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The map label for this gene is mmr

Identifier: 221230418

GI number: 221230418

Start: 2131218

End: 2131541

Strand: Direct

Name: mmr

Synonym: MLBr_01756

Alternate gene names: 221230418

Gene position: 2131218-2131541 (Clockwise)

Preceding gene: 221230406

Following gene: 221230420

Centisome position: 65.21

GC content: 58.95

Gene sequence:

>324_bases
GTGGCTTATCTGTTCCTCTTTTGCGCGATCTTTGTGGAGGTGGTGGCGACCACCCTGCTCAAGAGCACCGAAGGCTTCAC
TCGGCTGGTGCCAACCCTGGCTTGTCTGGCCGGCTACGCAGTAACTTTCACACTCCTGGCGCTGTCGATCTCACGCGGCA
TGAAGACAGACGTCGCCTATGCGTTGTGGTCGGCCATCGGCACGGCTGCCATCGTGCTGATCGCGGTGCTATTCCTCGAC
TCACCGGTATCCGTGGCGAAAGTCGTTGGCGTCGCGCTGATTATAGTCGGAGTGATCACGTTGAACCTGGCCGATGCCCA
TTGA

Upstream 100 bases:

>100_bases
AGCCAAACTATCGGCGAGCATCATGGCATCGACAAGCTGTCCGCTCCAGCAAGTCATTCGCCCGCTTTTCTCGTGTACAT
TTGTAGAATAGGGAGGCATT

Downstream 100 bases:

>100_bases
CCACCGCCCCAGATCGCCGTCCACGCGACCCCACCGGTCGCCAACAAGCGATCGTCCAGGCAGCTGGACGCAATAATCAC
CTGGGGGTCTCGACGAATCA

Product: putative multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MAYLFLFCAIFVEVVATTLLKSTEGFTRLVPTLACLAGYAVTFTLLALSISRGMKTDVAYALWSAIGTAAIVLIAVLFLD
SPVSVAKVVGVALIIVGVITLNLADAH

Sequences:

>Translated_107_residues
MAYLFLFCAIFVEVVATTLLKSTEGFTRLVPTLACLAGYAVTFTLLALSISRGMKTDVAYALWSAIGTAAIVLIAVLFLD
SPVSVAKVVGVALIIVGVITLNLADAH
>Mature_106_residues
AYLFLFCAIFVEVVATTLLKSTEGFTRLVPTLACLAGYAVTFTLLALSISRGMKTDVAYALWSAIGTAAIVLIAVLFLDS
PVSVAKVVGVALIIVGVITLNLADAH

Specific function: Multidrug efflux pump. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. Mmr (TC 2.A.7.1.2) subfamily

Homologues:

Organism=Escherichia coli, GI1786755, Length=102, Percent_Identity=38.2352941176471, Blast_Score=74, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MMR_MYCLE (Q9CBP1)

Other databases:

- EMBL:   AL583923
- RefSeq:   NP_302204.1
- ProteinModelPortal:   Q9CBP1
- EnsemblBacteria:   EBMYCT00000028090
- GeneID:   910737
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1756
- NMPDR:   fig|272631.1.peg.1076
- Leproma:   ML1756
- GeneTree:   EBGT00050000017346
- HOGENOM:   HBG740972
- OMA:   IAIISEV
- ProtClustDB:   CLSK799381
- BioCyc:   MLEP272631:ML1756-MONOMER
- GO:   GO:0006810
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 11192; Mature: 11060

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x29943e7c)-; HASH(0x2a5f5df4)-; HASH(0x2a5f778c)-; HASH(0x29ddddcc)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYLFLFCAIFVEVVATTLLKSTEGFTRLVPTLACLAGYAVTFTLLALSISRGMKTDVAY
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALWSAIGTAAIVLIAVLFLDSPVSVAKVVGVALIIVGVITLNLADAH
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
AYLFLFCAIFVEVVATTLLKSTEGFTRLVPTLACLAGYAVTFTLLALSISRGMKTDVAY
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALWSAIGTAAIVLIAVLFLDSPVSVAKVVGVALIIVGVITLNLADAH
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002