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The map label for this gene is aroE [H]

Identifier: 221229655

GI number: 221229655

Start: 626685

End: 627521

Strand: Direct

Name: aroE [H]

Synonym: MLBr_00515

Alternate gene names: 221229655

Gene position: 626685-627521 (Clockwise)

Preceding gene: 221229654

Following gene: 221229656

Centisome position: 19.18

GC content: 63.8

Gene sequence:

>837_bases
GTGTCCTTGACAGCGTGCGCTAACAAGGGGCCGCGAAAAGCTGGAATTATTGGTTCTCCAATCGCGCATTCCCGTTCCCC
GCACTTGCACCTGGCCGCTTACCGTGCACTGCGTCTCCACGACTGGACGTATGAGCGGATCGAATGCGATGCTGAAGAGC
TCCCGACTGTCGTTAGCGGGTTCGGGCCGCAGTGGGTCGGCGTTTCAGTGACCATGCCGGGCAAATTCGCCGCGCTGCGG
TTCGCCGATGAGCACACTGCACGTGCCAGCCTGGTTGGGTCGGCTAACACGCTGCTGCGGACCCAGCGCGGCTGGCGGGC
CGACAACACCGACATTGATGGTGTGGCGGGGGCGCTGGCGGCGATCGGGCCTTTGGCAGGGCGTGCGCTAGTGTGCGGGT
CGGGCGGCACTGCTCCGGCGGCTGTGATGGGGTTGGCTGAACTGGGCGTCACCGATATCACCGTTTTGGCACGCAATCCC
GACAAGGCGTCCCGGTTGGTCGATCTCGGGGTTCAGGTCGGTGTGGCGACCCGATTGTGCGGTCTGGACAGCGGTGGCTT
GGCAGATGAGGTGAAGGCTGCCGAAGTGCTGGTTAGTACGGTACCGGCAGATGTGGCTGCGCGGTATGTCGATGTCTTCG
CGACGGTCCCGGTGCTGCTAGATGCAATCTACGACCCGTGGCCTACGCCACTGGTCGCAGCGGTGTCCGCGGCGGGCGGC
CGAGTGATCAGCGGCTTGCAAATGCTGTTGCATCAAGCGTTTGCGCAGGTGGAGCAATTCACCGGGATGCCTGCACCGCG
AGAGGCGATGGCTTGTGCTCTGGCGGGTTTGCATTAG

Upstream 100 bases:

>100_bases
GACTGGCTGTACTTCGTCACCGTTGATACCCAGGGGACAACTCTGTTCACCAGGGATTATCAGCAGCATTTAACCAATAT
CGAACTCGCGAAGCACAACG

Downstream 100 bases:

>100_bases
CGTGCCGCGTATGCAGGATAGGGGCCGTTTGTGTGATGCTGATCTGGTTGGCCGGTACTGAGTTTATGACATCAATGTCC
CTGGCCACCATGAGCCTGGC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSLTACANKGPRKAGIIGSPIAHSRSPHLHLAAYRALRLHDWTYERIECDAEELPTVVSGFGPQWVGVSVTMPGKFAALR
FADEHTARASLVGSANTLLRTQRGWRADNTDIDGVAGALAAIGPLAGRALVCGSGGTAPAAVMGLAELGVTDITVLARNP
DKASRLVDLGVQVGVATRLCGLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDAIYDPWPTPLVAAVSAAGG
RVISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH

Sequences:

>Translated_278_residues
MSLTACANKGPRKAGIIGSPIAHSRSPHLHLAAYRALRLHDWTYERIECDAEELPTVVSGFGPQWVGVSVTMPGKFAALR
FADEHTARASLVGSANTLLRTQRGWRADNTDIDGVAGALAAIGPLAGRALVCGSGGTAPAAVMGLAELGVTDITVLARNP
DKASRLVDLGVQVGVATRLCGLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDAIYDPWPTPLVAAVSAAGG
RVISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH
>Mature_277_residues
SLTACANKGPRKAGIIGSPIAHSRSPHLHLAAYRALRLHDWTYERIECDAEELPTVVSGFGPQWVGVSVTMPGKFAALRF
ADEHTARASLVGSANTLLRTQRGWRADNTDIDGVAGALAAIGPLAGRALVCGSGGTAPAAVMGLAELGVTDITVLARNPD
KASRLVDLGVQVGVATRLCGLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDAIYDPWPTPLVAAVSAAGGR
VISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=270, Percent_Identity=29.2592592592593, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789675, Length=249, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320332, Length=283, Percent_Identity=31.8021201413428, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 28746; Mature: 28615

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTACANKGPRKAGIIGSPIAHSRSPHLHLAAYRALRLHDWTYERIECDAEELPTVVSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCHHHHCCCHHHCCHHHHC
FGPQWVGVSVTMPGKFAALRFADEHTARASLVGSANTLLRTQRGWRADNTDIDGVAGALA
CCCCEEEEEEECCCCEEEEEECCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHH
AIGPLAGRALVCGSGGTAPAAVMGLAELGVTDITVLARNPDKASRLVDLGVQVGVATRLC
HHHHHCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
GLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDAIYDPWPTPLVAAVSAAGG
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
RVISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SLTACANKGPRKAGIIGSPIAHSRSPHLHLAAYRALRLHDWTYERIECDAEELPTVVSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCHHHHCCCHHHCCHHHHC
FGPQWVGVSVTMPGKFAALRFADEHTARASLVGSANTLLRTQRGWRADNTDIDGVAGALA
CCCCEEEEEEECCCCEEEEEECCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHH
AIGPLAGRALVCGSGGTAPAAVMGLAELGVTDITVLARNPDKASRLVDLGVQVGVATRLC
HHHHHCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
GLDSGGLADEVKAAEVLVSTVPADVAARYVDVFATVPVLLDAIYDPWPTPLVAAVSAAGG
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
RVISGLQMLLHQAFAQVEQFTGMPAPREAMACALAGLH
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA