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The map label for this gene is argH

Identifier: 221230220

GI number: 221230220

Start: 1694817

End: 1696229

Strand: Direct

Name: argH

Synonym: MLBr_01413

Alternate gene names: 221230220

Gene position: 1694817-1696229 (Clockwise)

Preceding gene: 221230219

Following gene: 221230221

Centisome position: 51.86

GC content: 62.7

Gene sequence:

>1413_bases
ATGAGCACCAATCAGGGTTCGCTGTGGGGCGGGCGGTTCGCAGCCGGCCCTTCAGAGGCTCTGGTCGCGCTGAGCAAGTC
GACCCACTTCGACTGGGTGCTGGCTCCTTACGACATAACCGCGTCCCGGGCGCACACGAAAATGTTATTCCGAGCCGGAC
TGCTCAATGAAGAGCAACGCGACGGGTTGTTAGCGGGATTGGACAACCTCGCCGAGGACGTTGCCGACGGCAGTTTCCTA
CCACTGGTCACCGATGAGGACGTGCACGCTGCGTTGGAACGCGGACTGATCGATCGGGTCGGCCCTGACCTAGGCGGCCG
GCTGCGAGCCGGCCGGTCACGCAACGATCAGGTGGCCACGCTGTTCCGGATGTGGCTACGCGACGCAGTGCGGCGAGTCG
CTGCCGGCGCACTCGAGGTCGTCGATGCGCTGGCCAACCAAGCGGCCGAGCACTCGAGCACCATCATGCCTGGTAAGACC
CACCTGCAGTCTGCCCAGCCGATCCTGCTGGCACACCATTTGTTGGCACACGCTCATCCGTTGCTGCGTGATGTGGGCCG
GATTGTCGACTTCGACAAACGGGCCGCAGTGTCTCCGTATGGTTCGGGAGCATTGGCTGGCTCGTCGTTAGGCCTGGACC
CGGACGCGATGGCCCAGGACCTGGGGTTCCCGGCTGCAGCCGACAATTCCGTCGACGCGACCGCCGCTCGCGATTTTGCA
GCCGAGGCAGCGTTCGTCTTCGCCATGATCGCCGTCGACCTGTCGCGGCTCGCCGAAGACATCATTTTGTGGAGTTCGAC
CGAATTCGGCTATGCCAGGCTACATGATTCGTGGTCTACCGGAAGCTCGATAATGCCTCAGAAAAAGAATCCGGACATCG
CCGAACTGGCTCGCGGAAAGTCCGGGCGACTGATCGGAAACTTGGCTGGGTTGCTGGCGACACTGAAAGCTCAACCGCTC
GCCTACAACCGCGACCTGCAAGAAGACAAGGAGCCAGTGTTCGATTCGGTGGCCCAGCTGGAGCTGCTGCTTCCGGCGAT
GGCTGGTCTGGTAGCCAGCTTAACGTTCAACGTCGAGCGGATGGCTGCCCTAGCTCCTGCTGGCTATACACTGGCCACCG
ACATCGCTGAATGGCTTGTGCGCCAAGGTGTTCCCTTTCGATCCGCACATGAGGCCGCGGGTACCGCGGTGCGGGTGGCT
GAGGGTCGCGGCGTCGGACTTGAGGAACTGACCGACGACGAACTGGCTGCCATCAGCGCCAACTTGACGCCGCAGGTCCG
CGAGGTGCTAACAGTCGAGGGCTCGGTGTCGTCGCGAGCGGCTCGTGGTGGTACCGCGCCTAGTCAAGCAGCCAAGCAAC
TGACTGTGGTCCGCGCGAACGCAAACCAGTTGCGCCAACTCTTGATGCGCTAG

Upstream 100 bases:

>100_bases
AGCTCGCGGCACGTAGGGACTTACGGTGAGGTAAGAGTGTGATATTGAGCGCCCCGACAAGGCGTCGTCAGATCCACACT
TGGGGTGAAATGACAGGCCA

Downstream 100 bases:

>100_bases
AGCTGCACCCTCGTGCCAGTACAATATTGACCAGCGCATGTTAAAATAAACCGGCAGACGTGCTACTGCGATCGCAAATA
TAATCCGGCTCATTGGAGTG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSTNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLFRAGLLNEEQRDGLLAGLDNLAEDVADGSFL
PLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALEVVDALANQAAEHSSTIMPGKT
HLQSAQPILLAHHLLAHAHPLLRDVGRIVDFDKRAAVSPYGSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFA
AEAAFVFAMIAVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPL
AYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVERMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVA
EGRGVGLEELTDDELAAISANLTPQVREVLTVEGSVSSRAARGGTAPSQAAKQLTVVRANANQLRQLLMR

Sequences:

>Translated_470_residues
MSTNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLFRAGLLNEEQRDGLLAGLDNLAEDVADGSFL
PLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALEVVDALANQAAEHSSTIMPGKT
HLQSAQPILLAHHLLAHAHPLLRDVGRIVDFDKRAAVSPYGSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFA
AEAAFVFAMIAVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPL
AYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVERMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVA
EGRGVGLEELTDDELAAISANLTPQVREVLTVEGSVSSRAARGGTAPSQAAKQLTVVRANANQLRQLLMR
>Mature_469_residues
STNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLFRAGLLNEEQRDGLLAGLDNLAEDVADGSFLP
LVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALEVVDALANQAAEHSSTIMPGKTH
LQSAQPILLAHHLLAHAHPLLRDVGRIVDFDKRAAVSPYGSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFAA
EAAFVFAMIAVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLA
YNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVERMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVAE
GRGVGLEELTDDELAAISANLTPQVREVLTVEGSVSSRAARGGTAPSQAAKQLTVVRANANQLRQLLMR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=460, Percent_Identity=43.695652173913, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI68303542, Length=460, Percent_Identity=43.695652173913, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI68303549, Length=460, Percent_Identity=41.304347826087, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI68303547, Length=460, Percent_Identity=40.8695652173913, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=41.4096916299559, Blast_Score=324, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6321806, Length=464, Percent_Identity=39.4396551724138, Blast_Score=328, Evalue=8e-91,
Organism=Drosophila melanogaster, GI221473854, Length=458, Percent_Identity=41.4847161572052, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI78706858, Length=458, Percent_Identity=41.4847161572052, Blast_Score=340, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_MYCLB (B8ZRK9)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503636.1
- ProteinModelPortal:   B8ZRK9
- SMR:   B8ZRK9
- EnsemblBacteria:   EBMYCT00000085889
- GeneID:   7327221
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016253
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 49937; Mature: 49806

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLFRAGLLNEEQR
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHH
DGLLAGLDNLAEDVADGSFLPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAT
CHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LFRMWLRDAVRRVAAGALEVVDALANQAAEHSSTIMPGKTHLQSAQPILLAHHLLAHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
LLRDVGRIVDFDKRAAVSPYGSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
AEAAFVFAMIAVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHCCC
SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVER
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVAEGRGVGLEELTDDELAAISA
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCCHHHCCCHHHHHHCC
NLTPQVREVLTVEGSVSSRAARGGTAPSQAAKQLTVVRANANQLRQLLMR
CCCHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHEEEECCHHHHHHHHCC
>Mature Secondary Structure 
STNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLFRAGLLNEEQR
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHH
DGLLAGLDNLAEDVADGSFLPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAT
CHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LFRMWLRDAVRRVAAGALEVVDALANQAAEHSSTIMPGKTHLQSAQPILLAHHLLAHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
LLRDVGRIVDFDKRAAVSPYGSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHH
AEAAFVFAMIAVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHCCC
SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLVASLTFNVER
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVAEGRGVGLEELTDDELAAISA
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCCHHHCCCHHHHHHCC
NLTPQVREVLTVEGSVSSRAARGGTAPSQAAKQLTVVRANANQLRQLLMR
CCCHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA