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The map label for this gene is glcD [H]

Identifier: 221230021

GI number: 221230021

Start: 1276498

End: 1277859

Strand: Reverse

Name: glcD [H]

Synonym: MLBr_01103

Alternate gene names: 221230021

Gene position: 1277859-1276498 (Counterclockwise)

Preceding gene: 221230024

Following gene: 221230019

Centisome position: 39.1

GC content: 62.7

Gene sequence:

>1362_bases
GTGGGTGTTCTGACCAGCCTTATCGCCGGTCTGCCCGACGGGATGGTAGTCACTGATTCGGCCGTCACCGACGGCTACCG
GCATGACCGCGCCTTGGACCCGTCGGCAGGCAAACCGCTGGCCGTGGTTCAGCCACGACGCACTGACGAGGTGCAGACCG
TATTACGCTGGGCCAGCGCTAACCGGGTGCCGGTGGTGGCCCGGGGAGCCGGCAGCGGCCTGTCGGGCGGCGCTACTGCA
CTGGATGACGGGATCGTGCTGTCGACGGAAAAGATGCGCGACATCACGGTAGATCCAGTCACCCGCACCGCGGTTTGTCA
GCCCGGCCTGTTCAACGCGGAGGTAAAGAAGGCTGCCGCCGAACACGGGCTGTGGTATCCACCCGATCCGTCGTCGTTCG
AGATATGCAGCATTGGTGGCAACGTCGCCACCAATGCCGGCGGACTGTGCTGTGTGAAGTACGGCGTCACAGGCGACTAT
GTGCTGGGCATCCAGGTGGTGTTGGCCGACGGCACCGCGGTTCGGTTAGGTGGTCCGCGGCTCAAGGACGTTGCAGGACT
GAGCCTAACAAAGCTCTTCGTTGGCAGCGAAGGCACGCTGGGCATCATCACGGAAGTGACGCTGCGGCTGTTGCCCACCC
AAAACACGTCAAGCATCGTGGTGGCCACCTTCGCTTCGGTCCAGGCAGCTGTCGATGCAGTGTTGGGAGTCGCTGCTCGT
CTGCGTCCCGCAATGCTCGAATTTATGGATTCGGTGGCAATCAATGCCGTCGAGGACACCTTCCGAATGGGCCTGGACCG
CGAGGCAGCCGCCATGCTAGTGGCAGGCTCCGACGAACTTGGGCACGCAGGCACCGACGAAGCCAAACTGATCGGGGCTG
TGTTTGCCGAAAACGGTGCAACACAAGTATCGTCCACGAACGATCCAGACGAGGGCGAGGCGTTTGTTGCCGCCCGACGG
TTTTGCATTCCGGCGGTCGAAAGCAAGGGCTCACTGTTGCTCGAAGACGTCGGAGTGCCGCTGCCGGCGCTGGGCAAGTT
AGTTACTGGGATCGCTCACATCTCCACCGAGCGCAACCTGATGATTTCGGTGATCGCGCATGCCGGTGACGGCAACACCC
ACCCGCTGATCGTGTACAACCCCGCCGATGCCACGATGACGGAACGCGCCCATCGCGCGTTCGGAGAAATCATGGACATG
GCCGTCGGCCTCGGTGGCACCATCACCGGTGAGCACGGCGTCGGCCGGTTGAAACGACCATGGCTGGACGACTATCTCGG
GCCCGACGTGATGGAGCTAAACCAGCGCATCAAGCACGCATTGGACCCCTATGGCATCCTGAATCCCGGCGCGGCGATCT
GA

Upstream 100 bases:

>100_bases
TCCGTGTTAATCAGGCTTGTCTGTGTCAGGTGGCCGTAGCTGCGCGAGCTAGACCACGCACCAGAGTTGGTCGTCGATCC
CGGCCCCGTAGGATCGAAGC

Downstream 100 bases:

>100_bases
CCTGCGCGTGATGTCTCACAGGTTCCGGTTCACCACTGCCGACATCTGGCCCAATCCCTGGTCGATGTACCGAACCCTAC
GAGACCACGAGGCGGTGCAC

Product: putative oxidoreductase subunit

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRWASANRVPVVARGAGSGLSGGATA
LDDGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDY
VLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR
LRPAMLEFMDSVAINAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGATQVSSTNDPDEGEAFVAARR
FCIPAVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMDM
AVGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKHALDPYGILNPGAAI

Sequences:

>Translated_453_residues
MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRWASANRVPVVARGAGSGLSGGATA
LDDGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDY
VLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR
LRPAMLEFMDSVAINAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGATQVSSTNDPDEGEAFVAARR
FCIPAVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMDM
AVGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKHALDPYGILNPGAAI
>Mature_452_residues
GVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRWASANRVPVVARGAGSGLSGGATAL
DDGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDYV
LGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAARL
RPAMLEFMDSVAINAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGATQVSSTNDPDEGEAFVAARRF
CIPAVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMDMA
VGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKHALDPYGILNPGAAI

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=429, Percent_Identity=32.8671328671329, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI37595754, Length=452, Percent_Identity=31.4159292035398, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI119964728, Length=420, Percent_Identity=31.1904761904762, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501993, Length=220, Percent_Identity=29.0909090909091, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789351, Length=419, Percent_Identity=39.8568019093079, Blast_Score=278, Evalue=7e-76,
Organism=Escherichia coli, GI1787977, Length=491, Percent_Identity=23.2179226069246, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI48994907, Length=176, Percent_Identity=33.5227272727273, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI48994914, Length=194, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=473, Percent_Identity=32.5581395348837, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71992381, Length=473, Percent_Identity=31.5010570824524, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=33.3333333333333, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534361, Length=422, Percent_Identity=28.1990521327014, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17556096, Length=239, Percent_Identity=26.7782426778243, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320027, Length=450, Percent_Identity=28.8888888888889, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320023, Length=449, Percent_Identity=27.3942093541203, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6320764, Length=445, Percent_Identity=26.0674157303371, Blast_Score=122, Evalue=9e-29,
Organism=Drosophila melanogaster, GI18921117, Length=430, Percent_Identity=28.6046511627907, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24639277, Length=430, Percent_Identity=28.6046511627907, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24639275, Length=430, Percent_Identity=28.6046511627907, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24653753, Length=220, Percent_Identity=30.9090909090909, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 47105; Mature: 46974

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRWASA
CCHHHHHHHCCCCCEEEECCHHCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCC
NRVPVVARGAGSGLSGGATALDDGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAA
CCCEEEEECCCCCCCCCCCCCCCCEEEECHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHH
EHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDYVLGIQVVLADGTAVRLGGPR
HCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCEEEECCCC
LKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR
HHHHCCCEEEEEEECCCCCEEHHEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHH
LRPAMLEFMDSVAINAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
TQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNL
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCE
MISVIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMDMAVGLGGTITGEHGVGRLKRP
EEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
WLDDYLGPDVMELNQRIKHALDPYGILNPGAAI
CHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRWASA
CHHHHHHHCCCCCEEEECCHHCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCC
NRVPVVARGAGSGLSGGATALDDGIVLSTEKMRDITVDPVTRTAVCQPGLFNAEVKKAAA
CCCEEEEECCCCCCCCCCCCCCCCEEEECHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHH
EHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGVTGDYVLGIQVVLADGTAVRLGGPR
HCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCEEEECCCC
LKDVAGLSLTKLFVGSEGTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR
HHHHCCCEEEEEEECCCCCEEHHEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHH
LRPAMLEFMDSVAINAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENGA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
TQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNL
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCE
MISVIAHAGDGNTHPLIVYNPADATMTERAHRAFGEIMDMAVGLGGTITGEHGVGRLKRP
EEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
WLDDYLGPDVMELNQRIKHALDPYGILNPGAAI
CHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]