| Definition | Mycobacterium leprae Br4923 chromosome, complete genome. |
|---|---|
| Accession | NC_011896 |
| Length | 3,268,071 |
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The map label for this gene is dnaJ2
Identifier: 221229733
GI number: 221229733
Start: 757882
End: 759018
Strand: Direct
Name: dnaJ2
Synonym: MLBr_00625
Alternate gene names: 221229733
Gene position: 757882-759018 (Clockwise)
Preceding gene: 221229732
Following gene: 221229734
Centisome position: 23.19
GC content: 62.62
Gene sequence:
>1137_bases GTGGCACGCGATTATTACGGGCTGCTCGGCGTGAGCAGGAATGCCAGCGATGCGGACATCAAGCGTGCCTATCGCAAGCT AGCGCGCGAACTGCATCCCGACATCAATCCCGATGAGGCCGCGCAGGCGAAATTCAAGGAAATCAGCATGGCTTACGAGG TGCTGAGCGACCCGGAGAAGCGTCGGATCGTCGATTTGGGCGGGGATCCGATGGAAAACGCCGCAGCATCTCCGTCAGGG TTCGGTGGCTTTGGTGGCTTAGGTGATGTATTCGAAGCCTTCTTTGGCGGGAGTTCGGCATCACGTGGTCCCATCGGCCG GGTGCGGCCGGGCTCGGACTCGTTGTTGCCGATGTGGCTCGACCTTGAAGAGTGCGCAACCGGTGTCACCAAGCAGGTCA CCGTTGACACTGCAGTGCTATGTGACCGATGCCAGGGCAAGGGCACCAACGGTGATTCTGCGCCGATACCCTGCGACACA TGCGGGGGTCGCGGGGAGGTGCAGACCGTGCAGCGTTCACTGCTAGGTCAGATGGTGACCGCGCGGCCATGTCCCACCTG CCGGGGTGTTGGGGTCGTAATCCCCGACCCGTGCTGCCAATGCGTTGGCGACGGTAGGGTGCGCGCCCGTCGGGAGATCA CCGTCAAGATCCCCTCCGGTGTTGGCGACGGGATGCGGGTCCGACTTGCCGCCCAGGGTGAGGTTGGGCCCGGGGGAGGG CCAGCAGGCGACTTGTATGTCGAGGTCCACGAGCAGGCCCACGACATCTTTGTGCGCGACGGAGACGATCTGCACTGCAC AGTTTCGGTGCCGATGGTCGATGCGGCTCTAGGCACCACGATCACCGTAGATGCCATCTTGGATGGTATGAGTGAGATCG ATATTTCGCCGGGGACCCAACCGGGTTCGGTCATCGAACTGCGTGGCCAAGGGATGCCGCACTTGCGTTCCAACACGCGG GGCAATTTGCATGTTCACGTCGAGGTGATGGTCCCCACTCGGCTGGACCAGCATGACACCGAACTGCTACGCGAACTGAA GCGCCGTCGCAGCCGTGACGTGGCCGAGGTTCGTTCGACGCATGCGGCCGGCGGCGGACTGTTCAGCCGGCTGCGCGAGA CCTTTACCAATCGTTAG
Upstream 100 bases:
>100_bases ATATCGGCGAAGTTTTGGGTGCTCGGTGAACACGCACCCGCTACGGAATCTGTGGACAGCCGCTTAGAAGCGGCATAAGA CGCTGCTAGGAGAGTTAGGC
Downstream 100 bases:
>100_bases CACGGTTTTAACGGTTTTAGGGGCTCCACATGTGGTGAGCACATTGTTCTACGTCGACGCATTGCCCGATACCGGTACGG TAGCTGTGGTGGGTGGCGAC
Product: chaperone protein DnaJ
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 378; Mature: 377
Protein sequence:
>378_residues MARDYYGLLGVSRNASDADIKRAYRKLARELHPDINPDEAAQAKFKEISMAYEVLSDPEKRRIVDLGGDPMENAAASPSG FGGFGGLGDVFEAFFGGSSASRGPIGRVRPGSDSLLPMWLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSAPIPCDT CGGRGEVQTVQRSLLGQMVTARPCPTCRGVGVVIPDPCCQCVGDGRVRARREITVKIPSGVGDGMRVRLAAQGEVGPGGG PAGDLYVEVHEQAHDIFVRDGDDLHCTVSVPMVDAALGTTITVDAILDGMSEIDISPGTQPGSVIELRGQGMPHLRSNTR GNLHVHVEVMVPTRLDQHDTELLRELKRRRSRDVAEVRSTHAAGGGLFSRLRETFTNR
Sequences:
>Translated_378_residues MARDYYGLLGVSRNASDADIKRAYRKLARELHPDINPDEAAQAKFKEISMAYEVLSDPEKRRIVDLGGDPMENAAASPSG FGGFGGLGDVFEAFFGGSSASRGPIGRVRPGSDSLLPMWLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSAPIPCDT CGGRGEVQTVQRSLLGQMVTARPCPTCRGVGVVIPDPCCQCVGDGRVRARREITVKIPSGVGDGMRVRLAAQGEVGPGGG PAGDLYVEVHEQAHDIFVRDGDDLHCTVSVPMVDAALGTTITVDAILDGMSEIDISPGTQPGSVIELRGQGMPHLRSNTR GNLHVHVEVMVPTRLDQHDTELLRELKRRRSRDVAEVRSTHAAGGGLFSRLRETFTNR >Mature_377_residues ARDYYGLLGVSRNASDADIKRAYRKLARELHPDINPDEAAQAKFKEISMAYEVLSDPEKRRIVDLGGDPMENAAASPSGF GGFGGLGDVFEAFFGGSSASRGPIGRVRPGSDSLLPMWLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSAPIPCDTC GGRGEVQTVQRSLLGQMVTARPCPTCRGVGVVIPDPCCQCVGDGRVRARREITVKIPSGVGDGMRVRLAAQGEVGPGGGP AGDLYVEVHEQAHDIFVRDGDDLHCTVSVPMVDAALGTTITVDAILDGMSEIDISPGTQPGSVIELRGQGMPHLRSNTRG NLHVHVEVMVPTRLDQHDTELLRELKRRRSRDVAEVRSTHAAGGGLFSRLRETFTNR
Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon
COG id: COG0484
COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 J domain
Homologues:
Organism=Homo sapiens, GI205360838, Length=349, Percent_Identity=33.2378223495702, Blast_Score=185, Evalue=6e-47, Organism=Homo sapiens, GI205360840, Length=349, Percent_Identity=33.2378223495702, Blast_Score=185, Evalue=7e-47, Organism=Homo sapiens, GI5031741, Length=340, Percent_Identity=35.8823529411765, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI4504511, Length=336, Percent_Identity=33.0357142857143, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI194328760, Length=338, Percent_Identity=33.4319526627219, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI194328758, Length=338, Percent_Identity=33.4319526627219, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI7706495, Length=362, Percent_Identity=31.4917127071823, Blast_Score=132, Evalue=6e-31, Organism=Homo sapiens, GI194328762, Length=303, Percent_Identity=30.03300330033, Blast_Score=119, Evalue=3e-27, Organism=Homo sapiens, GI6631085, Length=370, Percent_Identity=28.3783783783784, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI5453690, Length=359, Percent_Identity=26.1838440111421, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI194306642, Length=102, Percent_Identity=48.0392156862745, Blast_Score=89, Evalue=6e-18, Organism=Homo sapiens, GI194306640, Length=102, Percent_Identity=48.0392156862745, Blast_Score=89, Evalue=6e-18, Organism=Homo sapiens, GI39204547, Length=168, Percent_Identity=33.9285714285714, Blast_Score=85, Evalue=1e-16, Organism=Homo sapiens, GI56687498, Length=109, Percent_Identity=44.954128440367, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI17388799, Length=104, Percent_Identity=50.9615384615385, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI4885495, Length=104, Percent_Identity=50.9615384615385, Blast_Score=84, Evalue=3e-16, Organism=Homo sapiens, GI72534740, Length=104, Percent_Identity=43.2692307692308, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI201862518, Length=126, Percent_Identity=35.7142857142857, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI56549115, Length=126, Percent_Identity=35.7142857142857, Blast_Score=80, Evalue=4e-15, Organism=Homo sapiens, GI201862587, Length=126, Percent_Identity=35.7142857142857, Blast_Score=80, Evalue=4e-15, Organism=Homo sapiens, GI23503241, Length=105, Percent_Identity=47.6190476190476, Blast_Score=80, Evalue=5e-15, Organism=Homo sapiens, GI47777312, Length=131, Percent_Identity=40.4580152671756, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI27151736, Length=105, Percent_Identity=46.6666666666667, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI88501736, Length=105, Percent_Identity=46.6666666666667, Blast_Score=77, Evalue=3e-14, Organism=Homo sapiens, GI21553335, Length=67, Percent_Identity=56.7164179104478, Blast_Score=76, Evalue=5e-14, Organism=Homo sapiens, GI22749377, Length=102, Percent_Identity=40.1960784313725, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI9558755, Length=169, Percent_Identity=32.5443786982249, Blast_Score=72, Evalue=8e-13, Organism=Homo sapiens, GI21361912, Length=62, Percent_Identity=50, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI5453980, Length=85, Percent_Identity=49.4117647058824, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI68077168, Length=63, Percent_Identity=53.968253968254, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI68077166, Length=63, Percent_Identity=53.968253968254, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1786197, Length=351, Percent_Identity=40.7407407407407, Blast_Score=244, Evalue=6e-66, Organism=Escherichia coli, GI1787235, Length=350, Percent_Identity=26.8571428571429, Blast_Score=130, Evalue=2e-31, Organism=Caenorhabditis elegans, GI17553096, Length=353, Percent_Identity=30.3116147308782, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17553098, Length=353, Percent_Identity=30.3116147308782, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17507263, Length=352, Percent_Identity=34.6590909090909, Blast_Score=152, Evalue=3e-37, Organism=Caenorhabditis elegans, GI17563890, Length=359, Percent_Identity=33.4261838440111, Blast_Score=145, Evalue=3e-35, Organism=Caenorhabditis elegans, GI212645553, Length=336, Percent_Identity=32.1428571428571, Blast_Score=124, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17534355, Length=356, Percent_Identity=26.9662921348315, Blast_Score=111, Evalue=6e-25, Organism=Caenorhabditis elegans, GI17554644, Length=99, Percent_Identity=53.5353535353535, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17554900, Length=86, Percent_Identity=43.0232558139535, Blast_Score=73, Evalue=3e-13, Organism=Caenorhabditis elegans, GI115532476, Length=65, Percent_Identity=55.3846153846154, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI86563276, Length=114, Percent_Identity=37.719298245614, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17551190, Length=74, Percent_Identity=52.7027027027027, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17510335, Length=77, Percent_Identity=49.3506493506493, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17538236, Length=90, Percent_Identity=43.3333333333333, Blast_Score=65, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6324265, Length=336, Percent_Identity=35.4166666666667, Blast_Score=161, Evalue=2e-40, Organism=Saccharomyces cerevisiae, GI6323870, Length=368, Percent_Identity=29.8913043478261, Blast_Score=130, Evalue=2e-31, Organism=Saccharomyces cerevisiae, GI6323119, Length=380, Percent_Identity=27.8947368421053, Blast_Score=122, Evalue=1e-28, Organism=Saccharomyces cerevisiae, GI6321094, Length=376, Percent_Identity=30.0531914893617, Blast_Score=110, Evalue=3e-25, Organism=Saccharomyces cerevisiae, GI6324252, Length=452, Percent_Identity=23.4513274336283, Blast_Score=90, Evalue=6e-19, Organism=Saccharomyces cerevisiae, GI6323813, Length=109, Percent_Identity=43.1192660550459, Blast_Score=72, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6324103, Length=63, Percent_Identity=57.1428571428571, Blast_Score=71, Evalue=3e-13, Organism=Saccharomyces cerevisiae, GI6320888, Length=95, Percent_Identity=43.1578947368421, Blast_Score=67, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6322194, Length=95, Percent_Identity=44.2105263157895, Blast_Score=67, Evalue=5e-12, Organism=Drosophila melanogaster, GI45549272, Length=370, Percent_Identity=31.6216216216216, Blast_Score=168, Evalue=6e-42, Organism=Drosophila melanogaster, GI45552811, Length=370, Percent_Identity=31.6216216216216, Blast_Score=168, Evalue=7e-42, Organism=Drosophila melanogaster, GI45552813, Length=370, Percent_Identity=31.6216216216216, Blast_Score=168, Evalue=7e-42, Organism=Drosophila melanogaster, GI24646562, Length=342, Percent_Identity=33.6257309941521, Blast_Score=149, Evalue=3e-36, Organism=Drosophila melanogaster, GI24646560, Length=342, Percent_Identity=33.6257309941521, Blast_Score=149, Evalue=3e-36, Organism=Drosophila melanogaster, GI24646558, Length=342, Percent_Identity=33.6257309941521, Blast_Score=149, Evalue=3e-36, Organism=Drosophila melanogaster, GI24646556, Length=342, Percent_Identity=33.6257309941521, Blast_Score=149, Evalue=3e-36, Organism=Drosophila melanogaster, GI21357547, Length=342, Percent_Identity=33.6257309941521, Blast_Score=149, Evalue=3e-36, Organism=Drosophila melanogaster, GI20129487, Length=340, Percent_Identity=34.4117647058824, Blast_Score=148, Evalue=5e-36, Organism=Drosophila melanogaster, GI24584014, Length=340, Percent_Identity=34.4117647058824, Blast_Score=148, Evalue=5e-36, Organism=Drosophila melanogaster, GI19920464, Length=351, Percent_Identity=29.3447293447293, Blast_Score=139, Evalue=4e-33, Organism=Drosophila melanogaster, GI28574949, Length=352, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=2e-24, Organism=Drosophila melanogaster, GI24658562, Length=366, Percent_Identity=26.5027322404372, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI24658555, Length=366, Percent_Identity=26.5027322404372, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI18858081, Length=375, Percent_Identity=28.8, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI24654066, Length=67, Percent_Identity=58.2089552238806, Blast_Score=83, Evalue=3e-16, Organism=Drosophila melanogaster, GI24654070, Length=67, Percent_Identity=58.2089552238806, Blast_Score=83, Evalue=3e-16, Organism=Drosophila melanogaster, GI24654068, Length=67, Percent_Identity=58.2089552238806, Blast_Score=83, Evalue=3e-16, Organism=Drosophila melanogaster, GI24654072, Length=67, Percent_Identity=58.2089552238806, Blast_Score=83, Evalue=3e-16, Organism=Drosophila melanogaster, GI161077138, Length=64, Percent_Identity=59.375, Blast_Score=82, Evalue=6e-16, Organism=Drosophila melanogaster, GI85726398, Length=108, Percent_Identity=42.5925925925926, Blast_Score=80, Evalue=3e-15, Organism=Drosophila melanogaster, GI21355911, Length=84, Percent_Identity=50, Blast_Score=80, Evalue=3e-15, Organism=Drosophila melanogaster, GI24668492, Length=69, Percent_Identity=47.8260869565217, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24762799, Length=104, Percent_Identity=42.3076923076923, Blast_Score=73, Evalue=4e-13, Organism=Drosophila melanogaster, GI21358273, Length=66, Percent_Identity=51.5151515151515, Blast_Score=69, Evalue=6e-12, Organism=Drosophila melanogaster, GI17648033, Length=96, Percent_Identity=41.6666666666667, Blast_Score=66, Evalue=4e-11, Organism=Drosophila melanogaster, GI24584630, Length=80, Percent_Identity=45, Blast_Score=65, Evalue=5e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): DNAJ2_MYCLE (Q49762)
Other databases:
- EMBL: U00016 - EMBL: AL583919 - PIR: S72599 - RefSeq: NP_301518.1 - ProteinModelPortal: Q49762 - EnsemblBacteria: EBMYCT00000028859 - GeneID: 909409 - GenomeReviews: AL450380_GR - KEGG: mle:ML0625 - NMPDR: fig|272631.1.peg.390 - Leproma: ML0625 - GeneTree: EBGT00050000015762 - HOGENOM: HBG635315 - OMA: RDISTAY - ProtClustDB: PRK14278 - BioCyc: MLEP272631:ML0625-MONOMER - GO: GO:0005737 - HAMAP: MF_01152 - InterPro: IPR012724 - InterPro: IPR002939 - InterPro: IPR001623 - InterPro: IPR008971 - InterPro: IPR015609 - InterPro: IPR003095 - InterPro: IPR001305 - Gene3D: G3DSA:1.10.287.110 - Gene3D: G3DSA:2.10.230.10 - PANTHER: PTHR11821 - PRINTS: PR00625 - SMART: SM00271
Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG; SSF46565 DnaJ_N; SSF49493 HSP40_DnaJ_pep; SSF57938 HSP_DnaJ_cys-rich
EC number: NA
Molecular weight: Translated: 40400; Mature: 40269
Theoretical pI: Translated: 6.06; Mature: 6.06
Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2; PS51188 ZF_CR
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.9 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 5.6 %Cys+Met (Translated Protein) 2.9 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 5.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MARDYYGLLGVSRNASDADIKRAYRKLARELHPDINPDEAAQAKFKEISMAYEVLSDPEK CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC RRIVDLGGDPMENAAASPSGFGGFGGLGDVFEAFFGGSSASRGPIGRVRPGSDSLLPMWL CEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE DLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSAPIPCDTCGGRGEVQTVQRSLLGQMVT EHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH ARPCPTCRGVGVVIPDPCCQCVGDGRVRARREITVKIPSGVGDGMRVRLAAQGEVGPGGG CCCCCCCCCCEEECCCHHHHHCCCCCEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCC PAGDLYVEVHEQAHDIFVRDGDDLHCTVSVPMVDAALGTTITVDAILDGMSEIDISPGTQ CCCCEEEEEECCCCEEEEECCCCEEEEEECCHHHHHHCCEEEHHHHHCCHHHCCCCCCCC PGSVIELRGQGMPHLRSNTRGNLHVHVEVMVPTRLDQHDTELLRELKRRRSRDVAEVRST CCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH HAAGGGLFSRLRETFTNR CCCCHHHHHHHHHHHCCC >Mature Secondary Structure ARDYYGLLGVSRNASDADIKRAYRKLARELHPDINPDEAAQAKFKEISMAYEVLSDPEK CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC RRIVDLGGDPMENAAASPSGFGGFGGLGDVFEAFFGGSSASRGPIGRVRPGSDSLLPMWL CEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE DLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSAPIPCDTCGGRGEVQTVQRSLLGQMVT EHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH ARPCPTCRGVGVVIPDPCCQCVGDGRVRARREITVKIPSGVGDGMRVRLAAQGEVGPGGG CCCCCCCCCCEEECCCHHHHHCCCCCEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCC PAGDLYVEVHEQAHDIFVRDGDDLHCTVSVPMVDAALGTTITVDAILDGMSEIDISPGTQ CCCCEEEEEECCCCEEEEECCCCEEEEEECCHHHHHHCCEEEHHHHHCCHHHCCCCCCCC PGSVIELRGQGMPHLRSNTRGNLHVHVEVMVPTRLDQHDTELLRELKRRRSRDVAEVRST CCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH HAAGGGLFSRLRETFTNR CCCCHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11234002