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The map label for this gene is hemH

Identifier: 221230440

GI number: 221230440

Start: 2185705

End: 2186715

Strand: Reverse

Name: hemH

Synonym: MLBr_01805

Alternate gene names: 221230440

Gene position: 2186715-2185705 (Counterclockwise)

Preceding gene: 221230441

Following gene: 221230438

Centisome position: 66.91

GC content: 60.53

Gene sequence:

>1011_bases
ATGCTTTTCGATGCAGCTCTACTTTTGTCCTTCGGCGGTCCGGACGGACCCGAGCAGGTGCGGCCGTTTCTGGAGAACGT
CACTCGGGGATGCAACGTGCCACCCGAACGCCTTGATGAAGTTACCAAGCATTACCTGCATTTCGGTGGAGTGTCGCCAA
TCAATGGGATCAACCTCGCCCTGGTCAATGAGCTGCAAGTGGAACTGGACCTGCCCGTCTATTTCGGCAACCGTAACTGG
GAACCCTACATAGAGGATTCCGTTGTGACCATGCGAGACGATGGTATTCGTTGTGCTGCTGTGTTCATCACGTCGGCGTG
GAGTGGCTATTCCAGTTGCACGCGATATGTTGAAGCCATTGCCCGTGCTCGTCGGCGAGCTGGTACGGGCGCGCCCAATC
TGGTTAAATTGCGGCCCTACTTCGATCATCCGCTTTTCGTCGAGATGTTCGTCGATGCCATCACGGCTGCTGCCGCCAGC
TTGCCCGCTGCGCTGCGCAGCGAAGCGCGGCTAGTGTTCACCGCGCATTCGGTTCCGGTGGCTACTGACCGACGCTGCGG
TCCTGCGCTCTATAGCCGCCAAGTCGGTTATGCTGCAAGGCTCGTCGCGGCCGGTGCTGGATACGCCGACTACGACCTGA
CCTGGCAGTCTCGGTCGGGGCCGCCGTATGTTCCGTGGTTAGCGCCCGATGTTGGCGATCAACTCATGACGCTGGCGTCC
GCCGGCACCAAAGCCGTCATCGTCTGTCCAATCGGGTTTGTCGCTGACCATATTGAGGTGGTGTGGGATCTAGATCACGA
ATTGCGATCTCAAGCAGACGCGGCGGGCGTCGCGTTCGCCCGGGCCGCTACACCTAACGCCGATCGGCGGTTCGCCCGGC
TGGCCGCAAGTTTGATCGACGAACTCACGCACGACCGCGTGCCCGTTCGGGTGAATGGCTCCGATCCGGTGCCGGGTTGC
CTGGCCAGCATCAATGGCGTGCCGTGCGATCTACCGCACTGTGTTGCGTAG

Upstream 100 bases:

>100_bases
TAAGACGGTGTGCGCGCTGTTGTCTGAGTGGTTGCCGGCTACTACCGGTAGCATCATCTATGCCGACGGCGGTGCTAGCA
CCCAACTACTCTAAACGGCA

Downstream 100 bases:

>100_bases
GTAGAGTCCGGCGTGGATTTGTATGGCGCGGTACAATCAGTCGGGCCAGGCCGAGTGCAGGATTGCGTTGACCGCCGCCA
TCCTTGCCGAACGTACCACC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLFDAALLLSFGGPDGPEQVRPFLENVTRGCNVPPERLDEVTKHYLHFGGVSPINGINLALVNELQVELDLPVYFGNRNW
EPYIEDSVVTMRDDGIRCAAVFITSAWSGYSSCTRYVEAIARARRRAGTGAPNLVKLRPYFDHPLFVEMFVDAITAAAAS
LPAALRSEARLVFTAHSVPVATDRRCGPALYSRQVGYAARLVAAGAGYADYDLTWQSRSGPPYVPWLAPDVGDQLMTLAS
AGTKAVIVCPIGFVADHIEVVWDLDHELRSQADAAGVAFARAATPNADRRFARLAASLIDELTHDRVPVRVNGSDPVPGC
LASINGVPCDLPHCVA

Sequences:

>Translated_336_residues
MLFDAALLLSFGGPDGPEQVRPFLENVTRGCNVPPERLDEVTKHYLHFGGVSPINGINLALVNELQVELDLPVYFGNRNW
EPYIEDSVVTMRDDGIRCAAVFITSAWSGYSSCTRYVEAIARARRRAGTGAPNLVKLRPYFDHPLFVEMFVDAITAAAAS
LPAALRSEARLVFTAHSVPVATDRRCGPALYSRQVGYAARLVAAGAGYADYDLTWQSRSGPPYVPWLAPDVGDQLMTLAS
AGTKAVIVCPIGFVADHIEVVWDLDHELRSQADAAGVAFARAATPNADRRFARLAASLIDELTHDRVPVRVNGSDPVPGC
LASINGVPCDLPHCVA
>Mature_336_residues
MLFDAALLLSFGGPDGPEQVRPFLENVTRGCNVPPERLDEVTKHYLHFGGVSPINGINLALVNELQVELDLPVYFGNRNW
EPYIEDSVVTMRDDGIRCAAVFITSAWSGYSSCTRYVEAIARARRRAGTGAPNLVKLRPYFDHPLFVEMFVDAITAAAAS
LPAALRSEARLVFTAHSVPVATDRRCGPALYSRQVGYAARLVAAGAGYADYDLTWQSRSGPPYVPWLAPDVGDQLMTLAS
AGTKAVIVCPIGFVADHIEVVWDLDHELRSQADAAGVAFARAATPNADRRFARLAASLIDELTHDRVPVRVNGSDPVPGC
LASINGVPCDLPHCVA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=277, Percent_Identity=28.8808664259928, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI60499021, Length=277, Percent_Identity=28.8808664259928, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17864156, Length=310, Percent_Identity=30, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45552018, Length=147, Percent_Identity=37.4149659863946, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_MYCLB (B8ZS79)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503856.1
- ProteinModelPortal:   B8ZS79
- SMR:   B8ZS79
- EnsemblBacteria:   EBMYCT00000085710
- GeneID:   7325889
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016242
- HOGENOM:   HBG697135
- OMA:   PINQQCR
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36315; Mature: 36315

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFDAALLLSFGGPDGPEQVRPFLENVTRGCNVPPERLDEVTKHYLHFGGVSPINGINLA
CCCCCEEHEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEE
LVNELQVELDLPVYFGNRNWEPYIEDSVVTMRDDGIRCAAVFITSAWSGYSSCTRYVEAI
EEEEEEEEEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHH
ARARRRAGTGAPNLVKLRPYFDHPLFVEMFVDAITAAAASLPAALRSEARLVFTAHSVPV
HHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCEEEEEECCCCC
ATDRRCGPALYSRQVGYAARLVAAGAGYADYDLTWQSRSGPPYVPWLAPDVGDQLMTLAS
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHC
AGTKAVIVCPIGFVADHIEVVWDLDHELRSQADAAGVAFARAATPNADRRFARLAASLID
CCCCEEEEECCHHHHHHHHHEECCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
ELTHDRVPVRVNGSDPVPGCLASINGVPCDLPHCVA
HHHCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLFDAALLLSFGGPDGPEQVRPFLENVTRGCNVPPERLDEVTKHYLHFGGVSPINGINLA
CCCCCEEHEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEE
LVNELQVELDLPVYFGNRNWEPYIEDSVVTMRDDGIRCAAVFITSAWSGYSSCTRYVEAI
EEEEEEEEEEEEEEECCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHH
ARARRRAGTGAPNLVKLRPYFDHPLFVEMFVDAITAAAASLPAALRSEARLVFTAHSVPV
HHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCEEEEEECCCCC
ATDRRCGPALYSRQVGYAARLVAAGAGYADYDLTWQSRSGPPYVPWLAPDVGDQLMTLAS
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHC
AGTKAVIVCPIGFVADHIEVVWDLDHELRSQADAAGVAFARAATPNADRRFARLAASLID
CCCCEEEEECCHHHHHHHHHEECCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
ELTHDRVPVRVNGSDPVPGCLASINGVPCDLPHCVA
HHHCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA