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The map label for this gene is 221230333

Identifier: 221230333

GI number: 221230333

Start: 1947563

End: 1949353

Strand: Direct

Name: 221230333

Synonym: MLBr_01624

Alternate gene names: NA

Gene position: 1947563-1949353 (Clockwise)

Preceding gene: 221230332

Following gene: 221230340

Centisome position: 59.59

GC content: 61.7

Gene sequence:

>1791_bases
ATGACCCAATCGGATCACCGCCACACGCGGCCAAGCAGCTACGGGGGAACTGTGTTGACGCAACGGGTCAGCCAAGCCAC
TGTCGAAGACAGCCGACCGTTGCGGGGTTGGCAACGTCGAGCAATGGTAAAGTATTTGGCCAGCCAACCACGCGACTTCC
TGGCCGTTGCCACGCCTGGATCCGGGAAAACAACGTTCGCCCTACGGGTGATGACCGAACTGCTGAACAGTCACGCTGTC
GAGCAGGTTACCGTCGTTGTTCCCACCGAGCACCTCAAGGTTCAGTGGACCCGGGCCGCGGCAACCCACGGTCTGGCCCT
GGACCCGAAATTTTCCAACACCAACCCGCGGACCTCGCCGGAGTATCACGGCGTGACGATGACCTACGCTCAAGTCGCCG
CACATCCGACACTGCACCGGGTGCGCACCGAAGGTCGCAGAACCTTGGTGATCTTTGATGAGATCCATCATGGCGGTAAC
GCCAAGGCTTGGGGCGACGCTATCCGAGAAGCCTTCAGCGACGCGACGCGCCGACTTGCACTGACGGGCACGCCATTTCG
CAGCGACGACAAGCCAATTCCGTTCGTCACCTACGCACTCGACGCGGACGGGCTGATGCATTCACAGGCCGACCACACCT
ATAGCTACGCCGAAGGCCTTGCCGACGGCGTAGTCCGGCCGGTGGTGTTCCTTGTCTATTCTGGGCAGGCGCGTTGGCGA
AATAGTGCGGGTGAAGAACACGCGGCTCGACTGGGCGAGCCGCTGTCTGCGGAACAGACCGCGCGGGCGTGGCGGACCGC
GCTGGACCCCTCTGGGGAATGGATGCCGGCGGTCATCTCCGCGGCCGATCAACGACTGCGCCAGCTTCGTACGCATGTAC
CCGACGCCGGTGGCATGATCATCGCATCCGATCAGACCGCAGCCCGCGCGTACGCCAACCTGCTGGCGCAAATGACCTCA
GAAACGCCGACGTTGGTGTTGTCCGACGACCCGGGATCTTCGGCCCGCATCACCGAATTCGCCAAGAACACCAGTCAGTG
GCTAATCGCAGTCCGGATGGTCTCTGAGGGCGTCGACATACCTCGGTTGTCGGTGGGGATCTATGCCACCAGTGCCTCAA
CGCCGTTGTTCTTCGCACAGGCTATCGGCCGGTTCGTGCGGTCTCGTCATCCAGGAGAAACCGCAAGCATATTCGTCCCG
TCGGTGCCTAATCTGCTGCAGCTGGCCAGTGAGTTGGAGACCCAGCGCAACCATGTGCTGGGCAAACCGCACCGCGAATC
AACCGACAATCCCCTCGGGGGCAATCCCGCCACGATGACACAAACCGAGCAAGACGACACTGAGAAGTATTTCACCGCAA
TAGGAGCCGACGCCGAACTGGATCAGATCATTTTTGATGGATCATCGTTCGGCACCGCTACTCCTGCCGGGAGCGAGGAA
GAAGCCTACTACCTCGGTATCCCTGGGTTGCTGGATGCCGACCAGATGCGAGCGCTGCTGCACCGCCGCCAAAACGAGCA
GCTCCAAAAGCGGACCGCTGCACAACAAGCATCATCAACACCGGATAGGACCTCCGGGGCGCCGGCGTCTGTGCATGGCC
AACTCCGCGAGCTGCGCCGCGAACTCAACTCGCTAGTCTCAATAGCCCATCACCATACCGGCAAGCCGCACGGCTGGATC
CACAACGAACTTCGACGACGCTGCGGAGGACCGCCGATCGCCGCTGCTACCCACGATCAACTCAAAGCACGCATCGATGC
CGTGCGGCAGCTCAACGCCGAGCCGTCGTAA

Upstream 100 bases:

>100_bases
CACCTGACCGCACTGGCGTGTACCACTGTATCCATCGTACTTTCTGCTGTAACAGAACTAATGTGGCATAATGCGATAGC
ACGCACTGAAAACATGAGAA

Downstream 100 bases:

>100_bases
ACACGGATTTAGCTCACCGCTCATCGGCCGGAGCGCTCTGCGCAAGTGCCGTTCAACCCACCGTTCGCAGTGCTGCATCG
CCACCCCCGGTCAGGCTTGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MTQSDHRHTRPSSYGGTVLTQRVSQATVEDSRPLRGWQRRAMVKYLASQPRDFLAVATPGSGKTTFALRVMTELLNSHAV
EQVTVVVPTEHLKVQWTRAAATHGLALDPKFSNTNPRTSPEYHGVTMTYAQVAAHPTLHRVRTEGRRTLVIFDEIHHGGN
AKAWGDAIREAFSDATRRLALTGTPFRSDDKPIPFVTYALDADGLMHSQADHTYSYAEGLADGVVRPVVFLVYSGQARWR
NSAGEEHAARLGEPLSAEQTARAWRTALDPSGEWMPAVISAADQRLRQLRTHVPDAGGMIIASDQTAARAYANLLAQMTS
ETPTLVLSDDPGSSARITEFAKNTSQWLIAVRMVSEGVDIPRLSVGIYATSASTPLFFAQAIGRFVRSRHPGETASIFVP
SVPNLLQLASELETQRNHVLGKPHRESTDNPLGGNPATMTQTEQDDTEKYFTAIGADAELDQIIFDGSSFGTATPAGSEE
EAYYLGIPGLLDADQMRALLHRRQNEQLQKRTAAQQASSTPDRTSGAPASVHGQLRELRRELNSLVSIAHHHTGKPHGWI
HNELRRRCGGPPIAAATHDQLKARIDAVRQLNAEPS

Sequences:

>Translated_596_residues
MTQSDHRHTRPSSYGGTVLTQRVSQATVEDSRPLRGWQRRAMVKYLASQPRDFLAVATPGSGKTTFALRVMTELLNSHAV
EQVTVVVPTEHLKVQWTRAAATHGLALDPKFSNTNPRTSPEYHGVTMTYAQVAAHPTLHRVRTEGRRTLVIFDEIHHGGN
AKAWGDAIREAFSDATRRLALTGTPFRSDDKPIPFVTYALDADGLMHSQADHTYSYAEGLADGVVRPVVFLVYSGQARWR
NSAGEEHAARLGEPLSAEQTARAWRTALDPSGEWMPAVISAADQRLRQLRTHVPDAGGMIIASDQTAARAYANLLAQMTS
ETPTLVLSDDPGSSARITEFAKNTSQWLIAVRMVSEGVDIPRLSVGIYATSASTPLFFAQAIGRFVRSRHPGETASIFVP
SVPNLLQLASELETQRNHVLGKPHRESTDNPLGGNPATMTQTEQDDTEKYFTAIGADAELDQIIFDGSSFGTATPAGSEE
EAYYLGIPGLLDADQMRALLHRRQNEQLQKRTAAQQASSTPDRTSGAPASVHGQLRELRRELNSLVSIAHHHTGKPHGWI
HNELRRRCGGPPIAAATHDQLKARIDAVRQLNAEPS
>Mature_595_residues
TQSDHRHTRPSSYGGTVLTQRVSQATVEDSRPLRGWQRRAMVKYLASQPRDFLAVATPGSGKTTFALRVMTELLNSHAVE
QVTVVVPTEHLKVQWTRAAATHGLALDPKFSNTNPRTSPEYHGVTMTYAQVAAHPTLHRVRTEGRRTLVIFDEIHHGGNA
KAWGDAIREAFSDATRRLALTGTPFRSDDKPIPFVTYALDADGLMHSQADHTYSYAEGLADGVVRPVVFLVYSGQARWRN
SAGEEHAARLGEPLSAEQTARAWRTALDPSGEWMPAVISAADQRLRQLRTHVPDAGGMIIASDQTAARAYANLLAQMTSE
TPTLVLSDDPGSSARITEFAKNTSQWLIAVRMVSEGVDIPRLSVGIYATSASTPLFFAQAIGRFVRSRHPGETASIFVPS
VPNLLQLASELETQRNHVLGKPHRESTDNPLGGNPATMTQTEQDDTEKYFTAIGADAELDQIIFDGSSFGTATPAGSEEE
AYYLGIPGLLDADQMRALLHRRQNEQLQKRTAAQQASSTPDRTSGAPASVHGQLRELRRELNSLVSIAHHHTGKPHGWIH
NELRRRCGGPPIAAATHDQLKARIDAVRQLNAEPS

Specific function: Unknown

COG id: COG1061

COG function: function code KL; DNA or RNA helicases of superfamily II

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To M.tuberculosis Rv2917

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1624_MYCLE (O33011)

Other databases:

- EMBL:   Z97369
- EMBL:   AL583922
- PIR:   B87112
- RefSeq:   NP_302119.1
- ProteinModelPortal:   O33011
- EnsemblBacteria:   EBMYCT00000028350
- GeneID:   910814
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1624
- NMPDR:   fig|272631.1.peg.991
- Leproma:   ML1624
- GeneTree:   EBGT00070000032301
- HOGENOM:   HBG322463
- OMA:   VVAPTEH
- ProtClustDB:   CLSK872122
- BioCyc:   MLEP272631:ML1624-MONOMER
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- SMART:   SM00487

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII

EC number: NA

Molecular weight: Translated: 65208; Mature: 65076

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSDHRHTRPSSYGGTVLTQRVSQATVEDSRPLRGWQRRAMVKYLASQPRDFLAVATPG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
SGKTTFALRVMTELLNSHAVEQVTVVVPTEHLKVQWTRAAATHGLALDPKFSNTNPRTSP
CCCHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEEHHHCCCCCEECCCCCCCCCCCCC
EYHGVTMTYAQVAAHPTLHRVRTEGRRTLVIFDEIHHGGNAKAWGDAIREAFSDATRRLA
CCCCEEEHHHHHHHCCHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEE
LTGTPFRSDDKPIPFVTYALDADGLMHSQADHTYSYAEGLADGVVRPVVFLVYSGQARWR
EECCCCCCCCCCCCEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHHC
NSAGEEHAARLGEPLSAEQTARAWRTALDPSGEWMPAVISAADQRLRQLRTHVPDAGGMI
CCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
IASDQTAARAYANLLAQMTSETPTLVLSDDPGSSARITEFAKNTSQWLIAVRMVSEGVDI
EECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHCCCCC
PRLSVGIYATSASTPLFFAQAIGRFVRSRHPGETASIFVPSVPNLLQLASELETQRNHVL
CEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCC
GKPHRESTDNPLGGNPATMTQTEQDDTEKYFTAIGADAELDQIIFDGSSFGTATPAGSEE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCC
EAYYLGIPGLLDADQMRALLHRRQNEQLQKRTAAQQASSTPDRTSGAPASVHGQLRELRR
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ELNSLVSIAHHHTGKPHGWIHNELRRRCGGPPIAAATHDQLKARIDAVRQLNAEPS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQSDHRHTRPSSYGGTVLTQRVSQATVEDSRPLRGWQRRAMVKYLASQPRDFLAVATPG
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
SGKTTFALRVMTELLNSHAVEQVTVVVPTEHLKVQWTRAAATHGLALDPKFSNTNPRTSP
CCCHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEEHHHCCCCCEECCCCCCCCCCCCC
EYHGVTMTYAQVAAHPTLHRVRTEGRRTLVIFDEIHHGGNAKAWGDAIREAFSDATRRLA
CCCCEEEHHHHHHHCCHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEE
LTGTPFRSDDKPIPFVTYALDADGLMHSQADHTYSYAEGLADGVVRPVVFLVYSGQARWR
EECCCCCCCCCCCCEEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHHC
NSAGEEHAARLGEPLSAEQTARAWRTALDPSGEWMPAVISAADQRLRQLRTHVPDAGGMI
CCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
IASDQTAARAYANLLAQMTSETPTLVLSDDPGSSARITEFAKNTSQWLIAVRMVSEGVDI
EECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHCCCCC
PRLSVGIYATSASTPLFFAQAIGRFVRSRHPGETASIFVPSVPNLLQLASELETQRNHVL
CEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCC
GKPHRESTDNPLGGNPATMTQTEQDDTEKYFTAIGADAELDQIIFDGSSFGTATPAGSEE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCCC
EAYYLGIPGLLDADQMRALLHRRQNEQLQKRTAAQQASSTPDRTSGAPASVHGQLRELRR
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ELNSLVSIAHHHTGKPHGWIHNELRRRCGGPPIAAATHDQLKARIDAVRQLNAEPS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002