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The map label for this gene is hisN [H]

Identifier: 221229752

GI number: 221229752

Start: 798775

End: 799542

Strand: Reverse

Name: hisN [H]

Synonym: MLBr_00662

Alternate gene names: 221229752

Gene position: 799542-798775 (Counterclockwise)

Preceding gene: 221229755

Following gene: 221229751

Centisome position: 24.47

GC content: 64.71

Gene sequence:

>768_bases
ATGTTAGCGCTGACGCTGGCCGACCGCGCAGACGCACTGACTAGCGCCCGTTTCGGCGCACTCAATCTGCGCGTCGACAC
CAAACCAGATCTTACTCCGGTCACCGACGCCGATCGCGCGGTCGAAGCCGATGTGCGTGCGGTACTCGGGCGCGAACGGC
CTAAAGACGGCATCCTGGGAGAAGAATACGGCGGTACAATAACTTTCAGTGGACAGCAGTGGATCGTCGACCCGATCGAC
GGCACCAAGAACTTCGTGCGCGGGGTGCCAGTGTGGGCCAGTTTGATCGCATTGCTCGAGGACGGGGTCCCCTCAATCGG
CGTCGTCAGCGCGCCCGCGCTGCAACGACGGTGGTGGGCAGCACGCGGCCAAGGCGCGTTCGTGGCGGTCGATGGGGTCC
CGCGCCGGCTAGCGGTGTCGGAGGTGGCCGACCTCAATTCGGCGAGTCTGTCATTCTCCAGCTTGTCCGGGTGGGCACAG
CGCGGTTTACGCGACCGGTTCCTTGAGTTGACCGACGCCGTGTGGCGGGTACGCGCCTACGGCGATTTCCTATCTTATTG
CCTGCTCGCTGAGGGAGCTATCGACGTCGCTGCCGAGCCGAAGGTATCGGTGTGGGACTTAGCTGCCCTCGACATCGTGG
TGCGCGAGGCGGGTGGAGTTCTGACCGGTCTCGACGGGACCCCCGGCCCGCATGGCGGCAGCGCTGTGGCGACAAACGGT
CGCCTGCACCAAGAGGTGCTGACCAGAATCGGCGCCACTGTGAAGTAG

Upstream 100 bases:

>100_bases
TGCTGACATAGATCGCTACGACGACGACGTAGACGTAGAGTGATCTAGGGGTCCCCAGCTTACGGGGAGAGGAGCGGTAC
GCATAGCTCAGGACAATCTG

Downstream 100 bases:

>100_bases
TTAACAGGATAATCCTACCTTACTCCAGAGTAAGGTAGGATTATCCGCATCGCCCCAACGATCTGAAGCTGCTGACATGA
CTGACACTGCTCCTAGTGCT

Product: putative monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MLALTLADRADALTSARFGALNLRVDTKPDLTPVTDADRAVEADVRAVLGRERPKDGILGEEYGGTITFSGQQWIVDPID
GTKNFVRGVPVWASLIALLEDGVPSIGVVSAPALQRRWWAARGQGAFVAVDGVPRRLAVSEVADLNSASLSFSSLSGWAQ
RGLRDRFLELTDAVWRVRAYGDFLSYCLLAEGAIDVAAEPKVSVWDLAALDIVVREAGGVLTGLDGTPGPHGGSAVATNG
RLHQEVLTRIGATVK

Sequences:

>Translated_255_residues
MLALTLADRADALTSARFGALNLRVDTKPDLTPVTDADRAVEADVRAVLGRERPKDGILGEEYGGTITFSGQQWIVDPID
GTKNFVRGVPVWASLIALLEDGVPSIGVVSAPALQRRWWAARGQGAFVAVDGVPRRLAVSEVADLNSASLSFSSLSGWAQ
RGLRDRFLELTDAVWRVRAYGDFLSYCLLAEGAIDVAAEPKVSVWDLAALDIVVREAGGVLTGLDGTPGPHGGSAVATNG
RLHQEVLTRIGATVK
>Mature_255_residues
MLALTLADRADALTSARFGALNLRVDTKPDLTPVTDADRAVEADVRAVLGRERPKDGILGEEYGGTITFSGQQWIVDPID
GTKNFVRGVPVWASLIALLEDGVPSIGVVSAPALQRRWWAARGQGAFVAVDGVPRRLAVSEVADLNSASLSFSSLSGWAQ
RGLRDRFLELTDAVWRVRAYGDFLSYCLLAEGAIDVAAEPKVSVWDLAALDIVVREAGGVLTGLDGTPGPHGGSAVATNG
RLHQEVLTRIGATVK

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=261, Percent_Identity=29.8850574712644, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI221625487, Length=261, Percent_Identity=29.8850574712644, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI7657236, Length=216, Percent_Identity=31.0185185185185, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1788882, Length=227, Percent_Identity=29.5154185022026, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790659, Length=185, Percent_Identity=31.3513513513514, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=241, Percent_Identity=31.5352697095436, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193202572, Length=235, Percent_Identity=30.6382978723404, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320493, Length=201, Percent_Identity=30.3482587064677, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357329, Length=201, Percent_Identity=31.8407960199005, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664918, Length=207, Percent_Identity=32.3671497584541, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357957, Length=205, Percent_Identity=30.2439024390244, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664926, Length=196, Percent_Identity=29.5918367346939, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664922, Length=237, Percent_Identity=25.7383966244726, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357303, Length=200, Percent_Identity=27, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27041; Mature: 27041

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALTLADRADALTSARFGALNLRVDTKPDLTPVTDADRAVEADVRAVLGRERPKDGILG
CEEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
EEYGGTITFSGQQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSIGVVSAPALQRRWWA
CCCCCEEEECCCEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCCCCEECCHHHHHHHHH
ARGQGAFVAVDGVPRRLAVSEVADLNSASLSFSSLSGWAQRGLRDRFLELTDAVWRVRAY
CCCCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDFLSYCLLAEGAIDVAAEPKVSVWDLAALDIVVREAGGVLTGLDGTPGPHGGSAVATNG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEECC
RLHQEVLTRIGATVK
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MLALTLADRADALTSARFGALNLRVDTKPDLTPVTDADRAVEADVRAVLGRERPKDGILG
CEEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
EEYGGTITFSGQQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSIGVVSAPALQRRWWA
CCCCCEEEECCCEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCCCCEECCHHHHHHHHH
ARGQGAFVAVDGVPRRLAVSEVADLNSASLSFSSLSGWAQRGLRDRFLELTDAVWRVRAY
CCCCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDFLSYCLLAEGAIDVAAEPKVSVWDLAALDIVVREAGGVLTGLDGTPGPHGGSAVATNG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEECC
RLHQEVLTRIGATVK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]