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The map label for this gene is 221230057

Identifier: 221230057

GI number: 221230057

Start: 1338927

End: 1339502

Strand: Reverse

Name: 221230057

Synonym: MLBr_01149

Alternate gene names: NA

Gene position: 1339502-1338927 (Counterclockwise)

Preceding gene: 221230059

Following gene: 221230056

Centisome position: 40.99

GC content: 55.9

Gene sequence:

>576_bases
ATGGCAATACATCTGACCCGCATCTACACACGCACTGGCGACAACGGGACGACGGGGTTGAGCGATTTCTCACGAGTCGC
GAAAACCGATCTCCGCCTCGTGGCGTACGCGGATTGCGACGAAACCAACTCCGCGATCGGCGTCGCACTTGCCCTGGGAA
ATCCCGACCAAAAAATCACTGACGTACTGCAACAGATCCAAAATGACTTATTCGACGCTGGCGCAGACCTGTCCACCCCC
ATGCAAGACTCGGTGAGAAATCCCGAATATCCCCAGCTAAGGATCACCCAGACACACATTGATCGGCTTGAAGAGTGGTG
CGACACATACAACACACCGTTACCAACACTGAACTCATTTGTGCTACCAGGTGGTTCGCCGTTGTCAGCGCTACTACACG
TCGCTCGTACCGTGGCGCGTCGAGCCGAACGATCAGCGTGGGCAGCTGTCGAAGCTCACCCGGGGGTGGTCAGTATGTTA
CCCGCGAAATACCTGAACCGACTCTCAGATCTGCTCTTTATCCTGTCACGGGTGGCTAATACAGGCAATGATGTGCTGTG
GCGACCAGGCGGCTGA

Upstream 100 bases:

>100_bases
AGCGGTATCGGCTTGTCAGTCAACTAGCTTGGCTTCTCCTCACTCCGCTGAGCGGAGTGAGGAGAAGCCAAGCTAGTTGA
CTTTAGTACCGTGTTTGGTC

Downstream 100 bases:

>100_bases
TGGCAAAAGCTGTAGTAACACAGGAGAATTACCATGAAAAACAATCGTCCGATTCTTCCGGCGACCGTTATGCCGCACTC
GCCTACCCGGACACACACAC

Product: hypothetical protein

Products: NA

Alternate protein names: Cob(I)alamin adenosyltransferase

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MAIHLTRIYTRTGDNGTTGLSDFSRVAKTDLRLVAYADCDETNSAIGVALALGNPDQKITDVLQQIQNDLFDAGADLSTP
MQDSVRNPEYPQLRITQTHIDRLEEWCDTYNTPLPTLNSFVLPGGSPLSALLHVARTVARRAERSAWAAVEAHPGVVSML
PAKYLNRLSDLLFILSRVANTGNDVLWRPGG

Sequences:

>Translated_191_residues
MAIHLTRIYTRTGDNGTTGLSDFSRVAKTDLRLVAYADCDETNSAIGVALALGNPDQKITDVLQQIQNDLFDAGADLSTP
MQDSVRNPEYPQLRITQTHIDRLEEWCDTYNTPLPTLNSFVLPGGSPLSALLHVARTVARRAERSAWAAVEAHPGVVSML
PAKYLNRLSDLLFILSRVANTGNDVLWRPGG
>Mature_190_residues
AIHLTRIYTRTGDNGTTGLSDFSRVAKTDLRLVAYADCDETNSAIGVALALGNPDQKITDVLQQIQNDLFDAGADLSTPM
QDSVRNPEYPQLRITQTHIDRLEEWCDTYNTPLPTLNSFVLPGGSPLSALLHVARTVARRAERSAWAAVEAHPGVVSMLP
AKYLNRLSDLLFILSRVANTGNDVLWRPGG

Specific function: Unknown

COG id: COG2096

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Cob(I)alamin adenosyltransferase family

Homologues:

Organism=Homo sapiens, GI16418349, Length=177, Percent_Identity=39.5480225988701, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115534154, Length=180, Percent_Identity=35, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDUO_MYCLE (P53523)

Other databases:

- EMBL:   U15186
- EMBL:   AL583920
- PIR:   T09970
- RefSeq:   NP_301843.1
- ProteinModelPortal:   P53523
- SMR:   P53523
- EnsemblBacteria:   EBMYCT00000028511
- GeneID:   910243
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1149
- NMPDR:   fig|272631.1.peg.715
- Leproma:   ML1149
- GeneTree:   EBGT00050000014642
- HOGENOM:   HBG645545
- OMA:   LEPLRSF
- ProtClustDB:   CLSK2517959
- BioCyc:   MLEP272631:ML1149-MONOMER
- GO:   GO:0005737
- InterPro:   IPR017858
- InterPro:   IPR002779
- InterPro:   IPR016030
- Gene3D:   G3DSA:1.20.1200.10
- PANTHER:   PTHR12213
- ProDom:   PD007457
- TIGRFAMs:   TIGR00636

Pfam domain/function: PF01923 Cob_adeno_trans; SSF89028 AdoCbl_synth_CblAdoTrfase-like

EC number: =2.5.1.17

Molecular weight: Translated: 20916; Mature: 20785

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: BINDING 28-28 BINDING 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHLTRIYTRTGDNGTTGLSDFSRVAKTDLRLVAYADCDETNSAIGVALALGNPDQKIT
CEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEECCCCHHHH
DVLQQIQNDLFDAGADLSTPMQDSVRNPEYPQLRITQTHIDRLEEWCDTYNTPLPTLNSF
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCE
VLPGGSPLSALLHVARTVARRAERSAWAAVEAHPGVVSMLPAKYLNRLSDLLFILSRVAN
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
TGNDVLWRPGG
CCCCEEECCCC
>Mature Secondary Structure 
AIHLTRIYTRTGDNGTTGLSDFSRVAKTDLRLVAYADCDETNSAIGVALALGNPDQKIT
EEEEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEECCCCHHHH
DVLQQIQNDLFDAGADLSTPMQDSVRNPEYPQLRITQTHIDRLEEWCDTYNTPLPTLNSF
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCE
VLPGGSPLSALLHVARTVARRAERSAWAAVEAHPGVVSMLPAKYLNRLSDLLFILSRVAN
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
TGNDVLWRPGG
CCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002