDGGLGMGH
EEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA