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The map label for this gene is murC

Identifier: 221229912

GI number: 221229912

Start: 1084564

End: 1086051

Strand: Direct

Name: murC

Synonym: MLBr_00915

Alternate gene names: 221229912

Gene position: 1084564-1086051 (Clockwise)

Preceding gene: 221229911

Following gene: 221229913

Centisome position: 33.19

GC content: 62.84

Gene sequence:

>1488_bases
GTGAACGCCGGCCAGTTGCCGCCCGAGTTGCAGCGGGTGCACATGGTGGGCATTGGGGGATCCGGGATGTCGGGTATTGC
GCGCATCCTGTTAGACCGGGGCGGTCTGGTGTCTGGCTCAGATGCCAAGGAGTCGCGTGTTGTGCACGCACTGCGGGCGC
GCGGCGCGCTGATCCGCATCGGACATGATGCGTCATTGCTGGACTTGCTGCCTGGCGGCGCTACCGCAGTCATTACCATC
CGCACTGCCATCCCCAAGACTAACCCCGAGCTGGTCGAAGCCCGGAGGCGCGGCATTCCGGTTCTATTGCGATCGGCCGT
GTTGGCCAGGCTGATGGATGGGTGTACCACGCTGATGGTTGCTGGCACACACGGCAAGACTACGACGACGTCGATGCTCG
TTGTGGCCCTGCAGCACTGTGGATGTGACCCATCCTTCGTGGTTGGCGGTGAGCTTGCCGTGGTGGGCACCAACGCCCAC
CACGGCCTCGGCGCCTGCTTCGTTGCCGAGGCCGACGAAAGCGATGGCTCGTTACTGGAATACACGCCCAACGTAGCGGT
GGTCACCAACATCGACTCCGATCACTTGGATTTCTACGGTAGTGTCGATGCTTATATCAGGGTGTTCGACTCCTTCGTGG
AGCGATTCGCACTGGGGGGAGCGCTCGTGGTGTGCAACGACGATCCTGGGGCGGCCGCGCTGGCCCGGCGCACCGCCGAG
CTTGGGATCCGGGTGTTGCGCTACGGCTCCGACGACCGGATAGGTGAGACCTTGGCCGCCAGGTTGTTGTCGTGGGAGCA
ACAGGGCACCGGAGCGGTCGCGCACATCCAGTTGGCTGGTCAACCAAACTCACGGGTGATGCGGCTACCGGTACCTGGGC
GACACATGGCGCTCAATGCGCTAGGTGCGTTGCTGGCGGCGATCGAGATTGGTGCGTCGACCGATGAAGTGCTCGACGGG
CTGGCTGGTTTCAGGGGTGTGCGTCGCCGCTTCGAACTGGTTGGGACTTCAGGAGTCGGCCAGGCCTCAAACTCGCTGGT
GCGGGTGTTCGACGACTACGCACACCATCCAACGGAGATCAGCGCGACGCTAGCGGCGTTCCGTATAATGCTTGAGCAGA
GCGGCGGCGGACGCTGCATCGTGGTGTTTCAGCCCCACCTATATTCGCGGACAAAGGCTTTGTCCAGAGAATTTGGTCGT
GCCCTGAGTGCTGCCGATGAGGTGTTCATCGTTGGTGTCAACGGTGCCCGCGAACAACCGCTTGCTGGCGTCAGCGGAGC
TAGTGTTGCTAAACATGTCAGCGTGCCGGTGCGCTATATACCAGACTATTCGGCGGTCGTCATAGAGGTTGCTGCTGCGG
CTGGCCCCGGCGACGTCATCGTTACGATGGGTATCGGCGACGTGGGCCTGCTGGGGCCGGAGATCGTTGCCGCGCTGCGG
GTCCGGGCCAACTGCAACACTCCCGGCTGTTCGGGAGTGTTGCAGTGA

Upstream 100 bases:

>100_bases
TGGGACATCGCGATGCGGCACATCATGTCGCCAAGGTGGCACTGGATCTGGCACGTGCAGAGCGTGACACGGCGTCAGGA
CGGTCGGCCGGAGGGAAACC

Downstream 100 bases:

>100_bases
CAGAGACGGACGAGGGTGCACCAGTCAACCATTCGGCGACGATGTGGGCTGTAGTGGGGGTGCCGCCCGTTTGCGGGGGA
CAACCGGGCGATTCGGGTGT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNAGQLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKESRVVHALRARGALIRIGHDASLLDLLPGGATAVITI
RTAIPKTNPELVEARRRGIPVLLRSAVLARLMDGCTTLMVAGTHGKTTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAH
HGLGACFVAEADESDGSLLEYTPNVAVVTNIDSDHLDFYGSVDAYIRVFDSFVERFALGGALVVCNDDPGAAALARRTAE
LGIRVLRYGSDDRIGETLAARLLSWEQQGTGAVAHIQLAGQPNSRVMRLPVPGRHMALNALGALLAAIEIGASTDEVLDG
LAGFRGVRRRFELVGTSGVGQASNSLVRVFDDYAHHPTEISATLAAFRIMLEQSGGGRCIVVFQPHLYSRTKALSREFGR
ALSAADEVFIVGVNGAREQPLAGVSGASVAKHVSVPVRYIPDYSAVVIEVAAAAGPGDVIVTMGIGDVGLLGPEIVAALR
VRANCNTPGCSGVLQ

Sequences:

>Translated_495_residues
MNAGQLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKESRVVHALRARGALIRIGHDASLLDLLPGGATAVITI
RTAIPKTNPELVEARRRGIPVLLRSAVLARLMDGCTTLMVAGTHGKTTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAH
HGLGACFVAEADESDGSLLEYTPNVAVVTNIDSDHLDFYGSVDAYIRVFDSFVERFALGGALVVCNDDPGAAALARRTAE
LGIRVLRYGSDDRIGETLAARLLSWEQQGTGAVAHIQLAGQPNSRVMRLPVPGRHMALNALGALLAAIEIGASTDEVLDG
LAGFRGVRRRFELVGTSGVGQASNSLVRVFDDYAHHPTEISATLAAFRIMLEQSGGGRCIVVFQPHLYSRTKALSREFGR
ALSAADEVFIVGVNGAREQPLAGVSGASVAKHVSVPVRYIPDYSAVVIEVAAAAGPGDVIVTMGIGDVGLLGPEIVAALR
VRANCNTPGCSGVLQ
>Mature_495_residues
MNAGQLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKESRVVHALRARGALIRIGHDASLLDLLPGGATAVITI
RTAIPKTNPELVEARRRGIPVLLRSAVLARLMDGCTTLMVAGTHGKTTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAH
HGLGACFVAEADESDGSLLEYTPNVAVVTNIDSDHLDFYGSVDAYIRVFDSFVERFALGGALVVCNDDPGAAALARRTAE
LGIRVLRYGSDDRIGETLAARLLSWEQQGTGAVAHIQLAGQPNSRVMRLPVPGRHMALNALGALLAAIEIGASTDEVLDG
LAGFRGVRRRFELVGTSGVGQASNSLVRVFDDYAHHPTEISATLAAFRIMLEQSGGGRCIVVFQPHLYSRTKALSREFGR
ALSAADEVFIVGVNGAREQPLAGVSGASVAKHVSVPVRYIPDYSAVVIEVAAAAGPGDVIVTMGIGDVGLLGPEIVAALR
VRANCNTPGCSGVLQ

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=489, Percent_Identity=34.9693251533742, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1790680, Length=492, Percent_Identity=29.0650406504065, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_MYCLB (B8ZQQ1)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503328.1
- ProteinModelPortal:   B8ZQQ1
- SMR:   B8ZQQ1
- EnsemblBacteria:   EBMYCT00000087018
- GeneID:   7324940
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000015779
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51589; Mature: 51589

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGQLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKESRVVHALRARGALIRI
CCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEE
GHDASLLDLLPGGATAVITIRTAIPKTNPELVEARRRGIPVLLRSAVLARLMDGCTTLMV
CCCCCHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
AGTHGKTTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAHHGLGACFVAEADESDGSLLE
ECCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCCCCCEEE
YTPNVAVVTNIDSDHLDFYGSVDAYIRVFDSFVERFALGGALVVCNDDPGAAALARRTAE
ECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
LGIRVLRYGSDDRIGETLAARLLSWEQQGTGAVAHIQLAGQPNSRVMRLPVPGRHMALNA
HCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEECCCCCHHHHHH
LGALLAAIEIGASTDEVLDGLAGFRGVRRRFELVGTSGVGQASNSLVRVFDDYAHHPTEI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHCCCCCHH
SATLAAFRIMLEQSGGGRCIVVFQPHLYSRTKALSREFGRALSAADEVFIVGVNGAREQP
HHHHHHHHHHEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
LAGVSGASVAKHVSVPVRYIPDYSAVVIEVAAAAGPGDVIVTMGIGDVGLLGPEIVAALR
CCCCCCCHHHHHCCCCEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHH
VRANCNTPGCSGVLQ
HCCCCCCCCCCCCCC
>Mature Secondary Structure
MNAGQLPPELQRVHMVGIGGSGMSGIARILLDRGGLVSGSDAKESRVVHALRARGALIRI
CCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEE
GHDASLLDLLPGGATAVITIRTAIPKTNPELVEARRRGIPVLLRSAVLARLMDGCTTLMV
CCCCCHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
AGTHGKTTTTSMLVVALQHCGCDPSFVVGGELAVVGTNAHHGLGACFVAEADESDGSLLE
ECCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCCCCCCEEEEEECCCCCCCEEE
YTPNVAVVTNIDSDHLDFYGSVDAYIRVFDSFVERFALGGALVVCNDDPGAAALARRTAE
ECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
LGIRVLRYGSDDRIGETLAARLLSWEQQGTGAVAHIQLAGQPNSRVMRLPVPGRHMALNA
HCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEECCCCCHHHHHH
LGALLAAIEIGASTDEVLDGLAGFRGVRRRFELVGTSGVGQASNSLVRVFDDYAHHPTEI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHCCCCCHH
SATLAAFRIMLEQSGGGRCIVVFQPHLYSRTKALSREFGRALSAADEVFIVGVNGAREQP
HHHHHHHHHHEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
LAGVSGASVAKHVSVPVRYIPDYSAVVIEVAAAAGPGDVIVTMGIGDVGLLGPEIVAALR
CCCCCCCHHHHHCCCCEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHH
VRANCNTPGCSGVLQ
HCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA