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The map label for this gene is cofC

Identifier: 221230368

GI number: 221230368

Start: 2024608

End: 2025258

Strand: Direct

Name: cofC

Synonym: MLBr_01680

Alternate gene names: 221230368

Gene position: 2024608-2025258 (Clockwise)

Preceding gene: 221230365

Following gene: 221230369

Centisome position: 61.95

GC content: 61.75

Gene sequence:

>651_bases
ATGAGTGGCACACGGGCTGGAGGCACAGCTGATGTCGGCTTGATCATCGCCGTTAAGCGGCTGGCCGCCGCCAAGACCAG
GCTAGGACCGGTCTTCTCGACTCGGACACGAGAGAATGTGGTGTTGGCCATGTTGGTAGACACCCTGACCGCAGCGGCAC
CCGTTTCAGCACTACGTTCAATCACCGTCATCACGCCCGATGAGGCCGCTGCCGCGGCAGCGGCCGAATTCGGAGCCGAG
ATTCTGGCCGATCCAACACCCGATGGTCATGGTGATCCACTGAATAACGCCATTGCCGCTGCGGAACACGCGATAGCTGG
ATCATTCTCCAATATCGTTGTACTGCAAGGAGATTTGCCTGCCTTACAGACACAGGAATTGTCCGAGGCAATCGCTGCCG
CCCGACACCATCAGCGCAGCTTCGTCGCTGATCGACTGGGTAGCGGAACCGCAGCGCTCTGCACGTTCGGAACCGCACTC
AACCCGCAGTTCGGTCCAGATTCATCCGCGCAACATCGCCGTTCAGGCGCGATCGAGCTTACGGGACCCTGGCCTGGCCT
GCGATGCGACGTCGACACGCCTGCCGATCTGGCCGCCGCACGCCGTCTGGGCATCGGAGCCGCCACCACGCGGGTGGTCG
CACATCTTTAG

Upstream 100 bases:

>100_bases
ATACCACGACACAACACTCTAGCGCGCAAATCGACTGCCACGGTCGAGCTCTCGTGACACTTGCAGGGAATGCAGCGACC
AACGCTGGCAGGATGACCTC

Downstream 100 bases:

>100_bases
CCCCAACCAGCTACAGGATCCCAAATGGTAAACAGCACACCAACGCGGAATGAATGGCCACAGCGTGATAGCAGCACCAT
CGGATGATGAGCAATGATCT

Product: hypothetical protein

Products: NA

Alternate protein names: LP guanylyltransferase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSGTRAGGTADVGLIIAVKRLAAAKTRLGPVFSTRTRENVVLAMLVDTLTAAAPVSALRSITVITPDEAAAAAAAEFGAE
ILADPTPDGHGDPLNNAIAAAEHAIAGSFSNIVVLQGDLPALQTQELSEAIAAARHHQRSFVADRLGSGTAALCTFGTAL
NPQFGPDSSAQHRRSGAIELTGPWPGLRCDVDTPADLAAARRLGIGAATTRVVAHL

Sequences:

>Translated_216_residues
MSGTRAGGTADVGLIIAVKRLAAAKTRLGPVFSTRTRENVVLAMLVDTLTAAAPVSALRSITVITPDEAAAAAAAEFGAE
ILADPTPDGHGDPLNNAIAAAEHAIAGSFSNIVVLQGDLPALQTQELSEAIAAARHHQRSFVADRLGSGTAALCTFGTAL
NPQFGPDSSAQHRRSGAIELTGPWPGLRCDVDTPADLAAARRLGIGAATTRVVAHL
>Mature_215_residues
SGTRAGGTADVGLIIAVKRLAAAKTRLGPVFSTRTRENVVLAMLVDTLTAAAPVSALRSITVITPDEAAAAAAAEFGAEI
LADPTPDGHGDPLNNAIAAAEHAIAGSFSNIVVLQGDLPALQTQELSEAIAAARHHQRSFVADRLGSGTAALCTFGTALN
PQFGPDSSAQHRRSGAIELTGPWPGLRCDVDTPADLAAARRLGIGAATTRVVAHL

Specific function: Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor

COG id: COG1920

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFC_MYCLB (B8ZS07)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503784.1
- ProteinModelPortal:   B8ZS07
- SMR:   B8ZS07
- EnsemblBacteria:   EBMYCT00000086078
- GeneID:   7324654
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017164
- HOGENOM:   HBG699055
- OMA:   LNADLPA
- ProtClustDB:   CLSK792205
- HAMAP:   MF_02114
- InterPro:   IPR002835
- TIGRFAMs:   TIGR03552

Pfam domain/function: PF01983 DUF121

EC number: =2.7.7.68

Molecular weight: Translated: 21982; Mature: 21851

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTRAGGTADVGLIIAVKRLAAAKTRLGPVFSTRTRENVVLAMLVDTLTAAAPVSALRS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHE
ITVITPDEAAAAAAAEFGAEILADPTPDGHGDPLNNAIAAAEHAIAGSFSNIVVLQGDLP
EEEECCCHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
ALQTQELSEAIAAARHHQRSFVADRLGSGTAALCTFGTALNPQFGPDSSAQHRRSGAIEL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCHHHHHCCCEEE
TGPWPGLRCDVDTPADLAAARRLGIGAATTRVVAHL
ECCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure 
SGTRAGGTADVGLIIAVKRLAAAKTRLGPVFSTRTRENVVLAMLVDTLTAAAPVSALRS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHE
ITVITPDEAAAAAAAEFGAEILADPTPDGHGDPLNNAIAAAEHAIAGSFSNIVVLQGDLP
EEEECCCHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
ALQTQELSEAIAAARHHQRSFVADRLGSGTAALCTFGTALNPQFGPDSSAQHRRSGAIEL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCHHHHHCCCEEE
TGPWPGLRCDVDTPADLAAARRLGIGAATTRVVAHL
ECCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA