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The map label for this gene is obgE

Identifier: 221230244

GI number: 221230244

Start: 1762600

End: 1764039

Strand: Reverse

Name: obgE

Synonym: MLBr_01465

Alternate gene names: 221230244

Gene position: 1764039-1762600 (Counterclockwise)

Preceding gene: 221230245

Following gene: 221230243

Centisome position: 53.98

GC content: 61.74

Gene sequence:

>1440_bases
ATGCCTCGGTTTGTCGATCGCGTCGTCATCCACACCTGGGCGGGTTCTGGCGGTAACGGCTGCGCTTCGATTCATCGCTC
AAAGTTCAAGCCGTTAGGTGGCCCTGATGGTGGCAATGGTGGCCGTGGCGGCAGCGTGGTCTTCGTCGTCGACCCTCATG
TGCACACCTTGTTGGACTTTCATTTCCGACCGCACATCACCGCGCCATCCGGCAAACAGGGTATGGGCAACAACCGTGAC
GGTGCAGCCGGCGCGGATCTGGAAGTCAAAGTCCCCGACGGCACCGTCGTCCTGGACGAAGACGGTCGGTTGCTAGCTGA
TCTGGTAGGCGCGGGCACTCGTTTCCAAGCCGCCGCTGGCGGTCGCGGCGGCTTGGGCAATGCAGCGCTCGCGTCGCGTA
CCCGCAAGGTGCCCGGCTTCGCACTGCTCGGTGAACAAGGCGAGTCTCGTGATCTCACCCTGGAGCTCAAGAGCGTTGCC
GATGTCGGTTTGATCGGGTTTCCTTCGGCCGGAAAGTCGTCCCTTGTGTCCGTGATCTCGGCGGCCAAACCCAAGATTGC
CGACTACCCGTTCACTACGCTTGTTCCCAATCTCGGCGTGGTCTCGGTCGGCGAACACGCGTTCACCGTCGCTGATGTGC
CTGGTTTAATCCCGGGAGCTTCGGCGGGGCGCGGCCTGGGTCTGGACTTTTTACGGCATATCGAGCGGTGCGCGGTGCTG
GTGCACGTGGTGGATTGTACGAGTGTAGAACCGGGGCGTGATCCGATCTTGGACATCGCCGCGCTGGAGGCCGAACTCGC
AGCTTATACCCCGACACTGCAAGGAGATACGACTTTGGGTGACTTTGCTGAGCGGCCCCGTGCGGTGGTGCTCAACAAAA
TCGATGTGCCGGACGCCCGCGAGCTCGCTGAATTCGTTTGCGACAACATTGCTGCCGAGCGCGGTTGGCCGGTGTTTAGT
GTGTCGACGGTCACTCGAGAAAACCTGCAGTCATTGATTTTCGGGCTGTGGCAGATGATCTCAGCGTACCACGCCGCGAG
GTCGGAGCCGGCGCCGGGACGGTCGCTGATTCGTCCGGTGCCTGTCGATGACAGCGGCTTTACCGTTGAACCGGACGGAC
AGGGCGGCTTTGTGGTTACCGGTACGCGACCCGAACGTTGGATTCATCAGACCAACTTCGATAACGCCGAAGCGGTCGGC
TATCTCGCCGACCGGCTGGCACGCCTCGGGGTAGAGGACGAACTGCTGCGGGTGGGTGCACAGCCGGGGTGTACAGTAAG
CATTGGTGGGATGACGTTCGATTGGGAGCCACAAAAGCCTGCGGGCCATCCGGTCGCAATGTCAGGCCGGGGTACCGACG
CGAGGTTGGAAAGTACCGACCCCGTTGGTACCGCTGAACGCAAGGTTGCGCGGCATCAGCGTCACAAACACGGTGGATGA

Upstream 100 bases:

>100_bases
CCTTCGCGCGAAATCGGTGTTTTGCAGGTAGTCATTCACGCGTTTTTTGCAAAACGTAGATTTCGGCACATGTGTTCGTT
GGCGGGTGAGAGGACCCCCG

Downstream 100 bases:

>100_bases
GCCGTGAGTGTACATCGCGACGCGATCAGAGCTGCTCGGAGTTTGGTCGTCAAGGTTGGGACTAACGCGCTCACCACATC
ATCCGGAGTATTCGATTCTA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MPRFVDRVVIHTWAGSGGNGCASIHRSKFKPLGGPDGGNGGRGGSVVFVVDPHVHTLLDFHFRPHITAPSGKQGMGNNRD
GAAGADLEVKVPDGTVVLDEDGRLLADLVGAGTRFQAAAGGRGGLGNAALASRTRKVPGFALLGEQGESRDLTLELKSVA
DVGLIGFPSAGKSSLVSVISAAKPKIADYPFTTLVPNLGVVSVGEHAFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
VHVVDCTSVEPGRDPILDIAALEAELAAYTPTLQGDTTLGDFAERPRAVVLNKIDVPDARELAEFVCDNIAAERGWPVFS
VSTVTRENLQSLIFGLWQMISAYHAARSEPAPGRSLIRPVPVDDSGFTVEPDGQGGFVVTGTRPERWIHQTNFDNAEAVG
YLADRLARLGVEDELLRVGAQPGCTVSIGGMTFDWEPQKPAGHPVAMSGRGTDARLESTDPVGTAERKVARHQRHKHGG

Sequences:

>Translated_479_residues
MPRFVDRVVIHTWAGSGGNGCASIHRSKFKPLGGPDGGNGGRGGSVVFVVDPHVHTLLDFHFRPHITAPSGKQGMGNNRD
GAAGADLEVKVPDGTVVLDEDGRLLADLVGAGTRFQAAAGGRGGLGNAALASRTRKVPGFALLGEQGESRDLTLELKSVA
DVGLIGFPSAGKSSLVSVISAAKPKIADYPFTTLVPNLGVVSVGEHAFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
VHVVDCTSVEPGRDPILDIAALEAELAAYTPTLQGDTTLGDFAERPRAVVLNKIDVPDARELAEFVCDNIAAERGWPVFS
VSTVTRENLQSLIFGLWQMISAYHAARSEPAPGRSLIRPVPVDDSGFTVEPDGQGGFVVTGTRPERWIHQTNFDNAEAVG
YLADRLARLGVEDELLRVGAQPGCTVSIGGMTFDWEPQKPAGHPVAMSGRGTDARLESTDPVGTAERKVARHQRHKHGG
>Mature_478_residues
PRFVDRVVIHTWAGSGGNGCASIHRSKFKPLGGPDGGNGGRGGSVVFVVDPHVHTLLDFHFRPHITAPSGKQGMGNNRDG
AAGADLEVKVPDGTVVLDEDGRLLADLVGAGTRFQAAAGGRGGLGNAALASRTRKVPGFALLGEQGESRDLTLELKSVAD
VGLIGFPSAGKSSLVSVISAAKPKIADYPFTTLVPNLGVVSVGEHAFTVADVPGLIPGASAGRGLGLDFLRHIERCAVLV
HVVDCTSVEPGRDPILDIAALEAELAAYTPTLQGDTTLGDFAERPRAVVLNKIDVPDARELAEFVCDNIAAERGWPVFSV
STVTRENLQSLIFGLWQMISAYHAARSEPAPGRSLIRPVPVDDSGFTVEPDGQGGFVVTGTRPERWIHQTNFDNAEAVGY
LADRLARLGVEDELLRVGAQPGCTVSIGGMTFDWEPQKPAGHPVAMSGRGTDARLESTDPVGTAERKVARHQRHKHGG

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=356, Percent_Identity=41.2921348314607, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI111955139, Length=307, Percent_Identity=36.4820846905537, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI111955063, Length=141, Percent_Identity=42.5531914893617, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI58761500, Length=128, Percent_Identity=32.8125, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789574, Length=353, Percent_Identity=41.643059490085, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=32.03125, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=338, Percent_Identity=38.4615384615385, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17552324, Length=318, Percent_Identity=32.0754716981132, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17509631, Length=130, Percent_Identity=33.0769230769231, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321962, Length=193, Percent_Identity=38.3419689119171, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321612, Length=107, Percent_Identity=40.1869158878505, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319281, Length=90, Percent_Identity=38.8888888888889, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=30.4964539007092, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129375, Length=331, Percent_Identity=37.7643504531722, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24585318, Length=243, Percent_Identity=38.6831275720165, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24640873, Length=128, Percent_Identity=32.03125, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640877, Length=128, Percent_Identity=32.03125, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640875, Length=128, Percent_Identity=32.03125, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_MYCLB (B8ZRN3)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503660.1
- ProteinModelPortal:   B8ZRN3
- SMR:   B8ZRN3
- EnsemblBacteria:   EBMYCT00000085499
- GeneID:   7325009
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000015858
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12296
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 50366; Mature: 50235

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFVDRVVIHTWAGSGGNGCASIHRSKFKPLGGPDGGNGGRGGSVVFVVDPHVHTLLDF
CCHHHCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
HFRPHITAPSGKQGMGNNRDGAAGADLEVKVPDGTVVLDEDGRLLADLVGAGTRFQAAAG
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHCCCCEEEECCC
GRGGLGNAALASRTRKVPGFALLGEQGESRDLTLELKSVADVGLIGFPSAGKSSLVSVIS
CCCCCCCHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSVGEHAFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVVDCTSVEPGRDPILDIAALEAELAAYTPTLQGDTTLGDFAERPRAVVLNKIDVPDAR
HEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEECCCCCHH
ELAEFVCDNIAAERGWPVFSVSTVTRENLQSLIFGLWQMISAYHAARSEPAPGRSLIRPV
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECC
PVDDSGFTVEPDGQGGFVVTGTRPERWIHQTNFDNAEAVGYLADRLARLGVEDELLRVGA
CCCCCCCEECCCCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCC
QPGCTVSIGGMTFDWEPQKPAGHPVAMSGRGTDARLESTDPVGTAERKVARHQRHKHGG
CCCCEEEECCEEEECCCCCCCCCCEEECCCCCCCEECCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PRFVDRVVIHTWAGSGGNGCASIHRSKFKPLGGPDGGNGGRGGSVVFVVDPHVHTLLDF
CHHHCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
HFRPHITAPSGKQGMGNNRDGAAGADLEVKVPDGTVVLDEDGRLLADLVGAGTRFQAAAG
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHCCCCEEEECCC
GRGGLGNAALASRTRKVPGFALLGEQGESRDLTLELKSVADVGLIGFPSAGKSSLVSVIS
CCCCCCCHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHH
AAKPKIADYPFTTLVPNLGVVSVGEHAFTVADVPGLIPGASAGRGLGLDFLRHIERCAVL
HCCCCCCCCCHHHHCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
VHVVDCTSVEPGRDPILDIAALEAELAAYTPTLQGDTTLGDFAERPRAVVLNKIDVPDAR
HEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEEECCCCCHH
ELAEFVCDNIAAERGWPVFSVSTVTRENLQSLIFGLWQMISAYHAARSEPAPGRSLIRPV
HHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECC
PVDDSGFTVEPDGQGGFVVTGTRPERWIHQTNFDNAEAVGYLADRLARLGVEDELLRVGA
CCCCCCCEECCCCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCC
QPGCTVSIGGMTFDWEPQKPAGHPVAMSGRGTDARLESTDPVGTAERKVARHQRHKHGG
CCCCEEEECCEEEECCCCCCCCCCEEECCCCCCCEECCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA