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The map label for this gene is fadE24 [H]

Identifier: 221229751

GI number: 221229751

Start: 797301

End: 798698

Strand: Reverse

Name: fadE24 [H]

Synonym: MLBr_00661

Alternate gene names: 221229751

Gene position: 798698-797301 (Counterclockwise)

Preceding gene: 221229752

Following gene: 221229750

Centisome position: 24.44

GC content: 61.16

Gene sequence:

>1398_bases
ATGACTGACACTGCTCCTAGTGCTAAGCCCTCTTCCGTTCGTCTCAAACGAGGCGGTCTTAGGTCCGGCGTCGGAATGCA
GCCACACAAGCGGACTGGATTTGACGTCGCAATTGCGATGCTTACTCCGCTTGTCGGCCAGGATTTTCTGGATAAATACC
ATCTGCGCTATCCGCTCAACCGAGCGTTGCGCTACGGGGTTAAGGCGACGTTCTCCACTGCCGCCGCCACCAGCCGGCAG
TTCAAGCGGGTGCAAAACCTGCGCGGTGGCGCAACCCGGCTACAGCCCAGCGGCAGGAACTACTTCGACCTGACGCCAGA
CGACAACCAAAAGTTGATCGTCGAAACTATCGACGAATTCAGCGCAGAGATACTGCGGCCTGCTGCTCACGACGCTGATG
AAGCCGCGGCCTACCCGCCCGACCTTATCGCCAAAGCCGCTAAGTTGGGCATCACCACGATCAACATTCCCGAGTATTTT
GACGGCATCGCCGAACGCCGTTCCAGTGTGACCAATGTGTTGGTGGCCGAGGCGCTGGCATATGGCGACATGGGATTGAC
GCTGCCGATTCTGGCCCCAGGCGGTGTGGCGGCTACACTAACCTATTGGGGCAGCGCCGATCAACAGGCCACCTACCTGA
AAGAGTTCACCGGCGAAAATGTCCCCCAGGCCTGTGTGGCCATCGCCGAACCCCAGCCGTTGTTCGACCCCACCCGGCTG
AAGACCATCGCCGTGCGCACCCCGTCCGGATACCGGCTCGACGGGGTGAAGTCATTGGTTCCGGCCGCGGCCAGCGCCGA
ACTGTTCATCATCGGTGCCCAGCTGAATGGCAAGCCAGCATTGTTCATCGTCGAGTCCTCGACTAAAGGCCTGACTGTCA
AGGCCGACCCTAGCATGGGGATTCGCGCTGCAGCCTTGGGCCAAGTTGAACTCTGCGGAGTGTCGGCGCCCTTGGACGCC
CGGCTGGGTGAAGACGACGCGACGGATAATGACTACTCTGAAGCGATCGCATTGGCCCGGCTAGGATGGGCGGCGCTGGC
GGTCGGCACCTCGCATGCAGTGCTGGACTATGTCATGCCGTACGTAAAAGAACGCGAAGCCTTTGGTGAGCCAATCGCGC
GTCGCCAGGCTGTCGCGTTCATGTGCGCCAACATCGCTATCGAGTTAGACGGGCTGCGGCTGATCACGTGGCGTGGCGCG
TCCCGCGCCGAACAAGGCCTCTCATTCGCCCGGGAAGCAGCACTGGCCAAGCGACTCGGCTCCGACAAAGCCATGCAAAT
CGGCCTGGACGGCGTGCAACTGCTGGGCGGTCACGGCTTCATCAAAGAGCACCCGGTCGAACGCTGGTATCGCGATCTGC
GGGCGATCGGTGTCGCCGAGGGCGTCGTAGTTATCTAG

Upstream 100 bases:

>100_bases
AGAATCGGCGCCACTGTGAAGTAGTTAACAGGATAATCCTACCTTACTCCAGAGTAAGGTAGGATTATCCGCATCGCCCC
AACGATCTGAAGCTGCTGAC

Downstream 100 bases:

>100_bases
GGAATCTAAAATCTGCATCTTCTTCAAAGCGAAAGATCAATCATGGCAATCAACCTGGAGCTATCGCGCAAGCTGCAAGC
GGTAATCGTTAAGACCCATC

Product: putative acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFLDKYHLRYPLNRALRYGVKATFSTAAATSRQ
FKRVQNLRGGATRLQPSGRNYFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLGITTINIPEYF
DGIAERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATLTYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRL
KTIAVRTPSGYRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMGIRAAALGQVELCGVSAPLDA
RLGEDDATDNDYSEAIALARLGWAALAVGTSHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGA
SRAEQGLSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIKEHPVERWYRDLRAIGVAEGVVVI

Sequences:

>Translated_465_residues
MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFLDKYHLRYPLNRALRYGVKATFSTAAATSRQ
FKRVQNLRGGATRLQPSGRNYFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLGITTINIPEYF
DGIAERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATLTYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRL
KTIAVRTPSGYRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMGIRAAALGQVELCGVSAPLDA
RLGEDDATDNDYSEAIALARLGWAALAVGTSHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGA
SRAEQGLSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIKEHPVERWYRDLRAIGVAEGVVVI
>Mature_464_residues
TDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFLDKYHLRYPLNRALRYGVKATFSTAAATSRQF
KRVQNLRGGATRLQPSGRNYFDLTPDDNQKLIVETIDEFSAEILRPAAHDADEAAAYPPDLIAKAAKLGITTINIPEYFD
GIAERRSSVTNVLVAEALAYGDMGLTLPILAPGGVAATLTYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRLK
TIAVRTPSGYRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMGIRAAALGQVELCGVSAPLDAR
LGEDDATDNDYSEAIALARLGWAALAVGTSHAVLDYVMPYVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGAS
RAEQGLSFAREAALAKRLGSDKAMQIGLDGVQLLGGHGFIKEHPVERWYRDLRAIGVAEGVVVI

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=367, Percent_Identity=27.5204359673025, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI4501859, Length=370, Percent_Identity=29.7297297297297, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI187960098, Length=409, Percent_Identity=28.361858190709, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4557231, Length=400, Percent_Identity=29, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI226958412, Length=366, Percent_Identity=25.9562841530055, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI7656849, Length=363, Percent_Identity=24.5179063360882, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI76496475, Length=367, Percent_Identity=26.4305177111717, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4557235, Length=367, Percent_Identity=26.4305177111717, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=25.7217847769029, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI226958414, Length=324, Percent_Identity=26.8518518518519, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503943, Length=421, Percent_Identity=26.8408551068884, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI7669494, Length=421, Percent_Identity=26.8408551068884, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI21361497, Length=345, Percent_Identity=23.1884057971014, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=367, Percent_Identity=25.0681198910082, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081958, Length=373, Percent_Identity=24.6648793565684, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=31.6353887399464, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17534899, Length=373, Percent_Identity=31.9034852546917, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=28.8409703504043, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17570075, Length=397, Percent_Identity=28.463476070529, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17508101, Length=361, Percent_Identity=27.4238227146814, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17534353, Length=369, Percent_Identity=24.1192411924119, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=300, Percent_Identity=26.3333333333333, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533517, Length=359, Percent_Identity=22.0055710306407, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985184, Length=344, Percent_Identity=24.4186046511628, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=25.7352941176471, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32563615, Length=242, Percent_Identity=28.5123966942149, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=367, Percent_Identity=22.3433242506812, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=30.0268096514745, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24660351, Length=402, Percent_Identity=30.8457711442786, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=28.2258064516129, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646207, Length=366, Percent_Identity=26.2295081967213, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21355753, Length=372, Percent_Identity=25.2688172043011, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363737, Length=384, Percent_Identity=24.7395833333333, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 49834; Mature: 49702

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFLDKYHLRYPLN
CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
RALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRNYFDLTPDDNQKLIVETIDEF
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEECCCCCCCEEHHHHHHHH
SAEILRPAAHDADEAAAYPPDLIAKAAKLGITTINIPEYFDGIAERRSSVTNVLVAEALA
HHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
YGDMGLTLPILAPGGVAATLTYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRL
HCCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHCCCCCCHHHHEECCCCCCCCCCCE
KTIAVRTPSGYRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMG
EEEEEECCCCCEECCHHHHCCCCCCCEEEEEEEEECCCEEEEEEECCCCCEEEEECCCCC
IRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALARLGWAALAVGTSHAVLDYVMP
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
YVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGASRAEQGLSFAREAALAKRLG
HHHHHHHHCCHHHHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHC
SDKAMQIGLDGVQLLGGHGFIKEHPVERWYRDLRAIGVAEGVVVI
CCCEEEECCCCEEEECCCCCHHCCCHHHHHHHHHHHHHCCCEEEC
>Mature Secondary Structure 
TDTAPSAKPSSVRLKRGGLRSGVGMQPHKRTGFDVAIAMLTPLVGQDFLDKYHLRYPLN
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
RALRYGVKATFSTAAATSRQFKRVQNLRGGATRLQPSGRNYFDLTPDDNQKLIVETIDEF
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEECCCCCCCEEHHHHHHHH
SAEILRPAAHDADEAAAYPPDLIAKAAKLGITTINIPEYFDGIAERRSSVTNVLVAEALA
HHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
YGDMGLTLPILAPGGVAATLTYWGSADQQATYLKEFTGENVPQACVAIAEPQPLFDPTRL
HCCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHCCCCCCHHHHEECCCCCCCCCCCE
KTIAVRTPSGYRLDGVKSLVPAAASAELFIIGAQLNGKPALFIVESSTKGLTVKADPSMG
EEEEEECCCCCEECCHHHHCCCCCCCEEEEEEEEECCCEEEEEEECCCCCEEEEECCCCC
IRAAALGQVELCGVSAPLDARLGEDDATDNDYSEAIALARLGWAALAVGTSHAVLDYVMP
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
YVKEREAFGEPIARRQAVAFMCANIAIELDGLRLITWRGASRAEQGLSFAREAALAKRLG
HHHHHHHHCCHHHHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHC
SDKAMQIGLDGVQLLGGHGFIKEHPVERWYRDLRAIGVAEGVVVI
CCCEEEECCCCEEEECCCCCHHCCCHHHHHHHHHHHHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]