| Definition | Mycobacterium leprae Br4923 chromosome, complete genome. |
|---|---|
| Accession | NC_011896 |
| Length | 3,268,071 |
Click here to switch to the map view.
The map label for this gene is nrdE [H]
Identifier: 221230409
GI number: 221230409
Start: 2094251
End: 2096332
Strand: Reverse
Name: nrdE [H]
Synonym: MLBr_01734
Alternate gene names: 221230409
Gene position: 2096332-2094251 (Counterclockwise)
Preceding gene: 221230410
Following gene: 221230408
Centisome position: 64.15
GC content: 54.32
Gene sequence:
>2082_bases ATGTTGAATCTGTACGATGCGGACGGCAAGATCCAATTCGACAAGGACGTACTCGCGGCCCGCCAATTCTTCCTGCAGCA TGTCAATCAGAACACGGTCTTTTTCCATAACCAGGACGAGAAGCTGGACTATCTGATCCGCGAGAATTACTACGAGCGTG AGGTGCTCGATCAGTACTCGCGTAACTTTGTCAAGTCGCTGCTGGATCGTGCCTACGCCAAGAAGTTTCGGTTCTCAACG TTTCTTGGTGCGTTCAAGTATTATACCTCTTACACGCTGAAGACGTTCGACGGGAAGCGGTATTTAGAGCGCCTCGAAGA CCGGGTCTGCATGGTCGCACTCACGTTGGCGGCCGGTGACACCGGCTTGGCCGAGAAGCTCGTCGACGAGATCATCGACG GCCGATTCCAGCCAGCTACCCCAACTTTTTTGAACTCGGGCAAGAAACAACGCGGCGAACCGGTGAGCTGTTTTTTGCTG CGCATTGAGGATAACATGGAGTCGATCGGGCGATCGGTCAACTCCGCGCTACAGCTATCCAAGCGTGGCGGAGGAGTTGC TTTGCTGCTGAGCAACATTCGTGAGCATGGTGCACCGATCAAGAACATCGAACACCAGTCTTCGGGCGTAATTCCGATCA TGAAGTTGCTTGAAGATGCGTTCTCGTATGCCAATCAGTTGGGCGCCCGCCAAGGCGCTGGTGCGGTGTACCTGCATGCT CATCACCCTGACATCTACCGCTTCTTGGACACTAAGCGGGAGAATGCCGACGAGAAGATCCGGATCAAGACGCTGAGCCT GGGGGTGATAATTCCCGACATCACCTTTGAGCTGGCTAAGCGTAACGAAGACATGTACCTGTTCTCGTCGTACGACGTCG AGCGGGTTTACGAGGTGCCGTTCGCCGATATTTCGGTGACTGAGAAGTATTATGAGATGCTCGATGACGCACGCATCCGC AAGACCAAGATCAAGGCGCGGGAGTTTTTCCAGAAGCTGGCCGAGCTGCAGTTCGAGTCCGGTTACCCCTATGTCATGTT CGAGGACACGGTGAACCGGGCCAACCCCATTGAAGGTAAGATCACTCACTCGAATCTATGCTCGGAGATCCTGCAGGTGT CCACGCCGTCGTTGTTTAACGACGACTTGTCGTATGCCAAAGTGGGCAAGGACATTTCATGTAACCTGGGATCGCTGAAC ATTGCCAAGACGATGGACTCACCGGATTTCGCGCAGACGGTTGAGGTGGCGATTCGCGCGTTGACTGCGGTGAGCGACCA GACGCACATCAAGTCGGTGCCCTCGATCGAGCAGGGTAACAATGATTCCCACGCGATCGGGCTGGGGCAGATGAACCTGC ATGGCTACTTGTCCCGTGAAGGAATCTTCTACGGTTCCGAAGAGGGAGTCGATTTCACCAACATTTACTTCTATACGGTG TTGTTTCACGTGTTGCTGGCTTCGAACTCTATCGCGATCGAACGAGGTACCTTCTTCAAAGGTTTCGAGCGGTCCAAGTA CGCGTCGGGAGAGTTCTTCGACAAATACATCGAGCAGACGTGGGAGCCGAAGACCGATAAAGTGCGTCAGTTATTCGCTG AGGCAGCGATCCGTATTCCGACCCAAAACGACTGGAAGCGGCTGAAGGAGTTGGTGGTCGCACACGGCATCTACAACCAG AACCTGCAGGCGGTGCCGCCGACCGGATCGATCTCCTATATCAACCATTCGACGTCGTCGATCCACCCGATCGTGTCGAA AGTTGAGATCCGTAAGGAAGGAAAAATTGGCCGAGTTTACTATCCGGCGCCCTATATGACCAATGACAATCTGCAGTACT ACCAGGACGCTTATGAGATCGGGTACCAGAAGATCATCGACACATACGCGGCGGCCACCCAGCACGTCGACCAAGGGCTC TCACTGACGTTGTTCTTCAAAGACACCGCCACCACCCGGGACGTGAACAAGGCGCAGATTTATGCGTGGCGCAAGGGAAT CAAGACGCTGTATTACATTCGGCTGCGGCAGATGGCGCTGGAAGGCACCGAAGTCGAGGGCTGCGTGTCTTGCACGCTGT AA
Upstream 100 bases:
>100_bases GTGGAAGGAACATTAGGTGCCACCAACCGCCACTGCAGAGCCGGTAACCGCCAGCACTCACATGTTGTCCAATGAAACAG ACTACCACGCGCTCAACGCT
Downstream 100 bases:
>100_bases GTTCCTCGGTTCCTCGCGAGTATGGATACTGCGACGCGATACGTCCGTGACCCGTCGCAGTATCCATACCCGCAAGCCGT TGAAGTGGTCGGGCTGTGCG
Product: ribonucleotide-diphosphate reductase subunit alpha
Products: NA
Alternate protein names: Ribonucleotide reductase R1 subunit [H]
Number of amino acids: Translated: 693; Mature: 693
Protein sequence:
>693_residues MLNLYDADGKIQFDKDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKSLLDRAYAKKFRFST FLGAFKYYTSYTLKTFDGKRYLERLEDRVCMVALTLAAGDTGLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLL RIEDNMESIGRSVNSALQLSKRGGGVALLLSNIREHGAPIKNIEHQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHA HHPDIYRFLDTKRENADEKIRIKTLSLGVIIPDITFELAKRNEDMYLFSSYDVERVYEVPFADISVTEKYYEMLDDARIR KTKIKAREFFQKLAELQFESGYPYVMFEDTVNRANPIEGKITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLN IAKTMDSPDFAQTVEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLSREGIFYGSEEGVDFTNIYFYTV LFHVLLASNSIAIERGTFFKGFERSKYASGEFFDKYIEQTWEPKTDKVRQLFAEAAIRIPTQNDWKRLKELVVAHGIYNQ NLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLQYYQDAYEIGYQKIIDTYAAATQHVDQGL SLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCTL
Sequences:
>Translated_693_residues MLNLYDADGKIQFDKDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKSLLDRAYAKKFRFST FLGAFKYYTSYTLKTFDGKRYLERLEDRVCMVALTLAAGDTGLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLL RIEDNMESIGRSVNSALQLSKRGGGVALLLSNIREHGAPIKNIEHQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHA HHPDIYRFLDTKRENADEKIRIKTLSLGVIIPDITFELAKRNEDMYLFSSYDVERVYEVPFADISVTEKYYEMLDDARIR KTKIKAREFFQKLAELQFESGYPYVMFEDTVNRANPIEGKITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLN IAKTMDSPDFAQTVEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLSREGIFYGSEEGVDFTNIYFYTV LFHVLLASNSIAIERGTFFKGFERSKYASGEFFDKYIEQTWEPKTDKVRQLFAEAAIRIPTQNDWKRLKELVVAHGIYNQ NLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLQYYQDAYEIGYQKIIDTYAAATQHVDQGL SLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCTL >Mature_693_residues MLNLYDADGKIQFDKDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKSLLDRAYAKKFRFST FLGAFKYYTSYTLKTFDGKRYLERLEDRVCMVALTLAAGDTGLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLL RIEDNMESIGRSVNSALQLSKRGGGVALLLSNIREHGAPIKNIEHQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHA HHPDIYRFLDTKRENADEKIRIKTLSLGVIIPDITFELAKRNEDMYLFSSYDVERVYEVPFADISVTEKYYEMLDDARIR KTKIKAREFFQKLAELQFESGYPYVMFEDTVNRANPIEGKITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLN IAKTMDSPDFAQTVEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLSREGIFYGSEEGVDFTNIYFYTV LFHVLLASNSIAIERGTFFKGFERSKYASGEFFDKYIEQTWEPKTDKVRQLFAEAAIRIPTQNDWKRLKELVVAHGIYNQ NLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLQYYQDAYEIGYQKIIDTYAAATQHVDQGL SLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCTL
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=682, Percent_Identity=25.6598240469208, Blast_Score=184, Evalue=2e-46, Organism=Escherichia coli, GI1789030, Length=693, Percent_Identity=72.4386724386724, Blast_Score=1071, Evalue=0.0, Organism=Escherichia coli, GI2367133, Length=566, Percent_Identity=27.0318021201413, Blast_Score=173, Evalue=3e-44, Organism=Caenorhabditis elegans, GI17555242, Length=640, Percent_Identity=25.625, Blast_Score=181, Evalue=9e-46, Organism=Saccharomyces cerevisiae, GI6320914, Length=654, Percent_Identity=24.9235474006116, Blast_Score=172, Evalue=1e-43, Organism=Saccharomyces cerevisiae, GI6322123, Length=653, Percent_Identity=25.7274119448698, Blast_Score=167, Evalue=4e-42, Organism=Drosophila melanogaster, GI17352481, Length=640, Percent_Identity=25, Blast_Score=174, Evalue=2e-43,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013346 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 - InterPro: IPR013554 [H]
Pfam domain/function: PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN; PF08343 RNR_N [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 79072; Mature: 79072
Theoretical pI: Translated: 6.73; Mature: 6.73
Prosite motif: PS00089 RIBORED_LARGE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLNLYDADGKIQFDKDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYS CCEEECCCCCEEECHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHH RNFVKSLLDRAYAKKFRFSTFLGAFKYYTSYTLKTFDGKRYLERLEDRVCMVALTLAAGD HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHEEEEEEECCCC TGLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSVNSALQLS CHHHHHHHHHHHCCCCCCCCCHHHCCCCHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHH KRGGGVALLLSNIREHGAPIKNIEHQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHA CCCCCEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE HHPDIYRFLDTKRENADEKIRIKTLSLGVIIPDITFELAKRNEDMYLFSSYDVERVYEVP CCCHHHHHHHHHCCCCCCEEEEEEEEEEEEECCHHHHHHHCCCCEEEEECCCHHHHEECC FADISVTEKYYEMLDDARIRKTKIKAREFFQKLAELQFESGYPYVMFEDTVNRANPIEGK CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCEEEEECCCCCCCCCCCE ITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTVEVAIRA EEHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH LTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLSREGIFYGSEEGVDFTNIYFYTV HHHHCCCHHHCCCCCCCCCCCCCCEEEEECCCCCEEEECCCEEECCCCCCCHHHHHHHHH LFHVLLASNSIAIERGTFFKGFERSKYASGEFFDKYIEQTWEPKTDKVRQLFAEAAIRIP HHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEECC TQNDWKRLKELVVAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVY CCHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEE YPAPYMTNDNLQYYQDAYEIGYQKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQI ECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHH YAWRKGIKTLYYIRLRQMALEGTEVEGCVSCTL HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC >Mature Secondary Structure MLNLYDADGKIQFDKDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYS CCEEECCCCCEEECHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHH RNFVKSLLDRAYAKKFRFSTFLGAFKYYTSYTLKTFDGKRYLERLEDRVCMVALTLAAGD HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHEEEEEEECCCC TGLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLLRIEDNMESIGRSVNSALQLS CHHHHHHHHHHHCCCCCCCCCHHHCCCCHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHH KRGGGVALLLSNIREHGAPIKNIEHQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHA CCCCCEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE HHPDIYRFLDTKRENADEKIRIKTLSLGVIIPDITFELAKRNEDMYLFSSYDVERVYEVP CCCHHHHHHHHHCCCCCCEEEEEEEEEEEEECCHHHHHHHCCCCEEEEECCCHHHHEECC FADISVTEKYYEMLDDARIRKTKIKAREFFQKLAELQFESGYPYVMFEDTVNRANPIEGK CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCEEEEECCCCCCCCCCCE ITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTVEVAIRA EEHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH LTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLSREGIFYGSEEGVDFTNIYFYTV HHHHCCCHHHCCCCCCCCCCCCCCEEEEECCCCCEEEECCCEEECCCCCCCHHHHHHHHH LFHVLLASNSIAIERGTFFKGFERSKYASGEFFDKYIEQTWEPKTDKVRQLFAEAAIRIP HHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEECC TQNDWKRLKELVVAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVY CCHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEE YPAPYMTNDNLQYYQDAYEIGYQKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQI ECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHH YAWRKGIKTLYYIRLRQMALEGTEVEGCVSCTL HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]