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The map label for this gene is inhA [H]

Identifier: 221230441

GI number: 221230441

Start: 2186722

End: 2187531

Strand: Reverse

Name: inhA [H]

Synonym: MLBr_01806

Alternate gene names: 221230441

Gene position: 2187531-2186722 (Counterclockwise)

Preceding gene: 221230442

Following gene: 221230440

Centisome position: 66.94

GC content: 60.99

Gene sequence:

>810_bases
ATGGCAGGACTGCTCGAAGGCAAAAGGATTCTGGTCAGCGGGATCATCACCGATTCGTCGATCGCGTTTCACATCGCCAA
GGTAGCCCAGGAAGCGGGGGCGCAGTTGGTGCTGACCGGATTCGACCGGTTGCGGCTGATTCAGCGTATAGCCGACCGGC
TGCCGGACAAGGCGCCGCTGATCGAACTTGACGTGCAGAACGAAGAGCACTTGGCCACGCTAGCCGAGCGGGTGACGGCC
GAGATCGGAGAAGGTAACAAGCTCGACGGCGTGGTGCACTCGATCGGCTTCATGCCGCAGACCGGGATGGGCACCAACCA
GTTCTTCGATGCGCCCTATGAGGACGTTTCCAAGGGTATCCACATCTCGACGTACTCGTACGCCTCGTTGGCCAAGGCGC
TGCTGCTGATCATGAACTCTGGCGGCTCCATCGTGGGCATGGATTTCGATCCGACCCGGGCCATGCCGGCTTACAACTGG
ATGACCGTGGCTAAGAGCGCGCTGGAGTCGGTCAATCGTTTTGTTGCGCGCGAGGCTGGCAAGTACGGTGTACGCTCCAA
TCTCGTTGCGGCGGGTCCTATCCGGACACTGGCGATGAGCGCTATCGTCGGTGGTGCGTTCGGCGAGGAGGCCGGTGCTC
AGATGCAGCTGCTCGAGGAGGGCTGGGATCAGCGTGCCCCGATCGGCTGGAACATGAAGGATCCCACGCCAGTCGCTAAG
ACGGTGTGCGCGCTGTTGTCTGAGTGGTTGCCGGCTACTACCGGTAGCATCATCTATGCCGACGGCGGTGCTAGCACCCA
ACTACTCTAA

Upstream 100 bases:

>100_bases
CATCCGAGGATGCCGGATACATCTCGGGCGCGGTGATCCCGGTCGATGGCGGCCTGGGTATGGGCCACTGAGAAAGTATC
GAACACATACAAGGACGAAC

Downstream 100 bases:

>100_bases
ACGGCAATGCTTTTCGATGCAGCTCTACTTTTGTCCTTCGGCGGTCCGGACGGACCCGAGCAGGTGCGGCCGTTTCTGGA
GAACGTCACTCGGGGATGCA

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MAGLLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRIADRLPDKAPLIELDVQNEEHLATLAERVTA
EIGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGIHISTYSYASLAKALLLIMNSGGSIVGMDFDPTRAMPAYNW
MTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAK
TVCALLSEWLPATTGSIIYADGGASTQLL

Sequences:

>Translated_269_residues
MAGLLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRIADRLPDKAPLIELDVQNEEHLATLAERVTA
EIGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGIHISTYSYASLAKALLLIMNSGGSIVGMDFDPTRAMPAYNW
MTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAK
TVCALLSEWLPATTGSIIYADGGASTQLL
>Mature_268_residues
AGLLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRIADRLPDKAPLIELDVQNEEHLATLAERVTAE
IGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGIHISTYSYASLAKALLLIMNSGGSIVGMDFDPTRAMPAYNWM
TVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAKT
VCALLSEWLPATTGSIIYADGGASTQLL

Specific function: Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide [H]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787545, Length=269, Percent_Identity=32.3420074349442, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR016040 [H]

Pfam domain/function: NA

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 28708; Mature: 28577

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRIADRLPDKAPL
CCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCE
IELDVQNEEHLATLAERVTAEIGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGI
EEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCE
HISTYSYASLAKALLLIMNSGGSIVGMDFDPTRAMPAYNWMTVAKSALESVNRFVAREAG
EEEECHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
KYGVRSNLVAAGPIRTLAMSAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAK
CCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHH
TVCALLSEWLPATTGSIIYADGGASTQLL
HHHHHHHHHCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
AGLLEGKRILVSGIITDSSIAFHIAKVAQEAGAQLVLTGFDRLRLIQRIADRLPDKAPL
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCE
IELDVQNEEHLATLAERVTAEIGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGI
EEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCE
HISTYSYASLAKALLLIMNSGGSIVGMDFDPTRAMPAYNWMTVAKSALESVNRFVAREAG
EEEECHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
KYGVRSNLVAAGPIRTLAMSAIVGGAFGEEAGAQMQLLEEGWDQRAPIGWNMKDPTPVAK
CCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHH
TVCALLSEWLPATTGSIIYADGGASTQLL
HHHHHHHHHCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8284673 [H]