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The map label for this gene is adhA [H]

Identifier: 221230406

GI number: 221230406

Start: 2087843

End: 2088931

Strand: Direct

Name: adhA [H]

Synonym: MLBr_01730

Alternate gene names: 221230406

Gene position: 2087843-2088931 (Clockwise)

Preceding gene: 221230405

Following gene: 221230418

Centisome position: 63.89

GC content: 58.13

Gene sequence:

>1089_bases
ATGAAGTCACACGTGTCAAAACACAGAAGAAAGAGAAGATTAGGTGCCATGACTACCGTCTCCGCTTACGCCGCCACGTC
GGCGACCGAACCGCTAACCAAGGTCACCATCAACCGCCGCGCCCCGGGTCCGCACGACGTAGCAATCCAGATCAAGTTCG
CCGGTATCTGCCACTCCGATATCCACACCGTAAAAGCTGAGTGGGGCCAACCGAATTACCCTGTGGTACCAGGCCATGAG
ATCGCTGGCGTGGTGACCGCGGTGGGCACTGAGGTCACCAAGCACAAGGTGGGCGACCGCGTCGGCGTGGGCTGCATGGT
GGGCTCTTGCGGTGAATGCAGCAGCTGCCTAGCTGGCATCGAGCAGTACTGTAAACGGGGCGCGACCTTTACCTACAACT
CGATCGGCACAGACGGCCAGTCAACACAAGGCGGCTACAGCCAGGCAATCGTCGTCGACGAGAACTTTGTCGTACACATA
CCCGATGCGCTACCGCTGGACGCCGCCGCACCGCTGCTGTGCGCGGGCATCACGCTCTACTCACCGCTTAGGCATTGGAA
TGCTAAGCCGGGCACGCGGCTCGCAATCATCGGTTTGGGCGGTCTCGGGCACATGGGTGTCAAGCTGGGCAGAAAGATGG
GCTGTGAAGTGACGGTGCTGTCCCAGTCGCTGAAGAAGATGGAGGACGGACTGCAGCTGGGCGCCAGCAACTATTACGCA
ACTGCCGATCCCGACACCTTCCGCAAACTACGTGGCAGTTTCGACCTGATTTTGAACACCGTCTCGGCGAATCTGGATCT
CGGCAAATACCTGAACCTGCTTGATGTCAACGGGACGCTCGTCGAGCTGGGCATTCCCGAGCACCCGATGTTGGTGCCGG
CATTCGCGCTGGCACTCATGCGGCGCAGCCTAGCTGGGTCGAACATCGGCGGGATCACCGAAACCCAGGAGATGATGAAT
TTCAGTGCTGAACATAGTGTTACACCGGAAATAGAGCTCATCGAACCGGACTACATCAACGAAGCCTATGAACGAGTGCT
GGCAAGCGACGTGCGGTACCGCTTCGTCATAAACATATCAAGTTTGTAA

Upstream 100 bases:

>100_bases
AGCGCAAGCGCGGTAAAGCCGGGCTAGCGAGTCACCACCATCGACCTAATTACTTACCCCGATTGAGGGGGCAGAGATAA
GCTTTCGGTATTCACAGCTA

Downstream 100 bases:

>100_bases
GGCTGTGACGTCGGCGCGGATTCGCCATGAACTGACTTCAGTCAGCATGGACGAATCCTGAGATGCCAGCCAACGGCTAG
CCAGAGACGAAGACATATCA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQIKFAGICHSDIHTVKAEWGQPNYPVVPGHE
IAGVVTAVGTEVTKHKVGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGTDGQSTQGGYSQAIVVDENFVVHI
PDALPLDAAAPLLCAGITLYSPLRHWNAKPGTRLAIIGLGGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYA
TADPDTFRKLRGSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVPAFALALMRRSLAGSNIGGITETQEMMN
FSAEHSVTPEIELIEPDYINEAYERVLASDVRYRFVINISSL

Sequences:

>Translated_362_residues
MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQIKFAGICHSDIHTVKAEWGQPNYPVVPGHE
IAGVVTAVGTEVTKHKVGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGTDGQSTQGGYSQAIVVDENFVVHI
PDALPLDAAAPLLCAGITLYSPLRHWNAKPGTRLAIIGLGGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYA
TADPDTFRKLRGSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVPAFALALMRRSLAGSNIGGITETQEMMN
FSAEHSVTPEIELIEPDYINEAYERVLASDVRYRFVINISSL
>Mature_362_residues
MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQIKFAGICHSDIHTVKAEWGQPNYPVVPGHE
IAGVVTAVGTEVTKHKVGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGTDGQSTQGGYSQAIVVDENFVVHI
PDALPLDAAAPLLCAGITLYSPLRHWNAKPGTRLAIIGLGGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYA
TADPDTFRKLRGSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVPAFALALMRRSLAGSNIGGITETQEMMN
FSAEHSVTPEIELIEPDYINEAYERVLASDVRYRFVINISSL

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=27.9452054794521, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI34577061, Length=384, Percent_Identity=26.5625, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4501929, Length=363, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=210, Percent_Identity=31.9047619047619, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073058, Length=273, Percent_Identity=26.3736263736264, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI71743840, Length=260, Percent_Identity=26.1538461538462, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71565152, Length=222, Percent_Identity=27.9279279279279, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=25.5681818181818, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=25.5681818181818, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=346, Percent_Identity=50, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=36.3372093023256, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI87081918, Length=315, Percent_Identity=27.3015873015873, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788075, Length=281, Percent_Identity=26.6903914590747, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788073, Length=219, Percent_Identity=29.6803652968037, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082125, Length=256, Percent_Identity=27.734375, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790045, Length=260, Percent_Identity=27.6923076923077, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787863, Length=137, Percent_Identity=34.3065693430657, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI226510992, Length=260, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788407, Length=222, Percent_Identity=26.1261261261261, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=328, Percent_Identity=28.6585365853659, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=26.8436578171091, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=353, Percent_Identity=26.3456090651558, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=212, Percent_Identity=30.188679245283, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=192, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=183, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=214, Percent_Identity=30.3738317757009, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=342, Percent_Identity=37.1345029239766, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319949, Length=329, Percent_Identity=34.6504559270517, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323961, Length=327, Percent_Identity=29.3577981651376, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=329, Percent_Identity=28.5714285714286, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=28.7461773700306, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=26.605504587156, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=237, Percent_Identity=31.2236286919831, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=301, Percent_Identity=26.578073089701, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=308, Percent_Identity=24.025974025974, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=297, Percent_Identity=25.9259259259259, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17737895, Length=214, Percent_Identity=31.3084112149533, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 38908; Mature: 38908

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQIKFAGICHSD
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECEECCC
IHTVKAEWGQPNYPVVPGHEIAGVVTAVGTEVTKHKVGDRVGVGCMVGSCGECSSCLAGI
HHHEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
EQYCKRGATFTYNSIGTDGQSTQGGYSQAIVVDENFVVHIPDALPLDAAAPLLCAGITLY
HHHHHCCCCEEECCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHH
SPLRHWNAKPGTRLAIIGLGGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYA
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCEEE
TADPDTFRKLRGSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVPAFALALM
CCCCHHHHHHCCCHHHEEEHHHCCCCHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHH
RRSLAGSNIGGITETQEMMNFSAEHSVTPEIELIEPDYINEAYERVLASDVRYRFVINIS
HHHHCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEEEEEE
SL
CC
>Mature Secondary Structure
MKSHVSKHRRKRRLGAMTTVSAYAATSATEPLTKVTINRRAPGPHDVAIQIKFAGICHSD
CCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECEECCC
IHTVKAEWGQPNYPVVPGHEIAGVVTAVGTEVTKHKVGDRVGVGCMVGSCGECSSCLAGI
HHHEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
EQYCKRGATFTYNSIGTDGQSTQGGYSQAIVVDENFVVHIPDALPLDAAAPLLCAGITLY
HHHHHCCCCEEECCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHH
SPLRHWNAKPGTRLAIIGLGGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYA
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCEEE
TADPDTFRKLRGSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHPMLVPAFALALM
CCCCHHHHHHCCCHHHEEEHHHCCCCHHHHEEEEECCCEEEEECCCCCCHHHHHHHHHHH
RRSLAGSNIGGITETQEMMNFSAEHSVTPEIELIEPDYINEAYERVLASDVRYRFVINIS
HHHHCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEEEEEE
SL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1427101; 12788972 [H]